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Keyword: cancercells

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  • Researchers discover gene that permanently stops cancer cell proliferation

    08/08/2012 12:28:15 PM PDT · by Red Badger · 16 replies
    Medical Express ^ | 08-01-2012 | Provided by Case Western Reserve University
    Researchers at Case Western Reserve University School of Medicine have discovered a mutant form of the gene, Chk1, that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without the addition of any chemotherapeutic drugs. This study illustrates an unprecedented finding, that artificially activating Chk1 alone is sufficient to kill cancer cells. "We have identified a new direction for cancer therapy and the new direction is leading us to a reduction in toxicity in cancer therapy, compared with chemotherapy or radiation therapy," said Dr. Zhang, assistant professor, Department of Pharmacology at the School of Medicine, and...
  • Many cancer cells found to have an 'eat me' signal in Stanford study

    12/22/2010 2:36:19 PM PST · by decimon · 13 replies · 2+ views
    Stanford University Medical Center ^ | December 22, 2010 | Unknown
    STANFORD, Calif. — Researchers at the Stanford University School of Medicine have discovered that many cancer cells carry the seeds of their own destruction — a protein on the cell surface that signals circulating immune cells to engulf and digest them. On cancer cells, this "eat me" signal is counteracted by a separate "don't eat me" signal that was described in an earlier study. The two discoveries may lead to better cancer therapies, and also solve a mystery about why a previously reported cancer therapy is not more toxic. In the study to be published Dec. 22 in Science Translational...
  • Scientists find way to force cancer cells to die of old age

    03/18/2010 12:47:46 AM PDT · by myknowledge · 9 replies · 440+ views
    The Daily Telegraph ^ | March 18, 2010 | Correspondents in Chicago
    INSTEAD of killing off cancer cells with toxic drugs, scientists have discovered a molecular pathway that forces them to grow old and die. Cancer cells spread and grow because they can divide indefinitely. But a study in mice showed that blocking a cancer-causing gene called Skp2 forced cancer cells to go through an aging process known as senescence - the same process involved in ridding the body of cells damaged by sunlight. If you block Skp2 in cancer cells, this process is triggered, Pier Paolo Pandolfi of Harvard Medical School in Boston and colleagues reported in the journal Nature.
  • Stem Cells: The Real Culprits in Cancer?

    06/26/2006 6:36:40 PM PDT · by neverdem · 13 replies · 615+ views
    Scientific American ^ | June 26, 2006 | Michael F. Clarke and Michael W. Becker
    A dark side of stem cells--their potential to turn malignant--is at the root of a handful of cancers and may be the cause of many more. Eliminating the disease could depend on tracking down and destroying these elusive killer cellsAfter more than 30 years of declared war on cancer, a few important victories can be claimed, such as 85 percent survival rates for some childhood cancers whose diagnoses once represented a death sentence. In other malignancies, new drugs are able to at least hold the disease at bay, making it a condition with which a patient can live. In 2001,...
  • Cancer cell 'executioner' found ~ synthetic molecule which caused cancer cells to self-destruct.

    08/27/2006 8:20:10 PM PDT · by Ernest_at_the_Beach · 138 replies · 3,774+ views
    BBC ^ | Sunday, 27 August 2006, 23:51 GMT 00:51 UK | BBC staff
    Cancer cell 'executioner' found Cancer cells keep dividing because the cell suicide process fails Scientists have developed a way of "executing" cancer cells.Healthy cells have a built-in process which means they commit suicide if something is wrong, a process which fails in cancer cells. The University of Illinois team created a synthetic molecule which caused cancer cells to self-destruct. Cancer experts said the study, in Nature Chemical Biology, offered "exciting possibilities" for new ways of treating the disease. These findings present an exciting new therapeutic strategy for the treatment of some cancers Dr Michael Olsen, Cancer Research UK One...