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High Tylenol Doses Linked to Liver Woes
Drudge report ^ | July 4, 2006 | CARLA K. JOHNSON - AP

Posted on 07/04/2006 4:49:03 PM PDT by RDTF

Healthy adults taking maximum doses of Tylenol for two weeks had abnormal liver test results in a small study, researchers found, raising concerns that even recommended amounts of the popular painkiller might lead to liver damage.

In the study, 106 participants took four grams of Tylenol _ equivalent to eight extra-strength Tylenol tablets _ each day for two weeks. Some took Tylenol alone and some took it with an opioid painkiller. Dummy pills were given to 39 others.

There were no alarming liver test results among the people who took the placebos. But nearly 40 percent of people in all the other groups had abnormal test results that would signal liver damage, according to the study that appears in Wednesday's Journal of the American Medical Association.

"I would urge the public not to exceed four grams a day. This is a drug that has a rather narrow safety window," said a study co-author, Dr. Neil Kaplowitz of the University of Southern California.

Heavy drinkers should take no more than two grams daily, Kaplowitz said.

(Excerpt) Read more at breitbart.com ...


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: health; medicine; tylenol; tylenolliverdamage
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1 posted on 07/04/2006 4:49:04 PM PDT by RDTF
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To: RDTF

Aghh!!!

I dont think it would hurt for me to go see a doc....I am wondering if this is the cause of the petichiae that have showed up on my body lately.


2 posted on 07/04/2006 4:51:43 PM PDT by aft_lizard (born conservative...I chose to be a republican)
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To: RDTF
Tylenol never bothered me until about 5 years ago, when it suddenly caused me to break out in burn-like sores. It took me 2 years to figure out the source, but through trial and error I was able to make a good guess.

The sores (Erythema-like) were very painful, and took a good two weeks to heal. I believe it's the Acetemetifin (sp?) in the Tylenol.

3 posted on 07/04/2006 4:53:08 PM PDT by Cementjungle
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To: aft_lizard

Could be typhoid fever.


4 posted on 07/04/2006 4:54:03 PM PDT by Graybeard58 (Remember and pray for Sgt. Matt Maupin - MIA/POW- Iraq since 04/09/04)
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To: RDTF
Let's see...this stuff has been around for 30 years, minimum, and now they're discovering this?
5 posted on 07/04/2006 4:54:29 PM PDT by Clara Lou (A conservative is a liberal who has been mugged by reality. --I. Kristol)
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To: RDTF

We almost lost our 14 year old daughter to liver failure caused by a Tylenol overdose. It is a very serious concern.


6 posted on 07/04/2006 4:55:58 PM PDT by Texasforever (I have neither been there nor done that.)
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To: Clara Lou

The docs have know this for years - it seems the media are just now finding out.


7 posted on 07/04/2006 4:57:00 PM PDT by Slings and Arrows (Pray for peace, prepare for war.)
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To: Clara Lou

There has been a link to tylenol, alchohol and liver damage for years. But from what I can recall, the alcohol element was considered key.


8 posted on 07/04/2006 4:57:25 PM PDT by RDTF ("We love death. The US loves life. That is the big difference between us two. Osama Bin laden)
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To: RDTF

I must be woozy from the heat outside... I thought the headline read "High Tylenol Doses Linked to Liver In Wolves."


9 posted on 07/04/2006 4:57:35 PM PDT by fieldmarshaldj (Cheney X -- Destroying the Liberal Democrat Traitors By Any Means Necessary -- Ya Dig ? Sho 'Nuff.)
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To: RDTF
Healthy adults taking maximum doses of Tylenol for two weeks had abnormal liver test results in a small study, researchers found, raising concerns that even recommended amounts of the popular painkiller might lead to liver damage.

The liver toxicity of acetaminophen (Tylenol) has been well understood for at least 40 years.

10 posted on 07/04/2006 4:58:37 PM PDT by Jim Noble (And you know what I'm talkin' 'bout!)
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To: fieldmarshaldj

or it's this! lol

One strong drink can make you 'blind drunk'

http://www.freerepublic.com/focus/f-news/1660389/posts


11 posted on 07/04/2006 4:59:06 PM PDT by RDTF ("We love death. The US loves life. That is the big difference between us two. Osama Bin laden)
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To: Graybeard58

Better not be. Isnt typhoid contracted from untreated water? Because I only drink coffee, bottled water and soda.


12 posted on 07/04/2006 4:59:43 PM PDT by aft_lizard (born conservative...I chose to be a republican)
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To: Clara Lou

It killed a good friend of ours in 1992 - she went to a wide variety of doctors who had no idea her liver damage was due to Tylenol which she took several times a week for years.

We did not make the connection until the famous law suit in the late 90's.

The coroner said she had the worst looking liver he had ever seen.


13 posted on 07/04/2006 5:00:08 PM PDT by spanalot
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To: fieldmarshaldj

I'd stay away from wolf liver, if I were you.


14 posted on 07/04/2006 5:00:16 PM PDT by Tax-chick ("Hyperbolic rodomontade of the most puerile type." ~ Aaron Elkins)
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To: Texasforever
We almost lost our 14 year old daughter to liver failure caused by a Tylenol overdose. It is a very serious concern.

Strange thing is that the tylenon/acetaminophen included with Vicodin like opiate pain killers is the MOST DANGEROUS component.

15 posted on 07/04/2006 5:01:16 PM PDT by A. Pole (George Orwell: "In times of universal deceit, telling the truth will be a revolutionary act.")
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To: RDTF
This has been covered for years. There was (I believe) a Frontline episode on Tylenol its connection to liver problems some years ago. Google this search string:

Tylenol "liver transplant"

to find out more.

16 posted on 07/04/2006 5:02:53 PM PDT by Steely Tom
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To: RDTF
High Tylenol Doses Linked to Liver Woes


17 posted on 07/04/2006 5:05:52 PM PDT by jdm
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To: aft_lizard; ironman73

You can get typhoid fever if you eat food or drink beverages that have been handled by a person who is shedding Salmonella Typhi. Rare in the U.S. But so is Cholera, which my son got a few years back while working for Tyson Foods.

I've pinged him with this post.


18 posted on 07/04/2006 5:06:17 PM PDT by Graybeard58 (Remember and pray for Sgt. Matt Maupin - MIA/POW- Iraq since 04/09/04)
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To: RDTF

I have MS and use an interferon. There have been several articles recently warning interferon users who regularly use Tylenol to premed before their shots to be very aware of liver problems.

Of course, if you take an interferon, you get regular blood work to detect liver problems, so as a population, we'd be alerted earlier to liver problems than the unsuspecting person that's popping the OTC drug, or those using pain pills containing tylenol and then taking tylenol on the side.

Ibuprophen is the drug of choice at our home, of course, the latest studies say it can damage your heart, so I guess it's a game of "pick your poison."


19 posted on 07/04/2006 5:09:14 PM PDT by dawn53
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To: Clara Lou
Let's see...this stuff has been around for 30 years, minimum, and now they're discovering this?

They've known for years that the liver has a hell of a time with acetomine . . . er . . . Tylenol, but if they suspected a study would confirm it, what incentive did the maker have to conduct a study?

20 posted on 07/04/2006 5:13:52 PM PDT by Petronski (I just love that woman.)
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To: RDTF; neverdem

Thanks for the post. Neverdem (((PING)))


21 posted on 07/04/2006 5:16:35 PM PDT by oxcart (Journalism [Sic])
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To: RDTF

The only reason I ever bought any of it was for my babies-- to avoid Rey's Syndrome. [I have no idea how to spell that.] I gave it to them as little as possible. For myself, I never saw anything wrong with aspirin.


22 posted on 07/04/2006 5:17:42 PM PDT by Clara Lou (A conservative is a liberal who has been mugged by reality. --I. Kristol)
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To: RDTF
In the study, 106 participants took four grams of Tylenol _ equivalent to eight extra-strength Tylenol tablets _ each day for two weeks.

Eight tablets a day for two weeks sounds like a lot to me. I mean when you have a headache, you take two and that usually does the trick. I would think that whatever ailment you are taking Tylenol for, if the pain is still there after taking 8 tablets a day, I would see a doctor before I kept taking the drug.

23 posted on 07/04/2006 5:18:22 PM PDT by Gerish (Feed your faith and your doubts will starve to death.)
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To: Clara Lou
Let's see...this stuff has been around for 30 years, minimum, and now they're discovering this?

Tylenol toxicity is well known in medical circles. As with anything, there comes a point where too much of a good thing becomes bad. Have you seen the Tylenol commercials and ads where the company tells people that if they don't use Tylenol per directions, the company would prefer that they not use it at all?

24 posted on 07/04/2006 5:19:12 PM PDT by fso301
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To: Slings and Arrows

True! And it's even worse for the intestinal tract!


25 posted on 07/04/2006 5:19:30 PM PDT by BossLady
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To: Clara Lou

This has been known since at least 1976..The media
reported on it then, and it became standard of
practice in the medical community...
The public, after generational turnover needs to be
reminded again....
But it is true, don't let the advertisers fool ya'...
so go slow with acetaminophen....
...


26 posted on 07/04/2006 5:19:34 PM PDT by Getready
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To: RDTF

Thanks, Drudge.
The health community has known this for years but the general public is encouraged to call us quacks so they pay the penalty for the Pharma interests who need the money badly.


27 posted on 07/04/2006 5:22:46 PM PDT by Spirited
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To: fso301
if they don't use Tylenol per directions, the company would prefer that they not use it at all?
Yes, I noticed those commercials. My antennae went up. I assumed that it was a bit of CYA. I don't purchase the stuff, so it was nothing to me.
28 posted on 07/04/2006 5:28:09 PM PDT by Clara Lou (A conservative is a liberal who has been mugged by reality. --I. Kristol)
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To: RDTF

The Tylenol murders occurred in the autumn of 1982, when seven people in the Chicago, Illinois, area in the United States died after ingesting Extra Strength Tylenol medicine capsules which had been laced with cyanide poison. This incident was the first known case of death caused by deliberate product tampering. The perpetrator has never been caught, but the incident led to reforms in the packaging of over-the-counter substance and federal anti-tampering laws.


29 posted on 07/04/2006 5:28:13 PM PDT by oxcart (Journalism [Sic])
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Comment #30 Removed by Moderator

To: RDTF
Since when is this news?

I thought it was well known that Tylenol could have adverse effects on the liver?

I've avoided tylenol for years because I drink a lot of beer.

31 posted on 07/04/2006 5:31:40 PM PDT by Jorge
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To: Clara Lou

There were early warnings about liver problems. I can't remember exactly when, but about 15-20 years ago. This is the reason I stuck with aspirin.


32 posted on 07/04/2006 5:36:27 PM PDT by AEMILIUS PAULUS (It is a shame that when these people give a riot)
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To: Jorge

This study used the highest recommended dose. Previous studies probably focused on alcohol with Tylenol or overdoses.


33 posted on 07/04/2006 5:40:37 PM PDT by Moonman62 (The issue of whether cheap labor makes America great should have been settled by the Civil War.)
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To: All

I don't take Tylonol for this very reason. Also be very careful taking other OTC pain killers; Advil, Naproxin, even aspirin in large doses for long periods of time.

http://kidney.niddk.nih.gov/kudiseases/pubs/analgesicnephropathy/index.htm


34 posted on 07/04/2006 5:44:33 PM PDT by RadioAstronomer (Senior member of Darwin Central)
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To: Gerish
Eight tablets a day for two weeks sounds like a lot to me. I mean when you have a headache, you take two and that usually does the trick. I would think that whatever ailment you are taking Tylenol for, if the pain is still there after taking 8 tablets a day, I would see a doctor before I kept taking the drug.

They are talking about people with chronic pain. The kind that does not go away. And since our legal system in their wisdom has decided that we can't have stuff that actually works like Vioxx many people rely on daily doses of OTC pain reliever just to get through the day. And if you are aspirin sensitive Tylenol is about the only thing out there.

35 posted on 07/04/2006 5:46:06 PM PDT by Harmless Teddy Bear (Sign up to donate monthly and you will be automatically entered in our "Win a Bear Hug Contest")
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To: dawn53

"it can damage your heart"

It can also damage your kidneys. I was turned down as a kidney donor because of my high usage.


36 posted on 07/04/2006 5:46:21 PM PDT by freeangel ( (free speech is only good until someone else doesn't like what you say))
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To: freeangel

See my post 34.


37 posted on 07/04/2006 5:47:02 PM PDT by RadioAstronomer (Senior member of Darwin Central)
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To: RDTF
Tylenol's been being studied over and over again for decades.

Healthy adults taking maximum doses of Tylenol for two weeks had abnormal liver test results in a small study, researchers found, raising concerns that even recommended amounts of the popular painkiller might lead to liver damage.

Now we have a "small study" in which some "healty adults" showed "abnormal" liver test results.

It's been known for a very long time that excessive use of Tylenol can cause liver damage, and that the difference between the approved over the counter dosage and what can cause problems isn't as great as it is with many other over the counter medicines.

The solution to that has been warnings on the label so that people are informed.

However, informing consumers doesn't make trial lawyer insanely rich. Lawsuits do.

38 posted on 07/04/2006 5:48:17 PM PDT by untrained skeptic
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To: oxcart

I recall reading about this case where it was claimed the murderer was caught. I believe it was a woman who poisoned her husband for his life insurance but tried to cover the crime by randomly poisoning others via placing cyanide in Tylenol. You might want to Google this.


39 posted on 07/04/2006 6:02:20 PM PDT by toddst
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To: RadioAstronomer

I just got a script for Naproxen for use as an antiinflamitory, joint problems caused by youthful indiscretions, brawling for the most part. I let the doctor know that I had some reservations about it because of potential kidney problems. He agreed that they might be a problem if over done and said essentially if it don't hurt, don't take it and limited the number of pills.


40 posted on 07/04/2006 6:06:58 PM PDT by Little Bill (A 37%'r, a Red Spot on a Blue State, rats are evil.)
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To: Gerish

Clearly, the test subjects didn't read the label directions.


41 posted on 07/04/2006 6:08:37 PM PDT by plangent
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To: Jorge; All

I agree. No one in my family uses Tylenol, because it just does not work.
As a former ICU nurse, I have a better reason. I watched a teen (13? 14?) die a slow death over 10 days because he decided to wash down a handful of Tylenol with two beers.
The hunt was on for a new liver when he passed on.....
He wasnt in too much pain for the 1st 3 or so days.


42 posted on 07/04/2006 6:12:32 PM PDT by carmenbmw (My cats name is Mean. He earned it.)
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To: Clara Lou

No. It's been known. Remember Empirin Compound or APCs? Aspirin, Phenacetin, Caffeine? They took phenacetin off the market. J&J had enough clout to keep acetaminophen on the market. One of the active metabolites of acetaminophen is, IIRC...phenacetin.


43 posted on 07/04/2006 6:20:03 PM PDT by jammer
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To: freeangel
I was turned down as a kidney donor because of my high usage.

Define high usage please, for those that may find themselves in similiar circumstances.

44 posted on 07/04/2006 6:23:31 PM PDT by vikzilla
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To: carmenbmw
The hunt was on for a new liver when he passed on..... He wasnt in too much pain for the 1st 3 or so days.

I'm glad to hear that...I mean that he wasn't in too much pain.

My Mom was just diagnosed with terminal cancer, spread mostly to her liver.
I pray every night that she will not suffer a painful death.

45 posted on 07/04/2006 6:23:43 PM PDT by Jorge
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To: Jorge

I am so sorry- my thoughts and prayers will be with you and your Mom..
I think that the worst pain in the situation that I describe is that the child only wanted to *scare* the parents, the girlfriend, etc.
He couldnt quite believe that what he did could actually kill him.
But it did.
Best of luck to you and your Mom, my friend! :-)


46 posted on 07/04/2006 6:34:31 PM PDT by carmenbmw (My cats name is Mean. He earned it.)
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To: carmenbmw
Thanks much!

My Mom has been a real angel through this..a great attitude and beautiful sense of humor...which has really made things easier for us kids.

I only hope I can be half as gracious when my time comes!

47 posted on 07/04/2006 6:53:01 PM PDT by Jorge
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To: RDTF

I didn't think it is any great news that Tylenol can damage the liver.

A friend of mine was detoxing at home from his fifth a day habit, and took some Tylenol PM to sleep.

Almost killed him, and for a while he was on the liver transplant list. Fortunately he was young enough that his liver was able to recover and he was able to recover his health.


48 posted on 07/04/2006 7:03:05 PM PDT by I_Like_Spam
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To: RDTF

Right after the excerpt stops, the qualifying explanation begins. It seems like the drug manufacturers have to create a Tylenol scare to panic people away from the most commonly used and effective pain remedy available in the world. Google or Ask.com the large body of research and read carefully.

The sponsor of this study wants us to believe that its product, OxyContin, an opinate, is far more innocent than big bad killer acetaminophen (paracetamol, elsewhere). The pain reliever of first resort should remain acetaminophen for its well-known safety and effectiveness relative to virtully everything else.

"Another co-author, Dr. Paul Watkins of the University of North Carolina, said he's less worried than Kaplowitz, noting that acetaminophen, the active ingredient in Tylenol, has been used for 50 years and has a good safety record.

The maker of Tylenol, McNeil Consumer & Specialty Pharmaceuticals, said its own research found much lower rates of abnormal liver results. The company's studies tracked high-dose users over longer periods than did the new study.

"It doesn't lead to liver disease and it usually resolves as patients continue to take acetaminophen," said Dr. Edwin Kuffner, senior director of medical affairs at McNeil.

The researchers had been hired by the drug company Purdue Pharma LP, maker of the prescription painkiller OxyContin, to find out why abnormal liver tests were showing up in people testing a combination drug containing the acetaminophen and the opiate hydrocodone.

Purdue Pharma stopped its hydrocodone study early because of the abnormal liver tests. Researchers Watkins and Kaplowitz thought they would find the culprit in hydrocodone's interaction with acetaminophen.

"Our jaws dropped when we got the data," Watkins said. "It doesn't have anything to do with the opiate. It's good ol', garden-variety acetaminophen."

Acetaminophen is more popular than aspirin or ibuprofen. Each week, one in five U.S. adults uses it for pain or fever, a 2002 survey found."


49 posted on 07/04/2006 7:03:33 PM PDT by MikeHu
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To: Clara Lou
and now they're discovering this?

No, the risk of liver damage from Tylenol has been know for some time.

50 posted on 07/04/2006 7:04:17 PM PDT by PAR35
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