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Keyword: alzheimersdisease

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  • Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway

    01/17/2008 10:35:30 PM PST · by neverdem · 7 replies · 334+ views
    Differential regulation of dynein and kinesin motor proteins by the microtubule associated protein tau. The Penn group found that dynein, which carries loads towards the interior of the nerve cell, maneuvers around tau; whereas, kinesin, which carries loads towards the outside of the nerve cell, detaches when it encounters tau. Credit: Credit: Ram Dixit, PhD, University of Pennsylvania School of Medicine Researchers at the University of Pennsylvania School of Medicine discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimer’s disease. Dynein and kinesin proteins transport...
  • Folding@Home - New Software for the PS3

    12/22/2007 12:29:27 PM PST · by texas booster · 56 replies · 547+ views ^ | 12/22/2007 | Noam Rimon
    As we approach one million PLAYSTATION 3 consoles participating in the Folding@Home program, we continue to improve the FAH client. With the new Firmware v2.1 we also prepared an updated version of FAH, which can soon be automatically downloaded by clicking on the FAH icon. This updated version includes the following new features: If you happen to be one of the people that wants to leave their machine running after they finished their late-night gaming session, but wish to shut it down after a limited period of time, we have a great tip for you: Go to Settings menu, select...
  • Mental Reserves Keep Brains Agile

    12/17/2007 9:29:40 PM PST · by neverdem · 22 replies · 133+ views
    NY Times ^ | December 11, 2007 | JANE E. BRODY
    My husband, at 74, is the baby of his bridge group, which includes a woman of 85 and a man of 89. This challenging game demands an excellent memory (for bids, cards played, rules and so on) and an ability to think strategically and read subtle psychological cues. Never having had a head for cards, I continue to be amazed by the mental agility of these septua- and octogenarians. The brain, like every other part of the body, changes with age, and those changes can impede clear thinking and memory. Yet many older people seem to remain sharp as a...
  • Faulty Wiring in the Aging Brain

    12/06/2007 8:53:34 PM PST · by neverdem · 64 replies · 176+ views
    ScienceNOW Daily News ^ | 5 December 2007 | Greg Miller
    Even seniors fortunate enough to avoid the horrors of Alzheimer's disease typically experience some declines in memory and other cognitive abilities. Little is known about why this happens, but a new study suggests that cognitive declines in healthy older adults may result when brain regions that normally work together become out of sync, perhaps because the connections between them break down. A team led by Harvard neuroscientists Jessica Andrews-Hanna and Randy Buckner used functional magnetic resonance imaging (fMRI) to monitor brain activity in 38 young adults, mostly 20-somethings, and 55 older adults, age 60 or above. The researchers focused on...
  • Progress Cited in Developing Alzheimer’s Diagnosis

    10/14/2007 1:24:25 PM PDT · by neverdem · 23 replies · 75+ views
    NY Times ^ | October 14, 2007 | ANDREW POLLACK
    Scientists reported progress today toward one of medicine’s long-sought goals: the development of a blood test that can accurately diagnose Alzheimer’s disease, and even do so years before truly debilitating memory loss. A team of scientists, based mainly at Stanford University, developed a test that was about 90 percent accurate in distinguishing the blood of people with Alzheimer’s from the blood of those without the disease. The test was about 80 percent accurate in predicting which patients with mild memory loss would go on to develop Alzheimer’s disease two to six years later. Outside experts called the results, published online...
  • Judge upholds decision that limits Alzheimer’s drug to few NHS patients

    08/10/2007 6:30:40 PM PDT · by neverdem · 14 replies · 677+ views ^ | August 11, 2007 | Nigel Hawkes
    A ruling by the national drug watchdog to limit access to an Alzheimer’s drug has been upheld by the High Court. The drug company Eisai challenged the National Institute for Health and Clinical Excellence (NICE) over its guidance that for most patients Eisai’s drug Aricept was not a cost-effective use of NHS resources. This was the first legal challenge to a NICE judgment and, except in one aspect, it was a failure. In the High Court yesterday Mrs Justice Dobbs ruled that on five out of six issues raised by Eisai and the Alzheimer’s Society, the challenge failed. NICE’s decision,...
  • Alzheimers curable

    05/28/2007 9:54:37 AM PDT · by neverdem · 36 replies · 1,230+ views
    The Daily Telegraph ^ | April 30, 2007 | NA
    DEGENERATIVE brain diseases, including Alzheimers, could one day be treated with drugs that can reverse distressing loss of memory, according to a study released Sunday. The very term "memory loss'' could be a misnomer in such cases, suggests the study, published in British journal Nature: that cherished recollection of a first kiss, seemingly destroyed by disease, may have simply been rendered inaccessible by obstructed neural pathways. In laboratory experiments, mice suffering the type of brain damage which in humans typically leads to dementia - robbing victims of the ability to remember past events or even to recognize loved ones -...
  • Immune Antibodies Penetrate Neurons To Clear Alzheimer's-Linked Amyloid

    05/28/2007 12:19:13 AM PDT · by neverdem · 7 replies · 723+ views ^ | 24 May 2007 | NA
    Immune Antibodies Penetrate Neurons To Clear Alzheimer's-Linked Amyloid - Discovery Could Advance Treatment For Alzheimer's, Immune Diseases Researchers at Weill Cornell Medical College have gotten much closer to understanding how immune-based therapies can treat Alzheimer's disease -- by studying how antibodies go inside brain cells to reduce levels of Alzheimer's-linked amyloid peptides that form plaques between neurons. "This internalization and activity of the antibody within the cell was a big surprise and something we really haven't appreciated in neurological medicine. It gives us new hope for the use of immunotherapy against Alzheimer's, while casting intriguing new light on other disease...
  • Omega-3 fatty acid tied to Alzheimer's prevention

    04/18/2007 9:41:08 PM PDT · by Coleus · 27 replies · 1,074+ views
    Star Ledger ^ | 04.18.07 | ANGELA STEWART
    A diet rich in a type of omega-3 fatty acid can help prevent Alzheimer's disease, and a newly discovered molecule might block enzymes in the brain that lead to plaque formations -- a hallmark of the progressive brain disorder -- two new studies suggest. In one of those studies, at the University of California, Irvine, scientists used genetically engineered mice and it is reportedly the first to show that an omega-3 fatty acid known as docosahexaenoic acid, or DHA for short, can slow the accumulation of tau, a protein that leads to plaque and tangles in brain tissue seen in...
  • Ron Reagan Shocker: Stem Cells WON'T Cure Alzheimer's

    07/13/2004 8:12:11 AM PDT · by kattracks · 91 replies · 3,029+ views
    NewsMax .com ^ | 7/13/04 | Carl Limbacher
    Ron Reagan, Jr., admitted Monday night that embryonic stem cell research will probably be absolutely useless in the quest to find a cure for Alzheimer's disease - throwing cold water on the big media's campaign to sell the controversial science as medically effective in battling the affliction that killed Reagan's father. "Alzheimer‘s is a disease, ironically, that probably won‘t be amenable to treatment through stem cell therapies," Reagan told MSBC's Chris Matthews. So why have he and his mother, former first lady Nancy Reagan, made stem cell research their cause celeb? "For people to suggest that [Nancy Reagan] shouldn’t support...
  • Fish Oil Linked to Lower Alzheimer’s Risk

    11/15/2006 1:31:05 AM PST · by neverdem · 30 replies · 997+ views
    NY Times ^ | November 14, 2006 | NICHOLAS BAKALAR
    A substance found in fish oil may be associated with a significantly reduced risk of developing Alzheimer’s and other dementias, researchers reported yesterday. The scientists found that people with the highest blood levels of an omega-3 fatty acid called docosahexaenoic acid, or DHA, were about half as likely to develop dementia as those with lower levels. The substance is one of several omega-3 polyunsaturated fatty acids found in fatty fish and, in small amounts, in some meats. It is also sold in fish oil or DHA supplements. The researchers looked for a reduced risk associated with seven other omega-3 fatty...
  • Study Shows Coffee May Prevent Alzheimer's ( and Diabetes, gallstones, and mild depression )

    11/06/2006 8:03:59 PM PST · by george76 · 52 replies · 1,104+ views
    CBS 4 ^ | Nov 6, 2006 | Dr. Dave Hnida
    A cup of coffee may do more than help start your day. A new study suggests coffee may go a long way toward protecting your brain cells from the damage of Alzheimer's disease and several other neurological diseases. The research, which came from the Alzheimer's Institute in Florida, found coffee protects the brain. Other studies have found no difference in brain protection whether someone drinks caffeinated or decaf so the "protector" may be one of the 70 other chemicals found in a cup of joe. Some good news is that it's not too late to start enjoying a cup of...
  • The Memory Hole

    11/02/2006 9:34:49 PM PST · by neverdem · 25 replies · 1,131+ views
    NY Times ^ | November 3, 2006 | DAVID SHENK
    ONE hundred years ago today, a 42-year-old German psychiatrist and neuropathologist named Alois Alzheimer shocked colleagues with his description of one woman’s autopsied brain. The woman was named Auguste Deter. Five years earlier, her husband had admitted her to Alzheimer’s psychiatric hospital in Frankfurt with a disturbing set of symptoms: memory trouble, aphasia (loss of the ability to use words), confusion, bursts of anger and paranoia. She had become a danger to herself in the kitchen and needed constant care. Alzheimer found his new patient sitting on a bed with a helpless expression. “What is your name?” he asked. “Auguste,”...
  • Huge cost of Alzheimer's

    09/21/2006 2:48:25 AM PDT · by John Carey · 1 replies · 241+ views
    The Washington Times ^ | September 21, 2006 | John E. Carey
    What are the costs of a progressive brain disease on an aging society? At the 10th International Conference on Alzheimer's Disease and Related Disorders (ICAD), in Madrid in July 2006, Dr. Anders Wimo of the Stockholm Gerontology Research Center and Aging Research Center at Karolinska Institute, Sweden, said worldwide costs of dementia care (combined direct and informal costs) is around $248 billion annually. This overlooks the fact many suffer the ill effects and still receive no care and that our aging population is growing at a breathtaking rate. "These startling cost estimates for Alzheimer's care clearly illustrate the great challenges...
  • Scientists Create Brain Cells, Development of Treatments for Alzheimers and Parkinson's

    06/15/2005 7:43:47 PM PDT · by Coleus · 27 replies · 3,135+ views
    LifesiteNews ^ | 06.14.05
    Scientists Create Brain Cells, Predict Possible Rapid Development of Treatments for Alzheimers and Parkinson's WASHINGTON, June 14, 2005 ( - American researchers have found a method of growing batches, or lines, of fully mature brain cells. This has often been predicted as the end of such neurological diseases as Parkinson’s, Alzheimer’s and Huntington’s. The ethical new technique mimics the brain’s own natural process of changing stem cells into neurons. For the moment, the research has been confined to mice, but the researchers are hopeful that their work can soon be transferred to human patients. Bjorn Scheffler, a neuroscientist at Florida...
  • Scientists make discovery in Alzheimer's

    08/11/2006 9:51:04 AM PDT · by neverdem · 52 replies · 2,428+ views
    Seattle Post-Intelligencer ^ | August 10, 2006 | LAURAN NEERGAARD
    AP MEDICAL WRITER WASHINGTON -- Scientists have discovered molecular janitors that clear away a sticky gunk blamed for Alzheimer's disease - until they get old and quit sweeping up. The finding helps explain why Alzheimer's is a disease of aging. More importantly, it suggests a new weapon: drugs that give nature's cleanup crews a boost. "It's a whole new way of thinking in the Alzheimer's field," said Dr. Andrew Dillin, a biologist at California's Salk Institute for Biological Studies who led the new research. The discovery, published Thursday by the journal Science, was made in a tiny roundworm called C....
  • Alzheimer's drug may be poison antidote - study (maybe for nerve agents)

    08/07/2006 7:33:14 PM PDT · by neverdem · 5 replies · 462+ views
    Reuters ^ | Aug 7, 2006 | Maggie Fox
    Health and Science Correspondent WASHINGTON, Aug 7 (Reuters) - An Alzheimer's pill that helps slow the brain damage caused by the disease may also protect against the effects of nerve gases and pesticides, U.S. researchers reported on Monday. They said the drug, marketed under the name Reminyl and Razadyne, completely protected guinea pigs against the nerve agents soman and sarin, as well as toxic amounts of pesticides. They gave the animals high doses of the poisons and treated them with Reminyl, known generically as galantamine, along with atropine, often given as an antidote for organophospate pesticides such as paraoxon. "To...
  • Blood Product Shows Promise in Treating Alzheimer’s

    07/19/2006 11:03:39 PM PDT · by neverdem · 6 replies · 516+ views
    The Perfidious NY Times ^ | July 19, 2006 | DENISE GRADY
    A blood product normally used to treat immune disorders and a type of leukemia may also slow or stop mental decline in people with Alzheimer’s disease, researchers reported yesterday at an Alzheimer’s conference in Madrid. The product is called IVIg (pronounced EYE-vig), for intravenous immunoglobulin, also known as gamma globulin. Made from pooled blood plasma, it is a thick soup of antibodies, the proteins made by the immune system to get rid of unwanted substances. It has been used for 30 years for other diseases and is dripped into a vein like a transfusion. But the findings in Alzheimer’s are...
  • Studies Link Diabetes to Risk of Alzheimer’s

    07/16/2006 7:03:22 PM PDT · by neverdem · 52 replies · 1,040+ views
    NY Terrorist Tip Sheet ^ | July 16, 2006 | DENISE GRADY
    Several new studies suggest that diabetes increases the risk of Alzheimer’s disease, adding to a store of evidence that links the disorders. The studies involve only Type 2 diabetes, the most common type, which is usually related to obesity. The connection raises an ominous prospect: that increases in diabetes, a major concern in the United States and worldwide, may worsen the rising toll from Alzheimer’s. The findings also add dementia to the cloud of threats that already hang over people with diabetes, including heart disease, strokes, kidney failure, blindness and amputations. But some of the studies also hint that measures...
  • New Clues to Down Syndrome-Alzheimer's Link

    07/07/2006 11:55:27 PM PDT · by neverdem · 12 replies · 920+ views
    ScienceNOW Daily News ^ | 6 July 2006 | Greg Miller
    Alzheimer's disease, a dreaded specter for many elderly, is far more likely to strike individuals with Down syndrome. Now, a study with a mouse model of Down syndrome may explain why. The work hints at potential targets for future drugs that fend off dementia--in people with Down syndrome and in the general population too. Down syndrome is caused by an extra copy of chromosome 21. It affects roughly 1 in 800 people, causing mild to moderate mental retardation and a range of other health problems, including early-onset dementia. By age 40, the brains of all people with Down syndrome develop...