Now - a debate that allows for an actual give and take without any grandstanding or stacked questions by moderators? Cruz would eviscerate her.
Yes, but anyone can make a comment aimed at the opponent, and if it is a strong one, the opponent will look weak if they fail to address it. All Cruz has to say during a debate is "Over the last six-and-a-half years, the rich have gotten richer and hard-working men and women across America have seen their lives get harder and harder. The people who have been hurt the most are the most vulnerable. Young people, Hispanics, African-Americans, single moms. This is the direct result of the policies that my esteemed opponent is espousing and promising."
If Hillary (or any opponent) does not counter that punch, they're toast.