Just saying what the doctor said to me.
Of course, I doubt if you will wake up every three hours in the night to take them.
Recommended dose was dropped to below 3.5 grams per day (extra strength tabs are 500 mg each so 7 tabs per day is maximum). If you take the time to read the literature, you can diminish the hepatotoxic effects by taking 600 mg of N-acetyl-cysteine as well as vitamin C. NAC is what is used in emergency rooms for an overdose. The problem is that as has been said, acetaminophen is used in so many other products that the dose becomes cumulative; pharmacists are concerned that a lot of the “high dose” pain killers contain acetaminophen as well. That is why the recommended dose was dropped.
As for ibuprofen, that also causes problems with the kidneys when used to excess. I’ve sworn off the stuff completely.