I've always been fond of Lotto's Transfiguration for it keeps alive something of the icon tradition of who this image is written. However, he switches the traditional placement of Moses and Elijah. The part in particular that I treasure about this painting is the motion of panic, disbelief, and even maybe divine joy on the part of the portrayal of St. John. It connects with the older tradition and brings forward to the early sixteenth century an element of the story sadly often missing in later works or the portrayals in films.
Sorry for the errors.. who=how....back to running after children and grandchildren.....
I also think that the Lotto is very ikon-like in its style, the placement of the figures (and the helpful labelling for the reader!) . . . which is why I thought of it and posted it. I can see Lotto's point - that the Law Giver is on Christ's right hand. And I hadn't noticed that amazing smile on St. John's face until you mentioned it . . . :-)