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New drug relieves pain from Fibromyalgia
The Commercial Appeal ^ | 2/17/03 | NA

Posted on 02/17/2003 12:25:36 PM PST by GailA

New drug relieves pain from Fibromyalgia February 17, 2003

Conventional medications, such as Tylenol, Motrin or even morphine, provide little relief to sufferers of fibromyalgia, a mysterious and debilitating pain disorder. But a new drug might be able to thwart the nerve signals that scientists believe trigger the pain.

"This is a real breakthrough not only because it works, but it proves fibromyalgia can be treated," says Dr. Leslie Crofford, a rheumatologist at the University of Michigan in Ann Arbor who has studied the new drug, pregabalin.

The syndrome affects an estimated 5.6 million Americans.

Pregabalin reduces the release of specific brain chemicals, such as glutamate and noradrenaline, that may cause pain, says Terry Griesing, a neurology researcher with Pfizer Inc.

The drug, which still needs FDA approval, could be on the market as early as 2004.


TOPICS: Business/Economy; Culture/Society; Extended News
KEYWORDS: fibromyalgia; pain
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FYI for my fellow suffers of Fibromalgia.
1 posted on 02/17/2003 12:25:36 PM PST by GailA
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To: GailA; SpookBrat
This is good news!
2 posted on 02/17/2003 12:27:11 PM PST by Jen
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To: 4ConservativeJustices
ping
3 posted on 02/17/2003 12:29:05 PM PST by Ff--150
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To: GailA
Thanks, Gail. My sister suffers from fibromyalgia. I emailed the article to her.
4 posted on 02/17/2003 12:29:43 PM PST by Wait4Truth (God Bless our President!)
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To: GailA
Thanks for the info. My Grandmother-in-law has been dibilitated by fybromyalgia for years and has tried every medication known (legal and illegal) to try and gain relief to no avail.

I'll pass this info along.

5 posted on 02/17/2003 12:31:32 PM PST by Damocles (sword of..)
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To: AntiJen; GailA
"The drug, which still needs FDA approval, could be on the market as early as 2004."

Hold on to some of that enthusiasm. I wouldn't hold my breath waiting on FDA approval next year, especially when it comcerns pain relieving medication. I've had DJD for 26 years and I've never seen a slower or ineffective regulatory agency.

6 posted on 02/17/2003 12:36:50 PM PST by bigfootbob
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To: GailA
Are there any trial programs?
7 posted on 02/17/2003 12:37:38 PM PST by mathluv
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To: GailA
I, too have FM. Take a look at www.fibromyalgiatreatment.com.
I began taking guaifensin a few weeks ago. It's supposed to help the kidneys get rid of phosphates that build up in our cells because our bodies can get rid of it like it should.

Guaifenesin is supposed to reverse fibro not just treat the pain. Kind of restrictive, though. Can't use any skin products with salicylates in them (or plant extracts) or take aspirin. One company does make salicylate free products, though.

If anybody has other info they can pass on, I'd appreciate it. My mother has FM very, very badly. Nothing has helped her. She hasn't tried guai yet. And I haven't been on it long enough to know for sure this is going to be the answer.
8 posted on 02/17/2003 12:41:23 PM PST by valleygal
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To: valleygal
Because of my inability to take many meds due to gastro-intestinal side effects I use mainly natural remedies for my FM. Malic Acid, St John's Wort, MSM and mild stretching exercise (which I'm very bad about not doing as regularly as I should.

Be sure you've had your Thyroid functions checked as most FMS sufferers are also Hypothyroid too.

SITES FMSnewtnews

http://www.ivillagehealth.com/library/nwh/content/0,,215912_227084,00.html">Ivillagehealth

healthrevolution

9 posted on 02/17/2003 12:51:37 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: mathluv
Not that I know of, check the drug company to see if they do.
10 posted on 02/17/2003 12:52:50 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: GailA
My college roommate takes Paxil and Elavil for it. She takes one drug by day and the other one by night. I ran this by my doctor and he said that drug mix is a no no. But Jeannie has been taking this drug mix for many years. Without them she was unable to do anything. With them she is able to teach school every day.
11 posted on 02/17/2003 12:59:14 PM PST by buffyt (Can you say President Hillary - Mistress of Darkness?.......Me neither!!!!!!!!!)
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To: GailA
This is fantastic news! I too suffer from Fibromyalsia.
12 posted on 02/17/2003 1:00:56 PM PST by Patriotic Bostonian
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To: GailA
Amer College Rheum Annual Meeting Presentation Oct 2002

Pregabalin Improves Pain Associated with Fibromyalgia Syndrome in a Multicenter, Randomized, Placebo-Controlled Monotherapy Trial

Leslie Crofford, I. Jon Russell, Philip Mease, Ann Corbin, James Young, Jr., Linda LaMoreaux, Susan Martin, Uma Sharma, Lloyd Knapp, Mark Versavel, R. Michael Poole

Purpose: Fibromyalgia syndrome (FMS) patients experience chronic widespread musculoskeletal pain in association with fatigue and sleep disturbance. There are no approved therapies, and treatments that are used often do not provide adequate relief. This 8-week randomized, double-blind, placebo-controlled, parallel-group monotherapy trial evaluated the efficacy and safety of pregabalin up to 450mg/day (150 mg TID) for reducing pain and associated symptoms in patients with FMS.

Methods: Patients meeting the ACR criteria for FMS completed a 1-week baseline phase and an 8-week fixed dose treatment phase (6 required visits). Patients (n=529) were randomized to receive placebo, 150, 300 or 450mg/day pregabalin at Visit 2. The primary efficacy parameter was pain, recorded by patients in a daily pain diary, using an 11-point numeric rating scale. The primary analysis was based on the endpoint mean pain score. Secondary efficacy measures included the Short Form McGill Pain Questionnaire (SF-MPQ), sleep quality diary, Medical Outcomes Study (MOS)-Sleep Scale, Multidimensional Assessment of Fatigue (MAF), Patient and Clinical Global Impression of Change (PGIC, CGIC), and SF-36 Health Survey.

Results: Pregabalin-treated patients (450mg/day) showed significant improvement in the endpoint mean pain score (-0.93; p<0.001) compared to placebo, and were significantly more likely to have 50% reduction in pain from baseline (29% vs. 13%, p = 0.003). The mean SF-MPQ total pain descriptor and visual analog scale (VAS) scores were significantly improved at each visit and at endpoint for the pregabalin 450mg/day treatment group compared to placebo. Mean sleep quality, fatigue, CGIC and PGIC scores at endpoint were significantly improved for patients receiving 300 and 450mg/day pregabalin. The MOS-Sleep Index score was significantly improved at endpoint for all doses. Four of 8 domains of the SF-36 were significantly improved at endpoint for the 450mg/day treatment group. Overall, 48 patients (9%) withdrew due to adverse events and 44 patients (8%) due to lack of efficacy. The most common adverse events were dizziness and somnolence. Most patients (78%) completed the trial and entered a follow-on safety trial.

Conclusions: Pregabalin is effective and safe for the treatment of pain at 450mg/day in patients with FMS in this study. Pregabalin additionally improved sleep quality, fatigue, global measures of improvement and quality of life.

Keywords: fibromyalgia, pregabalin, pain

13 posted on 02/17/2003 1:02:08 PM PST by Plutarch
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To: GailA
Thank you, thank you, thank you. I will watch as this drug makes it through the approval/rejection process. It might be worth our while to form as a group to "encourage" approval, or at least speed along the testing process. I'm currently managing my existence on steroids, muscle relaxants, Vioxx and occassional narcotics. Not sure how long some of my organs will keep tolerating some of these drugs, but the docs have hinted something like this might be coming. I know others that are narcotic dependent (addicted) and this would be a God-send. Let's keep our fingers crossed this proves to be an answer.
14 posted on 02/17/2003 1:03:20 PM PST by republicandiva
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To: valleygal
Well, I can tell you from personal experience that my "miracle" cure has been a combination of progesterone and Armour Thyroid.

All of the doctors that I went to said that those levels were normal. My mother stumbled upon a doctor that truly understands hormones, and when I went to him, it was a gift from God. All of the weird and painful symptoms that I had were things that he saw several times a day in his practice. I became symptom free after 4 months of treatment. It literally changed my life.

Do a google on Armour Thyroid or hypothyroidism and fibro. There's lots of info out there, but it takes a special doctor to be able to put the pieces together. Feel free to freepmail me if you have any questions.
15 posted on 02/17/2003 1:04:26 PM PST by Aggie Mama
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To: GailA
I have used malic acid, MSM and done the mild stretching as well as working out on the treadmill.

Guaifenesin is over the counter and is an expectorant found in cough medicines. Not supposed to take it in that form however, just the pure guai tablets.

I was on a low dose of Elavil years ago. Didn't like it. Made me too groggy in the morning. If you take a higher dosage it makes you want to eat all the time (my sis gained quite a bit of weight while on Elavil).
16 posted on 02/17/2003 1:10:06 PM PST by valleygal
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To: GailA
I have a problem with GERD, not sure if that's your problem or not. I take tagament on a regular basis because of this. I've found Vioxx can be a little difficult, but I will often cut the doseage. You might, however, want to ask your physician about Flexeril (Cimetidine - generic). It has absolutely NO GE side effects, but does wonders to relax the muscles at night and allows for better sleep...which in turn often lessens the triggers to Fibro. Just a thought, if you haven't already tried it.
17 posted on 02/17/2003 1:10:11 PM PST by republicandiva
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To: GailA
There is a DRUG-FREE PRODUCT on the market which is FDA-approved for anxiety, depression and insomnia. It has also been found to VERY helpful for fibromyalgia.

There have been something like 126 human studies and 29 animal studies.

18 posted on 02/17/2003 1:13:14 PM PST by Concerned
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To: Aggie Mama
Thanks, AM. I already use natural progesterone cream. Does that count? :)
19 posted on 02/17/2003 1:13:19 PM PST by valleygal
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To: Concerned
And the drug free product is...?
20 posted on 02/17/2003 1:15:39 PM PST by valleygal
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To: All
I've had fibromyalgia along with CFIDS for more than 20 years and one thing that has helped the most debilitating pain has been taking Malic Acid, also sold as Magnesium Malate. At one point I was in so much pain I couldn't walk or sleep and began taking the Malic Acid and within 48 hours the difference was remarkable. I make sure I take two tablets of it morning and night.
21 posted on 02/17/2003 1:20:30 PM PST by Maigret
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To: GailA
I think a good portion of fibro is caused by chronic infection. For instance, a very healthy friend had fibro for 6 months at one point and it turned out to be a bad tooth, the fibro disappeared in days of having the tooth pulled. (He hadn't realized the connection).

I got lyme disease a few years ago and in spite of a course of antibiotics suffer from fibro & fatigue since, I know its continuing infection, I just hate antibiotics, but I know of many people diagnosed with fibro & fatigue who improve on antibiotics.

It could also be fungal, parasties, whatever. I don't think people just "get" fibro for no reason. It is related to toxins thrown off by infection, and the body's inflammatory response to chronic infection.

Just a thot for the other sufferers--don't just live with it but explore the root causes.
22 posted on 02/17/2003 1:21:11 PM PST by equus
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To: Aggie Mama
I was untreated for Hypothyriod for YEARS, until the muscle spasms got so bad that I couldn't take a step with out my caves of my legs charley horsing. My FMS improved a lot once the doc got me on 1 mg synthroid. St John's Wort helps with the sleeplesness many FMS suffers go through.

DR Laura touts something called a Cuddleewe under quillt which is supposed to help too. There is a GOOD discription on FMS on the intro page Quilt

23 posted on 02/17/2003 1:21:14 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: valleygal
Just wondering if any of you folks have read Schwarzbein. She's got a very wholistic regimen, mostly based on nutrition, with other treatment as necessary. She doesn't focus in on FM, but keeps mentioning it as one of the maladies that occur when the metabolism gets out of balance.
24 posted on 02/17/2003 1:23:01 PM PST by Paul_B
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To: republicandiva
No not GERD. Side effects from the drugs themselves. My bowel nearly shut down, exteme acid that NOTHING could control, bowel and bladder spasms. ALL of which disappeared when the drugs were stopped. Lodine, Estrogen and Black Cohosh also produce the exact same side effects.
25 posted on 02/17/2003 1:24:20 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: GailA
As one who has gone through a very long and painful rehab, after a car accident some years ago, I do truly hope this is an effective treatment for those that need it. One piece of advice, don't give up, three minutes before the miracle.

Regards, Buck.

26 posted on 02/17/2003 1:24:56 PM PST by elbucko ("Cowboy Up!" (when ya' can))
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To: equus
Have you tried Colodial Silver instead? Got to watch the amount unless you want to turn blue like that politician who over dosed on it.
27 posted on 02/17/2003 1:28:07 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: republicandiva
I also suffer from GERD, just started taking Previcid. I have a thyroid condition and Reynauds Syndrome. I take Trazadone at night, but this last year has been the worst ever and I am thrilled at this news. Thanks to all Freepers for their input -- actually if I hadn't gotten Fibro and finally had to quit working ten years ago, I would never have found the Freepers. My Mum always said "when God closes a door he always opens a window".
28 posted on 02/17/2003 1:30:36 PM PST by Patriotic Bostonian
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To: GailA
Fibromyalgia Syndrome (FMS) -- Diagnosing Fibromyalgia

1990 American College of Rheumatology (ACR) FMS

Classification Criteria:

(Source: The Fibromyalgia Help Book, Fransen and Russell, p. 9)

Patient History: Widespread Aching.

Examination: Local Tenderness at 11 of 18 Specified Sites. Lasting 3 or More Months.

Prevalence: 90% of FMS Patients are Women / 10% of FMS Patients are Men.

FMS Symptoms

(Source: The Fibromyalgia Help Book, Fransen and Russell, pp. 7-14)

Soft Tissue Pain is the primary symptom of FMS. Usually occurring at 11 of 18 specified Tender Point sites. Tender Points detected by palpation at certain characteristic sites, were discovered by researchers about 20 years ago, which have become the hallmark for diagnosing fibromyalgia.

Sleep Disturbance occurs in 90% of FMS patients in one or more of the following forms of insomnia: difficulty falling asleep, frequent awakenings, inability to fall back to sleep, tossing and turning all night and early morning awakenings.

Fatigue is a major symptom of fibromyalgia.

Neurological Symptoms occur in about 25% of FMS patients and are reported as numbness and tingling in arms and legs, hands feel clumsy and swollen.

Headaches as a regular experience are reported by over 40% of FMS patients.

Irritable Bowel Syndrome is reported by 30% of FMS patients, whose experience includes intermittent bouts of diarrhea, constipation, crampy abdominal pain, bloating, gas and other digestive difficulties.

Interstitial Cystitis (IC) which is an inflammatory (possibly autoimmune) disorder affecting the wall of the bladder.

Subjective Swelling frequently reported as a swelling sensation of the hands, feet and ankles when there is no visible or palpable swelling present.

Joint Pain in the hands, wrists, elbows, neck, chest wall, hip, knees, ankles and feet are frequently reported by FMS patients.

Chest Wall Pain is reported by about 33% of FMS patients and before diagnostic tests are performed is mistaken for heart abnormalities.

Cold Sensitivity is reported by many FMS patients and almost 40% also have symptoms similar to those of Raynaud’s phenomenon, a condition in which small blood vessels in the hand overrespond to cold and develop spasms.

Memory and Concentration Difficulties are reported by 25% of FMS patients.

Commonly Occurring Conditions with FMS (Source: The Fibromyalgia Help Book, Fransen and Russell, p.15)

Osteoarthritis
Cervical and low back degenerative diseases
Rheumatoid arthritis
Systemic lupus erythematosus
Ankylosing spondylitis
Hypothyroidism
Thoracic outlet syndrome
Polymyalgia rheumatica
Lyme disease
Chronic fatigue syndrome
Prolapsed mitral valve
HIV infection
Myofascial pain syndrome
Sjogren’s syndrome

29 posted on 02/17/2003 1:32:27 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: valleygal
Well, my ob started my on the progesterone cream for PMS related symptoms, but when I went to the doctor that "cured" me, he said that you could bathe in the cream but it wouldn't be enough. The started me on a small dose of micronized progesterone (natural!! not the synthetic stuff) and increased my dosage to about 100 mg a day 3 weeks a month. There's a good book out there by a doctor called Uzzi Reiss "Natural Hormone Balance" and he gives all kinds of great info about women's horomones.

The Armour Thyroid I started out on the lowest dose as well. The thyroid medicine made all the difference with the tremendous fatigue, muscle cramps, mental fogginess, etc. The progesterone helped with the tingling, insomnia, and panic attacks.

All my symptoms started after I had a bad case of mono and after the birth of my 1st child. I had no idea how much hormones control everything about the body until I started getting better.
30 posted on 02/17/2003 1:35:28 PM PST by Aggie Mama
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To: Aggie Mama
http://www.usdoctor.com/thyroid.htm

OVERVIEW: Although thyroid disease was first noted in the lat 1800's and associated with obesity, swelling, and heart failure, the true importance of the thyroid gland in health escapes the focus of many physicians still today. Although many individuals suffer with exhaustion, mental dullness, depression, constipation, dry skin, brittle nails, joint aches and cold hands and feet, few doctors consider thyroid as the disease that is the cause.

ANATOMY: The thyroid gland is positioned below the Adam's apple and is shaped like a bow-tie. This walnut sized gland secretes the thyroid hormones that regulates all the functions of all the cells in the body. Thyroid hormone is necessary for every cell to forge energy (in the Krebs's cycle). Without thyroid, there is a lack of efficient energy product and therefore lethargy. This is called thyroid deficiency syndrome, A small decline in the production of thyroid hormones can have dramatic effects on the cells of the brain, heart, liver, kidney, skin and bones. Hypothyroidism, left untreated, is called myxedema. The swelling that is seen in the face of severe hypothyroid individuals can also occur in the lungs and heart. One hundred years ago, myxedema was a major cause of death.

What was recognized by Broda Barnes, M.D. in the 19330's is that there are more than one thyroid. The commonly prescribed thyroid preparations, Synthroid™, Unithroid™, and Levothryoid™ are varieties of thyroxin (T4). However, tri-iodothyronine (T3) which is marketed as Cytomel™ is the more active form of thyroid. Although young people are able to convert stored T4 to active T3, this does not occur as commonly in elderly. At 60 years of age, at least one-third of women are hypothyroid. Most of us in clinical practice and research believe that more than two-thirds of everyone over 55 is hypothyroid. Replacement of T4 without T3 often fails to relieve all the symptoms listed above: cold hands, fatigue, depression, and dry skin and nails. Medical references to the benefits of T3 can be found at MEDLINE.

CLINICAL MEASUREMENT: Broda Barnes, M.D. recognized that one of the primary effects of thyroid is to raise body temperature. A fat, hypothyroid child will be one degree Fahrenheit cooler than a thin, active child. The measurements of thyroid function include TSH, T3 (free), T4 (free). But normal blood tests do not tell the complete picture of thyroid disease.

The control of the thyroid gland is TRH, thyroid releasing hormone, in the hypothalamus, deep within the brain. With age, the hypothalamus fails to release adequate stimulation: it acts like it is asleep. This is called 'down-regulation.' Under normal conditions, the TRH triggers the pituitary in the midbrain to release TSH, thyroid stimulating hormone. TSH causes the thyroid to produce T3 and T4 from precursors: iodine, tryptophan and T2 (di-iodothyronine).

Doctors have been taught to look for elevated levels of TSH. This implies that the pituitary cannot recognize adequate blood levels of either T3 or T4. A TSH over 100 means the individual is severely hypothyroid. A TSH less than 1 (when not on thyroid replacement) implies that the thyroid is overactive and out-of-control.

But, those of us researching thyroid disease have learned that these thyroid tests are just 'tests at best.' If the patient complains of a low body temperature on awakening (basal body temperature) then there is inadequate thyroid hormone no matter what the blood tests show. If there is fatigue, dry skin, brittle hair and weight gain on a low calorie diet, then there is insufficient thyroid hormone.

THYROIDITIS: Some hypothyroidism, clinically diagnosed as thyroid deficiency syndrome, may be caused by a condition called Hashimoto's thyroiditis. Hashimoto's thyroiditis is an autoimmune disease in which the body's own immune defenses destroy its own thyroid gland. Most cases occur in women; the reason is unknown. Other cases of Hashimoto's thyroiditis occur in other autoimmune diseases, including insulin-dependent diabetes mellitus, pernicious anemia and myasthenia gravis. It may also occur with greater frequency in people who are left-handed or who have prematurely gray hair.

Hypothyroidism can also be caused by drug treatments (e.g. alpha-interferon, used to treat hepatitis C) or destruction of thyroid tissue by radioactive iodine treatment or surgery for conditions such as Grave's disease or thyroid cancer It can also have a genetic origin, in which case it may manifest shortly after birth.

NATURAL THYROID REPLACEMENT:

A major controversy in the treatment of hypothyroidism concerns the use of natural glandular concentrates or extracts containing thyroid hormone (e.g., Armour Desiccated Thyroid Hormone™ and other brands derived from the thyroid gland of the pig or cow) vs. Synthetic (laboratory-made) thyroid hormone (e.g. Synthroid™, Levothroid™™, Unithyroid™ etc.). The synthetic product is promoted by pharmaceutical companies and most endocrinologists. Armour Thyroid™ and other natural thyroid preparations such as Thyrolar™ contain natural thyroid hormone. Although these preparations have been criticized by some for being "impure" or "inconsistent" from dose to dose, it should be noted that Armour Thyroid™ is most natural thyroid preparations. Armour Thyroid™ is F.D.A. approved and certified by the United States Pharmacopeia (U.S.P.). Armour Thyroid™ contains all four thyroid preparations (T4, T3, T2 and T1) and therefore, most closely resemble natural hormone thyroid hormone. At the proper dose, natural thyroid hormone works quite well and are preferred by nearly all "natural" or "alternative" physicians. Peer review journal articles have proven the benefit of 'natural thyroid' and T3 to improve general well being and decreasing depression.

We will continue patients on synthetic T4 if they insist and offer them the option of using a slow release compounded T3 product. The pharmacist mixes Cytomel™ (T3) into a medium to slow the absorption over 12 hours. Cytomel™ is not used because it is absorbed and destroyed in less than 2 hours.

According to a classic study conducted in 1974 by Dr. James Issacs, a pioneering cardiovascular surgeon from Baltimore, people who took ½ grain of thyroid along with vitamins and minerals over a period of ten years showed significant improvement in cardiovascular function. Some doctors recommend this for people over age 40 who have no overt endocrine disease. It has been pointed out that, even if one is not experiencing symptoms, all endocrine glands are beginning to slow down at this stage of life. The most common comment from people taking 1/4 grain of natural thyroid is "I just feel a little more energetic overall. My thinking seems a little clearer, and my bowel function is a little better."

Even if someone is already taking thyroid supplementation, most can still take a 1/4 - ½ grain of natural thyroid and tyrosine. "Unless you are in very brittle condition -- and brittle means to an endocrinologist that the amount you take has to be exactly right on -- you might consider adding 1/4 grain of the natural thyroid gland itself, as it also nourishes the rest of the endocrine network."

31 posted on 02/17/2003 1:45:29 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: GailA
http://www.drlowe.com/

Our website is about "metabolic health." We define metabolic health in this way: A state in which the chemical processes in our cells are sufficient to provide us with at least two things: (1) resistance to sickness and disease, and (2) the vigor, stamina, and well-being needed to fully engage in all aspects of life. At drlowe.com, we focus on what impairs metabolic health, how to recover it, and how to optimize it.

We include a large amount of information on two common and potent causes of poor metabolic health— hypothyroidism and thyroid hormone resistance. We also include information on other causes of poor metabolic health. Among the causes are poor diet, nutritional deficiencies, low physical fitness, hormone imbalances, and various medications and environmental pollutants.

Poor metabolic health affects different people in different ways, resulting in a variety of symptoms. Doctors usually give people with different symptoms different diagnoses. For example, the most prominent symptoms of some people are chronic widespread aches and pains. These people's doctors are likely to give them the diagnosis of "fibromyalgia." The main symptoms of other people are lethargy and fatigue. Their doctors may diagnose their condition as "chronic fatigue syndrome." Still other people may have depression, and others poor concentration and memory. The entire list of potential symptoms is too long to include here. But we discuss them on many pages of drlowe.com. Few conventional doctors search out and correct the underlying metabolism-impeding factors we mentioned above. Instead, they prescribe one or more medicines, hoping to relieve the patients' troubling symptoms. The diagnoses the doctors give the patients are convenient labels needed to justify their prescribing the medicines.

Our view is that different sets of symptoms, diagnosed as different disorders, have a common underlying mechanism—abnormally slow metabolism (called "hypometabolism") caused by one or more of the metabolism-impairing factors we mentioned above. To clarify this concept is one of our goals on drlowe.com.

Another of our goals is to provide information about the treatment we've developed and refined for hypometabolism patients, whatever their symptoms and diagnoses. We call the treatment "metabolic rehabilitation." Metabolic rehab is a comprehensive treatment program designed to eliminate, control, or correct factors that are impairing the metabolism of the patient. The aim of rehab is for the patient to acquire normal metabolism and freedom from symptoms of slow metabolism. The rehab program is tailored to meet each patient's individual needs.

At drlowe.com, we also deal with a range of subjects related to fibromyalgia (often called fibromyalgia syndrome or FMS). These subjects include myofascial pain syndrome and trigger point therapy, chronic fatigue syndrome or CFS, fatigue and fibromyalgia, chronic pain, chronic pain management, T3, T4, TSH, the TRH stimulation test, Armour Thyroid (desiccated thyroid), Cytomel, Synthroid, so-called "Wilson's Syndrome," the wise use of caffeine and coffee, silicone breast implants, c Dr. Paul St. Amand and guaifenesin treatment for fibromyalgia, thyroid disease, metabolism of thyroid hormone, Chiari malformation and fibromyalgia, and surgery for fibromyalgia.

These two sites I turned up with Google using Armour Thyroid for search words.

32 posted on 02/17/2003 1:47:11 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: republicandiva
Flexeril= CYCLOBENZAPRINE, not cimetidine which is used to cut down stomach acid secretion
33 posted on 02/17/2003 1:50:27 PM PST by Cyman
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To: Cyman
2 more sites Fms support

Pulsemed.org

34 posted on 02/17/2003 1:53:59 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: GailA; All
Thanks for all the info. My fibro has been attributed to an auto accident some 20 years ago with underlying arthritis and permanent injury which, I think, has complicated the treatment. I am very interested to hear about the thyroid connection, though, and I will mention this next time I see my doc. Although he does regular screening, I don't remember any thyroid function tests being performed.

BTW, being partially disabled has also given me time for FreeRepublic and turned me into something of a political activist...got to have some outlet ; ^ ) I've bookmarked this thread and will keep in touch. Thanks again.

35 posted on 02/17/2003 2:11:58 PM PST by republicandiva
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To: Cyman; All
You're absolutely right - I also take cimetidine (Tagamet), which is why I confused the two (when you get to be middle-aged and have been on these drugs for decades, they all start to run together in your mind, what's left of your mind, that is ; ^ ).

But thanks for noting the correction in case anyone might be considering asking their physician about the drug. Cyclobenzaprine (Flexeril), IMHO, is a miracle drug and has probably saved my life as well as my sanity, and aside from the obvious sleepiness, has very few side effects.

36 posted on 02/17/2003 2:21:16 PM PST by republicandiva
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To: GailA
I would worry about taking a heavy metal. The "colloidal" thing is basically marketing. I'd think regular medications were safer.
37 posted on 02/17/2003 2:44:44 PM PST by equus
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To: AntiJen; RadioAstronomer
Thank you so much for the ping Jen. I'm dying today, by the way. Some days I just don't know how much more I can take. Sigh...
38 posted on 02/17/2003 2:45:01 PM PST by SpookBrat
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To: valleygal; GailA; AntiJen; Ff--150; Wait4Truth; Damocles; bigfootbob; mathluv; buffyt; ...
VALLEYGAL WROTE: "And the drug free product is...?"

It is called Alpha-Stim. The FACTORY can be found at http://www.alpha-stim.com .

FOUR BENEFITS:

1) It WORKS, typically effective on the FIRST use of 20 minutes (or hour).
2) One-time cost and no drug-interations.
3) Effective for a LOT of ailments.
4) Can be used by people who can't take certain drugs.

FOUR PROBLEMS:

1) Because they ARE FDA-approved, they REQUIRE a PRESCRIPTION.
2) Many Doctors are not familiar with Alpha-Stim and are "stuck" on prescribing drugs (with their recurring cost and drug-interactions) instead of something with a one-time cost and no negative interactions.
3) The factory will NOT sell to individuals...only through protected-territory Distributors (i.e. regular Distributors, NOT Multi-Level).
4) Since they ARE FDA-approved and REQUIRE a prescription, they are not pocket-change, but they CAN be covered by insurance.

I think I have opened a sticky situation, because although I do NOT sell them, after having found the Alpha-Stim to be EXTREMELY EFFECTIVE for several members of my own family, I WANT to sell them so I can help people who have never found anything which gives them relief.

Whether I get to sell them or not, I still like to tell people about them as often as I can. They WORK! And they work FAST.

I don't think I should really discuss it any more here. Send me a private FReepmail if you want to hear about my family's personal experience with Alpha-Stim.

39 posted on 02/17/2003 2:53:59 PM PST by Concerned
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To: equus; GailA
EQUUS WROTE: "I would worry about taking a heavy metal. The "colloidal" thing is basically marketing. I'd think regular medications were safer."

The problem the guy you are referring to had is that he was using MEGA-doses as a PREVENTATIVE measure, not as a result of NEEDING it at the time.

I use Colloidal Silver whenever I have a sore throat or sinus infection and the problem goes away quickly. It's GREAT! And it is MUCH faster than antibiotics.

40 posted on 02/17/2003 3:17:06 PM PST by Concerned
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To: GailA
My husband saw this thread and pointed it out to me. My sister suffers from fibromyalgia. I went to the Commercial Appeal website and e-mailed the article to her. Thanks for posting it!
41 posted on 02/17/2003 3:36:36 PM PST by SuziQ (A GRITS in snowy MA)
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To: valleygal
I began taking guaifensin a few weeks ago.

You mean like cough syrup, the kind that is an expectorant?

42 posted on 02/17/2003 3:38:06 PM PST by SuziQ (A GRITS in snowy MA)
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To: GailA
My mom suffers from this and it is horrible to see her in pain like this when I visit and she's only 66 years old.It's too bad they can't make a cure available faster. How she can stand it,is WAY beyond my comprehension.
43 posted on 02/17/2003 4:02:46 PM PST by Pagey (Hillary Rotten is a Smug , Holier-Than-Thou Socialist.)
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To: GailA
Do you know anything about neuropathy and how it may be related to FMS?
44 posted on 02/17/2003 5:05:15 PM PST by mathluv
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To: republicandiva
A few corrections are in order....Flexeril is (generic) cyclobenzaprine..Tagamet is Cimetidine.Vioxx has a lower side effect profile in regard to GERD, , but, as you have found, it is not Zero..Flexeril/cyclobenzaprine is a muscle relaxer that generally makes most folks sleepy, but occasionally causes overstimulation..
45 posted on 02/17/2003 5:31:45 PM PST by contrarian
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To: contrarian
as usual my slow posting did not catch your correction.. I will now shut my mouth and go back to lurking.....
46 posted on 02/17/2003 5:37:04 PM PST by contrarian
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To: equus
I rarely take antibiotics. I'd heard about the colodial silver. But never done any research on it.

My fibro started about a year after our 16 year old son Jeremy was murdered. Emotional upheavels are a frequent cause of FMS from what I've read. I also have Osteo-A in the C 6, 7, L 4 & 5 disc, and arthritis setting in in the index finger of my right hand.

I can't take Estrogen because of the gastro-intestinal side effects it produces, the natural as well as the chemical produce the same side effects.

47 posted on 02/17/2003 5:38:35 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: buffyt
I transcribe for several docs who have prescribed both an SSRI and amitriptyline. I think it's a relative no-no, not one of the hard and solid ones.
48 posted on 02/17/2003 5:39:49 PM PST by Spyder (Just another day in Paradise)
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To: republicandiva
If the doc says your border line MAKE him treat you any way. They kept saying that for nearly 2 decades with me. It took a trip to the hospital for a lung congestion and severe back spasms before they would treat me.
49 posted on 02/17/2003 5:41:23 PM PST by GailA (stop PAROLING killers Throw Away the Keys http://keasl5227.tripod.com/)
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To: GailA
Thanks for posting this. My wife suffers from fibromyalgia and I am forwarding this to her.
50 posted on 02/17/2003 5:43:29 PM PST by TroutStalker
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