The next generation of drones can perform maneuvers that would kill a pilot. If the remote pilot/operator felt it was warranted he could use the entire drone as a weapon. Autonomous control systems are getting scary good at not needing human interaction.
You’d just paint a box on the screen and tell the drone(s) to kill anything that enters the box.
Right now, in in the foreseeable future, no UAV can outperform a jet flown by a fighter-pilot.
Besides, there are many external environmental factors that the pilot experiences when engaged that help him max perform the platform, not the least of which is 360 deg situational awareness, airspeed (energy level), G-loading, weapon envelopes, thinking ahead from where you are to where you are going (or want to be), all these come together to give a complete picture.
Until UAVs can provide that seat-of-the-pants total environment feel and sensory input, there is no way a UAV can even come close to a manned fighter.
How about we field an unmanned tank on the battlefield, first, after all, it is a 2-G, 30-kt, two-dimensional maneuvering platform so it should be easier.
Learn to walk first, then fly.