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Keyword: cd47antibody

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  • Drug Combo Helps Immune System Fight Tumors

    06/10/2013 9:38:01 PM PDT · by neverdem · 4 replies
    ScienceNOW ^ | 30 May 2013 | Jocelyn Kaiser
    Enlarge Image Double whammy. Combining a SIRPa protein (CV1 mono) and the cancer drug rituximab virtually wiped out tumors in mice after 29 days. Credit: Adapted From K. Weiskopf et al., Science (2013) To avoid being destroyed by our immune systems, cancer cells engage in a bit of trickery. As they divide to form tumors, they fly under the radar of macrophages, immune cells whose job it is to ingest dead cells and dangerous invaders. Today, many cancer patients are treated with antibody drugs that work in part by marking tumor cells for destruction by macrophages. Although these drugs...