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PROVIGIL

From: Jake Sullivan To: Hillary Clinton Date: 2011-10-24 14:29 Subject: PROVIGIL

RELEASE IN FULL

From: Sullivan, Jacob J <SullivanJJ@state.gov> Sent: Tuesday, October 25, 2011 9:29 PM To: Subject: Provigil

So I was wrong that it was invented by the military, but right about military use of/interest in it. Background on the drug

below.

Provigil (Modafinil)

• Provigil is used to treat excessive sleepiness caused by narcolepsy or shift work sleep disorder (sleepiness during scheduled waking hours among people who work at night or on rotating shifts). It is also often prescribed to treat

excessive sleepiness in patients with Parkinson's, Alzheimer's, and multiple sclerosis. Additionally, it has also gained a following among students, truckers, and others who want to stay awake for extended periods of time.

o Modafinil was developed by the French firm Lafon and was approved by the FDA to treat narcolepsy in 1998. It is now

sold under the brand name Provigil by the Pennsylvania drugmaker Cephalon.

o Modafinil gained attention in the medical community because it is the first effective stimulant with no significant potential for abuse.

Modafinil is in a class of medications called wakefulness promoting agents; it works by changing the amounts of

certain natural substances in the area of the brain that controls sleep and wakefulness.

o The precise way that modafinil works is unknown: it seems to slow the release a GABA, a sleep promoter in the brain. It may also affect the histamine system, which is connected to sleep regulation.

o It can be used for two or three day stretches at a time, with few known side effects and little risk of addiction.

Provigil's impact on the body is different from other pick-me-ups, which tend to be indiscriminate in their function:

it confines its activity to the particular neurological processes connected with wakefulness and does not act as a broad stimulant. This is probably why it has not gained popularity as a street drug.

o Amphetamines, on the other hand, promote wakefulness by causing dopamine to flood to the brain. Dopamine is a

"broad hitter;" it sets the heart racing and makes the user feel high, impacting the entire central nervous system. Caffeine affects a different pathway that deals with the neurotransmitter adenosine, and is also a broad stimulant.

The military, for obvious reasons, is interested in the consequences of prolonged sleep deprivation and has tested

modafinil heavily, particularly on pilots.

o A study carried out by the Air Force Research Laboratory found that fatigued pilots on modafinil maintained flight accuracy within approximately 15-30 percent of baseline levels, whereas performance under the no-treatment condition

declined by as much as 60-100 percent. Here, benefits were most noticeable after 24-32 hours of continuous wakefulness. A French study yielded similar results and found that for missions of about 24 hours, modafinil for soldiers

is preferable to naps.

o In the U.S. military, modafinil has been approved for use on certain Air Force missions. The French, British, and Indian militaries have all expressed interest in modafinil.


1 posted on 08/24/2016 6:22:20 AM PDT by xzins
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More strong circumstantial evidence that Hillary is sick.


2 posted on 08/24/2016 6:22:48 AM PDT by xzins ( Free Republic Gives YOU a voice heard around the globe. Support the Freepathon!)
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To: xzins

Boom!


3 posted on 08/24/2016 6:26:19 AM PDT by Enlightened1
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To: xzins

“do the honorable thing”

There is no Clinton that knows what that means!


4 posted on 08/24/2016 6:27:32 AM PDT by CGASMIA68 (kant spell er punktuate,fluncked english.Gramer to!!)
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To: xzins
Hillary Clinton’s advisors once contacted NFL Commissioner Roger Goodell about her “cracked head.”

I guess getting in touch with a physician would be too much like what ordinary people do.

5 posted on 08/24/2016 6:28:11 AM PDT by Steely Tom (Vote GOP: A Slower Handbasket)
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To: xzins

How did this relate to State Dept. business? Did Colin Powell or Condi Rice ever have their staffs research drugs for them? Inquiring minds want to know. As the old saying goes, “Where there’s smoke, there’s fire,” comes to mind.


6 posted on 08/24/2016 6:28:19 AM PDT by txrefugee
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To: xzins

Modafinil is not classically a Parkinson’s drug, but can be used in preventing sleep attacks in PD patients, Mostly used in sleep disorder patients, sleep apnea, narcolepsy, and shift worker sleep disorders. Sometimes (off label) used by middle aged executives who feel they are losing their edge. It can make patients more obsessive and paranoid


8 posted on 08/24/2016 6:33:26 AM PDT by HangnJudge (Cthulhu for President, why vote for a lesser Evil)
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To: xzins

I think a good exorcism is what she needs.


10 posted on 08/24/2016 6:36:51 AM PDT by Old Yeller (Hillary is Satan's spiritual advisor.)
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To: xzins
The presidency is not something to play with just because you want to be the first female to hold the position.

We're talking about Hillary Clinton! Sne's been running for POTUS for over 40 years!

She has no concern fort the country!

12 posted on 08/24/2016 6:39:03 AM PDT by lonestar (Texan for Trump)
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To: xzins

Placing a bet here: The Hillary campaign needs to stop the bleeding and garner sympathy. They need to do so in a way that doesn’t confirm her own medical ailments. My prediction is that the emails pointing to research about various prescription meds, Parkinson’s Disease, etc., etc. will be explained away as research for medical problems BILL has. Hillary was clearly just being a loving and devoted wife to the man she has loved all these years.

I can hear the new lie now: “This is a very private matter. We were hoping not to have to air it in public but, because it has become such a distraction to the real issues we should be taking about, our sleazy, mud-slinging political enemies have forced us to disclose this very painful and very personal matter. We won’t address it further, and won’t take any questions, and hope that the American public will be understanding as we live and deal with Bill’s affliction in private.”


13 posted on 08/24/2016 6:39:41 AM PDT by Be Free (I believe in gun control. The more people that control their own guns, the safer we'll all be.)
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To: xzins

Oh, it’s even worse—there are now stories circulating that Secret Service agents were directly talking with three of the best hospitals in the USA that specialize in neurological surgery just very recently. I wonder what patient would need that type of surgery....


14 posted on 08/24/2016 6:40:03 AM PDT by RayChuang88 (FairTax: America's Economic Cure)
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To: xzins

Most people who have heard of Provigil (Modafinil) and who hear that Hillary looked into it, are just going to think that she investigated how she might be able to function better with less sleep. Apparently many executives use it for that purpose so even if she actually took it for a while this is not going to prove that Hillary has Parkinson;s disease and will just make her seem like a hard-working Secretary of State.


16 posted on 08/24/2016 6:41:05 AM PDT by wideminded
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To: xzins

Provigil is not indicated for any of the diseases listed in the article.

It has an indication for excessive daytime sleepiness, which is popularly called narcolepsy.

It is used off label for alertness (e.g. jet fighter pilots), ADHD, Alzheimer’s, etc.


19 posted on 08/24/2016 6:51:01 AM PDT by oblomov (We have passed the point where "law," properly speaking, has any further application. - C. Thomas)
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To: xzins

“The presidency is not something to play with just because you want to be the first female to hold the position.”
How much honor can she have, knowing full well she will have to steal the election through manipulated voting machines and ID fraud, Just as the 1012 election was stolen?


22 posted on 08/24/2016 6:56:14 AM PDT by ArtDodger
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To: xzins

Ya can’t fix crooked...... EOM ....


23 posted on 08/24/2016 6:56:15 AM PDT by VRWC For Truth (FU Klintoons)
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To: xzins
I'm starting to feel concern for her... it's low level but my sub-conscience is kicking in... Could someone have poisoned her?
25 posted on 08/24/2016 7:01:52 AM PDT by GOPJ (Leftist agitators employ fascist tactics Kyle Olson. FRAUD IS DONE BY VOTING THOSE WHO DON'T SHOW UP)
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To: xzins

FOCUS ON FOUNDATION! Who cares what she’s got going on in her pantsuit. It’s nothing to what she’s got coming in the nine circles of hell where she is going.


26 posted on 08/24/2016 7:10:02 AM PDT by Cats Pajamas (That chicken necked buck tooth varmint Hillary is headed toward the nine circles of hell)
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To: xzins
Hmm. Maybe Hillary was asking for a friend?

"Yeah, that's it. That's the ticket!"


31 posted on 08/24/2016 7:19:15 AM PDT by COBOL2Java (Trump is to the political class what Uber is to taxicab companies)
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To: xzins

I suspect that research was for Bill.


32 posted on 08/24/2016 7:19:49 AM PDT by Ms Mable
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To: xzins

Why didn’t she just ask her doctor?


35 posted on 08/24/2016 7:37:07 AM PDT by ilovesarah2012
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To: xzins

Jake Sullivan - Wikipedia, the free encyclopedia
https://en.m.wikipedia.org/wiki/Jake_Sullivan

Shared via Bing search


36 posted on 08/24/2016 7:41:37 AM PDT by ilovesarah2012
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