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Keyword: cfs

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  • Characteristic chemical signature for chronic fatigue syndrome identified

    09/25/2016 7:55:50 AM PDT · by Seizethecarp · 7 replies
    ScienceDaily ^ | August 29, 2016 | Unattributed
    Chronic fatigue syndrome (CFS) is a mysterious and maddening condition, with no cure or known cause. But researchers, using a variety of techniques to identify and assess targeted metabolites in blood plasma, have identified a characteristic chemical signature for the debilitating ailment and an unexpected underlying biology: It is similar to the state of dauer, and other hypometabolic syndromes like caloric restriction, diapause and hibernation. Dauer is the German word for persistence or long-lived. It is a type of stasis in the development in some invertebrates that is prompted by harsh environmental conditions. The findings are published online in the...
  • Bad science misled millions with chronic fatigue syndrome. Here’s how we fought back

    09/22/2016 7:38:17 AM PDT · by Seizethecarp · 97 replies
    STAT NEWS ^ | September 21, 2016 | JULIE REHMEYER
    If your doctor diagnoses you with chronic fatigue syndrome, you’ll probably get two pieces of advice: Go to a psychotherapist and get some exercise. Your doctor might tell you that either of those treatments will give you a 60 percent chance of getting better and a 20 percent chance of recovering outright. After all, that’s what researchers concluded in a 2011 study published in the prestigious medical journal the Lancet, along with later analyses. Problem is, the study was bad science. And we’re now finding out exactly how bad. Under court order, the study’s authors for the first time released...
  • New study shows chronic fatigue syndrome may have to do with gut microbes

    09/17/2016 6:07:34 PM PDT · by Seizethecarp · 46 replies
    WaPo ^ | June 30, 2016 | Ariana Eunjung Cha
    “Our work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn’t normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease,” said Maureen Hanson, a professor of molecular biology and genetics at Cornell. “Furthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin.” In a study published this month in the journal Microbiome, Cornell University researchers looked at stool and blood samples of 48 people diagnosed with chronic fatigue syndrome (or more formally, myalgic encephalomyelitis) and at 39 healthy volunteers. They found two...
  • Chronic fatigue syndrome is a physical disorder, not a psychological illness, panel says(SEID)

    03/02/2015 3:54:03 PM PST · by Seizethecarp · 39 replies
    Washington Post ^ | February 10, 2015 | Lenny Bernstein
    Chronic fatigue syndrome is a "serious, debilitating" condition with a cluster of clear physical symptoms — not a psychological illness — a panel of experts reported Tuesday as it called for more research into a disease that may affect as many as 2.5 million Americans. "We just needed to put to rest, once and for all, the idea that this is just psychosomatic or that people were making this up, or that they were just lazy," said Ellen Wright Clayton, a professor of pediatrics and law at Vanderbilt University, who chaired the committee of the Institute of Medicine, the health...
  • Distinct stages to chronic fatigue syndrome identified

    03/02/2015 11:53:10 AM PST · by Seizethecarp · 18 replies
    BBC ^ | February 27, 2015 | Unattributed
    Distinct changes in the immune systems of patients with ME or chronic fatigue syndrome have been found, say scientists. Increased levels of immune molecules called cytokines were found in people during the early stages of the disease, a Columbia University study reported. The US research team, who published their findings in the journal Science Advances, tested blood samples from nearly 300 ME patients and around 350 healthy people. They found specific patterns of immune molecules in patients who had the disease for up to three years. These patients had higher levels of of cytokines, particularly one called interferon gamma, which...
  • The Unbreakable Laura Hillenbrand

    12/18/2014 7:04:32 PM PST · by Seizethecarp · 21 replies
    New York Times ^ | December 18, 2014 | WIL S. HYLTON
    ...Bill Darron drove down the alley behind Laura Hillenbrand’s house (with) a Norden bombsight. Since 1987, Hillenbrand has been sick with chronic fatigue syndrome, which has mostly confined her indoors for the last quarter century. When she explained this to Darron, he agreed to bring the Norden from New Jersey on his next visit to Washington. Now, as he made the final calibrations, Hillenbrand returned to the room, and he offered her a brief tutorial. He showed her how to position herself above the monocular eyepiece, guide the cross hairs toward a target on the map, then lock the sight...
  • Brains of People with Chronic Fatigue Syndrome Offer Clues About Disorder

    12/03/2014 11:08:37 AM PST · by Seizethecarp · 55 replies
    New York Times ^ | November 24, 2014 | David Tuller
    Patients with chronic fatigue syndrome are accustomed to disappointment. The cause of the disorder remains unknown; it can be difficult to diagnose, and treatment options are few. Many patients are still told to seek psychiatric help. But two recent studies — one from investigators at Stanford a few weeks ago and another from a Japanese research team published earlier this year — have found that the brains of people with chronic fatigue syndrome differ from those of healthy people, strengthening the argument that serious physiological dysfunctions are at the root of the condition. Both studies were small, however, and their...
  • Chronic fatigue syndrome from vagus nerve infection: A psychoneuroimmunological hypothesis

    02/22/2014 7:00:16 PM PST · by Seizethecarp · 40 replies
    Medical Hypotheses ^ | June 21, 2013 | Michael B. VanElzakker
    Chronic fatigue syndrome (CFS) is an often-debilitating condition of unknown origin. There is a general consensus among CFS researchers that the symptoms seem to reflect an ongoing immune response, perhaps due to viral infection. Thus, most CFS research has focused upon trying to uncover that putative immune system dysfunction or specific pathogenic agent. However, no single causative agent has been found. In this speculative article, I describe a new hypothesis for the etiology of CFS: infection of the vagus nerve. When immune cells of otherwise healthy individuals detect any peripheral infection, they release proinflammatory cytokines. Chemoreceptors of the sensory vagus...
  • First Physical Evidence of Gulf War Illness Discovered in Veterans' Brains

    03/20/2013 10:36:00 PM PDT · by Seizethecarp · 11 replies
    University Medical Center (GUMC) researchers for the first time have discovered that veterans who suffer from “Gulf War Illness” have physical changes in their brains that may account for pain from actions as simple as putting on a shirt. Brain scans of 31 veterans with the illness, compared to 20 control subjects, revealed anomalies in the bundles of axons, also known as nerve fibers, that connect brain areas involved in the processing and perception of pain and fatigue. The Georgetown findings, published online today in PLOS ONE, could provide insight into the mysterious medical symptoms reported by Gulf War veterans,...
  • Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome

    12/30/2012 7:18:29 AM PST · by Seizethecarp · 32 replies
    PLOS ONE ^ | November 14, 2012 | Alison Beaumont, et al
    Background Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not as yet been examined in CFS. The objective of this study was to examine the relationship between HRV and cognitive performance in patients with CFS. Results Patients with CFS showed no deficits in performance accuracy, but were significantly slower than healthy controls. CFS was further characterized by low and unresponsive HRV; greater heart rate (HR) reactivity and prolonged HR-recovery after cognitive challenge....
  • Panel rejects experimental chronic fatigue syndrome drug

    12/23/2012 9:17:26 PM PST · by Seizethecarp · 9 replies
    Nature ^ | December 21, 2012 | Heidi Ledford
    A drug for chronic fatigue syndrome that spent decades in clinical development and won fervent patient support has been turned down for approval by a committee of advisers to the US Food and Drug Administration (FDA) who voted 9–4 against it. The drug, named Ampligen (rintatolimod), has not been shown to be effective or safe, the committee determined on 20 December. “Key deficiencies included inadequate evidence of effectiveness or safety, inadequacy of drug–drug interaction studies, lack of carcinogenicity assessment, lack of anti-drug antibody determination, and inadequate analytical methods and drug product specifications,” the agency wrote in one of several sections...
  • CDC Study of Morgellons an Insult to Sufferers

    01/27/2012 9:34:09 AM PST · by stillafreemind · 23 replies
    Yahoo Voices ^ | Jan. 27th, 2012 | Sherry Tomfeld
    If you suffer from Morgellons disease, you have been waiting for a CDC study to be completed. The study was for the purpose of finding out what causes the heinous disease. The report says there is no reason for Morgellon symptoms, unless you want to blame it on patients' mental health. Once again, a disease is said to be a mental disease because there are no other answers for it.
  • Both key papers on CFS retroviral involvement retracted, but Lipkin’s virus hunt proceeds

    12/27/2011 10:39:09 PM PST · by Seizethecarp · 3 replies ^ | December 27, 2011 | Unattributed
    A multi-center research team is now searching for evidence of murine gamma retroviruses or other viral involvement in 150 well-defined, geographically diverse chronic fatigue syndrome patient samples. The study, led by Columbia University’s “virus hunter,” Ian Lipkin, and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) expects to have results some time in 2012. As Dr. Lipkin has suggested, CFS “smells like a viral disease,” and his lab will be using “next generation” genetic sequencing in the CFS study. (According to him, this technology has allowed identification of 500 new viruses so far.) Meanwhile, Both the Lo-Alter...
  • Controversial CFS Researcher Arrested and Jailed

    11/19/2011 9:17:56 PM PST · by neverdem · 12 replies
    ScienceInsider ^ | 19 November 2011 | Jon Cohen
    Judy Mikovits, who has been in the spotlight for the past 2 years after Science published a controversial report by her group that tied a novel mouse retrovirus to chronic fatigue syndrome (CFS), is now behind bars. Sheriffs in Ventura County, California, arrested Mikovits yesterday on felony charges that she is a fugitive from justice. She is being held at the Todd Road Jail in Santa Paula without bail. But ScienceInsider could obtain only sketchy details about the specific charges against her. The Ventura County sheriff's office told ScienceInsider that it had no available details about the charges and was...
  • Viral Theory Is Set Back in Chronic Fatigue Study (XMRV link to ME/CFS fails)

    09/23/2011 11:48:43 AM PDT · by Seizethecarp · 2 replies
    New York Times ^ | September 22, 2011 | David Tuller
    Dashing the hopes of many people with chronic fatigue syndrome, an eagerly awaited study coordinated by government health agencies has not confirmed a link between the illness and a virus called XMRV or others from the same class of mouse leukemia viruses. Two research groups had earlier reported an association between chronic fatigue syndrome and the group of viruses, known as murine leukemia viruses, or M.L.V.’s, raising hopes that a treatment or cure could be found. But later studies did not substantiate the link, and many researchers suggested that that the initial findings were the result of contamination of laboratory...
  • New Data Spark Retraction Request for Chronic Fatigue Virus Study

    06/03/2011 10:19:46 PM PDT · by neverdem · 10 replies
    ScienceNOW ^ | 31 May 2011 | Jon Cohen
    Enlarge Image Buggy research? Increasing evidence suggests that contamination explains ties between CFS and XMRV, pictured here in a cross-sectional illustration and an electron micrograph. Credit: Bob Silverman/Cleveland Clinic/Illustration by David Schumick; (inset, right) Lombardi et al., Science You cannot un-ring a bell, but you can retract a scientific study. Then again, as a raging debate over a Science paper that linked a mouse retrovirus to chronic fatigue syndrome (CFS) makes clear, retractions can be a tall order, too. In conjunction with their decision to publish two additional papers that strongly question the link between the virus, known as...
  • Study finds clue to chronic fatigue, chronic Lyme

    02/23/2011 7:28:58 PM PST · by decimon · 5 replies
    Associated Press ^ | February 23, 2011 | Unknown
    Scientists have discovered proteins in spinal fluid that can distinguish people with two mysterious illnesses that mimic each other — chronic fatigue syndrome and a kind of chronic Lyme disease. Wednesday's study is small and needs verification. But specialists called it a promising start at clearing some of the confusion surrounding two illnesses with similar symptoms and no good means of diagnosis. "It's a very important first step," said Dr. Suzanne Vernon of the Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association of America.
  • XMRV: Study Shows Virus Can Cause ‘Persistent Infection’ in Monkeys (ME/CFS related virus)

    02/19/2011 9:00:49 PM PST · by Seizethecarp · 9 replies
    Wall Street Journal Health Blog ^ | February 17, 2011 | Amy Dockser Marcus
    The debate over what XMRV may do to humans continues. But at least in a small group of monkeys, one thing is clear, according to a new study. “The virus causes chronic, persistent infection,” says Robert Silverman of the Cleveland Clinic, a co-author of the paper, which was published online yesterday in the Journal of Virology. Moreover, the new research suggests that in these monkeys, at least, the virus can be difficult to detect in blood, even though it’s taken root in the body. This is a tantalizing finding because it raises the prospect that someone could be infected with...
  • XMRV and CFS – It’s not the end (Retrovirology articles overstate case against XMRV link to CFS)

    12/22/2010 10:15:36 PM PST · by Seizethecarp · 5 replies
    Virology Blog ^ | December 22, 2010 | Professor Vincent Racaniello
    Yesterday the Chicago Tribune published my reaction to the four papers on the retrovirus XMRV published this week in the journal Retrovirology. I was quoted as saying ”These four papers are probably the beginning of the end of XMRV and CFS”. I wish to retract this statement and explain my reasons for doing so. Upon re-reading three of the four Retrovirology papers it became clear to me that they show that identification of XMRV can be fraught with contamination problems, but they do not imply that previously published studies are compromised by these findings. Clearly any new studies done on...
  • American kayakers say crocodile came from behind, ripping guide from his boat

    12/22/2010 7:00:05 AM PST · by Manic_Episode · 9 replies · 1+ views
    Associated Press ^ | December 21, 2010 | JEFF BARNARD
    For weeks, three kayakers exploring a series of rivers through the heart of Africa came together in a close formation designed to ward off hippo and crocodile attacks whenever they paddled the quiet green glides between thundering stretches of whitewater. The boaters — two Americans and a South African — traveled some 1,000 miles of river this way, through some of the densest concentrations of man-killing wildlife in the world. They were on a quiet stretch of the Lukuga River in Congo, paddling just 4 or 5 feet apart, when a crocodile slipped up from behind and ripped trip leader...