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Keyword: cfs

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  • The Unbreakable Laura Hillenbrand

    12/18/2014 7:04:32 PM PST · by Seizethecarp · 21 replies
    New York Times ^ | December 18, 2014 | WIL S. HYLTON
    ...Bill Darron drove down the alley behind Laura Hillenbrand’s house (with) a Norden bombsight. Since 1987, Hillenbrand has been sick with chronic fatigue syndrome, which has mostly confined her indoors for the last quarter century. When she explained this to Darron, he agreed to bring the Norden from New Jersey on his next visit to Washington. Now, as he made the final calibrations, Hillenbrand returned to the room, and he offered her a brief tutorial. He showed her how to position herself above the monocular eyepiece, guide the cross hairs toward a target on the map, then lock the sight...
  • Brains of People with Chronic Fatigue Syndrome Offer Clues About Disorder

    12/03/2014 11:08:37 AM PST · by Seizethecarp · 55 replies
    New York Times ^ | November 24, 2014 | David Tuller
    Patients with chronic fatigue syndrome are accustomed to disappointment. The cause of the disorder remains unknown; it can be difficult to diagnose, and treatment options are few. Many patients are still told to seek psychiatric help. But two recent studies — one from investigators at Stanford a few weeks ago and another from a Japanese research team published earlier this year — have found that the brains of people with chronic fatigue syndrome differ from those of healthy people, strengthening the argument that serious physiological dysfunctions are at the root of the condition. Both studies were small, however, and their...
  • Chronic fatigue syndrome from vagus nerve infection: A psychoneuroimmunological hypothesis

    02/22/2014 7:00:16 PM PST · by Seizethecarp · 40 replies
    Medical Hypotheses ^ | June 21, 2013 | Michael B. VanElzakker
    Chronic fatigue syndrome (CFS) is an often-debilitating condition of unknown origin. There is a general consensus among CFS researchers that the symptoms seem to reflect an ongoing immune response, perhaps due to viral infection. Thus, most CFS research has focused upon trying to uncover that putative immune system dysfunction or specific pathogenic agent. However, no single causative agent has been found. In this speculative article, I describe a new hypothesis for the etiology of CFS: infection of the vagus nerve. When immune cells of otherwise healthy individuals detect any peripheral infection, they release proinflammatory cytokines. Chemoreceptors of the sensory vagus...
  • First Physical Evidence of Gulf War Illness Discovered in Veterans' Brains

    03/20/2013 10:36:00 PM PDT · by Seizethecarp · 11 replies
    University Medical Center (GUMC) researchers for the first time have discovered that veterans who suffer from “Gulf War Illness” have physical changes in their brains that may account for pain from actions as simple as putting on a shirt. Brain scans of 31 veterans with the illness, compared to 20 control subjects, revealed anomalies in the bundles of axons, also known as nerve fibers, that connect brain areas involved in the processing and perception of pain and fatigue. The Georgetown findings, published online today in PLOS ONE, could provide insight into the mysterious medical symptoms reported by Gulf War veterans,...
  • Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome

    12/30/2012 7:18:29 AM PST · by Seizethecarp · 32 replies
    PLOS ONE ^ | November 14, 2012 | Alison Beaumont, et al
    Background Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not as yet been examined in CFS. The objective of this study was to examine the relationship between HRV and cognitive performance in patients with CFS. Results Patients with CFS showed no deficits in performance accuracy, but were significantly slower than healthy controls. CFS was further characterized by low and unresponsive HRV; greater heart rate (HR) reactivity and prolonged HR-recovery after cognitive challenge....
  • Panel rejects experimental chronic fatigue syndrome drug

    12/23/2012 9:17:26 PM PST · by Seizethecarp · 9 replies
    Nature ^ | December 21, 2012 | Heidi Ledford
    A drug for chronic fatigue syndrome that spent decades in clinical development and won fervent patient support has been turned down for approval by a committee of advisers to the US Food and Drug Administration (FDA) who voted 9–4 against it. The drug, named Ampligen (rintatolimod), has not been shown to be effective or safe, the committee determined on 20 December. “Key deficiencies included inadequate evidence of effectiveness or safety, inadequacy of drug–drug interaction studies, lack of carcinogenicity assessment, lack of anti-drug antibody determination, and inadequate analytical methods and drug product specifications,” the agency wrote in one of several sections...
  • CDC Study of Morgellons an Insult to Sufferers

    01/27/2012 9:34:09 AM PST · by stillafreemind · 23 replies
    Yahoo Voices ^ | Jan. 27th, 2012 | Sherry Tomfeld
    If you suffer from Morgellons disease, you have been waiting for a CDC study to be completed. The study was for the purpose of finding out what causes the heinous disease. The report says there is no reason for Morgellon symptoms, unless you want to blame it on patients' mental health. Once again, a disease is said to be a mental disease because there are no other answers for it.
  • Both key papers on CFS retroviral involvement retracted, but Lipkin’s virus hunt proceeds

    12/27/2011 10:39:09 PM PST · by Seizethecarp · 3 replies
    ProHealth.com ^ | December 27, 2011 | Unattributed
    A multi-center research team is now searching for evidence of murine gamma retroviruses or other viral involvement in 150 well-defined, geographically diverse chronic fatigue syndrome patient samples. The study, led by Columbia University’s “virus hunter,” Ian Lipkin, and sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) expects to have results some time in 2012. As Dr. Lipkin has suggested, CFS “smells like a viral disease,” and his lab will be using “next generation” genetic sequencing in the CFS study. (According to him, this technology has allowed identification of 500 new viruses so far.) Meanwhile, Both the Lo-Alter...
  • Controversial CFS Researcher Arrested and Jailed

    11/19/2011 9:17:56 PM PST · by neverdem · 12 replies
    ScienceInsider ^ | 19 November 2011 | Jon Cohen
    Judy Mikovits, who has been in the spotlight for the past 2 years after Science published a controversial report by her group that tied a novel mouse retrovirus to chronic fatigue syndrome (CFS), is now behind bars. Sheriffs in Ventura County, California, arrested Mikovits yesterday on felony charges that she is a fugitive from justice. She is being held at the Todd Road Jail in Santa Paula without bail. But ScienceInsider could obtain only sketchy details about the specific charges against her. The Ventura County sheriff's office told ScienceInsider that it had no available details about the charges and was...
  • Viral Theory Is Set Back in Chronic Fatigue Study (XMRV link to ME/CFS fails)

    09/23/2011 11:48:43 AM PDT · by Seizethecarp · 2 replies
    New York Times ^ | September 22, 2011 | David Tuller
    Dashing the hopes of many people with chronic fatigue syndrome, an eagerly awaited study coordinated by government health agencies has not confirmed a link between the illness and a virus called XMRV or others from the same class of mouse leukemia viruses. Two research groups had earlier reported an association between chronic fatigue syndrome and the group of viruses, known as murine leukemia viruses, or M.L.V.’s, raising hopes that a treatment or cure could be found. But later studies did not substantiate the link, and many researchers suggested that that the initial findings were the result of contamination of laboratory...
  • New Data Spark Retraction Request for Chronic Fatigue Virus Study

    06/03/2011 10:19:46 PM PDT · by neverdem · 10 replies
    ScienceNOW ^ | 31 May 2011 | Jon Cohen
    Enlarge Image Buggy research? Increasing evidence suggests that contamination explains ties between CFS and XMRV, pictured here in a cross-sectional illustration and an electron micrograph. Credit: Bob Silverman/Cleveland Clinic/Illustration by David Schumick; (inset, right) Lombardi et al., Science You cannot un-ring a bell, but you can retract a scientific study. Then again, as a raging debate over a Science paper that linked a mouse retrovirus to chronic fatigue syndrome (CFS) makes clear, retractions can be a tall order, too. In conjunction with their decision to publish two additional papers that strongly question the link between the virus, known as...
  • Study finds clue to chronic fatigue, chronic Lyme

    02/23/2011 7:28:58 PM PST · by decimon · 5 replies
    Associated Press ^ | February 23, 2011 | Unknown
    Scientists have discovered proteins in spinal fluid that can distinguish people with two mysterious illnesses that mimic each other — chronic fatigue syndrome and a kind of chronic Lyme disease. Wednesday's study is small and needs verification. But specialists called it a promising start at clearing some of the confusion surrounding two illnesses with similar symptoms and no good means of diagnosis. "It's a very important first step," said Dr. Suzanne Vernon of the Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association of America.
  • XMRV: Study Shows Virus Can Cause ‘Persistent Infection’ in Monkeys (ME/CFS related virus)

    02/19/2011 9:00:49 PM PST · by Seizethecarp · 9 replies
    Wall Street Journal Health Blog ^ | February 17, 2011 | Amy Dockser Marcus
    The debate over what XMRV may do to humans continues. But at least in a small group of monkeys, one thing is clear, according to a new study. “The virus causes chronic, persistent infection,” says Robert Silverman of the Cleveland Clinic, a co-author of the paper, which was published online yesterday in the Journal of Virology. Moreover, the new research suggests that in these monkeys, at least, the virus can be difficult to detect in blood, even though it’s taken root in the body. This is a tantalizing finding because it raises the prospect that someone could be infected with...
  • XMRV and CFS – It’s not the end (Retrovirology articles overstate case against XMRV link to CFS)

    12/22/2010 10:15:36 PM PST · by Seizethecarp · 5 replies
    Virology Blog ^ | December 22, 2010 | Professor Vincent Racaniello
    Yesterday the Chicago Tribune published my reaction to the four papers on the retrovirus XMRV published this week in the journal Retrovirology. I was quoted as saying ”These four papers are probably the beginning of the end of XMRV and CFS”. I wish to retract this statement and explain my reasons for doing so. Upon re-reading three of the four Retrovirology papers it became clear to me that they show that identification of XMRV can be fraught with contamination problems, but they do not imply that previously published studies are compromised by these findings. Clearly any new studies done on...
  • American kayakers say crocodile came from behind, ripping guide from his boat

    12/22/2010 7:00:05 AM PST · by Manic_Episode · 9 replies · 1+ views
    Associated Press ^ | December 21, 2010 | JEFF BARNARD
    For weeks, three kayakers exploring a series of rivers through the heart of Africa came together in a close formation designed to ward off hippo and crocodile attacks whenever they paddled the quiet green glides between thundering stretches of whitewater. The boaters — two Americans and a South African — traveled some 1,000 miles of river this way, through some of the densest concentrations of man-killing wildlife in the world. They were on a quiet stretch of the Lukuga River in Congo, paddling just 4 or 5 feet apart, when a crocodile slipped up from behind and ripped trip leader...
  • XMRV: Raising the Issue of Contamination. (Brits try to debunk XMRV-CFS link, US objects)

    12/21/2010 9:39:38 AM PST · by Seizethecarp · 5 replies
    Wall Street Journal ^ | December 20, 2010 | Amy Dockser Marcus
    Four papers published today in the journal Retrovirology—and a fifth one commenting on the papers—demonstrated how easy it is for mouse contamination to skew lab experiments involving the virus XMRV. But they are unlikely to resolve the debate over whether XMRV is linked to diseases like chronic fatigue syndrome or prostate cancer, especially since the authors of the papers disagree on the interpretation of their data. Greg J. Towers from University College London, a senior author of one of the papers, told the Health Blog that his group’s findings indicate that ”XMRV is not a human pathogen.” But John M....
  • New Blood-Screening Advised (FDA likely to screen out ME/CFS due to link to XMRV)

    12/16/2010 4:21:12 PM PST · by Seizethecarp · 14 replies
    Wall Street Journal ^ | DECEMBER 15, 2010. | AMY DOCKSER MARCUS
    An advisory committee to the federal Food and Drug Administration is recommending that people with chronic fatigue syndrome be barred from donating blood, amid concerns a retrovirus may be linked to the disease. The recommendation by the panel must now be reviewed by the FDA, which typically follows the advice of such panels but is not required to do so. An FDA spokeswoman said there was no timetable yet on a final decision. Judy Mikovits, who led the team of researchers that published the study in Science linking XMRV to chronic fatigue syndrome, said Tuesday's decision is a victory for...
  • XMRV virus found in 25% of breast cancer samples says U. of Utah research team

    11/25/2010 7:36:00 PM PST · by Seizethecarp · 10 replies
    World International Property Organization ^ | November 18, 2010 | Ila Ramnaresh Singh (lead inventor)
    [0003] The present inventors discovered that Xenotropic murine leukemia-related retrovirus (XMRV) has a strong link with human cancer, including prostate cancer and breast cancer. XMRV may also be associated with cervical cancer, hematologic malignancies, including lymphomas and leukemias, and non-cancerous conditions such as chronic fatigue syndrome and other neuroimmune diseases. This disclosure describes a series of methods to detect XMRV infection, and for use of that information in the diagnosis [0109] Additionally, 178 cases of breast cancer were examined for the presence of XMRV using the described methods. Approximately 25% of breast cancers contained either XMRV proviral DNA sequences or...
  • Gearing Up for the Big Search for XMRV (virus linked to ME/CFS)

    11/17/2010 5:39:55 PM PST · by Seizethecarp · 2 replies
    WSJ ^ | November 17, 2010 | Amy Dockser Marcus
    Since a group of researchers published a paper in Science last year suggesting the retrovirus XMRV is linked to chronic fatigue syndrome, scientists have been debating the accuracy of that finding. Now a study designed to address that issue once and for all is moving forward. Clinicians who treat CFS patients, scientists and others convened recently in New York, where virus hunter Ian Lipkin is based. Lipkin was asked by NIH and NIAID to head up the study. At least three labs have agreed to test fresh blood samples for XMRV. Two labs, at FDA/NIH and the Whittemore-Peterson Institute, have...
  • Chronic-Fatigue Link to Virus Disputed

    06/30/2010 9:26:42 PM PDT · by Seizethecarp · 59 replies · 2+ views
    Wall Street Journal Health Blog ^ | JUNE 30, 2010 | AMY DOCKSER MARCUS
    Two groups of researchers studying a potential link between chronic-fatigue syndrome and a virus called XMRV have reached contradictory conclusions, according to people familiar with the findings. One group found a link, and the other didn't. Their reports were held from publication after being accepted by two science journals—a rare move that has caused a stir among scientists in the field. ------ Scientists at the Food and Drug Administration and the National Institutes of Health, including NIH infectious-disease specialist Harvey Alter, recently finished research that came to a conclusion similar to that of the Science paper—that XMRV, or xenotropic murine...
  • Further Evidence of an XMRV-Chronic Fatigue Syndrome Connection?

    06/30/2010 9:09:51 PM PDT · by Seizethecarp · 5 replies
    Wall Street Journal Health Blog ^ | June 23, 2010 | Amy Dockser Marcus
    A report that a respected NIH expert supported an association between the XMRV virus and chronic fatigue syndrome is causing a buzz among CFS patient activists, researchers and clinicians. According to a press release issued by a Dutch magazine, one of the slides presented at a recent workshop in Zagreb by Harvey Alter, chief of the infectious disease section at the NIH’s clinical center, supports the link between XMRV and CFS reported last year in Science. This is significant because studies published later by other groups have produced conflicting results. Alter is a well-known figure in the infectious-disease world; his...
  • Chronic Fatigue Syndrome Attacked Again

    01/11/2010 12:37:17 PM PST · by neverdem · 44 replies · 1,395+ views
    ScienceNOW Daily News ^ | 6 January 2010 | Sam Kean
    Enlarge ImageControversial link. A previous study of chronic fatigue syndrome pointed to a retrovirus found in cancerous prostate cells (magnified in inset).Credit: ROBERT SCHLABERG AND HARSH THAKER Here we go again. Late last year, scientists seemed to be homing in on the cause of chronic fatigue syndrome (CFS)—excessive tiredness and other symptoms that have no known biological cause--by finding a supposed viral link. But a new paper challenges that link, a development that may plunge the field back into the same confusion and acrimony that has characterized it for years. Many CFS patients report that their symptoms began after...
  • A Case of Chronic Denial

    10/26/2009 12:08:01 AM PDT · by neverdem · 5 replies · 730+ views
    NY Times ^ | October 21, 2009 | HILLARY JOHNSON
    EARLIER this month, a study published in the journal Science answered a question that medical scientists had been asking since 2006, when they learned of a novel virus found in prostate tumors called xenotropic murine leukemia virus-related virus, or XMRV: Was it a human infection? XMRV is a gammaretrovirus, one of a family of viruses long-studied in animals but not known to infect people. In animals, these retroviruses can cause horrendous neurological problems, immune deficiency, lymphoma and leukemia. The new study provided overwhelming evidence that XMRV is a human gammaretrovirus — the third human retrovirus (after H.I.V. and human lymphotropic...
  • Is a Virus the Cause of Fatigue Syndrome?

    10/13/2009 12:57:21 PM PDT · by neverdem · 18 replies · 960+ views
    NY Times ^ | October 13, 2009 | DENISE GRADY
    Could a virus be the cause of chronic fatigue syndrome? A study published last week in the journal Science... --snip-- Further testing after the paper was written found the virus in nearly 98 percent of about 300 patients with the syndrome, Dr. Mikovits said. --snip-- The study received a mixed review from Dr. William C. Reeves, who directs public health research on the syndrome at the Centers for Disease Control and Prevention. He called the research exciting but preliminary, and said he was surprised that a prestigious journal like Science had published it, because the researchers did not state the...
  • Virus linked to chronic fatigue syndrome - Prostate cancer pathogen may be behind the disease...

    10/08/2009 9:32:37 PM PDT · by neverdem · 38 replies · 2,416+ views
    Nature News ^ | 8 October 2009 | Lizzie Buchen
    Prostate cancer pathogen may be behind the disease once dubbed 'yuppie flu'. A study on chronic fatigue syndrome (CFS) has linked the mysterious and controversial disease to a recently discovered retrovirus. Just last month researchers found the same virus to be associated with aggressive prostate tumours.Chronic fatigue syndrome is seen as a serious but poorly defined disease.PUNCHSTOCK CFS is marked by debilitating exhaustion and often an array of other symptoms, including memory and concentration problems and painful muscles and joints. The underlying cause of the disease is unknown; it is diagnosed only when other physical and psychiatric diseases have been...
  • Chronic Fatigue Syndrome No Longer Seen as ‘Yuppie Flu’

    05/30/2008 11:02:06 PM PDT · by neverdem · 77 replies · 209+ views
    NY Times ^ | DAVID TULLER
    For decades, people suffering from chronic fatigue syndrome have struggled to convince doctors, employers, friends and even family members that they were not imagining their debilitating symptoms. Skeptics called the illness “yuppie flu” and “shirker syndrome.” --snip-- Dr. Reeves responded that understanding of the disease and of some newer research technologies is still in its infancy, so methodological disagreements were to be expected. He defended the population-based approach as necessary for obtaining a broad picture and replicable results. “To me, this is the usual scientific dialogue,” he said. Dr. Jose G. Montoya, a Stanford infectious disease specialist pursuing the kind...
  • Chronic Fatigue Syndrome May Be Genetically Related (CDC)

    04/21/2006 11:56:39 PM PDT · by neverdem · 19 replies · 1,239+ views
    medi lexicon ^ | 21 Apr 2006 | Christian Nordqvist
    According to researchers from the Centers for Disease Control and Prevention (CDC), USA, your genes may be an important contributory factor to the development of Chronic Fatigue Syndrome (CFS). 227 patients, all with CFS, were evaluated for two days. Their blood and urine samples were also tested. 20,000 genes were examined. You can read about this study in the journal Pharmacogenomics. CFS is also known as ME (myalgic encephalomyelitis) According to head researcher, Dr. William Reeves, this study has uncovered the first credible evidence of a biological basis for CFS. He explained that the genetic make-up of our body is...
  • Less Sleep, More Energy

    01/16/2005 3:03:17 AM PST · by The Raven · 22 replies · 1,584+ views
    Barry Yeoman and Reader's Digest ^ | Oct 2005 | Barry Yeoman
    PATRICIA PRATTIS JENNINGS, 63, FIRST TOOK PROVIGIL during a 2003 trip to Europe. Her doctor thought the drug—meant to help users suffering from a lack of sleep stay awake without jittery side effects—might counteract the jet lag that had plagued her throughout four globe-hopping decades as a pianist with the Pittsburgh Symphony Orchestra. Her first morning in Switzerland, she popped half a pill. Her usual fatigue disappeared almost instantly. "I felt great all day and for a number of days after that," she says. The drug worked so well that she gave her husband some when he complained of feeling...
  • Fish oil tablets 'could fight chronic fatigue syndrome'

    09/05/2002 8:48:23 AM PDT · by truthandlife · 55 replies · 4,734+ views
    BBC News ^ | 9/5/02
    Chronic fatigue syndrome or ME may be caused by a chemical imbalance in the brain, according to doctors. They have also suggested that taking certain fish oil supplements may help to alleviate some of the symptoms associated with the condition. Chronic fatigue syndrome affects an estimated 243,000 people of all ages in the UK. It causes a wide range of symptoms including muscle pain, memory loss, and severe exhaustion which can last many years and leave victims bed-ridden. Dr Basant Puri and colleagues at Hammersmith Hospital in London used state-of-the-art scanning technology to assess chemical activity in the brain. They...
  • Veterans deserve our respect (University bans any recognition of Remembrance Day)

    11/11/2003 9:04:06 AM PST · by Grig · 15 replies · 262+ views
    National Post ^ | Claire Hoy
    Veterans deserve our respect The student council at the University of Guelph banned any recognition of Remembrance Day You probably didn't know Pte. John Smith Berry of the 48th Highlanders of Canada. I didn't either. But no doubt, like all of us, he had family and friends who knew and loved him. But most of those are likely gone now. So too were the hopes and dreams that Berry, like all young people, must have harboured, dreams which died with him on that battlefield in Italy on October 5, 1944. There is a brass plaque in his honour, and several...