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Lizard Spit Drug Controls Diabetes, Cuts Weight
Reuters ^ | 08/25/03

Posted on 08/26/2003 6:09:21 AM PDT by nypokerface

PARIS (Reuters) - Exenatide, an experimental diabetes drug derived from lizard saliva, not only controls patients' blood sugar levels but also cuts their weight, its developers said on Monday.

Amylin Pharmaceuticals Inc and Eli Lilly and Co released new study findings on the efficacy of exenatide at the 18th Congress of the International Diabetes Federation in Paris.

The drug, derived from the saliva of a lizard known as the Gila monster, is the first in a new class of therapies for type 2, or adult-onset, diabetes and is on track to be submitted for approval by regulators in 2004. Analysts forecast annual sales could top $500 million after three years.

The Gila monster lizard lives in the Arizona desert, only eating about four times a year. Its salivary secretions help prevent a sudden surge in blood sugar levels in response to these infrequent but large meals.

The latest exenatide test involved 155 patients who had failed to reach target glucose levels on established diabetes drugs metformin and sulfonylurea, or a combination of the two.

When researchers added injections of exenatide, 44 percent of patients who completed 24 weeks of treatment achieved glucose level averages within the target range, the companies said.

Patients also lost on average 7.5 pounds.

Amylin CEO, Dan Bradbury, told Reuters that being able to control the blood sugar levels of so many patients who had previously failed therapy was a "pretty exciting result."

The most frequently reported side effect in the study was mild to moderate nausea, which decreased with continued treatment.


TOPICS: Culture/Society; Extended News
KEYWORDS: diabetes

1 posted on 08/26/2003 6:09:21 AM PDT by nypokerface
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To: nypokerface
Great. If I ever get diabetes, I'll keep a Gila monster around and have it bite me on the leg periodically.
2 posted on 08/26/2003 6:10:49 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: dirtboy
Didn't Sharon Stone try to off her husband this way?
3 posted on 08/26/2003 6:19:09 AM PDT by billb
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To: dirtboy
I seem to recall that in order to deploy their venom, they have to kind of chew rather than just bite. You might just want to leave it attached permanently...
4 posted on 08/26/2003 6:20:10 AM PDT by general_re (A clear conscience is usually the sign of a bad memory.)
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To: general_re
I seem to recall that in order to deploy their venom, they have to kind of chew rather than just bite. You might just want to leave it attached permanently...

I could just hang one off an earlobe, wouldn't be any stranger than what some of the kids are wearing nowadays.

5 posted on 08/26/2003 6:21:38 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: dirtboy
I'll keep a Gila monster around and have it bite me on the leg periodically.

That will most certainly result in rapid weight loss.

6 posted on 08/26/2003 6:21:55 AM PDT by templar
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To: dirtboy
"Hey, is that a lizard in your pants, or are you just happy to see me?"
7 posted on 08/26/2003 6:25:13 AM PDT by general_re (A clear conscience is usually the sign of a bad memory.)
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To: general_re
Here's my fashion accessory:


8 posted on 08/26/2003 6:25:25 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: nypokerface
How do they get the spit out of the lizards?
9 posted on 08/26/2003 6:26:27 AM PDT by LurkedLongEnough
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To: nypokerface
RE:Lizard Spit Drug Controls Diabetes, Cuts Weight
 
So does a low-carb diet (lizard spit optional lol)
10 posted on 08/26/2003 6:27:30 AM PDT by tomakaze
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To: dirtboy
"Sorry, I have to pass on dessert - I left my lizard at home..."
11 posted on 08/26/2003 6:27:30 AM PDT by general_re (A clear conscience is usually the sign of a bad memory.)
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To: tomakaze
So does a low-carb diet (lizard spit optional lol)

Instead of using syrup on your pancakes, just have a lizard drool on them.

12 posted on 08/26/2003 6:28:12 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: general_re
"Sorry, I have to pass on dessert - I left my lizard at home..."

Pretty soon we'll have B.B. King affixing a Gila monster to his arm in television commercials.

13 posted on 08/26/2003 6:29:02 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: LurkedLongEnough
How do they get the spit out of the lizards?

Show the males a picture of Helen Thomas - Gila monsters are the only animals to find her attractive.

14 posted on 08/26/2003 6:29:59 AM PDT by dirtboy (Press Alt-Ctrl-Del to reset this tagline)
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To: dirtboy

Actually, I think you're required to french-kiss the lizard within a half-hour of each meal for it to be effective. If you don't stop eating out of revulsion (hence the weight-loss) your blood sugar will drop as it bites your lip and it's venom starts to flow into your bloodstream.

Seriously, how do researchers come up with this stuff? Was someone in the uber-secret Arizona lab staring, bored out of his/her skull, staring out of the window one day - spots a roaming gila monster, and decides "hey, I've got nothing better to do. I'll grab that lizard, let it drool into my mouth, and use my government grant money to pay for research into what it does to me?" Waddya wanna bet he was expecting to find another free psychotropic drug source, i.e. toad-licking?

15 posted on 08/26/2003 6:30:20 AM PDT by Alex Murphy (Athanasius contra mundum!)
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To: dirtboy
re:Instead of using syrup on your pancakes, just have a lizard drool on them.
 
Now *that's* a photoshop waiting to happen.
Aunt Jeguana's Syrup lol.
16 posted on 08/26/2003 6:30:46 AM PDT by tomakaze
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To: tomakaze
What? Diet and Exersize? What kind of radical fringe nut are you?

Thats work! I want a pill!
17 posted on 08/26/2003 6:32:48 AM PDT by LaraCroft ('Bout time)
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To: nypokerface
Lizard Lick, NC
18 posted on 08/26/2003 6:34:57 AM PDT by Constitution Day
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To: dirtboy
Will he name his lizard "Lucille"?

What about Wilford Brimley? He could tie his Quaker Oats commercials together with his diabetes commercials. "Lizard spit - it's the right thing to do."

19 posted on 08/26/2003 6:35:25 AM PDT by general_re (A clear conscience is usually the sign of a bad memory.)
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To: LurkedLongEnough
"How do they get the spit out of the lizards?"


By showing them pics of naked lady lizards
20 posted on 08/26/2003 6:36:53 AM PDT by bethelgrad (for God, country, and the Corps OOH RAH!)
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To: Alex Murphy
"Actually, I think you're required to french-kiss the lizard..."

I think you mean freedom-kiss.

Anyway, I think Dave Barry would agree that Lizard Spit would be a great name for a rock band.

21 posted on 08/26/2003 6:43:01 AM PDT by Jaxter ("A government that robs Peter to pay Paul can always depend upon the support of Paul."- Shaw)
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To: nypokerface


22 posted on 08/26/2003 6:53:33 AM PDT by PBRSTREETGANG
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To: dirtboy
The article said salive. You'll have to French (sorry) kiss a gila monster. No biting though.
23 posted on 08/26/2003 6:59:55 AM PDT by orchid (Defeat is worse than death, you have to LIVE with defeat.)
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To: LurkedLongEnough
just put the lizard in a pickup truck and hand them a styrofoam cup.
24 posted on 08/26/2003 7:05:20 AM PDT by vin-one (I wish i had something clever to put in this tag)
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To: LurkedLongEnough
Present the lizard with a picture of Hillary Clinton.
25 posted on 08/26/2003 7:08:44 AM PDT by Eric in the Ozarks
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To: dirtboy
So Ozzie was on to something? Or was it a bat's head?
26 posted on 08/26/2003 7:13:01 AM PDT by ARepublicanForAllReasons (Where would we be, in 2003, if we had elected "The Tree"?)
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To: Eric in the Ozarks
Present the lizard with a picture of Hillary Clinton.

We're trying to produce lizard spit, not lizard vomit.

27 posted on 08/26/2003 7:13:57 AM PDT by Alex Murphy (Athanasius contra mundum!)
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To: nypokerface
Lizard spit. Sounds like an ingredient to a witch's brew. Modern medicine has some amazing roots, eh?
28 posted on 08/26/2003 7:15:38 AM PDT by Paul_B
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To: ARepublicanForAllReasons
Ozzy's always been on something...oh wait, you asked if Ozzy was on to something. Never mind.
29 posted on 08/26/2003 7:15:42 AM PDT by Alex Murphy (Athanasius contra mundum!)
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To: LurkedLongEnough
How do they get the spit out of the lizards?

They get ten year old boys to goad them into a spitting contest.

30 posted on 08/26/2003 7:17:04 AM PDT by Protagoras (Putting government in charge of morality is like putting pedophiles in charge of children.)
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To: nypokerface
I have diabetes. I forwarded this piece to my doctor with the title "Uh oh."

--Boris

31 posted on 08/26/2003 7:23:45 AM PDT by boris (Education is always painful; pain is always educational.)
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To: Constitution Day
"Lizard Lick, NC"


Relatives went on to found Toad Suck, Arkansas
32 posted on 08/26/2003 7:41:37 AM PDT by Grammy
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To: Alex Murphy
Seriously, how do researchers come up with this stuff? ... use my government grant money to pay for research into what it does to me?"

You are almost there! There is some research dude that has a passion for Gila Monsters. There is a pile of grant money at NIH or the Diabeties Foundation for research into diabeties. The research dude just combines the two in his grant application and voila, a funded research project.

I would bet you could find research on Gila Monster saliva and AIDS and heart disease too, by the same dude.

33 posted on 08/26/2003 7:44:51 AM PDT by dmcnash
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To: Grammy
Relatives went on to found Toad Suck, Arkansas

There's a Bill Clinton joke in there, but I'm going to pass. ;^)

34 posted on 08/26/2003 7:47:01 AM PDT by Constitution Day
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To: Howlin; Ed_NYC; MonroeDNA; widgysoft; Springman; Timesink; dubyaismypresident; Grani; coug97; ...
Just damn.

If you want on the new list, FReepmail me. This IS a high-volume PING list...

35 posted on 08/26/2003 7:47:39 AM PDT by mhking
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To: dirtboy
I could just hang one off an earlobe, wouldn't be any stranger than what some of the kids are wearing nowadays.

...and who said lizards can't help mankind...they DO have a nasty bite...terrible painful wound, however. :/

36 posted on 08/26/2003 7:49:49 AM PDT by skinkinthegrass (Just because you're paranoid,doesn't mean they aren't out to get you. :)
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To: nypokerface
8 or 10 years ago researchers at Clarkson University were working on a remedy for airsickness based on a chemical which they isolated from cockroach eyebells. Now my question is what are these researchers smoking to come up with the brainstorms to try this stuff....And where can I get some!?!?
37 posted on 08/26/2003 7:52:45 AM PDT by YankeeinOkieville (Compost happens.)
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To: YankeeinOkieville
eyebells?
lol
38 posted on 08/26/2003 9:03:27 AM PDT by Grammy
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To: netmilsmom; BlindedByTruth
Ping Ping Ping a Ding
39 posted on 08/26/2003 9:11:22 AM PDT by JonathansMommie (How are inlaws different from out laws? Out laws Are wanted!!)
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To: Alex Murphy
(Present the lizard with a picture of Hillary Clinton. )
"We're trying to produce lizard spit, not lizard vomit."

LOL!!!!

40 posted on 08/26/2003 10:25:15 AM PDT by LurkedLongEnough
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To: JonathansMommie
hey, I wonder if there's any Weight Watchers points for lizard spit, lol
41 posted on 08/26/2003 9:48:55 PM PDT by BlindedByTruth (Get the U.S out of the U.N! That is the blind truth by this blind man!)
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To: BlindedByTruth
LOLOLOLOLOL That's Funny Maybe it's worth 2 points
42 posted on 08/27/2003 6:43:30 AM PDT by JonathansMommie (Men are like Animals...........Some Make Better Pets..)
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To: nypokerface
So after a big meal you've got to go drain your lizard?
43 posted on 08/27/2003 6:45:14 PM PDT by gitmo (Americans are learning world geography ... one war at a time.)
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