Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Tarantula Venom Could Lead to New Effective Painkillers
Sci-News.com ^ | Feb 17, 2014 | NA

Posted on 04/27/2014 8:10:28 PM PDT by neverdem

Using an innovative screening method, a team of scientists from Australia and the United States has discovered a peptide in the venom of the Peruvian green velvet tarantula (Thrixopelma pruriens) that blunts activity in pain-transmitting neurons.

Tarantula. Image credit: Michael Gäbler / CC BY 3.0.

Tarantula. Image credit: Michael Gäbler / CC BY 3.0.

The novel method, named toxineering, has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.

Dr Michael Nitabach from Yale School of Medicine and his colleagues screened toxins from a variety of tarantula species to find one that blocked TRPA1, an ion channel on the surface of pain-sensing neurons that is implicated in inflammation and neuropathic pain.

By generating a small library of mutated versions of the tarantula toxin, they identified Protoxin-I – a 35-residue peptide from the venom of the Peruvian green-velvet tarantula – that blocks TRPA1 but has no effect on activity of other channels on the surface of neurons.

“The beauty of the system is we can also screen engineered toxins not found in nature, and identify higher-potency and more specific molecular variants that lack deleterious effects on essential nerve functions,” said Dr Nitabach, who is the lead author of a paper published in the journal Current Biology...

(Excerpt) Read more at sci-news.com ...


TOPICS: Culture/Society
KEYWORDS: tarantulavenom; toxineering; trpa1; venom
Navigation: use the links below to view more comments.
first 1-5051-75 next last
It's a little old.
1 posted on 04/27/2014 8:10:28 PM PDT by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem
Tarantulas?

You go first..............

2 posted on 04/27/2014 8:21:06 PM PDT by doorgunner69
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

its never old if you havent heard it before..........................


3 posted on 04/27/2014 8:22:04 PM PDT by Red Badger (Soon there will be another American Civil War. Will make the first one seem like a Tea Party........)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
Q: What do you get when you cross a tarantula with a horse?

A: I don't know but if it bites you, you can ride it to the hospital.

4 posted on 04/27/2014 8:22:12 PM PDT by PJ-Comix (ObamaCare unsubsidized PAID Enrollment Prediction: 66,666)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
Ours are all black, and fuzzy not like the one pictured.

Love it when they scare the crap out of the Liberal relatives visiting imposing on us. Usually gets rid of them quickly, but limited to July, and August when the Tarantulas are out, and about.

5 posted on 04/27/2014 8:25:17 PM PDT by rockinqsranch (Dems, Libs, Socialists, call 'em what you will. They ALL have fairies livin' in their trees.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Interesting stuff. There have been recent developments using the venom of a nasty little bugger called the cone snail for painkillers as well.


6 posted on 04/27/2014 8:27:07 PM PDT by DemforBush (A repo man is always intense.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

To paraphrase Commander Montgomery “Scotty” Scott: “Does it go well with scotch?”

CC


7 posted on 04/27/2014 8:27:33 PM PDT by Celtic Conservative (tease not the dragon for thou art crunchy when roasted and taste good with ketchup)
[ Post Reply | Private Reply | To 1 | View Replies]

To: rockinqsranch

Wanna see a grown man scream like a school girl ? Pot one near me.

But I will be screaming like a very MANLY school girl mind you...


8 posted on 04/27/2014 8:28:07 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 5 | View Replies]

To: neverdem

Try it on Obama first.


9 posted on 04/27/2014 8:35:33 PM PDT by Rembrandt (Part of the 51% who pay Federal taxes)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Norm Lenhart

Hi Norm.

:)


10 posted on 04/27/2014 8:36:01 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 8 | View Replies]

To: neverdem

What is botox, but poison. I could see these things being used for good.


11 posted on 04/27/2014 8:38:52 PM PDT by losinmyreligion
[ Post Reply | Private Reply | To 1 | View Replies]

To: Salamander

Away from me evil woman! ;)


12 posted on 04/27/2014 8:42:28 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 10 | View Replies]

To: Norm Lenhart

*sob!*

/slithers away


13 posted on 04/27/2014 8:46:42 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 12 | View Replies]

To: Salamander

As lone as you don’t crawl way on 8 legs, slithering is just fine ;)


14 posted on 04/27/2014 8:54:46 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 13 | View Replies]

To: Salamander

http://www.youtube.com/watch?v=q_HwBYBPeNg


15 posted on 04/27/2014 8:58:44 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 13 | View Replies]

To: Norm Lenhart

16 posted on 04/27/2014 8:59:12 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 14 | View Replies]

To: HiTech RedNeck

https://www.youtube.com/watch?v=PfWTOgWybys


17 posted on 04/27/2014 9:00:10 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 15 | View Replies]

To: Norm Lenhart
I will be screaming like a very MANLY school girl

I'm thinking that if you put one near Obama you would NOT get a manly scream...

Especially since his efforts at throwing a baseball embarrass girl pitchers everywhere... ;-)

18 posted on 04/27/2014 9:01:34 PM PDT by NoCmpromiz (John 14:6 is a non-pluralistic comment.)
[ Post Reply | Private Reply | To 8 | View Replies]

To: Salamander

Nope gotta be a real one.

And you know something else? It freaking SUCKS living in AZ with the tarantulas, the camel spiders, the wolf spiders, the damn scorpions...

Why am I here again? ;)


19 posted on 04/27/2014 9:09:15 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 16 | View Replies]

To: neverdem

We used to spot tarantulas outside, around our grandparents house. Where we live now, we just have black widows.


20 posted on 04/27/2014 9:11:00 PM PDT by Jane Long (While Marxists continue the fundamental transformation of the USA, progressive RINOs assist!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: NoCmpromiz

It takes practice to scream girlishly like a REAL man. And he’s too busy with golf to bother. I on the other hand scream manly, forcefully and often during the tarantula migrations.

VERY manly. Like a Greek God manly!

Sort of...


21 posted on 04/27/2014 9:13:51 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 18 | View Replies]

To: Norm Lenhart

Because of the Sonoran and Rosy Boas?


22 posted on 04/27/2014 9:14:27 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 19 | View Replies]

To: Salamander; HiTech RedNeck
Got to admit *Tito & Tarantula* kicks the kid's a$$, LOL!
23 posted on 04/27/2014 9:16:08 PM PDT by The Cajun (tea party!!!, Sarah Palin, Mark Levin, Ted Cruz, Mike Lee, Louie Gohmert......Nuff said.)
[ Post Reply | Private Reply | To 17 | View Replies]

To: The Cajun

Viva Larriva!

[I went off and got lost in the other T&T videos] :D


24 posted on 04/27/2014 9:17:13 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 23 | View Replies]

To: The Cajun

But THIS kid sits on the keyboard when he is finished.

http://www.youtube.com/watch?v=T2f8uNkLYng


25 posted on 04/27/2014 9:18:55 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 23 | View Replies]

To: HiTech RedNeck
The little punk!

:)

26 posted on 04/27/2014 9:20:28 PM PDT by The Cajun (tea party!!!, Sarah Palin, Mark Levin, Ted Cruz, Mike Lee, Louie Gohmert......Nuff said.)
[ Post Reply | Private Reply | To 25 | View Replies]

To: Salamander

Because of things the size of softballs that walk on ceilings and fall on you at 3 AM and you wake up with it on your chest ;)


27 posted on 04/27/2014 9:20:41 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 22 | View Replies]

To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Vitamin D and its effect on weight loss examined in new study

The strange tension between theology and science

Diabetes Complication Rates Drop Among U.S. Adults

Low-carb ketogenic diet takes on low-fat diet for diabetes: Undisputed winner

FReepmail me if you want on or off my health and science ping list.

28 posted on 04/27/2014 9:21:12 PM PDT by neverdem (Register pressure cookers! /s)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Norm Lenhart

But it’s FURRY. Pet it!


29 posted on 04/27/2014 9:21:56 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 27 | View Replies]

Are the stars out tonight?
I don't know if it's cloudy or bright
I only have eyes for you, dear.


30 posted on 04/27/2014 9:22:13 PM PDT by UCANSEE2 (Lost my tagline on Flight MH370. Sorry for the inconvenience.)
[ Post Reply | Private Reply | To 20 | View Replies]

To: HiTech RedNeck

Oh I do! One swift/hard pet to the side. then spend the next half hour finding the damn thing and killing it. Out of feelings of love. An act of love really. I love my house tarantula free!

Then being up the rest of the night looking for how it got in and any of his friends.


31 posted on 04/27/2014 9:24:46 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 29 | View Replies]

To: Norm Lenhart

They mean no harm.

...unlike me.

;D


32 posted on 04/27/2014 9:26:09 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 27 | View Replies]

To: Norm Lenhart

http://insects.about.com/od/spiders/f/what-do-tarantulas-eat.htm


33 posted on 04/27/2014 9:28:12 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 31 | View Replies]

To: UCANSEE2

They’re my favorites!

[mostly because we have no Black Widows here]


34 posted on 04/27/2014 9:29:05 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 30 | View Replies]

To: Norm Lenhart

Niiiiiiiice tarantula.


35 posted on 04/27/2014 9:29:51 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 31 | View Replies]

To: Salamander

I can kill a tarantula without remorse. You? well I’ll think about it if you drop one on me...And then send liberals to your house with the keys to your trike!!!

Am I evil? Yes...yes I am...
http://www.youtube.com/watch?v=-u-HCHCuHMg


36 posted on 04/27/2014 9:32:17 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 32 | View Replies]

To: HiTech RedNeck
Norm doesn't ~really~ have a big spider problem.


37 posted on 04/27/2014 9:32:45 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 33 | View Replies]

To: HiTech RedNeck

DEAAAADDDD tarantula.....


38 posted on 04/27/2014 9:32:52 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 35 | View Replies]

To: Norm Lenhart

It catches mice. That’s as good as a cat!


39 posted on 04/27/2014 9:33:01 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 36 | View Replies]

To: Salamander

It aint fuzzy. No problem ‘)


40 posted on 04/27/2014 9:33:34 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 37 | View Replies]

To: Norm Lenhart

Most of them have enough sense not to bite something too big to digest.


41 posted on 04/27/2014 9:34:18 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 38 | View Replies]

To: HiTech RedNeck

So do Basset hounds. The ultimate dog.


42 posted on 04/27/2014 9:34:23 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 39 | View Replies]

To: Norm Lenhart; Salamander
Oh... get a room, you two.


43 posted on 04/27/2014 9:34:37 PM PDT by UCANSEE2 (Lost my tagline on Flight MH370. Sorry for the inconvenience.)
[ Post Reply | Private Reply | To 27 | View Replies]

To: HiTech RedNeck

Hear that? Off in the distance? that’s the sound of Normie not caring what the little fuzzy intends.


44 posted on 04/27/2014 9:35:44 PM PDT by Norm Lenhart (How's that 'lesser evil' workin' out for ya?)
[ Post Reply | Private Reply | To 41 | View Replies]

To: Norm Lenhart
EEEEeeeeeeeeeek
45 posted on 04/27/2014 9:36:49 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 44 | View Replies]

To: Norm Lenhart

He would eat Metallica.

https://www.youtube.com/watch?v=Lkog0sNuz9Y

:)

[liberals wouldn’t know what to do with it, especially after the last tune up...it’s running a 110” mix]


46 posted on 04/27/2014 9:37:17 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 36 | View Replies]

To: Salamander
They’re my favorites!

Gee... I can't imagine why.

\; )

47 posted on 04/27/2014 9:38:09 PM PDT by UCANSEE2 (Lost my tagline on Flight MH370. Sorry for the inconvenience.)
[ Post Reply | Private Reply | To 34 | View Replies]

To: UCANSEE2

LOL


48 posted on 04/27/2014 9:38:23 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 43 | View Replies]

To: Salamander

110 inch mix??


49 posted on 04/27/2014 9:38:49 PM PDT by HiTech RedNeck (Embrace the Lion of Judah and He will roar for you and teach you to roar too. See my page.)
[ Post Reply | Private Reply | To 46 | View Replies]

To: UCANSEE2

They’re so black and *shiny*.

[seriously...can somebody mail me a few deceased ones? I have a jewelry idea]


50 posted on 04/27/2014 9:40:42 PM PDT by Salamander (Minstrel In The Gallery)
[ Post Reply | Private Reply | To 47 | View Replies]


Navigation: use the links below to view more comments.
first 1-5051-75 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson