Keyword: autoimmunedisease

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  • Glenn Beck Poisoned?

    03/21/2014 6:27:01 PM PDT · by politisite · 46 replies
    Simple Clean Living ^ | 3/21/2014 | Kathryn Milliron
    Usually I don’t talk about political or news figures, but I ran across this article and it really got my attention. Glenn Beck is a controversial media figure and many people either like him or hate him. But that is not the focus of this article. The question is, is he being poisoned by a person? No. Glenn has been dealing with neuropathy for awhile and has been to see lots of different medical specialists to get to the root of his issue. The doctors believed that he was being poisoned…by the food that he had been eating. He had...
  • Interleukin-6: a new therapeutic target in systemic sclerosis?

    05/08/2013 3:50:30 PM PDT · by neverdem · 2 replies
    Clinical & Translational Immunology ^ | 12 April 2013 | Steven O'Reilly, Rachel Cant, Marzena Ciechomska and Jacob M van Laar
    Abstract Interleukin-6 (IL-6) is a classic pro-inflammatory cytokine critical in mounting an effective immune response. It is secreted by a wide array of cell types; however, its effector cells are more restricted, owing to the fact that very few cells, except lymphocytes and hepatocytes, express the functional membrane IL-6 receptor thus reducing the number of IL-6-responsive cells. Trans-signalling, the shedding of the membrane-bound form of the IL-6 receptor into the local microenvironment, greatly increases the range of cells that can respond. IL-6 has been demonstrated to have a pivotal role in the pathogenesis of rheumatoid arthritis, Castleman’s disease and Crohn’s...
  • Salty Food May Be a Culprit in Autoimmune Diseases

    03/08/2013 7:29:35 PM PST · by neverdem · 42 replies
    ScienceNOW ^ | 6 March 2013 | Mitch Leslie
    Enlarge Image Don't pass the salt. The food flavoring prompts generic T cells like these to specialize into TH17 cells that stimulate autoimmune diseases, new findings suggest. Credit: N. Yosef et al., Nature 495 (6 March) © 2013 Nature Publishing Group For decades, doctors have been admonishing us to cut back on salt to reduce the odds of a heart attack or stroke. Now, there may be a new reason to avoid the seasoning: Studies on rodents and cultured cells, reported today, reveal that dietary salt might promote autoimmune diseases such as multiple sclerosis and inflammatory bowel disease. The...
  • New synthetic molecules treat autoimmune disease in mice

    12/25/2011 11:25:41 AM PST · by decimon · 26 replies
    A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. Prof. Irit Sagi of the Biological Regulation Department and her research group have spent years looking for ways to home in on and block members of the matrix metalloproteinase (MMP) enzyme family. These proteins...
  • Researcher contends multiple sclerosis is not a disease of the immune system

    12/22/2011 3:19:09 PM PST · by decimon · 11 replies
    An article to be published Friday (Dec. 23) in the December 2011 issue of The Quarterly Review of Biology argues that multiple sclerosis, long viewed as primarily an autoimmune disease, is not actually a disease of the immune system. Dr. Angelique Corthals, a forensic anthropologist and professor at the John Jay College of Criminal Justice in New York, suggests instead that MS is caused by faulty lipid metabolism, in many ways more similar to coronary atherosclerosis (hardening of the arteries) than to other autoimmune diseases. Framing MS as a metabolic disorder helps to explain many puzzling aspects of the disease,...
  • Self-regulation of the immune system suppresses defense against cancer

    12/21/2011 8:17:19 AM PST · by decimon · 16 replies
    It is vital that the body's own immune system does not overreact. If its key players, the helper T cells, get out of control, this can lead to autoimmune diseases or allergies. An immune system overreaction against infectious agents may even directly damage organs and tissues. Immune cells called regulatory T cells ("Tregs") ensure that immune responses take place in a coordinated manner: They downregulate the dividing activity of helper T cells and reduce their production of immune mediators. "This happens through direct contact between regulatory cell and helper cell," says Prof. Peter Krammer of DKFZ. "But we didn't know...
  • Intestine crucial to function of immune cells, research shows (MS? RA?)

    12/12/2011 6:28:36 PM PST · by decimon · 20 replies
    University of Toronto ^ | December 12, 2011
    TORONTO, Canada—Researchers at the University of Toronto have found an explanation for how the intestinal tract influences a key component of the immune system to prevent infection, offering a potential clue to the cause of autoimmune disorders like rheumatoid arthritis and multiple sclerosis. "The findings shed light on the complex balance between beneficial and harmful bacteria in the gut," said Prof. Jennifer Gommerman, an Associate Professor in the Department of Immunology at U of T, whose findings were published online by the scientific journal, Nature. "There has been a long-standing mystery of how certain cells can differentiate between and attack...
  • A Unifying Theory of Autoimmune Disease

    05/25/2011 2:10:48 PM PDT · by neverdem · 20 replies
    Harvard Medical School ^ | May 5, 2011 | NA
    Carbohydrate activates B cells in skin, connective tissues Researchers led by HMS Associate Professor of Medicine Julia Wang offer a new, unifying theory on the origins of autoimmune diseases. In two related papers in the May 2011 issue of the American Journal of Pathology, the team outlines a process by which a carbohydrate abundant in skin and connective tissue called dermatan sulfate turns traitorous. The resulting disease may be systemic, as in lupus or rheumatoid arthritis, or localized, as in Type 1 diabetes or Graves’ disease. Only a tiny subset of molecules in the body are known to have the...
  • Type 2 diabetes, like type 1, may be an autoimmune disease, researchers say

    04/18/2011 6:54:18 PM PDT · by Pining_4_TX · 19 replies
    The Los Angeles Times ^ | 04/18/11 | Thomas H. Maugh II
    Type 2 diabetes, like Type 1, may be an autoimmune disease, but the immune system's target cells are different, Stanford researchers said Sunday. The discovery sheds new light on how obesity contributes to the onset of Type 2 diabetes and could lead to new types of treatment for the disorder, the researchers reported in the journal Nature Medicine.
  • Gene linked to autoimmune diseases - Rare variants of a single gene seem to make patients...

    06/17/2010 9:11:03 PM PDT · by neverdem · 37 replies · 607+ views
    Nature News ^ | 16 June 2010 | Alla Katsnelson
    Differences in the sequence of a single gene may be partly responsible for causing around 2% of relatively common autoimmune disorders including diabetes and arthritis. The gene codes for an enzyme called sialic acid acetylesterase (SIAE) that regulates the immune system's B cells — the cells responsible for producing antibodies against foreign invaders. In 24 of 923 people with conditions such as Crohn's disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, the gene was present in a variant form. For the past five years, genome-wide screens of large groups of patients have searched for commonly occurring...
  • Narcolepsy: A Case of the Body Attacking Itself?

    05/05/2009 9:51:29 AM PDT · by neverdem · 5 replies · 522+ views
    ScienceNOW Daily News ^ | 4 May 2009 | Gisela Telis
    Enlarge ImageMystery disease. Scientists monitor a narcoleptic patient. Credit: Donna E. Natale Planas/Miami Herald/MCT/Newscom The millions of people who suffer from narcolepsy might have their immune system to blame. Researchers have tied the disabling sleep disorder to two immune system genes, suggesting that it's an autoimmune disease. The discovery may eventually lead to improved narcolepsy treatments. Narcolepsy affects 1 in every 2000 people, making it about as common as multiple sclerosis. The disorder encompasses an odd constellation of symptoms, including overwhelming daytime drowsiness, uncontrollable sleep attacks, and cataplexy, a sudden loss of muscle tone after an intense emotional outburst,...
  • Take a chill pill, T cell

    06/20/2008 8:05:03 PM PDT · by neverdem · 5 replies · 226+ views
    Science News ^ | June 19th, 2008 | Tia Ghose
    A receptor on infection-fighting cells may be a novel target for drugs that fight autoimmune disease. TURNING ON ITSELFAfter mice were made allergic to a protein, researchers injected the same protein into mouse lungs to cause a disease that mimics asthma. The lung tissue of normal mice (left) shows more severe inflammation than that of mice lacking the gene for the DR3 receptor (right). Because DR3 plays a crucial role in immune cells attacking healthy tissue, the receptor may be a target for drugs that treat autoimmune disorders like asthma or multiple sclerosis.Siegel, Françoise Meylan In people with autoimmune diseases...
  • Body Reveals Its Inflammation 'Off Switch'

    10/01/2006 6:32:34 PM PDT · by blam · 23 replies · 1,403+ views
    New Scientist ^ | 10-1-2006 | Deb McKenzie
    Body reveals its inflammation 'off switch' 18:00 01 October 2006 NewScientist.com news service Deb MacKenzie Researchers have shed light on how the body switches off its immune response, a key step towards understanding autoimmune diseases and controlling inflammation. When immune cells die, they transform into “sponges” that soak up the molecules responsible for causing inflammation, researchers have discovered. The new information may lead to better drugs to treat inflammatory disorders, such as eczema. Inflammation is characterised by a red, painful swelling around a wound caused by blood fluids, proteins and immune cells flooding into an area of the body in...
  • Northwestern U. study uses ADULT stem cells to strengthen immune system

    09/02/2006 9:37:18 PM PDT · by Coleus · 3 replies · 293+ views
    The Daily Colonial, ^ | 02.07.06 | Joanna Allerhand
    EVANSTON, Ill. -- A recent Northwestern University study found that a new treatment using stem cells might extend the lives of patients with lupus. Stem cell treatments could help patients with severe cases who have not responded to other options, according to a study published in the Feb. 1 issue of The Journal of the American Medical Association. Lupus is a disease that causes patients' immune systems to become unable to distinguish between foreign substances and normal parts of the body. This causes the immune system to attack the patient's own cells and tissues instead of protecting them. Researchers, including...
  • Stem cells for lupus

    06/15/2006 9:51:23 PM PDT · by Coleus · 6 replies · 395+ views
    News 8 Austin ^ | 06.13.06
    Lupus is a chronic inflammatory disease that can affect various parts of the body, especially the skin, joints, blood, and kidneys. The body's immune system normally makes proteins called antibodies to protect the body against viruses, bacteria and other foreign materials. In lupus, these antibodies mistake normal cells in the body’s tissues for foreign bodies and attack them. For most people, lupus is a mild disease affecting only a few organs. For others, it may cause serious and even life-threatening problems. The exact cause of lupus is unknown. More than 16,000 Americans develop lupus each year. According to the Lupus...
  • Breakthrough in Autoimmune Disease Research - Stem Cell Research Gives New Hope to Patients

    04/10/2006 8:00:51 PM PDT · by neverdem · 27 replies · 1,804+ views
    ABC News Internet Ventures ^ | April 10, 2006 | NA
    Before seeking out Dr. Richard Burt of Northwestern Memorial Hospital, Kathy Hammons could barely care for her children as a result of the effects of lupus, an autoimmune disease in which the body attacks itself. She had been on oxygen for two years, was constantly fatigued, and was overweight from the steroids used to control her disease. "I would say before this option, they [lupus patients] hit a brick wall," Burt said. "They had nothing more, no further treatments." Burt's pioneering research, however, offered a new option. His breakthrough procedure uses a patient's stem cells to treat extremely severe cases...
  • Trying to Shut Off the Body's Friendly Fire

    06/05/2005 1:20:38 PM PDT · by neverdem · 56 replies · 2,004+ views
    NY Times ^ | June 5, 2005 | ANDREW POLLACK
    ROXANNE PEREZ had never really been sick in her life until, at age 27, the roof began falling in. During a Fourth of July weekend at the beach in 2000, she was rushed to an emergency room suffering from convulsions. In the months after, she had blood transfusions and her spleen removed. Then, in 2001, she suffered a heart attack that left her heart permanently weakened. Ms. Perez, who lives in San Antonio, had to give up her job, her home and car and move in with her parents. Now 32, she suffers from frequent fatigue, made worse when she...