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Why Smokers Are Skinny
SciencceNOW ^ | 9 June 2011 | Sarah C.P. Williams

Posted on 06/12/2011 12:02:11 AM PDT by neverdem

Craving an afternoon snack? Take a drag on a cigarette, and your hunger will likely disappear. Smoking is the number one cause of preventable deaths in the Unites States and other developed countries, causing lung cancer, heart disease, and chronic bronchitis. But smokers are, on average, skinnier than nonsmokers. New research reveals how nicotine, the active ingredient in cigarettes, works in the brain to suppress smokers' appetites. The finding also pinpoints a new drug target for nicotine withdrawal—and weight loss.

The nicotine receptor in the brain has 15 subunits; they can combine in a multitude of ways to form different receptors with different jobs. Nicotine can bind to each combination and spur a cascade of distinct events; some lead to the addictive properties of cigarettes, others to an increase in blood pressure or a feeling of relaxation. It's long been known that nicotine causes a slump in appetite, and scientists suspected that this worked through receptors associated with reward and behavior reinforcement. After all, the brain considers both cigarettes and food to be rewards. But the new finding suggests that appetite has its own pathway.

Behavioral neuroscientist Marina Picciotto of Yale University set out to study whether activating one particular nicotine receptor, dubbed α3β4, had antidepressant effects on mice. But as postdoctoral researcher Yann Mineur was caring for the mice, which had received drugs engineered to stimulate only α3β4 receptors, he noticed a side effect: the mice were eating less.

"Before this study, we really didn't think that this type of receptor would have such a big role in the brain in food intake," Picciotto says. She and Mineur went on to show that nicotine does, in fact, bind to α3β4 receptors, which then send a signal throughout the rest of the brain, signaling satiety. It's indistinguishable from the signal the brain propagates after eating a large meal. Mice that received the drug binding to the α3β4 receptor ate half the amount of food as untreated mice in the 2 hours following administration of the drug. Their body fat dropped 15% to 20% over 30 days, the team reports online today in Science.

Since the weight gain that comes with stopping smoking is often one deterrent for smokers to quit, Picciotto suggests that the new pathway could be targeted by pharmaceuticals to suppress appetite during the initial stages of smoking cessation. In addition, such a drug could have wider reach as an appetite suppressant to aid in weight loss, without the health hazards tied to cigarette smoke.

Neil Grunberg, a behavioral neuroscientist at the Uniformed Services University of the Health Sciences in Bethesda, Maryland, was the first to prove, through rat studies in 1982, that nicotine causes a decrease in appetite. He says the new study is a step forward in understanding the phenomenon he first observed.

"Most people had accepted that the decrease in appetite was caused through a dopamine-reward pathway and left it at that," Grunberg says. "So I think the most important contribution of this paper is to prove that there is another whole pathway that nicotine is working through."

Grunberg notes, however, that the study looks only at male mice. In his previous work, he has found differences in the effects of nicotine on weight between males and females. Females, he says, experience larger weight loss when they start smoking and a larger weight gain if they quit. Whether this means nicotine is working through an additional, hormone-regulated pathway in the female brain is yet to be determined.

Picciotto says her group is repeating the experiments on female mice. "We're also still trying to get back to that original question we had," she says: "Does this also have antidepressant actions?"


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: nicotinereceptor; obesity; smoking; weightloss
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1 posted on 06/12/2011 12:02:16 AM PDT by neverdem
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To: neverdem

“Tricking” your brain is probably not a good idea over the long run. I wonder what other side effects that could trigger? The best way to lose weight is to portion your food and drink a lot of water.


2 posted on 06/12/2011 12:09:42 AM PDT by Sprite518
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To: neverdem
Why Smokers Are Skinny

Because you're looking at skinny smokers. Try looking in a city with fat people, and you'll see fat smokers.

3 posted on 06/12/2011 12:09:49 AM PDT by kittycatonline.com
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To: Sprite518

>> “Tricking” your brain is probably not a good idea over the long run.

It’s only a matter of tricking the stupid part of the brain.


4 posted on 06/12/2011 12:12:47 AM PDT by Gene Eric (*** Jesus ***)
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To: neverdem

“Smoking is the number one cause of preventable deaths “

I had no idea that death was ‘preventable’


5 posted on 06/12/2011 12:22:34 AM PDT by esoxmagnum
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To: kittycatonline.com

you’ve never smoked before.

Two things that satisfy your hunger...tobacco and coffee. Been there done that. Alcohol also will temporarily suppress hunger pangs. A person can get by comfortably for a long time on only alcohol, tobacco, and coffee. Add something oily now and then like sunflower seeds, french fries, bacon, hashbrowns, or plain doughnuts and you can survive almost indefinitely without discomfort.


6 posted on 06/12/2011 12:22:52 AM PDT by mamelukesabre (Si Vis Pacem Para Bellum (If you want peace prepare for war))
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Comment #7 Removed by Moderator

To: neverdem

I can tell you why EX-smokers bloat up like a freaking beachball (smoked for 30 years and even if I gained a “few” pounds quitting was the 3rd smartest thing I ever did)!

1) You get HUNGRY! The cigs were suppressing your appetite (the point of the article I gather)

2) Food tastes GOOD! When the cilia stop laying down, they rise up and start telling your body “HEY This is freaking GOOD!” Everything for the first year or so after the taste buds reawaken tastes like ambrosia! You really see that food was God’s way of telling you He loves you and wants you to be happy.


8 posted on 06/12/2011 12:30:59 AM PDT by freedumb2003 (Herman Cain 2012)
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To: Gene Eric

I think it’s dangerous to trick this portion of your brain. How about finding a way to stimulate the facts and logic portion of your brain?

I would be willing to bet that most people that have this issue is because they have a lack of self discipline. Another word for it is your “Will” factor. How willing you are to do anything.


9 posted on 06/12/2011 12:33:31 AM PDT by Sprite518
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To: esoxmagnum; neverdem

>>“Smoking is the number one cause of preventable deaths “

I had no idea that death was ‘preventable’<<

O M G!! That is one of the funniest posts I have read on FR!!!

Sheldon was right, there is a gap between when we of these generations will die and when we can transfer our consciousness to a cyborg...


10 posted on 06/12/2011 12:34:09 AM PDT by freedumb2003 (Herman Cain 2012)
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To: Sprite518
Another word for it is your “Will” factor. How willing you are to do anything.

Will Wheaton!!!!! You will pay for this!!!!!!

11 posted on 06/12/2011 12:36:03 AM PDT by freedumb2003 (Herman Cain 2012)
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To: freedumb2003

well sure. when everything tastes like dirt, you eat less. Gosh, whodathunk?


12 posted on 06/12/2011 12:36:08 AM PDT by mamelukesabre (Si Vis Pacem Para Bellum (If you want peace prepare for war))
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To: Don W

>> FOAD.. STFU...

Pipe down, fatty.


13 posted on 06/12/2011 12:39:05 AM PDT by Gene Eric (*** Jesus ***)
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To: freedumb2003

3) You also forget the effect that a starved body experiences when finally getting food. The body balloons up to a huge point because the body is desperate to operate on minimal calories and the body greedily seizes and stores whatever fats it can get into it’s body. It’s the same effect of someone recovering from anorexia. Then to protect the stored nutrients, the body refuses to just let go, it clings to whatever it can get.


14 posted on 06/12/2011 12:44:21 AM PDT by Niuhuru (The Internet is the digital AIDS; adapting and successfully destroying the MSM host.)
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To: neverdem

All the smokers I know are over weight. They over eat and smoke and don’t do any exercise. Don’t know one skinny smoker.


15 posted on 06/12/2011 12:48:26 AM PDT by MissMack99 (BO Stinks!)
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To: neverdem

bookmark


16 posted on 06/12/2011 12:48:28 AM PDT by GOP Poet (Obama is an OLYMPIC failure.)
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To: freedumb2003

Though I like many of your postings, this time I say:

Horse bits!

EVERYTHING tasted like rabbits raisins for the first 3 years after quitting smoking. My (ex)wife was concerned about me because I wouldn’t eat until the food was cold, and I ate less than half what was set out for me because it smelled horrid and tasted worse.

1) I had LITTLE appetite. Food repulsed me.

2) Meat tasted like dirty socks, and vegetables tasted like uncooked oatmeal mixed with bits of straw, with the occasional rat dropping added for variety. Veggies were the pleasant sensation of overcooked squash that smelled like weeks old catbox.

FOOD WAS DISGUSTING, but I put on a LOT of weight. More than some calorie counter can account for, even in a worst case scenario.

As a previous poster said, it’s far easier to tell the never-smoked from the reformed smokers. If they only knew how utterly foolish they ARE.


17 posted on 06/12/2011 12:51:08 AM PDT by Don W (You can forget what you do for a living when your knees are in the breeze.)
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To: Niuhuru

>>Then to protect the stored nutrients, the body refuses to just let go, it clings to whatever it can get.<<

Well, that is my new story and I am sticking to it!

;) :)

(seriesly, I used to be skinny as a rail — picture a shorter but same proportioned Bobby from L&O:CI. My weight sort of tracked the same way, but it is like seasons 4-6 happened in a month)


18 posted on 06/12/2011 12:51:59 AM PDT by freedumb2003 (Herman Cain 2012)
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To: Don W; kittycatonline.com; dixiechick2000

I respect smokers rights and I used to smoke and my wife still does

But that was no way to speak using the f bomb to an obvious freeper woman who may well be an older grandma...way uncalled for

I understand the resentment of smoke nazis but the f flame should be used more selectively


19 posted on 06/12/2011 12:55:03 AM PDT by wardaddy (ok...so far I am Palin/Rubio 2012....i can explain easy..just ask)
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To: Gene Eric

How about you read and try to understand the big concepts, profound descriptions, and polysyllabic words that I use, rather than focus on the acronyms I use so the simple-minded can follow along. Or is that all you can understand?


20 posted on 06/12/2011 12:55:28 AM PDT by Don W (You can forget what you do for a living when your knees are in the breeze.)
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To: Don W

>>FOOD WAS DISGUSTING, but I put on a LOT of weight. More than some calorie counter can account for, even in a worst case scenario.<<

Wow, I am amazed. I have talked to other ex-smokers and they had the same reaction as I (and I had not heard of what you experienced until this post). But we see in the article and some follow-ups that the body does weird (and unfair!) things when we kick the habit.

>>As a previous poster said, it’s far easier to tell the never-smoked from the reformed smokers. If they only knew how utterly foolish they ARE.<<

We had a family reunion a few years ago. My sisters and brothers had all quit smoking (I was the only really smoking addict and I had quit by that time). The next generation had stayed smoke-free. But the LATTER generation (my grand nieces and nephews) were smoking.

And you can tell them about the expense, the wheezing, the difficulty in quitting, etc. etc. etc. It is like yelling at the wall.

It was discouraging but some of them have quit. We can have hope.


21 posted on 06/12/2011 12:58:40 AM PDT by freedumb2003 (Herman Cain 2012)
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To: wardaddy

I went to the site directly from the links here on FR. The first post there is:

Posted At : May 24, 2011 6:05 PM | Posted By : Alan McCollough
Related Categories: Money

This is a note more for myself rather than for the general public, but whatever. For the last year, I paid to subscribe to Trader Fred’s info over at www.tsp.gov. Can’t say the performance was any good, though, so it’s back to going solo.

Today, I moved my TSP allocations into the S fund, which equates to the Dow Jones U.S. Completion Total Stock Market Index, aka $DWCPF.

So, today, May 24th, $DWCPF is trading at $699.06. I’ll have to keep an eyeball on it if it starts tanking, and bail out. Or, if it shoots up, may be I leap out and capture profits. Or just do nothing at all or let ‘er ride.

There is a DUDE’s name attached, if you follow.


22 posted on 06/12/2011 1:01:05 AM PDT by Don W (You can forget what you do for a living when your knees are in the breeze.)
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To: Don W

Don Don Don!!!!

Dial it down a little!!!! ;) :)

We ALL get/got frustrated with the weight penalty, especially when we were pretty proud of looking not half bad.

Part of me has been interested in those new electronic cigarette. But I am SO paranoid about it leading me back to the real thing I just put the thought away.

You and I both know it is true: cigarette addiction is the worst monkey on your back ever. And we also know ONE PUFF will land us back into wheeze-land smoking.

I have never used heroin, but all I have read says it is harder to kick smoking than H.

It makes me feel a little better when I watch Cops and see H and Meth addicts... ;)


23 posted on 06/12/2011 1:05:44 AM PDT by freedumb2003 (Herman Cain 2012)
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To: neverdem

With the increasingly high cost of cigarettes, they can’t afford to eat.


24 posted on 06/12/2011 1:06:20 AM PDT by ETL (ALL (most?) of the Obama-commie connections at my FR Home page: http://www.freerepublic.com/~etl/)
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To: Don W

Geez, Don. You’re an adult. Start smoking again. It’s okay.


25 posted on 06/12/2011 1:09:58 AM PDT by healy61
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To: Gene Eric
It’s only a matter of tricking the stupid part of the brain.

Unfortunately the stupid part of my brain has bigger biceps than the smart part. So we do what the stupid part tells us to.

26 posted on 06/12/2011 1:10:38 AM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: wardaddy; Don W; kittycatonline.com; dixiechick2000

>>I understand the resentment of smoke nazis but the f flame should be used more selectively<<

I cannot speak for Don, but I can say there is an ever-present undercurrent of anger for people who quit smoking after having started. Yes, it was us who started (I was 11 yo btw) and yes it was us who later had to take the hit for that.

I really feel for Don, since at least I got to enjoy that which made me larger.

But there is always that feeling we were sort of ripped off — and that we had to shed something we enjoyed immensely. For MARRIED non-smokers, imagine having to give up sex (which has a smoking component as well). FOREVER. And being afraid to look at porn.. (OK, that is as far as I will draw out the analogy).

That is what we did. And we have a lot of resentment — at least I do.

And as an ex-smoker you know of what I speak W/D.

I leave it to Don to follow up, according to his own conscience.


27 posted on 06/12/2011 1:13:39 AM PDT by freedumb2003 (Herman Cain 2012)
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To: MissMack99

there is a pix of a blonde smoker on my homepage five one...105...that’s one

I smoked till 34....20 years ago....six five 190 then ..... 225 now

Laura Bush, Sela Ward, Ann Coulter, Lauren Hutton, Peggy Noonan, obama, Nicole kidman, my Daughters...also on page all thinnish

However...yes...lower class whites and many minorities who tend to be fat...esp...the women....also smoke

Its drive, lack of discipline and little sense of responsibility...it’s not a coincidence they are fatter, poorer and smoke....although with this economy lots of new uptown poor folks now too with just bad luck

It is enough to start smoking...


28 posted on 06/12/2011 1:14:13 AM PDT by wardaddy (ok...so far I am Palin/Rubio 2012....i can explain easy..just ask)
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To: TigersEye

>>Unfortunately the stupid part of my brain has bigger biceps than the smart part. So we do what the stupid part tells us to.<<

So many jokes, so few that can follow FR rules..


29 posted on 06/12/2011 1:14:54 AM PDT by freedumb2003 (Herman Cain 2012)
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To: neverdem

I thought this was common knowledge about nicotine (from chew as well as smoke).


30 posted on 06/12/2011 1:15:56 AM PDT by HiTech RedNeck (Hawk)
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To: Don W

If it’s a man then he can defend himself...my bad...but the moniker sure sounded catladyish

I would never F on a known freeper woman..not even Howlin back in the day


31 posted on 06/12/2011 1:18:50 AM PDT by wardaddy (ok...so far I am Palin/Rubio 2012....i can explain easy..just ask)
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To: wardaddy; kristinn

>>I would never F on a known freeper woman..not even Howlin back in the day<<

A gentleman never does. Now, when it gets fun is when people mis-gender Kristinn...


32 posted on 06/12/2011 1:21:54 AM PDT by freedumb2003 (Herman Cain 2012)
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To: freedumb2003

So, what rule did I break there, skippy? lol


33 posted on 06/12/2011 1:24:58 AM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: Sprite518

“Tricking” your brain is probably not a good idea over the long run.

Ask any liberal...


34 posted on 06/12/2011 1:25:53 AM PDT by tet68 ( " We would not die in that man's company, that fears his fellowship to die with us...." Henry V.)
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To: freedumb2003; kittycatonline.com; dixiechick2000; healy61; Gene Eric

Thanks for the calming words. They actually helped.

I also apologize to any I offended with my undisciplined misuse of language. I know better, but let frustration get the better of me. 12 hour OT days sometimes do that, and I feel badly about losing myself that easily. That’s not an excuse, but an attempt at explanation.


35 posted on 06/12/2011 1:27:30 AM PDT by Don W (You can forget what you do for a living when your knees are in the breeze.)
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To: TigersEye

>>So, what rule did I break there, skippy? lol<<

You didn’t break any rules. It is my response that would have done so. Just think about how a smarta$$ might have responded to that post in a locker room...

:)


36 posted on 06/12/2011 1:27:56 AM PDT by freedumb2003 (Herman Cain 2012)
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To: freedumb2003
I'm sorry I mistook your meaning but no smartass response is coming to mind. Which is odd because I live on smartass. lol

You should have just told it. How bad could it be? ;^)

37 posted on 06/12/2011 1:31:10 AM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: Don W; kittycatonline.com; dixiechick2000; healy61; Gene Eric; wardaddy

>>I know better, but let frustration get the better of me. <<

And, well, Don, you are the first FReeper that has EVER happened to! Good thing it was on a friendly thread!

:)

(Classy apology if anyone wants my opinion...)


38 posted on 06/12/2011 1:31:40 AM PDT by freedumb2003 (Herman Cain 2012)
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To: wardaddy

I too *WAS* skinny until I quit smoking. A little bit under 6’ and 150-160. Quit, and as I said above, KABOOM, 50 lbs in 6 months.

I now look at pics and wonder who the bonerack is, until I recognize/identify my bent nose...


39 posted on 06/12/2011 1:32:30 AM PDT by Don W (You can forget what you do for a living when your knees are in the breeze.)
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To: TigersEye

>>The stupid part of my brain has bigger biceps than the smart part.<<

Something along the lines of “the controlling part of my brain has veins but no biceps and thinks it is the smart part...”

I can go no further...


40 posted on 06/12/2011 1:34:21 AM PDT by freedumb2003 (Herman Cain 2012)
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To: freedumb2003

Not any more! Got in one train wreck too many.


41 posted on 06/12/2011 1:38:12 AM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: Gene Eric
"I am literally at my wit's end..." -Don W

Gene, trust him when he says that. I've seen this guy around here before. He IS at 'wit's end' -- literally.

42 posted on 06/12/2011 1:41:33 AM PDT by LittleBillyInfidel (This tagline has been formatted to fit the screen. Some content has been edited.)
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To: tet68

they said Tricking, not Removing


43 posted on 06/12/2011 1:44:25 AM PDT by SF_Redux (Sarah stands for accountablility and personal responsiblity, democrats can't live with that)
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To: All

Come on, when it comes to food, eat classic French.

Best ways to eat vegetables, packed with taste, minimal nutrition and flavor lost in preparation. Decent meat portions, can use low cost cuts of meat and braise them - same thing, more flavor, more nutrition. Sauces are not nearly as bad a people think - they make the meal. Soups !

Portions are automatically smaller because they are flavorful and satisfying.

They literally wrote the book on food.

And... back in the day - people here in America used many of the basic techniques and approaches to food !!!

We’ve just lost it all cuz we’re eating at junky chain restaurants and buying stuff in a box instead of raw ingredients. Many times grandma was the last in her line to cook anything real. When she says “stock” she’s not talking about shares.

Anyone can do it - I’m an idiot and I can make a decent meal in 20 minutes.

Nothing better, it works. Cuz you’re completely satisfied with only a reasonable amount of calories.

Have a cigar/smoke now and then to top it off.

Virtually limitless variation, easy once you get the hang of it.

You’ll get to your “right” weight (not anorexic) and be overflowing with ENERGY, cuz yer eatin’ right !

Just do a little strenuous exercise that makes your muscles sore now and then and your fat burning machine will get turned back on. Give it a go, it’s a whole new world.

Jacques Pepin’s fast food series shows you things that are real easy just to ease into the idea and get started and get some success.

Then find the cookbook La Bonne Cuisine. It explains a bit about the “restaurant” way of preparing, but basically explains things from the point of view of a home cook. Written by a home cook. Gives you the virtually every technique, i.e., knife, what pans to use and why (please stainless or cast iron cooking surfaces IYKWGFY), different cooking processes. It’s like a cooking course that you can just work your way through and use as a reference. It’s detailed so just expect to take your time (years) and have fun.

God put all the delicious and nutritous food all around us - we just have to get up and get it.

IMHO.


44 posted on 06/12/2011 1:45:31 AM PDT by PieterCasparzen (Conservative Christian Capitalists - I encourage you to visit my Profile)
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To: freedumb2003

Try the eCig. There IS a learning curve with them, but I love them. My shortness of breath quit stopped in less than a week. I am not trying to quit smoking, just make it healthier - but if your intent is to quit, you can order ejuice in decreasing amounts of nicotine until you are “vaping” 0% nicotine. At that point, you may just like the habit, or stop altogether. But do try them, just remember that you will likely have to find the equipment best suited to you.

My recommendation, a 510 Tank system. The regular tanks are easy to fill and maintain. FYI, I have not gained weight using the eCig.


45 posted on 06/12/2011 1:58:44 AM PDT by LinnieBeth (Go Herman)
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To: LinnieBeth
Try the eCig. There IS a learning curve with them, but I love them

NOOOO!! Don't suggest that! It scares me too much after 10+ years of complete smoke-freeosity!

But it is heartening there is an option for people to get off physical flame-invoked cigs. Just as technology have us Metformin for diabetes, there is now a possible place to for for cig smokers where they can stop killing themselves.

46 posted on 06/12/2011 2:03:20 AM PDT by freedumb2003 (Herman Cain 2012)
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To: LittleBillyInfidel; Don W

>>Gene, trust him when he says that. I’ve seen this guy around here before. He IS at ‘wit’s end’ — literally. <<

That was the end point in the original text-based ADVENTURE game!


47 posted on 06/12/2011 2:04:32 AM PDT by freedumb2003 (Herman Cain 2012)
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To: PieterCasparzen

>>Have a cigar/smoke now and then to top it off.<<

That part is the problem.

Trust me, for a regular smoker, a single PUFF, much less an entire cigarette, is the path back to smoking.

If I sound like an AA person, it is because I am THAT afraid of going back to smoking. It took 30 years to get hooked and I have been off them over 10. I can’t take the chance — nor can most “ex-”smokers (we are all smokers — we just won’t do it now)


48 posted on 06/12/2011 2:07:50 AM PDT by freedumb2003 (Herman Cain 2012)
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To: HiTech RedNeck
I thought this was common knowledge about nicotine (from chew as well as smoke).

About this nicotine receptor controlling satiety, dubbed α3β4, I think not. Dopamine pathways were the consensus, IMHO.

49 posted on 06/12/2011 2:10:11 AM PDT by neverdem (Xin loi minh oi)
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To: Sprite518
The best way to lose weight is to portion your food and drink a lot of water.

Do you speak from the point as a smoker or just a dietitian? Or are you a scientist who stayed at a Holiday Inn last night and so is now a food and health expert?

I have been drinking at least 2 gallons of water a day for 20+ years.. when I was a smoker and now. Currently I use the nicotine gum and still drink the water. Still now as always I would love to smoke. Water and food metering has not helped.

I have never eaten a great deal of food, but I have stayed in decent shape in spite of having M.S. Frankly, I probably have a lower body fat index than most NON smokers, and I venture to say most who are reading this thread.

So the non expert advice is of virtually NO value to me, nor anyone else who has been or is a smoker. We can read those OPINIONS you provide from your obvious NON dietitian or smoker point of view anywhere.

As opinions they are about worthless. They never did anything to assist me on quiting nicotine or smoking. Maybe you should walk in the shoes before saying if they are good or bad.

Thanks for the concern though.

/expert advice
50 posted on 06/12/2011 2:19:29 AM PDT by JSteff ((((It was ALL about SCOTUS. Most forget about that and HAVE DOOMED us for a generation or more.))))
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