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Obesity is Inflammatory Disease, Rat Study Shows
Sci-News.com ^ | Dec 5, 2013 | NA

Posted on 05/01/2014 3:12:41 PM PDT by neverdem

Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself.

Zucker Rat, a pet rat that has developed diabetes as a result of a genetic disorder that causes obesity. Image credit: Joanna Servaes / CC BY-SA 3.0.

Zucker Rat, a pet rat that has developed diabetes as a result of a genetic disorder that causes obesity. Image credit: Joanna Servaes / CC BY-SA 3.0.

“This important new finding links obesity and high fat, high sugar diets with changes in immune cells and inflammatory status, highlighting an emerging realization that obesity is an inflammatory disease,” Dr Fairlie said.

“Drugs designed to block certain inflammatory proteins, as in this report, may be able to prevent and treat obesity, which in turn is a major risk factor for type 2 diabetes, heart disease, stroke, kidney failure, limb amputation, and cancers.”

To make the discovery, the team discovered the first potent, selective and orally bioavailable small molecule antagonists of PAR2 and characterized their functional responses in inflammatory cellular and animal models.

They found that PAR2 expression is increased in vivo in adipose tissue from obese humans and rats, stimulated in vitro in human macrophages by the dietary fatty acid palmitic acid, and inhibited in vivo and in vitro by a PAR2 antagonist. This...

(Excerpt) Read more at sci-news.com ...


TOPICS: Australia/New Zealand; Culture/Society; Extended News; Testing
KEYWORDS: immunology; inflammation; obesity; type2diabetes
Inflammation is part of the immune system. PAR2 is quite different from ppar gamma, peroxisome proliferator-activated receptor (PPAR) γ.
1 posted on 05/01/2014 3:12:41 PM PDT by neverdem
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To: neverdem

Gibsmedat!


2 posted on 05/01/2014 3:16:50 PM PDT by null and void ( They don't think think they are above the law. They think they are the law.)
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To: neverdem
Obesity is Inflammatory Disease, Rat Study Shows...

So, watch out... Christie could burst into flames at any moment?

3 posted on 05/01/2014 3:16:58 PM PDT by C210N (When people fear government there is tyranny; when government fears people there is liberty)
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To: neverdem
..highlighting an emerging realization that obesity is an inflammatory disease…

And such a cruelly capricious one too, as it only seems to randomly strike overeaters!

4 posted on 05/01/2014 3:18:39 PM PDT by Flycatcher (God speaks to us, through the supernal lightness of birds, in a special type of poetry.)
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To: C210N


5 posted on 05/01/2014 3:26:34 PM PDT by JoeProBono (SOME IMAGES MAY BE DISTURBING VIEWER DISCRETION IS ADVISED;-{)
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To: null and void
I've read the title three times now, I keep substituting Obama for Obesity at first glance. Subconscious mind I guess.
6 posted on 05/01/2014 3:30:46 PM PDT by Fair Paul
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To: neverdem
And all this time I thought it was chocolate cake and cheeseburgers that “inflamed” my midsection.
7 posted on 05/01/2014 3:32:11 PM PDT by Gay State Conservative (Stalin Blamed The Kulaks,Obama Blames The Tea Party)
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To: neverdem

Imagine, Facebook was invented by a lab rat.


8 posted on 05/01/2014 3:35:45 PM PDT by skeeter
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To: neverdem
Oh, for Pete's sake.

Obesity is the result of eating foods that spike blood sugar levels: wheat, sugar, and starches are the primary culprits.

Cut those out of your diet and you'll be skinny as a rail. No expensive research needed.

9 posted on 05/01/2014 3:37:04 PM PDT by BfloGuy ( Even the opponents of Socialism are dominated by socialist ideas.)
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To: neverdem

Rather than trying to block the inflammatory biochemical process, why not try to avoid the inflammatory triggers?

Like cutting back on processed carbohydrates and the industrial seed oils and eating more actual food?


10 posted on 05/01/2014 3:37:48 PM PDT by jdege
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To: neverdem

So does this mean my lardass-edness really ain’t my fault?


11 posted on 05/01/2014 3:41:27 PM PDT by snuffy smiff (Socialism is the philosophy of failure, the creed of ignorance, and the gospel of envy.)
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To: jdege

What? You want to be healthy too?


12 posted on 05/01/2014 3:42:45 PM PDT by B4Ranch (Name your illness, do a Google & YouTube search with "hydrogen peroxide". Do it and be surprised.)
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To: neverdem

And political studies show that RATS are an inflammatory disease.


13 posted on 05/01/2014 3:43:51 PM PDT by MIchaelTArchangel (Have a wonderful day!)
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To: MIchaelTArchangel

Watch Tiny Hamsters Eat Tiny Burritos
http://time.com/83362/watch-tiny-hamsters-eat-tiny-burritos/


14 posted on 05/01/2014 3:45:52 PM PDT by TurboZamboni (Those who make peaceful revolution impossible will make violent revolution inevitable.-JFK)
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To: null and void

In my experience, PAR2 was a handy method of checking the integrity of archive files :)

They know what it is. They know what it does. They know its benefits. So I’m only half-joking when I say why not issue it as a drug straight away?


15 posted on 05/01/2014 4:17:39 PM PDT by relictele (Principiis obsta & Finem respice - Resist The Beginnings & Consider The End)
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To: TurboZamboni

Hahahahaha! Cute!


16 posted on 05/01/2014 4:20:23 PM PDT by skr (May God confound the enemy)
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To: neverdem
When obese rats on a diet high in sugar and fat

No idea why they would use a diet high in both sugar and fat simultaneously. Some believe that each is the cause of obesity, though the newest evidence clearly indicates that high sugar and other rich carbos are the cause of obesity.

Many fats are good for us.

17 posted on 05/01/2014 4:20:55 PM PDT by Will88
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To: Will88
Many fats are good for us.

I don't think Christie is one of them.

18 posted on 05/01/2014 4:33:54 PM PDT by LambSlave
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To: neverdem

Lol.
No way its from too damn much food. Nope!


19 posted on 05/01/2014 4:43:24 PM PDT by bill1952 (taxes don't hurt the rich, they keep YOU from becoming rich.)
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To: BfloGuy

Oh, for Pete’s sake.

Obesity is the result of eating foods that spike blood sugar levels: wheat, sugar, and starches are the primary culprits.

Cut those out of your diet and you’ll be skinny as a rail. No expensive research needed.


100% true. Every word a winner. Insulin spikes tell the body to store fat and create cravings for more sugar and starches. It is not complex.


20 posted on 05/01/2014 5:20:14 PM PDT by 2big2fail
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To: Will88

“Many fats are good for us.”

Yes, but not the ones we are told are good for us. The worst are the ‘Essential’ Omega 6 fats...corn oil, soybean oil, canola oil etc. The good fats are the saturated fats, especially the mcfa in coconut oil.

Obesity, along with all of the other evidences of metabolic syndrome are inflammatory diseases. This is also true of cardiovascular disease and Alzheimer’s.


21 posted on 05/01/2014 5:40:27 PM PDT by GGpaX4DumpedTea (I am a Tea Party descendant...steeped in the Constitutional Republic given to us by the Founders)
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To: null and void

bookmark


22 posted on 05/01/2014 9:45:30 PM PDT by GOP Poet
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To: relictele
I’m only half-joking when I say why not issue it as a drug straight away?

Good point, and I'll give you a good reason: what if being thin is more problematic than being fat? Stay with me here. There was a study linked on Drudge recently that proved that overweight people survived longer and had better outcomes than their thinner counterparts when confronted with certain types of cancers.

I'm not advocating for morbid obesity, but I think we, as a society, need to have a serious discussion about what's considered "healthy," because the current social standard is not, IMO.

23 posted on 05/02/2014 8:05:58 AM PDT by rarestia (It's time to water the Tree of Liberty.)
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