Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Down syndrome reversed in newborn mice with single injection
ABC ^ | 9/5/2013 | Staff

Posted on 09/05/2013 9:54:28 AM PDT by Titus-Maximus

US researchers have found a way to reverse Down syndrome in newborn lab mice by injecting an experimental compound that causes the brain to grow normally.

The study, published in the Science Translational Medicine journal, offers no direct link to a treatment for humans but scientists are hopeful it may offer a path towards future breakthroughs.

There is no cure for Down syndrome, which is caused by the presence of an additional chromosome and results in intellectual disabilities, distinctive facial features and other health problems.

The team at Johns Hopkins University of Medicine, in Baltimore, used lab mice that were genetically engineered to have extra copies of about half the genes found on human chromosome 21, leading to Down syndrome-like conditions such as smaller brains and difficulty learning to navigate a maze.

On the day the mice were born, scientists injected them with a small molecule known as a sonic hedgehog pathway agonist.

(Excerpt) Read more at abc.net.au ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: downsyndrome; prolife
Injections helped both memory and learning, they are rushing inoculations to the White House, if it works with mice, it should work with rats....
1 posted on 09/05/2013 9:54:28 AM PDT by Titus-Maximus
[ Post Reply | Private Reply | View Replies]

To: Titus-Maximus
To those unfamiliar with the world of medical research,anything that comes out of Harvard,Hopkins,Mayo Clinic and a few others is *absolutely* listened to by the wider medical world.
2 posted on 09/05/2013 9:58:15 AM PDT by Gay State Conservative (If Obama Had A City It Would Look Like Detroit)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus
Didn't I see this in a movie forty years ago?


3 posted on 09/05/2013 9:58:27 AM PDT by billorites (freepo ergo sum)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

“if it works with mice, it should work with rats....”

LOL


4 posted on 09/05/2013 9:58:55 AM PDT by Not gonna take it anymore (If Obama were twice as smart as he is, he would be a wit)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus
scientists injected them with a small molecule known as a sonic hedgehog pathway agonist.

Oh, great. Now Sega will want compensation for trademark infringement.
5 posted on 09/05/2013 9:59:35 AM PDT by Dr. Sivana (There's no salvation in politics.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

Hmmmm, White House lab Rats ... I’m undecided on this one.


6 posted on 09/05/2013 10:00:20 AM PDT by shove_it (long ago Orwell and Rand warned us of 0bama's America)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

LMFAO


7 posted on 09/05/2013 10:01:15 AM PDT by Rannug ("God has given it to me, let him who touches it beware.")
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

“reversed” ?

Up syndrome?

Ok..shouldn’t joke on this.

It would be wonderful to see this come to fruition!

Pro-Aborts will be sorry to see an end to the abortion of 90% of those diagnosed, pre-natal.

Obamacare will find a way to stall any progress in this area.


8 posted on 09/05/2013 10:03:38 AM PDT by G Larry (Let his days be few; and let another take his office. Psalms 109:8)
[ Post Reply | Private Reply | To 1 | View Replies]

To: billorites

Nice catch! I saw that movie in school and it was very memorable! ‘Flowers for Algernon’


9 posted on 09/05/2013 10:04:02 AM PDT by MeganC (A gun is like a parachute. If you need one, and don't have one, you'll never need one again.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: shove_it

I dimly remember a cartoon about mice in the White House...


10 posted on 09/05/2013 10:07:12 AM PDT by GeronL
[ Post Reply | Private Reply | To 6 | View Replies]

To: Titus-Maximus
Oh how wonderful..I still say these are little angels sent to us to remind us no matter what always keep a smile..those precious little angels I love so much..I don't have a downs child but my daughter worked for MHMR and she was a teacher for these bright little children..They give out lots of hugs..
11 posted on 09/05/2013 10:13:09 AM PDT by PLD
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

I predict that some parents of kids with Down’s syndrome will protest a potential cure.


12 posted on 09/05/2013 10:13:54 AM PDT by dangerdoc (see post #6)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Titus-Maximus

LOL - I nominate you for the post of the day!!!


13 posted on 09/05/2013 10:15:54 AM PDT by taxcontrol
[ Post Reply | Private Reply | To 1 | View Replies]

To: dangerdoc

Likely. Some people find perverse pleasure in having family member with some defect. It becomes a social identity for them.


14 posted on 09/05/2013 10:17:53 AM PDT by Myrddin
[ Post Reply | Private Reply | To 12 | View Replies]

To: billorites

my exact thought.


15 posted on 09/05/2013 10:20:00 AM PDT by mountn man (The Pleasure You Get From Life Is Equal To The Attitude You Put Into It)
[ Post Reply | Private Reply | To 3 | View Replies]

To: Titus-Maximus

Please do not insult rats in that manner. They are lawyers, period.

Old joke! Many research labs have discontinued using rats for experiments and have begun using lawyers instead. When asked why the researchers replied that:
1. There are more lawyers than rats;
2. employees do not get nearly as attached to lawyers as they sometimes do with rats, and
3. there are just somethings that rats just wont do.


16 posted on 09/05/2013 10:20:27 AM PDT by dirtymac (1)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Myrddin

17 posted on 09/05/2013 10:22:26 AM PDT by mountn man (The Pleasure You Get From Life Is Equal To The Attitude You Put Into It)
[ Post Reply | Private Reply | To 14 | View Replies]

To: MeganC

See to me that the name of the movie was the name of the “slow” character, who became brilliant.


18 posted on 09/05/2013 10:27:30 AM PDT by wizr (We are "one Nation, under God " or "one nation, trod under ". Keep the Faith.)
[ Post Reply | Private Reply | To 9 | View Replies]

To: Myrddin
“Likely. Some people find perverse pleasure in having family member with some defect. It becomes a social identity for them.”

Absolutely. My stepson is a dwarf and he and my wife dropped out of several support groups because of the victim mentality. She raised him to overcome, not look for special treatment.

19 posted on 09/05/2013 10:27:31 AM PDT by CrazyIvan (Obama phones= Bread and circuits.)
[ Post Reply | Private Reply | To 14 | View Replies]

To: MeganC

Seems to me that the name of the movie was the name of the “slow” character, who became brilliant.


20 posted on 09/05/2013 10:28:39 AM PDT by wizr (We are "one Nation, under God " or "one nation, trod under ". Keep the Faith.)
[ Post Reply | Private Reply | To 9 | View Replies]

To: Titus-Maximus; All

As the father of a young man who has Down Syndrome [he’ll be 16 yro next month] anything that will give him an advantage would be very helpful. From what I understand this would only give a brain boost but not change physical appearance. People do judge on looks, so that is a strike against them. So I would like a chance for them to get a boost in brain power.


21 posted on 09/05/2013 10:31:10 AM PDT by TMSuchman (John 15;13 & Exodus 21:22-25 Pacem Bello Pastoribus Canes [shepard of peace,dogs of war])
[ Post Reply | Private Reply | To 1 | View Replies]

To: wizr
See to me that the name of the movie was the name of the “slow” character, who became brilliant.


22 posted on 09/05/2013 10:36:42 AM PDT by Bubba Ho-Tep ("More weight!"--Giles Corey)
[ Post Reply | Private Reply | To 18 | View Replies]

To: wizr

You’re right. The movie was “Charly.” The novella was titled “Flowers for Algernon.”

Regards,


23 posted on 09/05/2013 10:37:56 AM PDT by VermiciousKnid (Sic narro nos totus!)
[ Post Reply | Private Reply | To 20 | View Replies]

To: Titus-Maximus
sonic hedgehog pathway agonist.

I *knew* playing video games would make me a molecular biologist.

24 posted on 09/05/2013 10:38:09 AM PDT by Lazamataz (Early 2009 to 7/21/2013 - RIP my little girl Cathy. You were the best cat ever. You will be missed.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Bubba Ho-Tep; VermiciousKnid

Thanks to you both. Loved the movie. It seems that the more we learn, the more we realize how little we really know.


25 posted on 09/05/2013 10:42:23 AM PDT by wizr (We are "one Nation, under God " or "one nation, trod under ". Keep the Faith.)
[ Post Reply | Private Reply | To 22 | View Replies]

To: Bubba Ho-Tep

The movie is based on the short story “Flowers for Algernon”. (sp?)_


26 posted on 09/05/2013 10:46:57 AM PDT by longtermmemmory (VOTE! http://www.senate.gov and http://www.house.gov)
[ Post Reply | Private Reply | To 22 | View Replies]

To: Titus-Maximus
I've wondered about they acquire Lab mice that have these diseases that they use “to cure”

Since it is so rare, how does one acquire mice with Downs Syndrome...

Hmmmmmm.

27 posted on 09/05/2013 10:49:09 AM PDT by RedMonqey ("Gun-free zones" equal "Target-rich environment.")
[ Post Reply | Private Reply | To 1 | View Replies]

To: billorites

I thought about Stephen King’s “Lawn Mower Man”


28 posted on 09/05/2013 10:51:07 AM PDT by RedMonqey ("Gun-free zones" equal "Target-rich environment.")
[ Post Reply | Private Reply | To 3 | View Replies]

To: dangerdoc

“I predict that some parents of kids with Down’s syndrome will protest a potential cure.”


They already have! The some parents and support groups are worried they will be denied their Special Heritage just like the scum who said the same thing when certain individuals could have their hearing restored.

We have to share this planet with some might sick and evil people.


29 posted on 09/05/2013 11:00:28 AM PDT by Wurlitzer (Nothing says "ignorance" like Islam! 969)
[ Post Reply | Private Reply | To 12 | View Replies]

To: wizr

You’re right! The book was ‘Flowers for Algernon’ and that’s how I always think of it instead of what Hollywood called it.


30 posted on 09/05/2013 11:09:19 AM PDT by MeganC (A gun is like a parachute. If you need one, and don't have one, you'll never need one again.)
[ Post Reply | Private Reply | To 20 | View Replies]

To: wizr

the short story was Flowers.


31 posted on 09/05/2013 11:09:31 AM PDT by wiggen (The teacher card. When the racism card just won't work.)
[ Post Reply | Private Reply | To 18 | View Replies]

To: Titus-Maximus

Downs Syndrome reversed?? Every cell in the body of a person with Downs Syndrome has an extra 23rd chromosome. I suspect they mean they believe they can mitigate the effects from the extra chromosome. Color me very skeptical.


32 posted on 09/05/2013 11:19:01 AM PDT by originalbuckeye (Never yield to force; never yield to the apparently overwhelming might of the enemy)
[ Post Reply | Private Reply | To 1 | View Replies]

To: dangerdoc

They won’t get a fight from me. I would do anything to help my boy with Down’s . I haven’t seen a Downs mafia like the deaf anti-implant mafia.


33 posted on 09/05/2013 11:20:04 AM PDT by USNBandit (sarcasm engaged at all times)
[ Post Reply | Private Reply | To 12 | View Replies]

To: wizr

Flowers for Algernon was the short story.
Charly was one film, Lawnmower Man was an interesting variation.


34 posted on 09/05/2013 11:31:32 AM PDT by Verbosus (/* No Comment */)
[ Post Reply | Private Reply | To 20 | View Replies]

To: Titus-Maximus
Sonic The hedgehog!

No wonder it works!

35 posted on 09/05/2013 11:42:22 AM PDT by Mr. K (Lies, Damned Lies, Statistics, and then Democrat Talking Points.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: GeronL
I dimly remember a cartoon about mice in the White House...

During the Clinton administration, there were reports of huge rats infesting the White House premises.

Reporters covering the White House claimed the rats were as large as house cats and boldly walked around during the day seemingly unafraid of people.

I thought at first that they meant the regular democ-rats, but they were real rats.

36 posted on 09/05/2013 12:01:48 PM PDT by Slyfox (Without the Right to Life, all other rights are meaningless.)
[ Post Reply | Private Reply | To 10 | View Replies]

To: wizr

Yes, the movie was called “Charly”, the book was called “Flowers for Algernon”.


37 posted on 09/05/2013 12:04:30 PM PDT by Boogieman
[ Post Reply | Private Reply | To 18 | View Replies]

To: USNBandit

I only say so because we live in such a perverse culture, good is called bad and bad is called good.


38 posted on 09/05/2013 12:05:01 PM PDT by dangerdoc (see post #6)
[ Post Reply | Private Reply | To 33 | View Replies]

To: USNBandit

Well there was no anti-implant mafia until the implants became available.... so we will have to wait and see.


39 posted on 09/05/2013 12:05:31 PM PDT by Boogieman
[ Post Reply | Private Reply | To 33 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson