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Locked on 05/23/2020 1:16:19 PM PDT by Jim Robinson, reason:

duplicate http://www.freerepublic.com/focus/f-news/3847897/posts



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Remdesivir for the Treatment of Covid-19 Preliminary Report
New England Journal of Medicine ^ | 5/22/20 | Various Doctors

Posted on 05/23/2020 11:26:42 AM PDT by LRoggy

BACKGROUND

Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious.

METHODS

We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.

RESULTS

A total of 1063 patients underwent randomization. The data and safety monitoring board recommended early unblinding of the results on the basis of findings from an analysis that showed shortened time to recovery in the remdesivir group. Preliminary results from the 1059 patients (538 assigned to remdesivir and 521 to placebo) with data available after randomization indicated that those who received remdesivir had a median recovery time of 11 days (95% confidence interval [CI], 9 to 12), as compared with 15 days (95% CI, 13 to 19) in those who received placebo (rate ratio for recovery, 1.32; 95% CI, 1.12 to 1.55; P<0.001). The Kaplan-Meier estimates of mortality by 14 days were 7.1% with remdesivir and 11.9% with placebo (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04). Serious adverse events were reported for 114 of the 541 patients in the remdesivir group who underwent randomization (21.1%) and 141 of the 522 patients in the placebo group who underwent randomization (27.0%).

(Excerpt) Read more at nejm.org ...


TOPICS:
KEYWORDS: fauci; hydroxycholoroquine; remdesivir
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Is this BETTER?

Saint Fauci touted this drug and it BOMBED. Only helped those also taking oxygen supplementation.

Meanwhile Amy Klobuchar had to admit her husband did take Hydroxycholoroquine and it DID WORK: https://www.rightjournalism.com/audio-failed-presidential-candidate-amy-klobuchar-finally-and-reluctantly-admits-that-her-husband-took-hydroxychloroquine/?fbclid=IwAR0smN4wul4nSrX4nh1PeQTcGBNUldOL94vX9wW9yYN1tt-9dekWKMJr4vc

1 posted on 05/23/2020 11:26:42 AM PDT by LRoggy
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To: LRoggy

Rest , plenty of fluids and Vit D ?


2 posted on 05/23/2020 11:29:17 AM PDT by butlerweave
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To: LRoggy

http://www.freerepublic.com/focus/f-news/3847897/posts

Back for more punishment?


3 posted on 05/23/2020 11:32:41 AM PDT by null and void (By the pricking of my lungs, Something wicked this way comes ...)
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To: All
If that decreased death rate holds up, it will be well worth pursuing on a large scale.

In addition, the faster recovery time will also be a major development (fewer hospital beds and resources being taken up, lessened chance of complications).

This is just one study, but reducing the death rate from 11.9% to 7.1% is a 68% reduction. If a million people were infected and experiencing the same effects as the test group, Remdesivir might save 48,000 lives.

4 posted on 05/23/2020 11:34:55 AM PDT by BushMeister ("We are a nation that has a government - not the other way around." --Ronald Reagan)
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To: LRoggy
"Serious adverse events were reported for 114 of the 541 patients in the remdesivir group . . . "

Only 21% serious side effects! This is clearly the way to go! To hell with the Trump drug HCQ! /s
5 posted on 05/23/2020 11:36:01 AM PDT by Steve_Seattle
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To: LRoggy; neverdem; ProtectOurFreedom; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ...
DAMMIT!!!

We're going to have to go back the the cheap, readily available, effective treatment the Orange Man Bad advocated over a month ago!

too bad about the 150,000 that died since then...

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

The false positive rate was 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's or one old fart’s life, it's worth it.

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

The false positive rate was 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's or one old fart’s life, it's worth it.

6 posted on 05/23/2020 11:39:59 AM PDT by null and void (By the pricking of my lungs, Something wicked this way comes ...)
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To: LRoggy

The politicization of coronavirus treatments is the single weirdest thing about the whole pandemic. That Red Team is rooting for one particular treatment, and Blue Team is scoffing at it, neither side with a ton to go on scientifically, is a new low for our nation.


7 posted on 05/23/2020 11:40:16 AM PDT by babble-on
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To: Steve_Seattle
"Serious adverse events were reported for 114 of the 541 patients in the remdesivir group . . . "

Sounds bad.

Unless you finish the sentence.

... and 141 of the 522 patients in the placebo group who underwent randomization...

8 posted on 05/23/2020 11:54:00 AM PDT by semimojo
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To: LRoggy
Saint Fauci touted this drug and it BOMBED.

They unblinded the study early. Remdesivir was effective enough that it would have been unethical to keep it from the placebo group

We need more bombs like this.

9 posted on 05/23/2020 11:57:07 AM PDT by semimojo
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To: LRoggy

How is it ethical to give someone a placebo and watch them die?


10 posted on 05/23/2020 11:58:24 AM PDT by Lurkina.n.Learnin (The Revolution Will Not Be Televised but It Will Be Livestreamed)
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To: Lurkina.n.Learnin

In situations like this, “placebo” usually means “best prevailing treatment,” not “sugar pill.”


11 posted on 05/23/2020 12:01:32 PM PDT by untenured
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To: LRoggy

they stop the study becauseit shows that the drug helps


12 posted on 05/23/2020 12:01:46 PM PDT by nikos1121
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To: LRoggy

.


13 posted on 05/23/2020 12:03:46 PM PDT by sauropod (Quarantine is when you restrict sick people, tyranny is when you restrict healthy people.)
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To: BushMeister

Studies with HCL+ when given in first stages shows 90%+ recovery. Seems like HCL is the best thing out there currently when used with Zinc and an antibiotic.


14 posted on 05/23/2020 12:10:21 PM PDT by billyboy15
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To: semimojo

And HCL had less side effects and in studies from France and here had a 90% plus cure rate and in the case of the NY Dr either one or no deaths.


15 posted on 05/23/2020 12:12:57 PM PDT by billyboy15
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To: billyboy15

The disease itself has a 90+% recovery, with no treatment at all.


16 posted on 05/23/2020 12:46:39 PM PDT by babble-on
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To: Steve_Seattle
"Serious adverse events were reported for 114 of the 541 patients in the remdesivir group . . . "

Surely giving them the official big pharma drug and having a quarter of the patients developing permanent liver damage and multiple organ failure is preferable to the alternative of giving them the HCQ/Zpack/Zinc cocktail which exposes them to the risk of runny stool for a few days. /s

17 posted on 05/23/2020 12:53:06 PM PDT by Sirius Lee (They are openly stating that they intend to murder us. Prep if you want to live.)
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To: null and void

Trump was right again.


18 posted on 05/23/2020 12:55:47 PM PDT by bgill (Idiots. CDC site doesn't recommend wearing a mask to protect from COVID-19)
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To: semimojo
"Unless you finish the sentence ... and 141 of the 522 patients in the placebo group who underwent randomization..."

Regardless of what happened in the placebo group, a 21% rate of serious adverse reactions is terrible. It's not much of a selling point to say, "Our drug only had 21% serious negative side-effects compared to 27% in the placebo group!"
19 posted on 05/23/2020 12:58:15 PM PDT by Steve_Seattle
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To: BushMeister

“This is just one study, but reducing the death rate from 11.9% to 7.1% is a 68% reduction. If a million people were infected and experiencing the same effects as the test group, Remdesivir might save 48,000 lives.”

Go to minute 49 of this hearing and listen 15 minutes”

https://www.hsgac.senate.gov/covid-19-how-new-information-should-drive-policy

These are top ICU experts saying they have a 3 step covid protocol which is close to 100% effective

Remsdesivir is an expensive moneymaker for the drug companies. Worthless.


20 posted on 05/23/2020 1:05:50 PM PDT by SecAmndmt (Arm yourselves!)
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