I don't think so. While a devout Catholic and a great man, Charles V did not exactly live the life of a saint. Ironically, this proved to be a good thing for Christendom as his illegitimate son Don Juan of Austria led the Catholic forces to victory at Lepanto. But the Emperor's troops once sacked Rome, which probably didn't endear him to the Church.
Italian troops seized the Papal States; sixty years later, they made a deal.
Charles V was the only obstacle to the Protestant seizure of Europe.