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Forget Resveratrol, Tannins Key to Heart Health from Wine
Scientific American, ^ | November 29, 2006 | David Biello

Posted on 11/29/2006 8:10:17 PM PST by neverdem

Wine's beneficial effects on heart health depend more on the traditional vintner's art than the wonder molecule resveratrol.

Resveratrol, a molecule found in the skin of red grapes, among other places, has been found to have a host of health effects, most recently prolonging the life spans of obese mice. But the natural wonder drug does not play a role in the beneficial effects of wine drinking, according to research published in the November 28 issue of Nature. "There are some fascinating effects of resveratrol in animal systems," notes plant biochemist Alan Crozier of the University of Glasgow. "To get similar doses into humans through red wine, you would have to consume more than 1,000 liters of red wine a day."

Because drinking that much wine is beyond even the hardiest oenophile--yes, even those in France--Crozier and his colleague Roger Corder of Queen Mary's School of Medicine and Dentistry in London set out to identify exactly the compounds in red wine that promote heart health. Using the endothelial cells that line human artery walls, the researchers tested which compounds in wine had the greatest effect. The tests showed that flavonoids called oligomeric procyanidins--essentially condensed tannins, the compounds that impart bitterness to young reds--suppressed production of the peptide responsible for hardening arteries. Such procyanidins can make up as much as 50 percent of the bioactive compounds in a given wine, the researchers observed. "Resveratrol," Crozier notes, "is available at one one-hundredth or one one-thousandth of the levels of procyanidin." Corder adds: "The role of resveratrol in the health benefits of wine has been popularized without any scientific evidence to support it, given the amounts needed for these actions are approximately 1,000-fold greater than could be achieved by wine consumption."

Using French census data, the two researchers then compared regions that had unusually long-lived men with the wine produced in those areas. The Nuoro province of Sardinia and the Gers region of southwestern France both support relatively more men who survive past 75 years of age. Not coincidentally, these regions also produce local wines that are as much as four times richer in procyanidins than other wines. Traditional wine-making techniques proved key: by allowing the grapes to linger on the vine for as long as possible and then leaving them to ferment for as long as four weeks (compared with the more typical one-week period of major wineries, which keeps the level of harsh tannins low), vintners in these regions produce prodigious amounts of procyanidin.

Also crucial are the type of grape involved (Tannat in Gers, a small, seedy fruit rarely grown outside the southwest of France) and the elevation at which it is grown (ultraviolet helps catalyze the production of procyanidins in the high-elevation vineyards of Sardinia). "It is not something that in theory is unique to these areas," Crozier adds. "It could become more widespread." Of course, understanding exactly how procyanidins work in the human body remains to be investigated, and the researchers plan to dose people with the compound in a future clinical trial. In the meantime, a few glasses of wine--particularly a full-bodied one--remain a recipe for a stronger heart.


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: health; hearthealth; medicine; resveratrol; tannins

1 posted on 11/29/2006 8:10:19 PM PST by neverdem
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To: neverdem
Resveratrol, a molecule found in the skin of red grapes, among other places, has been found to have a host of health effects, most recently prolonging the life spans of obese mice.

I will be right back. Gotta run down and get a gallon of Gallo Merlot for my fat wino rats. Willard had a coronary yesterday, and Ben is lookin' a bit stroked out.

2 posted on 11/29/2006 8:16:59 PM PST by ARealMothersSonForever (We shall never forget the atrocities of September 11, 2001.)
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To: neverdem

I'm waiting patiently to hear the improved health results from drinking bourbon and smoking cigars. Until then, don't wake me.


3 posted on 11/29/2006 8:18:16 PM PST by saganite (Billions and billions and billions-------and that's just the NASA budget!)
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To: ARealMothersSonForever

So, if a glass of wine is good for you, then the whole bottle must be REALLY good for you. :^)


4 posted on 11/29/2006 8:30:42 PM PST by mkmensinger
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To: neverdem

bump


5 posted on 11/29/2006 8:34:03 PM PST by ThePythonicCow (We are but Seekers of Truth, not the Source.)
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To: neverdem

Isn't there something healthful they can find about rum?

Rum RUm RUM rUM ruM rum rum rum rum...

Oh well, nevermind....


6 posted on 11/29/2006 8:46:44 PM PST by muffaletaman
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To: mkmensinger
So, if a glass of wine is good for you, then the whole bottle must be REALLY good for you. :^)

Dangifiknow. It makes happy rats ;)

7 posted on 11/29/2006 8:51:06 PM PST by ARealMothersSonForever (We shall never forget the atrocities of September 11, 2001.)
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To: neverdem

For those of us who won't spend a dime on French wine, a young Cabernet Sauvignon from the United States or Australia is the way to go since these are high in tannin content. They are a bit aggressive for my palate but I suppose the health benefits are worth developing an appreciation for them.


8 posted on 11/29/2006 9:12:27 PM PST by Unmarked Package
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To: neverdem
In the meantime, a few glasses of wine--particularly a full-bodied one--remain a recipe for a stronger heart.

Doesn't the Holy Bible speak of "wine that maketh glad the heart of man"? (Psalms 104:15)

:P

9 posted on 11/29/2006 9:18:15 PM PST by Map Kernow ("I tremble for my country when I reflect that God is just..." ---Thomas Jefferson)
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To: Unmarked Package

10 posted on 11/29/2006 9:22:18 PM PST by Dick Vomer (liberals suck......... but it depends on what your definition of the word "suck" is.)
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To: neverdem

Thanks for this post. I stayed up late researcing this crap and was on the verge of spending a lot of money on it. https://secure19.nexternal.com/shared/StoreFront/default.asp?CS=longevinex&BusType=BtoC&Count1=708995997&Count2=626136422&CategoryID=2&Target=products%2Easp

More information here:
http://scienceblogs.com/terrasig/2006/11/revisiting_resveratrol_for_agi.php


11 posted on 11/29/2006 9:25:45 PM PST by elfman2 (An army of amateurs doing the media's job.)
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To: neverdem

self-ping


12 posted on 11/29/2006 9:30:48 PM PST by Free Vulcan (Show them no mercy, for you shall receive none!)
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To: Dick Vomer
Hah! While a young Cabernet Sauvignon can be aggressive to the palate, a potent bum wine like MD 20/20 is downright homicidal! However, it's great for cleaning corroded terminals on car batteries. :-)
13 posted on 11/29/2006 9:31:35 PM PST by Unmarked Package
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To: elfman2

For those who don't drink wine, eat red apples.


14 posted on 11/29/2006 9:31:44 PM PST by Moonman62 (The issue of whether cheap labor makes America great should have been settled by the Civil War.)
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To: Moonman62

I like apples with my wine.


15 posted on 11/29/2006 9:39:29 PM PST by jonrick46
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To: jonrick46

Cheese goes good with apples and wine.


16 posted on 11/29/2006 9:42:42 PM PST by Moonman62 (The issue of whether cheap labor makes America great should have been settled by the Civil War.)
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To: Moonman62

Ever think the low heart attack rates of wine drinkers are just due the personality of wine drinkers? While your and my anger at Democrats sends artery hardening adrenaline pumping into our veins, the French say se la vie sipping bourdeaux as Islamists torch their rides home.


17 posted on 11/29/2006 9:58:18 PM PST by elfman2 (An army of amateurs doing the media's job.)
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To: saganite

Well, by maintaining blood level of 86 proof one becomes resistant to most infections [but subject to spontaneous combustion]. Just look at ted kennedy - when was the last time any infection got him?


18 posted on 11/29/2006 10:08:11 PM PST by GSlob
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To: elfman2

Thanks for the links.


19 posted on 11/29/2006 10:13:24 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Free Vulcan

ditto


20 posted on 11/29/2006 10:29:58 PM PST by Aria (Terri: Do not ask for whom the bell tolls; it tolls for theeii)
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To: Moonman62

Grape juice works well too if you don't drink.


21 posted on 11/29/2006 10:55:43 PM PST by pandoraou812 ( zero tolerance and dilligaf?)
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To: pandoraou812

There is a company called Longevinex which puts 40 mg of bio-active resveratrol in a medical grade capsule which solves the problem of how do you get enough red wine extract?


22 posted on 01/10/2007 5:02:27 PM PST by WayneLusvardi (It's more complex than it might seem)
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