Skip to comments.Vitamin B3 May Help Kill Superbugs
Posted on 10/07/2012 11:17:41 AM PDT by CutePuppy
Nicotinamide, commonly known as vitamin B3, may help the innate immune system kill antibiotic-resistant staph bacteria, the so-called "superbugs". In lab work done with mice and human blood, researchers found high doses of the vitamin increased the ability of immune cells to kill the bacteria by 1,000 times.
The discovery opens the door to a new arsenal of tools for dealing with antibiotic-resistant bacterial infections, such as those caused by methicillin-resistant S. aureus or MRSA, that have killed thousands of people around the world. They are increasing in hospitals and nursing homes, and also rising in prisons, among athletes, people in the military, and other places where many people are in close and frequent contact.
The team members behind the work are from Cedars-Sinai Medical Center, the Linus Pauling Institute at Oregon State University (OSU), the University of California Los Angeles (UCLA), and other research centers. They write about it in a paper published online this week in the Journal of Clinical Investigation. ..... < snip >
..... Potential for Use with Antibiotics ..... < snip >
..... "It's a way to tap into the power of the innate immune system and stimulate it to provide a more powerful and natural immune response," ..... < snip >
..... Some believe the widespread use of antibiotics, coupled with mismanagement of their doses, creates an evolutionary pressure that helps increase the emergence and spread of resistant strains. ..... < snip >
..... Gene Mutation Causes Vulnerability to Bacterial Infection ..... < snip >
..... nicotinamide can "switch on" some of the disabled anti-microbial genes ..... < snip >
..... The researchers found that in human blood, vitamin B3 was able to wipe out the staph infection in a few hours. ..... < snip >
..... "This vitamin is surprisingly effective in fighting off and protecting against one of today's most concerning public health threats."
Approaches like this could help reduce dependence on antibiotics, he added.
The doses used in the study were megadoses, at therapeutic levels, which are much much bigger than the amount of vitamin B3 in a normal diet. However, such levels have been used safely in humans for other medical reasons.
But this fact, together with the findings of this study, are not sufficient reason for people to start medicating themselves with high doses of vitamin B3. ..... < snip >
Niacin supplements such as Slo-Niacin may cause a minor side effect of "flushing" reaction in some people (http://www.nlm.nih.gov/medlineplus/druginfo/natural/924.html - Niacin and niacinamide (Vitamin B3))
Niacinomide is used in "no-flush" B3 supplements to eliminate discomfort of side effect but doesn't have some positive effects of the conversion of niacin into niacinamide in the body (http://en.wikipedia.org/w/index.php?printable=yes&title=Nicotinamide - Nicotinamide).
"Flushing" discomfort usually gets worse in people who consume alcohol (possibly because of better absorption of niacin into the blood) so sometimes niacin is used in conjunction with alcohol dependency treatments or therapy.
"This could cause a major change in treatment for infections alongside conventional antibiotics to help bolster patients immune system. "I would like to see in patient clinical trials but cannot see why this couldn't be used straight away in infected patients."
< snip > ..... Prof Mark Enright, of the University of Bath, said: "Neutrophils are really the front line against infections in the blood and the use of nicotinamide seems safe at this dose to use in patients as it is already licensed for use.
"This could cause a major change in treatment for infections alongside conventional antibiotics to help bolster patients immune system.
"I would like to see in patient clinical trials but cannot see why this couldn't be used straight away in infected patients."
I’m taking 2 grams a day.
May could would
“Niacin flush” helps kick my migraines.
excellent news. Appreciate the post.
I don't mind the flush and how it makes my nose run, but I've heard that other things will mitigate the flushing. Might be vitamin B6? I don't recall.
I had heard Michael Savage talk about it briefly and was impressed enough by what he said about it to do my own research to see if he was right. I've been taking it ever since.
Last time I took it, I flushed so badly I looked sunburnt. And it *felt* a bit like a burn. I’ve been afraid to touch it since. Interesting about the alcohol connection. Maybe that is why I reacted. I do enjoy wine with dinner often.
Chemicals that can inhibit B3 include alcohol, sulfa drugs and estrogen.
However, the best approach to avoiding resistant bacteria is likely a proactive one. Most of us have between 300-1000 different kinds of bacteria in us, but most of the physical space is occupied by just 30-40 different kinds.
Most people have at least some types of drug resistant bacteria in them, but are unharmed because their “good” bacteria severely limit the physical room for growth of the “bad” bacteria. However disease, radiation, poisons and toxins, and most definitely antibiotics can wipe out enough of the “good” bacteria so that the “bad”, antibiotic resistant bacteria can have a population explosion.
The direct way to deal with this is to reestablish the dominant “good” bacteria. This can be done by physically inserting a large amount of “good” bacteria in the intestines via an endoscope, by enema, or by oral consumption of what are called “probiotic” bacteria, sold in stores in live culture yoghurt, lactobacillus milk, and other products.
In practical terms, the consumption of probiotics should be standard practice when antibiotics are used.
More troubling is when the resistant bacteria create an infection outside of the GI tract, often due to injury or surgery. This is more where an effect as might exist with vitamin B3 would be very useful.
First “flush” usually comes as a surprise, it’s magnified because it’s unexpected unless you have been specifically warned about the effect. Once you have experienced it and know what to expect it, it is much less “scary.”
One way to avoid the “experience” of the flush is to take niacin before going to sleep (maybe trying it instead of wine that day) or ease into it with smaller dosage. That said, there is no predictable reaction to niacin; everyone’s reaction will be different - from none to rapidly coming “sunburn” that disappears just as fast (or slowly) as it came on - usually within first hour of taking.
I love the niacin flush. I've heard that niacin is really good for cholesterol and other things... I don't mind the flush and how it makes my nose run
I'm taking 2 grams a day.
Yes, niacin often has this effect due to its vasodilating properties.
One thing to keep in mind is that conversion of niacin into niacinamide (evidenced by "flush" reaction) may be somewhat hard on the liver, so investigate and consider taking the Deglycyrrizinated Licorice (DGL) or Milk Thistle supplements or eating artichokes (thistle family plant) along with niacin.
I’m taking niacin because every statin on the market gives me muscle aches (the liver damage warning symptom).
Antibiotics may be life savers but a lot of doctors prescribe antibiotics without giving this factor much thought or warning patients that a robust probiotic regime is essential when taking antibiotics due to massive proliferation of "bad" bacteria in the stomach and potentially in the blood supply. Of these, Candida Albicans is one of the most aggressive and difficult to displace.
Along with probiotics, the use of prebiotic nutrition and food rich in prebiotics (such as Jerusalem artichokes etc.) has deserved and recently received more attention. Prebiotic (nutrition) - Wikipedia
The direct way to deal with this is to reestablish the dominant good bacteria. ... In practical terms, the consumption of probiotics should be standard practice when antibiotics are used.
Amen! Thanks for a lot of good info.
Niacin is significantly less “toxic” to liver than statins and should be safe for most people, without precaution, in doses less than 3g.
However, individuals taking large doses might “err on the side of safety” and consider taking or eating some thistle family products or foods, to help the liver do its job, since it may not be the only “toxin” they consume during the day.
I have to throw in a concern that the use of probiotics with antibiotics cannot be haphazard. In most cases used with a significant break between each other, but it is relatively such a new study that there is a dearth of research out there.
And because so many dangerous bacteria are developing resistance, from tuberculosis to gonorrhea, researchers are becoming increasingly desperate to create anything that can destroy them.
Hopefully there will be a lot more research soon.
Oh, I will!
Thanks. :). I knew about the flush, and the first 2 days I took it I flushed mildly, but day 3 was the bad one. I probably did have wine the night before, although I can’t be sure. I will likely try it again. My BP has been creeping up and I really don’t want to be harassed by my doctor to go on meds. Looking for natural/nutritional things first. I’m only 44.
As usual: Supposition / Thesis > Testing / Research > Treatment / Cure
Not a medical advice, but take a look at magnesium supplements. Many people today don't have enough magnesium in their diets, so their balance / ratio of magnesium to sodium is woefully inadequate.
Some forms of magnesium (e.g., taurate, malate, gluconate, glycinate, orotate) are chelated (bound) and may provide amino acids and are much better absorbed by the body than most popular magnesium oxide (which is almost useless as a source of magnesium as it is ill-absorbed in the stomach and is a mild softener / laxative, as is magnesium sulfate aka Epsom salt).
So do some research, but it may be a natural way that works for you to reduce BP.
Ditto what CutePuppy said.
That said... I am sure you know, but some people may get confused by the term nicotinic acid which has nothing in common with nicotine, except for [relatively mild] vasodilating effect.
FReepmail me if you want on or off my combined microbiology/immunology ping list.
Sucks when you are menopausal and a drinker...scared the living daylights out of me first time. I just stick with the B complex now that gets me to that level.
The liver pathology is separate and distinct from the muscle pathology.
A drug handbook said at 6 - 12 weeks for 6 months, then periodically.
That's a fungus, not a bacteria.
Yep, but the muscles ache due to the bloodstream accumulating toxins the impaired liver either dumps into the bloodstream or can no longer filter out.
At least that's my understanding.
"Doc, it hurts when I do this (take statins)."
"Well, don't do that!"
True, my bad. While talking about bacteria I interchangeably used the wrong type of microorganism, in the right context - effect of antibiotics and probiotics on gut microflora.
Speaking of which - Vitamin B3 also seems to be a powerful antifungal that is being used or considered in conjunction with treatments of resistant Candida overgrowth.
Vitamin B3 as a Novel Approach to Treat Fungal Infections - Science Daily, 2010 August 10
Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine. Infections by the yeast Candida albicans represent a significant public health problem and a common complication in immunodeficient individuals such as AIDS patients, cancer patients undergoing chemotherapy and recipients of organ transplants. While some treatments are available, their efficacy can be compromised by the emergence of drug-resistant strains. The current study shows that a C. albicans enzyme, known as Hst3, is essential to the growth and survival of the yeast. Researchers found that genetic or pharmacological inhibition of Hst3 with nicotinamide, a form of vitamin B3, strongly reduced C. albicans virulence in a mouse model. Both normal and drug-resistant strains of C. albicans were susceptible to nicotinamide. In addition, nicotinamide prevented the growth of other pathogenic Candida species and Aspergillus fumigatus (another human pathogen), thus demonstrating the broad antifungal properties of nicotinamide. ..... < snip >
A team of scientists from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have identified vitamin B3 as a potential antifungal treatment.
Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine.
Infections by the yeast Candida albicans represent a significant public health problem and a common complication in immunodeficient individuals such as AIDS patients, cancer patients undergoing chemotherapy and recipients of organ transplants. While some treatments are available, their efficacy can be compromised by the emergence of drug-resistant strains.
The current study shows that a C. albicans enzyme, known as Hst3, is essential to the growth and survival of the yeast. Researchers found that genetic or pharmacological inhibition of Hst3 with nicotinamide, a form of vitamin B3, strongly reduced C. albicans virulence in a mouse model. Both normal and drug-resistant strains of C. albicans were susceptible to nicotinamide. In addition, nicotinamide prevented the growth of other pathogenic Candida species and Aspergillus fumigatus (another human pathogen), thus demonstrating the broad antifungal properties of nicotinamide. ..... < snip >
Fungizone, aka Amphotericin B, the drug for systemic Candida infections, is called by some amphoterrible because it’s bad news. Thanks for the link & info.
myopathy and statins not hepatitis
That search strategy gets 1381 citations at Pubmed, i.e. muscle pain or weakness without liver damage.
That's a fungus, not a bacteria.
In other words, then, there's a fungus among us.
Niacinamide is commonly used in multiple doses to roll back incipient dementia (alzheimers).
Could be a good move to take it regularly.
I have a problem with ants invading the house. I spread out tablets of B3, outside and inside, and it didn’t help any. What to do?
Better get a new house.
Correct. Doctor Daniel G. Amen, the preeminent brain-imaging specialist and brain expert at Amen Clinic and UC of Irvine, also warns against deficiencies of Vitamins B6, B9 (folic acid) and B12 for maintaining memory functions.
He also emphasizes that about two thirds of the people are deficient in Vitamin D3 which he calls a "memory vitamin" because it appears to actually remove beta-amyloid (protein "plaques" and "tangles") from the brain and cerebral blood vessels.
Studies have also shown that adults with optimal levels of vitamin D performed better on cognitive and brain-processing speed tests. Dr. Amen recommends 2,000IU daily, but checking the blood level first since individuals synthesize and absorb vitamin D3 differently - same, of course, should be said for most other vitamins, supplements and medications.
What to do?
Studies are ongoing but some suggest boric acid. Obama administration offered an innovative solution of designing ObamaCare experiment as a way of creating a distraction big enough for almost anyone to forget about ants invasion.
The results of ObamaCare experiment at this point are inconclusive since ObamaCare hasn't yet been fully implemented, and may prove to be YAP (yet another problem) on top of the anthill, rather than distraction.
I have been taking 2000 units per day slow acting niacin for years as prescribed
The immunity angle. Death in a hospital or later from infection is very likely
dissolve some borax in dilute karo syrup and they will collect it and die
My doctor prescribed Niaspan (prescription Vit B3) to manage cholesterol, it is good to know this information about other effects.
Eating a light snack before taking it will reduce the flushing, but after I have been taking it for awhile I hardly notice the effect anymore.
If you like the flushing effect, take it on an empty stomach and bite the pill breaking it up...Holi Mackerel Der Andy...
Yes, niacin is usually prescribed to increase HDL and decrease total cholesterol levels, often simultaneously with the course of statins.
Eating a light snack before taking it will reduce the flushing...
If you like the flushing effect, take it on an empty stomach and bite the pill breaking it up...
Getting "high" on niacin raised to an art form! Kudos, sir, you know how to party!