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Fructose risk factor for metabolic syndrome, diabetes mellitus, and hypertension
FOODCONSUMER ^ | 06/25/2013 | David Liu, PHD

Posted on 06/26/2013 12:02:26 AM PDT by neverdem

Tuesday June 25, 2013 (foodconsumer.org) -- A new report published in Journal of Nutrition and Metabolism suggests that eating foods or drinking beverages with fructose may increase risk of endothelial dysfunction, insulin resistance/diabetes mellitus type 2 and hypertension.

Z. Khitan and D. H. Kim, the authors of the report, from Marshall University Joan Edwards School of Medicine in Huntington, WV, USA say that uric acid resulting from uncontrolled fructose metabolism is the risk factor for metabolic syndrome and diabetes mellitus.

What happens, according to the report, after fructose is ingested is that the sugar in the liver bypasses two highly regulated steps in glycolysis by glucokinase and phosphofructokinase, both subject to regulation by the concentration of their metabolic byproducts.  Fructose, on the other hand, is metabolized by fructokinase (KHK), which has no negative feedback system leading to intracellular phosphate depletion and the rapid generation of uric acid when AMP deaminase is activated.

Uric acid, which is commonly known to be associated with gout, is also known to be linked to endothelial dysfunction, insulin resistance (diabetes mellitus) and hypertension.

Other studies have shown that eating fructose can cause damage to the liver leading to hepatic steatosis or non-alcoholic fatty liver disease, type 2 diabetes mellitus and other chronic diseases.

One study led by Kylie Kavanagh and colleagues at Wake Forest Baptist Medical Center confirms in animal models that eating foods with fructose causes damage to the liver even if there is no weight gain resulting from such a dietary practice.

Early studies have shown fructose and intake of high calories may play a role in the development of obesity and fatty liver diseases, but not all studies are consistent.

The Kavanagh et al. found over the six-week period, a high fructose diet more than doubled liver damage as compared to those on a control diet.

The study is released in the June 19 online edition of the American Journal of Clinical Nutrition.

In a previous trial, Kavanagh's team allowed monkeys to eat as much as they wanted of a low-fat diet high in added fructose for seven years, as compared to controls fed a low-fructose, low-fat diet for the same period.  Those on a high fructose low fat diet gained 50% more weight and were three times more likely to develop diabetes mellitus, hepatic steatosis or non-alcoholic fatty liver disease than those on the low fructose, low fat diet.

Fructose is high in sucrose and high fructose corn syrup (now called corn sugar), which are commonly used in foods and beverages.  Fructose is also found in many fruits, but fruits are generally considered healthier than added fructose.

Because sugars are generally associated with increased risk of type 2 diabetes mellitus, artificial sweeteners are used, particularly in diet beverages.  But even diet soda increases the risk for diabetes mellitus.

Some sugars including glucose and maltose may be healthier. But they are not as sweet as fructose.  It should be noted that starch such as rice starch and wheat starch, which is made of glucose, is safe to eat. 

Many other things such as trans-fat and red meat can also increase risk of type 2 diabetes mellitus while curcumin cna help prevent the disease. (reporting by David Liu, PHD)


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: diabetes; fructose; hfcs; hypertension; metabolicsyndrome; nafld; type2diabetes
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Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

1 posted on 06/26/2013 12:02:26 AM PDT by neverdem
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
FReepmail me if you want on or off the diabetes ping list.
2 posted on 06/26/2013 12:10:51 AM PDT by neverdem (Register pressure cookers! /s)
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To: FBD

Bookmark


3 posted on 06/26/2013 12:21:06 AM PDT by FBD (My carbon footprint is bigger than yours)
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To: neverdem
Back when Durk Pearson and Sandy Shaw were big names in the life extension movement, they published a book or 2 on the subject. I seem to recall them recommending that people use powdered fructose in place of regular table sugar.

This is one of the few times when they seem to have come down on the (as it turns out) wrong side of an issue.

4 posted on 06/26/2013 12:22:42 AM PDT by pbmaltzman
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To: pbmaltzman

I remember watching them YEARS ago. I always wondered what happened to them.


5 posted on 06/26/2013 12:39:07 AM PDT by gattaca ("Empty heads are fond of long titles" Old German Proverb.)
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To: neverdem

I have long suspected that the massive shift from cane sugar to corn syrup as our primary food sweetener has been the primary cause of the stunning increase in the nation’s obesity. I have also been very suspicious of corn syrup’s link to diabetes.

If either or both of these prove true, then it is also true that they are politically induced health disasters as corn syrup was substituted for cane sugar because of high prices caused by cane sugar tariffs.

Ain’t crony government wonderful?!


6 posted on 06/26/2013 12:52:15 AM PDT by DakotaGator (Weep for the lost Republic! And keep your powder dry!!)
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To: neverdem
Fructose is also found in many fruits, but fruits are generally considered healthier than added fructose.

That's because fruits are politically correct ... in more ways than one.

7 posted on 06/26/2013 12:53:04 AM PDT by Mr Ramsbotham (Laws against sodomy are honored in the breech.)
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To: Mr Ramsbotham

HFCS. High fructose corn syrup. One of the main reasons of American obesity.


8 posted on 06/26/2013 1:02:42 AM PDT by D Rider
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To: pbmaltzman
Back when Durk Pearson and Sandy Shaw were big names in the life extension movement,...

I'm assuming the reasoning is that table sugar is composed of molecules of fructose mated to molecules of glucose. Fructose tastes much sweeter than glucose. So, by using fructose only and leaving out the glucose, you can achieve the same amount of sweetening with a smaller amount of added sugar.

9 posted on 06/26/2013 1:10:15 AM PDT by j. earl carter
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To: DakotaGator

I have long suspected that the massive shift from cane sugar to corn syrup as our primary food sweetener has been the primary cause of the stunning increase in the nation’s obesity.


Lets define the problem just a little differently. It Is not the type of sugar but the increase in use of ALL sugars. When I grew up it was a big deal to get a candy bar. Kool aid the sugary drink was being advertised. Sugar was something we bought in town, not produced on the farm so we used it sparingly.


10 posted on 06/26/2013 1:11:42 AM PDT by PeterPrinciple
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To: DakotaGator

Iowa’s fault!


11 posted on 06/26/2013 1:20:46 AM PDT by rfp1234 (Arguing with a marxist is like playing Chess with a Pigeon.)
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To: Mr Ramsbotham

And because they have other nutrients like vitamins and fiber. Your post did make me smile, though.


12 posted on 06/26/2013 1:27:45 AM PDT by snarkytart
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To: neverdem
And another “renowned doctor” says wheat, corn, dairy products, and sugar of all kinds is the problem and certainly meat, possibly fish too.

But we already know baked goods, cell phones, high tension power lines, carbon dioxide, lead and chrome in our water, radon in our basements and artificial sweeteners in our soda are killing us.

Since this is just the start it's no wonder the median age in the U.S. has dropped to about 15. Well hasn't it?

There's still fuels, fracking, fertilizer and fries. I can barely drag myself to a breakfast Quarter Pounder.

13 posted on 06/26/2013 1:46:14 AM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough)
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To: D Rider
Thank Japan. HFCS was invented by Japan in the late 1960s, and came to the U.S. in the early 1970s.

http://www.drweil.com/drw/u/QAA400442/High-Fructose-Corn-Syrup-Too-Sweet-to-Eat.html

If I find anything with high fructose corn syrup in it, it goes right back on the shelf. I also watch out for artificial colors.
14 posted on 06/26/2013 1:55:09 AM PDT by conservative98
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To: neverdem

bm


15 posted on 06/26/2013 1:57:58 AM PDT by skinkinthegrass (who'll take tomorrow,$pend it all today;who can take your income & tax it all away..0'Blowfly can :)
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To: neverdem

This is why I am on the ISAGENIX program
NO artificial sweetners, no high fructose corn syrup, no steroids in the protein, no anti-biotics, no pesticide , all natural processing

http://www.jimbancroft.isagenix.com

40 pounds since January, 41 inches, too


16 posted on 06/26/2013 2:58:57 AM PDT by RaceBannon (Telling the truth about RINOS, PAULTARDS, Liberals and Muslims has become hate speech)
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To: DakotaGator

sugars and steroids and toxins in the food
also lack of nutrients in the soil, we eat more because our bodies demand nutrients, not calories, and we eat as many calories as we can to get the nutrients we need

http://www.jimbancroft.isagenix.com


17 posted on 06/26/2013 3:00:27 AM PDT by RaceBannon (Telling the truth about RINOS, PAULTARDS, Liberals and Muslims has become hate speech)
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To: neverdem

Many studies have arrived at the same conclusion, that HFCS is bad for you.

Sucrose, which is cane or beet sugar, is fructose and glucose chemically bonded together. The body takes it and breaks the bond, processes the glucose and fructose up to a point then shuts down the cleaving and no more fructose or glucose enters your system.

HFCS, as noted in the study, bypasses the bodies control mechanism and you get all the problems noted. So with less total input of “sugar” (which is what HFCS is called by the corn industry and many others) you get a magnified impact on your health.


18 posted on 06/26/2013 3:32:46 AM PDT by KeyWest (Help stamp out taglines! They are obamanations.)
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To: count-your-change
Since this is just the start it's no wonder the median age in the U.S. has dropped to about 15. Well hasn't it?

But looking on the bright side, by eliminating just a few of the risk factors identified by the advocacy groups, we could clearly prevent at least 2,500% of the mortality in the United States today.

19 posted on 06/26/2013 3:41:12 AM PDT by sphinx
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To: neverdem

Sucrose is likewise a risk factor. In general, grain is a risk factor and most people eat too much of it.


20 posted on 06/26/2013 3:47:15 AM PDT by Neoliberalnot (Marxism works well only with the uneducated and the unarmed.)
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To: neverdem
intake of high calories may play a role in the development of obesity

Well, now, THERE is some news for you!

21 posted on 06/26/2013 4:02:10 AM PDT by Izzy Dunne (Hello, I'm a TAGLINE virus. Please help me spread by copying me into YOUR tag line.)
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To: sphinx
And raise the average age of babies being born! Now the gluten, dairy, peanut, fragrance, and smoke sensitive can cruise the restaurants demanding fructose free or court costs and fees.

Soon the only approved things will be soy, sodomy and organic marijuana.

22 posted on 06/26/2013 4:04:56 AM PDT by count-your-change (you don't have to be brilliant, not being stupid is enough)
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To: snarkytart
And because they have other nutrients like vitamins and fiber.

But those 'healthy' features don't negate the affects of the fructose content. 12 oz of OJ has about 36 g. A 12 oz can of soft drink has about 40 g.

23 posted on 06/26/2013 4:22:22 AM PDT by Right Wing Assault (Dick Obama is more inexperienced now than he was before he was elected.)
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To: neverdem
Uric acid, which is commonly known to be associated with gout...

Some kidney stones, too.

24 posted on 06/26/2013 4:24:11 AM PDT by Right Wing Assault (Dick Obama is more inexperienced now than he was before he was elected.)
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To: pbmaltzman

They may have somewhat come down on the wrong side of the issue, true. However, I’ll bet they never recommend the MASSIVE DOSES of fructose that people ingest to cause diabetes.


25 posted on 06/26/2013 4:25:18 AM PDT by numberonepal (First they came for Sarah, then they came for Herman.....)
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To: neverdem

Conclusion: eating food is will kill you. Previous studies have shown that eating food is necessary for survival. The package in front of me asks: How can I have a balanced treat? Their answer: Coated in rich Nestle chocolate, RAISINETS offers REAL FRUIT in every serving. That means “natural” fructose which according to the article is better than processed fructose.


26 posted on 06/26/2013 4:34:59 AM PDT by palmer (Obama = Carter + affirmative action)
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To: count-your-change

“I can barely drag myself to a breakfast Quarter Pounder. “

Well done satire.


27 posted on 06/26/2013 4:43:33 AM PDT by sergeantdave (No, I don't have links for everything I post)
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To: Mr Ramsbotham

“That’s because fruits are politically correct ... in more ways than one.”

Just let me repeat that for ya

“That’s because fruits are politically correct ... in more ways than one.”

LOL


28 posted on 06/26/2013 4:44:03 AM PDT by faucetman ( Just the facts, ma'am, Just the facts)
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To: Neoliberalnot
Sucrose is likewise a risk factor. In general, grain is a risk factor and most people eat too much of it.

Healthy Greenlander Inuits eat blocks and blocks of seal blubber.

29 posted on 06/26/2013 5:21:13 AM PDT by imardmd1
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To: neverdem

Fructose occurs naturally in fruit.

Are they talking about high fructose corn syrup?


30 posted on 06/26/2013 6:03:53 AM PDT by metmom (For freedom Christ has set us free; stand firm therefore & do not submit again to a yoke of slavery)
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To: neverdem
Fructose is also found in many fruits, but fruits are generally considered healthier than added fructose.

"generally"???? There's a big difference between eating an apple, and snarfing down a 2 liter bottle of Mountain Dew. :-)

The author of this article could use some time on FR to learn a bit of critical reasoning.

31 posted on 06/26/2013 6:33:12 AM PDT by wbill
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To: PeterPrinciple; DakotaGator

I suspect you are both right, and it is both the quantity and quality of sweetener that is problematic.


32 posted on 06/26/2013 6:36:56 AM PDT by 9YearLurker
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To: neverdem
Many other things such as trans-fat and red meat can also increase risk of type 2 diabetes mellitus while curcumin cna help prevent the disease.

Lots of good data on turmeric curcumin Here and Here.

I get mine at Puritan's Pride and Swanson Health Products.

33 posted on 06/26/2013 11:19:48 AM PDT by Art in Idaho (Conservatism is the only Hope for Western Civilization.)
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To: neverdem

BookMark


34 posted on 06/26/2013 11:21:15 AM PDT by thesearethetimes... ("Courage, is fear that has said its prayers." Dorothy Bernard)
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To: D Rider

Thank you ADM.


35 posted on 06/26/2013 11:22:25 AM PDT by dfwgator
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To: DakotaGator
I have long suspected that the massive shift from cane sugar to corn syrup as our primary food sweetener has been the primary cause of the stunning increase in the nation’s obesity.

Metabolically, there's no meaningful difference between cane sugar and corn syrup. Both are about half fructose.

But there is one critical difference. Corn syrup is cheaper. So the manufacturers use a lot more of it.

36 posted on 06/26/2013 12:20:31 PM PDT by jdege
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To: D Rider
HFCS. High fructose corn syrup. One of the main reasons of American obesity.

Yeah, it can't be the fact that we consume more energy than we expend because of our sedentary lifestyle. The fact that we're a nation of fatties has to be because of something beyond our control. The food industry is making us fat. Bastards.

37 posted on 06/26/2013 1:31:29 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: rfp1234

North Dakata sugar beets


38 posted on 06/26/2013 1:43:07 PM PDT by RedhairRedhair (I STILL love my (scab made) Toyota)
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To: KeyWest
The body takes it and breaks the bond, processes the glucose and fructose up to a point then shuts down the cleaving and no more fructose or glucose enters your system.

Huh?

HFCS, as noted in the study, bypasses the bodies control mechanism and you get all the problems noted.

Bypasses the bodies control mechanism? Huh?

So with less total input of “sugar” (which is what HFCS is called by the corn industry and many others) you get a magnified impact on your health.

What specific "magnified" impact are you claiming?

If HFCS is bad for you then so is sucrose. Either one, in moderation, is not bad for you in any way - unless you're a diabetic.

39 posted on 06/26/2013 1:44:42 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: jdege
Metabolically, there's no meaningful difference between cane sugar and corn syrup. Both are about half fructose.

Sucrose is half fructose and half glucose. Corn syrup is more than 90% glucose.

But there is one critical difference. Corn syrup is cheaper. So the manufacturers use a lot more of it.

There are many reasons manufacturers use corn syrup instead of sucrose. Cost is one.

40 posted on 06/26/2013 1:48:28 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: rfp1234; neverdem

First, there are studies that “prove” almost anything. HFCS happens to be the villain of the moment. There are just as many studies and scientists who say that our bodies treat HFCS the same as any other sugar.

Second, the reason we have HFCS is everything is another unintended consequence of government interference in the market. Due to the protections given to sugar growers in the US, we pay an inflated price for cane sugar. Food companies switched to HFCS to save money. I don’t like HFCS because of the taste. I think the health concerns are overblown.

BTW, another consequence of sugar quotas and tariffs is that poor countries in the Caribbean can’t sell us their sugar and remain poor. Instead of trade, we give them massive amounts of foreign aide. As a result of the demands of sugar growers and the peridy of politicians, American consumers and taxpayers get the shaft.

Now that corn is becoming increasingly expensive due to another government boondoggle, ethanol, perhaps manufacturers will go back to sugar, even though it still costs more than it should.


41 posted on 06/26/2013 2:03:14 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: neverdem
Egad! Is there fructose in beer? No?

Whew. That stuff can be hard on yer liver...

42 posted on 06/26/2013 2:22:34 PM PDT by Billthedrill
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To: Mase

High Fructose Corn Syrup is 55% fructose - and it’s that, in particular, that is the largest single source of calories in the Standard American Diet.


43 posted on 06/26/2013 3:51:36 PM PDT by jdege
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To: jdege

It’s high-density caloric content, the body doesn’t handle so much so quickly, so it quickly just turns it to fat.


44 posted on 06/26/2013 3:53:20 PM PDT by dfwgator
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To: Pining_4_TX
There are just as many studies and scientists who say that our bodies treat HFCS the same as any other sugar.
Exactly. HFCS is just as toxic as sucrose.
45 posted on 06/26/2013 3:57:01 PM PDT by jdege
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To: Mase
If HFCS is bad for you then so is sucrose.
Exactly.
Either one, in moderation, is not bad for you in any way - unless you're a diabetic.
Actually, the body can handle quite high doses of either - occasionally. It's chronic consumption at "moderate" levels that causes the problems.
46 posted on 06/26/2013 4:08:06 PM PDT by jdege
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To: jdege
High Fructose Corn Syrup is 55% fructose

In post #36 you said corn syrup. Are you talking about corn syrup or high fructose corn syrup? They are two very different products. Additionally, there are two forms of hfcs being used today in foods and beverages. One is 55% fructose, and is used primarily in beverages, the other is 42% fructose, and is used mostly in foods, especially bakery.

and it’s that, in particular, that is the largest single source of calories in the Standard American Diet.

Yeah, American consume more sugar than they should, mostly from beverages. So what? They are essentially identical products, so it really doesn't matter if manufacturers use sucrose or hfcs in their products.

47 posted on 06/26/2013 4:41:51 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: jdege
HFCS is just as toxic as sucrose.

Just about everything is toxic in the right quantities. Making a statement that sucrose is just as toxic as HFCS is meaningless.

As any student who has taken a class in toxicology can tell you, Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy.

48 posted on 06/26/2013 4:45:24 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: jdege
Actually, the body can handle quite high doses of either

A healthy body is easily capable of handling high amounts of either, that is true.

It's chronic consumption at "moderate" levels that causes the problems.

Chronic consumption? What does that mean? Are you trying to tell us that moderate consumption of table sugar causes problems? Really? My grandmother lived to be 96 and ate what I would consider to be a lot more than a moderate amount of sugar on a daily basis.

What do you define as moderate, and what "problems" does this kind of consumption lead to?

49 posted on 06/26/2013 4:53:15 PM PDT by Mase (Save me from the people who would save me from myself!)
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To: Izzy Dunne

intake of high calories may play a role in the development of obesity

Well, now, THERE is some news for you!


That’s just a bunch of new age, psychobabble hooey! Next you’ll say that exercising and eating less leads to weight loss!


50 posted on 06/26/2013 5:14:11 PM PDT by Rides_A_Red_Horse (Why do you need a fire extinguisher when you can call the fire department?)
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