Skip to comments.B-vitamins may delay Alzheimer’s onset
Posted on 05/24/2013 11:03:22 PM PDT by neverdem
UK researchers have found that high doses B-vitamins including folic acid, vitamin B12 and vitamin B6 can slow down brain tissue atrophy, a wasting process associated with Alzheimers disease.
David Smith of the University of Oxford, and colleagues, used randomised controlled trials to test the long-term effects of B-vitamins on the brain health of elderly people with mild cognitive impairment, who were classed as having an increased risk of dementia. They found the brains of those treated with B-vitamins shrank less over a two year period than those given a placebo, and experienced less atrophy in regions of grey matter especially vulnerable to Alzheimers.
They also showed that the supplements effectively reduced blood concentrations of homocysteine, high levels of which have been linked to Alzheimers and cognitive impairment.
The work suggests addressing non-genetic aspects of Alzheimers may identify better treatment options. Alzheimers is the most common cause of dementia, with over 25 million sufferers worldwide. Several potential treatments have failed in recent clinical trials.
G Douaud et al, Proc. Natl. Acad. Sci., USA, 2013, DOI: 10.1073/pnas.1301816110
If I’m not mistaken, too much B6 can contribute to neuropathy, and some prefer folate to folic acid. Do the research.
up to 40% of cases judged to be alzheimers/dementia are really b vitamin deficiencies. they gave these people b vita,ins and saw great improvement.
Folate is just a salt of folic acid, so if it's sodium folate, that makes sense.
Toxic neuropathy. excerpt;
Cisplatin and high-dose pyridoxine are used more frequently to produce robust models of peripheral neuropathy in animals. Statins do appear to cause peripheral neuropathy.I tnink I'd rather risk a peripheral neuropathy than a central one like Alzheimers.
Thanks for the links.
Did not do a damn thing for my mom. Even when she was in Alzheimers pop had her take b-vitamins. Nothing Latest fad to push sales at walgreens....
My wife temporarily experienced that from too much B-6. Too much or too little - both result in problems.
Vitamin B-Ready might produce four hour erections...But then again, it might not.
I think B12 is the widely unrecognized hero regarding nerve health. Poor diet, malabsorption, vegetarian diets can contribute to losses in B12. I also read that magnesium helps to facilitate B12 supplementation.
>> I tnink I’d rather risk a peripheral neuropathy than a central one like Alzheimers.
I would love to see a study done on whether those who physically and routinely exercise get Alzheimer’s versus those who do not.
I'm sorry for your loss, but was the diagnosis confirmed by an autopsy. The last I read, the only way that diagnosis is confirmed is by an autopsy or an accidental biopsy secondary to severe, penetrating head trauma. Alzheimer's disease is not the only dementia. They need to see extracellular beta amyloid plaques and neurofibrillary tangles inside the nerve cells with a specimen under a microscope, IIRC. There are other signs and symptoms that suggest Alzheimers disease, but you need that specimen to confirm it.
Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe.
In some people genetics seems to come into play. Regardless, exercise is good for its own sake. It has many benefits
if you are talking about lowering homocysteine, how about betaine?? works better than the b vitamins.