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FDA approves first human embryonic stem cell safety trial (3 days after Pres. Bush left)
Scientific American ^ | 1-23-09 | Jordan Lite

Posted on 02/02/2009 7:07:22 PM PST by STARWISE

Federal regulators have green-lighted the first trial of an embryonic stem-cell treatment in humans.

The U.S. Food and Drug Administration (FDA) gave the go-ahead for Geron Corporation to start a phase I safety trial of its therapy GRNOPC1 for spinal cord injuries, the Menlo Park, Calif.–based company announced today.

It first sought permission for the trial four years ago and spent much of the last year trying to satisfy the FDA’s concerns about it.

"This marks the beginning of what is potentially a new chapter in medical therapeutics—one that reaches beyond pills to a new level of healing: the restoration of organ and tissue function achieved by the injection of healthy replacement cells,” Thomas Okarma, Geron's president and CEO, said in a statement today.

The trial will involve up to 10 patients and will test whether it is safe to inject nerve cells from embryos into the site of their injuries, according to Geron. A study published in 2005 in the Journal of Neuroscience found that giving rats the injections seven days after a spinal cord injury improved their motor function.

Wise Young, director of The W. M. Keck Center for Collaborative Neuroscience at Rutgers University, hailed the FDA’s decision, but says his expectations are tempered.

“It’s a big deal—it’s a long time in coming. There’s a lot of hope riding on this,” Young tells ScientificAmerican.com. But he cautions that people should not expect "a miraculous result" from this initial trial.

"I do believe cellular therapy will have a beneficial effect," he says, "but it’s very important to understand that we’re just starting. We have a long road to go.”

Geron and FDA officials told The Wall Street Journal that it was a coincidence that the announcement came just three days after George Bush left the White House. Bush restricted federal funding of embryonic stem cell research.

"The FDA looks to the science on these types of issues, and we approve [such applications] based on a showing of safety," FDA spokesperson Karen Riley told the Journal. “Political considerations have no role in this process."

Pres. Obama said during his campaign that he would lift the ban on federal funding of research on embryonic stem-cell lines produced after August 9, 2001. But he told CNN on January 18 that he may ask Congress to undo it.

Lawmakers passed legislation three times during the Bush administration that would have erased the limit and allowed research on stem cells from embryos at fertility clinics (with donors' consent) that would otherwise be discarded; Bush vetoed them all.

"I like the idea of the American people's representatives expressing their views on an issue like this," Obama told CNN.

That may not be a bad thing, Young says. “If he were to reverse this on his own, it takes Congress off the hook.

It’s much more important that Congress makes sure this doesn’t happen again,” he says. “What is worrisome is that if Obama did just reverse the rule, stem cells would be a political football in Congress to trade for something else.

It’s really important from the viewpoint of the advocacy community that legislation is passed so other presidents don’t come in and say, ‘I will forbid this.’”


TOPICS: Breaking News; Constitution/Conservatism; Front Page News; Government; Politics/Elections
KEYWORDS: abortion; abovemypaygrade; ameirca2point0; bho44; bhoabortion; bhoethics; cloning; cultureofdeath; culturewar; deathindustry; embryonicstemcells; embryos; fda; firsthundreddays; geneticcannibalism; ghouls; graverobbers; infanticide; junkscience; notbreakingnews; obama; obamatruthfile; prolife; pseudoscience; slaughter; suckers
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Geron and FDA officials told The Wall Street Journal that it was a coincidence that the announcement came just three days after George Bush left the White House. Bush restricted federal funding of embryonic stem cell research.

~~~~

God help us. We were blessed with a staunch protector of innocent human life ... life is a commodity now. God bless you, Pres. George Bush. Pray for America.

1 posted on 02/02/2009 7:07:23 PM PST by STARWISE
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To: nickcarraway; sandyeggo; Lady In Blue; fatima; NYer; ELS; Salvation; elcid1970; RobbyS; ...

~~Sad ping!


2 posted on 02/02/2009 7:09:46 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: STARWISE

I hope this falls flat on its ass. The Embryonic Stem Cell Research gets us nowhere.


3 posted on 02/02/2009 7:11:16 PM PST by benjibrowder (Looking forward to kicking Obama out of office in 2012.)
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To: STARWISE

Very sad indeed. I do not think we will ever get a moral President as President Bush was. He believed in life and fought to preserve it and to protect it on all fronts.


4 posted on 02/02/2009 7:12:56 PM PST by jveritas (God Bless our brave troops)
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To: STARWISE

The baby killers have been set loose!


5 posted on 02/02/2009 7:13:19 PM PST by FlingWingFlyer (I wish it was 20 January 2013. I've had enough of this crap already.)
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To: STARWISE

Where is the photo of the wilting flowers? This is sad beyond belief.


6 posted on 02/02/2009 7:13:19 PM PST by littlehouse36
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To: STARWISE

This makes it sounds like they are taking cells directly from fetuses instead of limited lines grown in the lab - quite a change if that is really what they are doing.


7 posted on 02/02/2009 7:14:55 PM PST by gondramB (Preach the Gospel at all times, and when necessary, use words.)
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To: FlingWingFlyer

Why is anyone surprised? ELECTIONS HAVE CONSEQUENCES.


8 posted on 02/02/2009 7:15:15 PM PST by Hildy
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To: STARWISE

“~~Sad ping!”

Very sad. Experimenting on human embryos, reversing the Mexico City Policy so tax dollars are paid for abortions in other countries, etc..

Evil is spreading like wildfire.


9 posted on 02/02/2009 7:17:11 PM PST by Sun (Pray that God sends us good leaders. Please say a prayer now.)
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To: jveritas
“He believed in life”

Even more he was intelligent. He realized science was showing NON embryonic cells have more promise.

10 posted on 02/02/2009 7:18:04 PM PST by JSteff (It was ALL about SCOTUS. Most forget about that and may have doomed us for a generation or more.)
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To: JSteff

Agree 100%.


11 posted on 02/02/2009 7:20:57 PM PST by jveritas (God Bless our brave troops)
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To: Hildy
Hopefully many of the dummies are now seeing this. But many more dummies are too busy to care.

Their apathy towards getting the real story is part of what will doom us for several years.

12 posted on 02/02/2009 7:21:11 PM PST by JSteff (It was ALL about SCOTUS. Most forget about that and may have doomed us for a generation or more.)
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To: gondramB

“instead of limited lines grown in the lab”

In this case most likely contaminated lines. They have been for years. One of the many reasons that this type of research FAILS.


13 posted on 02/02/2009 7:21:37 PM PST by swmobuffalo ("We didn't seek the approval of Code Pink and MoveOn.org before deciding what to do")
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To: STARWISE

“I like the idea of the American people’s representatives expressing their views on an issue like this.” -BO

Roe v. Wade didn’t allow the American people to express their views on an issue like this.


14 posted on 02/02/2009 7:21:39 PM PST by madameguinot (Our Father's God to Thee, Author of Liberty)
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To: STARWISE
FDA approves first human embryonic stem cell safety trial (3 days after Pres. Bush left)...yeah, Mike Huckman reported the story this way on CNBC when it first came out last week - as though suddenly the clouds had parted, all the light of heaven had descended on earth, and science was saved because Obama was now president - no mention of the fact that study would have had to have been in progress for years - meaning it was undertaken with every anticipation that it could be effectively completed - mid-Bush administration - one has to marvel at the ingenuity of the loony left in finding ways to spin any story toward their orthodoxy......
15 posted on 02/02/2009 7:22:47 PM PST by Intolerant in NJ
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To: STARWISE
"I do believe cellular therapy will have a beneficial effect," he says, "but it’s very important to understand that we’re just starting. We have a long road to go.”

Translation: "We have all these dead babies. There must be something we can do with them."

Why read Mary Shelley's Frankenstein when you can pick up a newspaper?

16 posted on 02/02/2009 7:23:46 PM PST by SamuraiScot
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To: STARWISE; xzins; wagglebee; wmfights

I for one would rather DIE than use an embryonic stem cell to prolong my life.


17 posted on 02/02/2009 7:24:58 PM PST by P-Marlowe (LPFOKETT GAHCOEEP-w/o*)
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To: benjibrowder
This makes me think of the reason d'etre of "I am Legend" - the "cure" that turns into a plague that basically kills everyone. Or worse.

We've brought it on ourselves...

18 posted on 02/02/2009 7:27:20 PM PST by Starfleet Command
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To: STARWISE

If they are ready for human trials now, they were doing the research during the entire Bush administration...they just were doing it without federal funding.


19 posted on 02/02/2009 7:27:55 PM PST by Amelia
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To: STARWISE
And people continue to claim that having a pro-life President doesn't make any difference.....

Pray for America!

20 posted on 02/02/2009 7:29:45 PM PST by ohioWfan (Thank you PRESIDENT BUSH!!!)
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To: Intolerant in NJ

So then, did they break the law with respect to the ban on embryonic stem-cell research?

And, given my experiences with government, NOTHING of the scale of a big project like this would EVER get done in 3 days.

Something smells rotten here...


21 posted on 02/02/2009 7:30:14 PM PST by OneWingedShark (Q: Why am I here? A: To do Justly, to love mercy, and to walk humbly with my God.)
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To: Hildy; StarFan; PhiKapMom
Why is anyone surprised? ELECTIONS HAVE CONSEQUENCES.

That's right, Hildy. That includes those "principled" types who vote third party, or who "stay home" on election day, enabling 'RATs to acquire more power.

22 posted on 02/02/2009 7:30:36 PM PST by nutmeg (No terrorist attacks on U.S. soil since 9/11/01. Thank you President Bush.)
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To: STARWISE; jveritas; Wolfstar; snugs; DrDeb

President George W. Bush holds 14-month-old Trey Jones of Cypress, Texas, following his remarks about stem cell research policy legislation in the East Room of the White House Wednesday, July 19, 2006. "Each of these children was adopted while still an embryo, and has been blessed with the chance to grow up in a loving family," said the President of children sharing the stage with him. "These boys and girls are not spare parts. They remind us of what is lost when embryos are destroyed in the name of research." Trey Jones was first introduced to the President during a White House visit in May 2005. White House photo by Kimberlee Hewitt
23 posted on 02/02/2009 7:33:02 PM PST by silent_jonny ("All I want is to enter my house justified" - Joel McCrea, Ride The High Country)
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To: nutmeg; All

No Need For Embryonic Stem Cells

###

STEM CELL RESEARCH — (House of Representatives - September 10, 2008)


The SPEAKER pro tempore. Under a previous order of the House, the gentleman from Florida (Mr. Weldon) is recognized for 5 minutes.

Mr. WELDON of Florida . Mr. Speaker, this summer has been a breath-taking one for stem cell researchers around the world, but not because of embryonic stem cells or cloning. Building on important work published last year showing that it is possible to reprogram an adult cell back to its primitive embryonic-like state, researchers led by Doug Melton at Harvard University have done what was thought impossible only a few short years ago.

Melton and his team used mice to show that it is possible to directly reprogram support cells or exocrine cells of the pancreas into insulin-producing beta cells without ever removing any cells from the pancreas.

Amazingly, it appears that one adult cell type has been directly and specifically transformed into another adult cell type.

In other words, a simple injection of three critical reprogramming factors successfully produced insulin-producing beta cells and gave patients with diabetes and their families new reason to hope in the power of regenerative medicine.

Melton and his colleagues have brought us one step closer to what many have called the ``holy grail’’ of regenerative medicine.

He has shown that, in principle, it is possible to induce the body to heal itself by reprogramming one cell type into another.

Imagine that; your beta cells can no longer make insulin and you are diabetic, perhaps because of immune destruction of your insulin-producing cells like in Type I diabetes, or perhaps because, like in Type II diabetes, your insulin-producing cells have just given up.

If the work Melton describes can be reproduced in human patients, diabetes patients would have to receive a simple injection, maybe two or three times, and with that, their pancreas could resume producing insulin and they would be cured of their diabetes, no longer requiring insulin injections, no longer requiring painful pinpricks.

Of course, Melton’s work is a long way from the clinic. Mice are not people, and some of the details must be modified to ensure that the injection is safe and won’t cause tumors.

But this work represents an enormous step forward and should be pursued with all of the resources NIH can provide.

This exciting news comes on the heels of another announcement also this summer, that researchers from Harvard and Columbia have used the reprogramming protocol to create 21 disease-specific stem cell lines that will enable researchers to intimately study diseases such as Lou Gehrig’s disease, Type I diabetes, Parkinson’s and muscular dystrophy.

And it is important to note that this technique also

***does not require the creation, destruction or even the presence of human embryos.***

These cells may not be ready to transplant into humans in the near term, but they will be available for research today and for use in screening for drugs.

So in a few short months, the promise of regenerative medicine comes closer to reality. Just last year, scientists and cloning advocates told us that we had to do human cloning—or at least to create cloned human embryos—so that we could accomplish these two goals that were deemed essential for moving regenerative medicine forward; creating disease-specific cell lines, and regenerating stem cells that could be a perfect match for patients affected by these diseases.

Both of these goals have been accomplished with the reprogramming protocol; no cloning, no human embryo stem cells required. To say it another way, there is no medical reason to proceed with research into cloning human embryos for their stem cells because that science is obsolete, it is more cumbersome, it is more expensive. We have a better, quicker, easier way to do it.

Rest here:

http://www.lifewatch.org/noneedforembryos.html#STEM_CELL_RESEARCH


24 posted on 02/02/2009 7:34:36 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: silent_jonny

Thank you Johnny for this very nice post. I greatly missed President Bush.


25 posted on 02/02/2009 7:34:43 PM PST by jveritas (God Bless our brave troops)
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To: silent_jonny

Praise the Lord for Pres. Bush. Sad ... sad
turn of events. Zero just couldn’t wait to
jump on it and start the destruction.


26 posted on 02/02/2009 7:36:22 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: OneWingedShark

“So then, did they break the law with respect to the ban on embryonic stem-cell research?”

I think the ban was on using our tax money for the reasearch, not on the research itself.


27 posted on 02/02/2009 7:36:43 PM PST by Western Phil
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To: Western Phil

>>“So then, did they break the law with respect to the ban on embryonic stem-cell research?”
>
>I think the ban was on using our tax money for the reasearch, not on the research itself.

I see. Too bad... I’m in the mood to see heads crushed on a REAL moral high-ground.


28 posted on 02/02/2009 7:38:26 PM PST by OneWingedShark (Q: Why am I here? A: To do Justly, to love mercy, and to walk humbly with my God.)
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“As to diseases,
make a habit of two things—
to help, or at least do no harm.”

###

Human Pluripotent Stem Cells without Cloning or Destroying Embryos

Stem cell research and resources

http://www.stemcellresearch.org/


29 posted on 02/02/2009 7:39:15 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: STARWISE
Zero just couldn’t wait to jump on it and start the destruction.

Not defending Obama, but I doubt he had anything to do with it.

The company had to have been doing this research for quite a while. The research itself was not banned, it's just that federal money couldn't be used to pay for it.

30 posted on 02/02/2009 7:39:50 PM PST by Amelia
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Adult stem cells still trump embryonic

http://www.mercatornet.com/articles/adult_stem_cells_still_trump_embryonic/


31 posted on 02/02/2009 7:40:08 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: STARWISE

Ya know...the year 1984 is my favorite year ever...but the book...yeah..it’s coming to life.


32 posted on 02/02/2009 7:48:52 PM PST by My Favorite Headache (An oath to a liar is no oath at all)
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To: silent_jonny; STARWISE

THANK YOU for the photo and the alert . . . We have replaced a godly man who values ALL life (particularly the most innocent and vulnerable among us) with a secular man who values no life unless that life serves some utilitarian purpose, e.g., voting ‘Democrat’ on election day.

I miss President Bush more and more every day!


33 posted on 02/02/2009 7:48:56 PM PST by DrDeb
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To: Amelia

Right .... now, we get to pay for the killing.
That’s a HUGE contrast to Pres. Bush’s ethics.


34 posted on 02/02/2009 7:50:16 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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To: STARWISE
God help us. We were blessed with a staunch protector of innocent human life ... life is a commodity now. God bless you, Pres. George Bush. Pray for America.

Yes, but the crowd that delighted in calling him Jorge are happy. That's so much more important than having a consistent defender of human life in the WH.

McCain is many things I disagreed with, but he has a pretty good record on life issues. His choices for SCOTUS might not have been perfect if he made them, but...well, you know the rest.

35 posted on 02/02/2009 7:51:09 PM PST by Darkwolf377 (Pro-Life Capitalist American Atheist and Free-Speech Junkie)
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To: gondramB

Embryonic stem cells have to be harvested at a particular point in development. I believe that the embryo must be around 4-5 days old, for truly embryonic stem cells to be harvested. Any later and the cells are no longer pluripotent, and would be considered adult stem cells. The article didn’t make that very clear, but scientifically that is the only way it can work.


36 posted on 02/02/2009 8:00:36 PM PST by ga medic
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To: jveritas

Aside from his supporting Amnesty and this Stimulus, I will miss GWB a lot.

Embryo to Bush= A Human life
Embryo to Soetoro= “Punishment” or a lab experiment


37 posted on 02/02/2009 8:01:08 PM PST by omega4179 (1.20.13 end of an error)
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To: benjibrowder

**The Embryonic Stem Cell Research gets us nowhere.**

Private firms have been working on Embryonic Stem cell all along. THe Federal did not BAN research .. it just banned Federal $$$ for research.

So far, ALL EMBRYONIC Tests have caused 1 thing 100% of the time... CANCER!! ADULT Stem cell research, however, has paralyzed people able to move their feet.


38 posted on 02/02/2009 8:02:00 PM PST by gwilhelm56 (MULLAH HUSSEIN - which part of "Congress shall make no Law" - do you NOT UNDERSTAND??)
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To: STARWISE

The fight just got much harder. Stay the course - God IS on our side.


39 posted on 02/02/2009 8:03:10 PM PST by SoldierDad (Proud Dad of a U.S. Army Infantry Soldier presently instructing at Ft. Benning.)
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To: jveritas
Thank you Johnny for this very nice post. I greatly missed President Bush.

I guess I trashed him as much as anyone given my disappointment on many issues. But good grief. After the last few weeks I dearly miss the man. What we face is much worse than I expected.

40 posted on 02/02/2009 8:03:31 PM PST by plain talk
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To: plain talk

We will miss even more as time goes on. We have seen nothing yet.


41 posted on 02/02/2009 8:06:12 PM PST by jveritas (God Bless our brave troops)
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To: JSteff

My greatest disappointment when the Republicans held Congress is that they didn’t make it illegal to destroy the human embryos that are stored by fertility clinics. I have never understood why they didn’t take that step.


42 posted on 02/02/2009 8:12:16 PM PST by DeepThought42 (He who dares, wins.)
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To: AdmSmith; Berosus; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; justiceseeker93; ..

Doctor Mengele ping.


43 posted on 02/02/2009 8:14:30 PM PST by SunkenCiv (https://secure.freerepublic.com/donate/____________________ Profile updated Monday, January 12, 2009)
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To: gwilhelm56

>>So far, ALL EMBRYONIC Tests have caused 1 thing 100% of the time... CANCER!! <<

Searching... I can’t find any previous examples of human trials at all.


44 posted on 02/02/2009 8:17:43 PM PST by gondramB (Preach the Gospel at all times, and when necessary, use words.)
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To: STARWISE

Do people think because an American president declares war against science that research around the world ceases on a decree from George Bush. Science like everything else simply moves offshore out of the reach of American Luddites.

Allowing religious based politics to dictate scientific research is akin to witchdoctors deciding what experiments will be conducted at the CERN Lab.

America is losing it’s scientific edge, just look at how the Japanese have mastered space technology I wouldn’t be surprised that they become the new leaders as NASA’s financial mistakes mire it in catching up.

Please in regards to scientific research, lead, follow or get out of the way.


45 posted on 02/02/2009 8:19:49 PM PST by DoingTheFrenchMistake
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To: wagglebee

embryonic experimentation ping


46 posted on 02/02/2009 8:24:06 PM PST by Gene Eric
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To: Amelia
The President's ban on the funding of embryonic stem cells is what has led scientists to look for other means of developing stem cells..........umbilical, adult, etc........and find great success.

That will all change under Obama, and this unfunded research, which hasn't been successful, will now get funding, and more unborn children will die.

Who said it upthread? Elections have consequences.

This is a bad one.

47 posted on 02/02/2009 8:27:37 PM PST by ohioWfan (Thank you PRESIDENT BUSH!!!)
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To: DoingTheFrenchMistake
1. President Bush never "declared war against science." He denied funding to experimenting on human beings.

2. This is not "religious based politics." It is what is moral and what is right. Being pro-life is not just for the religious. It's for anyone who has a fundamental respect for human life.

3. Not funding the destruction of babies hasn't caused America to lose its edge.

It appears that you have gotten ahold of some propaganda that has led you down a path of lies. Adult stem cell research has flourished since President Bush courageously stood on the side of life.

We owe him a debt of gratitude, not more mindless attacks.

48 posted on 02/02/2009 8:33:01 PM PST by ohioWfan (Thank you PRESIDENT BUSH!!!)
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To: STARWISE

They will farm human life in its earliest form to be used as ingredients for what they call ‘medicine’. In my opinion, this is depraved and twisted.


49 posted on 02/02/2009 8:36:27 PM PST by Gene Eric
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To: DoingTheFrenchMistake
Please in regards to scientific research, do not mutilate or destroy human life.

President George W. Bush holds 14-month-old Trey Jones of Cypress, Texas, following his remarks about stem cell research policy legislation in the East Room of the White House Wednesday, July 19, 2006.

"Each of these children was adopted while still an embryo, and has been blessed with the chance to grow up in a loving family," said the President of children sharing the stage with him.

"These boys and girls are not spare parts. They remind us of what is lost when embryos are destroyed in the name of research." Trey Jones was first introduced to the President during a White House visit in May 2005.

~~~~

I guess if it were up to you, these precious children would be just carved up into frozen parts so they could be "useful" in your world.

God bless and protect the innocent babes.

50 posted on 02/02/2009 8:37:27 PM PST by STARWISE ( They (LIBS-STILL) think of this WOT as Bush's war, not America's war- Richard Miniter))
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