Posted on 04/09/2020 7:11:23 AM PDT by SeekAndFind
“The question becomes then, “At how low a dose?” Instead of 200 mg or 400 mg, can we drink 60 mg of quinine in 3 glasses of tonic water and get some protection?”
The wife and I have purchased tonic water and actually, its like drinking grapefruit juice...the taste that is.
Been taking that and Zinc.
“Tonic water contains no more than 83 mg of quinine per liter—a much lower concentration than the 500 to 1,000 mg in the therapeutic dose of quinine tablets.”
https://www.health.harvard.edu/bone-and-muscle-health/will-tonic-water-prevent-nighttime-leg-cramps
So you’d need three liters to get over 240 mg of quinine.
Ask your RA doc about it, for some side effets are very nasty.
I'd heard 20 mg per glass, and calculated roughly 2 liters. But, that's to reach the currently known protective dose.
I'm wondering whether the dose-immunity response curve is linear, or has a thresh-hold. If I wanted to be pretty safe today, I'd take the higher dose given the current sketchy knowledge we have. But we don't have a full take on mechanism of prevention, or degree of prevention versus dosage.
One interesting thing I've read is that there is a cumulative effect of intracellular build up which takes 30 to 40 days to flush out (to half-life?), much longer than the 12 hour or so blood half-life.
If that's true, and one is willing to do a slow build-up, what is the level that works, and how high does it go?
To quote Rutger Hauer in Blade Runner, "Questions. Yes, many questions."
A few weeks ago, I bought a bunch of tonic water just in case - 30 one liter bottles over a few weeks. Also, picked up a couple bottles of Quercitin. Now that HCQ production is being ramped up, I’m less concerned about keeping my supply as treatment, and subsequently shifted my focus to prophylaxsis. I figure I’ll draw down my supply over the next 30 days.
Therefore... I’m consuming 1 liter of diet tonic water per day, along with 1000 mg Quercitin, 50 mg zinc, 10K i.u. vitamin D3, and 500 mg vitamin C.
If the maintenance dose is 310 mg HCQ per week, that works out to less than 50 mg per day. I know its not apples to apples, but there’s 60-80 mg quinine per liter of tonic water.
Interactions with metformin are potentially VERY dangerous. Don’t self medicate.
My bad for speed-reading “weekly” as “daily.” Thanks!
That means the soda treatment could work, albeit with a very slow load.
“A liter a day keeps the coroner away!”
The drug is everywhere in malaria areas. That’s why Trump talked to the Indian PM.
From Wiki:
India makes up over 75% of the total number of malaria cases in Southeast Asia.
So yes, they use it.
Interesting statements.
If Dr. Oz says it, my default position would be it’s not true, but anything is possible.
RE:If Dr. Oz says it, my default position would be it’s not true
Which particular statement of his do you doubt? He made several. You doubt ALL of it? If so, it would be interesting to understand your reasons.
Bottoms up! ...or else it’s tits up!
I was given hyrdoxychloroquine by the Army before a planned 3 week deployment to Afghanistan as a preventive measure to prevent me getting Malaria. It was standard procedure for all troops going to Afghanistan and Iraq. It was given under the name Mefloquine. The trip ended up being canceled two weeks before our departure after the bombing of the US Embassy in Kabul in 2007 and it was decided that a pair of Army historians to visit their subordinate Military History Detachments was not a priority.
MUST WATCH VIDEO!
Dr. Zelenko update! Inspiring! Watch the WHOLE THING! Full of nuggets spread throughout. Also Dr. Karladine Graves with additional info and perspective.
There’s not many people here who get into mathematics very much, but for the few who do, I want to run this by you to see if you disagree:
The article states that some outfit called Share Care has already looked at 9 million health records and identified 14,000 lupus patients on hydroxychloroquine. They say that’s a “tiny biopsy” of America. I want to take issue with “tiny”; it could be “huge.” The numbers:
We have over 450,000 cases in a country of about 325 million people. 450,000/325,000,000 = .001385, or about .14% of us have been confirmed cases. That means that 99.86% have not been so identified, or .9986 of the population.
That means that if you pick one person at random, there is a .9986 out of 1.0000 chance he isn’t a confirmed case, i.e., a 99.86% probability. Now, if you pick a second person out of the population, the odds that both are non-cases is .9986x.9986, or .9972 (a 99.72% chance). Picking three healthy people, the odds are .9986x.9986x.9986=.9958 (99.58%) That calculation is just .9986 cubed or to the 3rd power. Here are some more numbers, really the odds of not getting a person with a confirmed case after n tries:
1 person — .9986
2 people — .9972
3 people — .9958
4 — .9944
5 — .9930 (still over a 99% chance of all healthy. Step it up some now
10 people — .9861 (If you have a” y to the x” key on your calculator, use it with x=10. So .9986 y to the 10 = .9861
20 people — .9724 (Still more than a 97% chance of no cases, but it’s getting interesting, right?)
50 people — .9323
100 people — .8693 (Hmm, 13% chance of a confirmed case)
200 people — .7556
500 people — .4963 (Okay, slightly better than 50% of finding one)
1,000 people — .2464
2,000 people — .0607 (Going down pretty fast now, right?)
4,000 people — .0037 (Whoa!, less than half a percent chance of no cases with 10,000 picks to go?)
5,000 people — .0009 (That’s just under 1/10 of one percent)
7,000 people — .000055 (under 1/100 of one percent; put another way a 99.9945% chance of having a confirmed case by now.
14,000 people — .000000003 chance of no cases (not going to happen, in other words)
Conclusions:
1. The numbers in the article are reported wrong (high probability)
2. The people gathering the numbers have been missing cases (also probable)
3. However, if true as reported, it is a near certainty that long-term hydroxychloroquine use protects against Covid-19.
4. Or my math approach to the probabilities is wrong (decent chance, so please explain if you think so)
Sorry, I forgot to add a key point: per the article ZERO of the 14,000 lupus patients have a confirmed case of Covid-19.
btt
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