I played Xenodaga and tried to destroy reality once.... But I settled for making clean water in Fallout 3 instead.
Of course the hooker in New Vegas was kinda cool...
I played the text-only Avalon Hill “B-1 Nuclear Bomber” on my super awesome cassette drive hooked up to my sweet Atari 400.
I have not been able to live out my fantasies of nuking a variety of Soviet cities.