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Cholesterol drug cuts heart risks, spurs new debate on cost
The Seattle PI ^ | Sunday, March 19, 2017 | Cholesterol drug cuts heart risks, spurs new debate on cost Marilynn Marchione

Posted on 03/19/2017 8:30:36 PM PDT by steve86

Repatha cut by 20 percent the combined risk of having either a heart attack, stroke or a heart-related death. That happened to nearly 6 percent of people on Repatha versus more than 7 percent on the dummy drug. The benefit grew with longer use, and was 25 percent the second year, said Sabatine, who consults for Amgen and other drugmakers.

The drug cut by 15 percent a broader set of problems — the ones above plus hospitalization for chest pain or an artery-opening procedure. Nearly 10 percent of folks on Repatha had one versus more than 11 percent on the dummy drug

(Excerpt) Read more at seattlepi.com ...


TOPICS: Business/Economy; Culture/Society; News/Current Events
KEYWORDS: newclasslipiddrug; statin
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Controversy continues...
1 posted on 03/19/2017 8:30:36 PM PDT by steve86
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To: steve86

Not a statin but is a cholesterol-lowering medication.

Many of the existing statin-based arguments against lipid-lowering therapy will apply.

I take a statin myself, as does my 100 YO mother (for the last decade and a half or more).


2 posted on 03/19/2017 8:37:26 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: steve86

Anyone who is on maintenance drugs know the pricing scheme is confusing and unfair. There are more riddles to this complex maze that there should be.


3 posted on 03/19/2017 8:38:47 PM PDT by BipolarBob (I just got done celebrating Black History Month. Obama and Kaepernick are both history. Hurray!)
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To: steve86

What is still unknown is as to why the drugs work so well—there is something about an anti-inflammation benefit others have suggested for the reason.


4 posted on 03/19/2017 8:46:43 PM PDT by Scram1
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To: steve86

Repatha cut by 20 percent the combined risk of having either a heart attack, stroke or a heart-related death. That happened to nearly 6 percent of people on Repatha versus more than 7 percent on the dummy drug.


So, placebo had a more widespread effect. ...and how was the cut in risk measured if not by number of people having an effect?


5 posted on 03/19/2017 9:01:39 PM PDT by lepton ("It is useless to attempt to reason a man out of a thing he was never reasoned into"--Jonathan Swift)
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To: steve86

My wife and I both have taken all kinds of statins. Neither of us saw any benefits. The only results I saw was severe leg pain.

Seeing some results with fish oil. But the best results have been from exercise and dropping 40 lbs.

Seeing cardiologist on Tuesday. Will ask about repatha. My pharmacist, who handles my blood thinner treatment, mentioned repatha last week.


6 posted on 03/19/2017 9:04:14 PM PDT by Terry Mross (How long has it been since you've haowl of ..... Democrat whip ass chili?)
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To: steve86

“Many of the existing statin-based arguments against lipid-lowering therapy will apply.”

What arguments are those? I ask because my cardiologist wants to double my Crestor dosage because he wants to lower my LDL. On the other hand my HDL is uncommonly high and my primary says I shouldn’t worry about it.


7 posted on 03/19/2017 9:04:28 PM PDT by be-baw (still seeking)
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To: lepton

Ah...the 6% vs. 7% is the portion that had the heart attack or stroke, or heart-related death.


8 posted on 03/19/2017 9:05:05 PM PDT by lepton ("It is useless to attempt to reason a man out of a thing he was never reasoned into"--Jonathan Swift)
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To: steve86

Meyers provides atorvastatin/lipitor for free



Move your prescription. Show up and they give it to you. Easy peasy Japanesey. If you pay for other prescriptions go to GOODRX.Com They negotiate rates much lower than retail. Just print out the thing and hand it to the pharmacy. Kinda makes me think of Trump's plan.
9 posted on 03/19/2017 9:05:53 PM PDT by LesbianThespianGymnasticMidget (God punishes Conservatives by making them argue with fools. Go Trump!)
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To: steve86

“!

For every 200 people treated with Repatha for roughly two years, three fewer people would suffer a heart attack, stroke or heart-related death. But looked at by themselves, deaths were not reduced by the drug.

“That’s a big benefit,” said Dr. Marc Sabatine, the study leader, from Brigham and Women’s Hospital in Boston. For millions of people with heart disease or high risk for it like those in the study, “it’s worth it to be on this medicine.”

But Dr. Donald Lloyd-Jones, preventive medicine chief at Northwestern University and an American Heart Association spokesman, called the results modest and “not quite what we hoped or expected.”


10 posted on 03/19/2017 9:09:52 PM PDT by Grampa Dave ( Remember during Trump Tower Spydgate, there were No American fingerprints; just Obama's...!!!!:))
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To: Terry Mross

I tried 3 different statins, never lasted more than a month. Changed doctors who would not listen. My current PCP, who is also a shooter, listens and she has me on red rice yeast and niacin from a place in Oregon. My HDL is crazy high too which elevates my total. I lost 20 pounds, exercise regularly, eat what I want, drink and I am around 200 with good BP. stress seems to increase my cholesterol more than any other single issue.


11 posted on 03/19/2017 9:11:40 PM PDT by bravo whiskey (Never bring a liberal gun law to a gun fight.)
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To: Terry Mross

Dropping weight, exercising, taking good fish oil and eating a lot of fruits, veggies will definitely prolong your life. Good for you.

My doc is accustomed to having me turn down drugs….told me his mother won’t take them either. So he prescribes things like fish oil and even electrolytes to put in water while I exercise. Carrying water bottle around the gym is so common, I had to paint my name on it with nail polish.


12 posted on 03/19/2017 9:14:12 PM PDT by Veto! (Opinions freely dispensed as advice)
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To: Terry Mross

My understanding is that the medication is HUGELY expensive. So some insurances may be reluctant to cover it.


13 posted on 03/19/2017 9:17:11 PM PDT by House Atreides (Send BOTH Hillary & Bill to prison.)
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To: Terry Mross

I was on a a stain, a Crestor generic. Lots of muscle pain and aches. Happy I’m no longer taking it.


14 posted on 03/19/2017 9:19:43 PM PDT by tumblindice
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To: tumblindice

PS Like stories above, lost a lot of weight, exercise and eat right, lots of water


15 posted on 03/19/2017 9:21:24 PM PDT by tumblindice
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To: BipolarBob

No riddles, a recent study showed Amazon natives had near perfect arteries. 100% compared to 20%. This says heart disease is 100% diet lifestyle not a magic pill.


16 posted on 03/19/2017 9:21:42 PM PDT by TheNext
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To: steve86

Maybe it’s statistically “significant” but looks like not very, over the placebo, in real life.

Diet and lifestyle changes could have made HUGE improvements. Cholesterol is essential for our brains. We don’t need to remove it in order to lower heart problem risks.


17 posted on 03/19/2017 9:27:20 PM PDT by Yaelle
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To: Grampa Dave

Only 1.5% benefit vs 100% lifestyle benefit.


18 posted on 03/19/2017 9:27:41 PM PDT by TheNext
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To: steve86

Have had a problem with LDL cholesterol since menopause. Have tried and failed one statin after the other, all for the same reason:muscle pain that reduces me to a motionless mass of pain. Have been taking flax seed oil (omega 3) since and my HDL level is in the 90s, very protective.

Primary doc keeps trying to tempt me with the latest statin kid on the block but the muscle pain problem always comes back, even with CoQ 10.


19 posted on 03/19/2017 9:29:06 PM PDT by Catmom (We're all gonna get the punishment only some of us deserve.)
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To: steve86

I was taking statins; developed an allergic reaction - my tongue swelled up. I had to stop taking it immediately.

However, many years later, I discovered another product which is not toxic to me: Citrus Bergamot. It’s made from the oranges grown in Southern Italy. I found the product at The Vitamin Shoppe.

A 60 day supply is only $38.00 - and I had a 146 point decrease in my LDL, and a small increase in my HDL, which had always been steadily over 60, after my doctor and I agreed to a 120 day test, and at the end of each 30 days, a new blood test to see what was happening.

My doctor was stunned at the results. I have both types of cholesterol - food, and genetically inherited.

It’s an easy test to do - one capsule daily for 120 days - followed by blood checks every 30 days.


20 posted on 03/19/2017 9:33:48 PM PDT by CyberAnt ("Peace Through Strength")
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