Keyword: fibrosis

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  • Interleukin-6: a new therapeutic target in systemic sclerosis?

    05/08/2013 3:50:30 PM PDT · by neverdem · 2 replies
    Clinical & Translational Immunology ^ | 12 April 2013 | Steven O'Reilly, Rachel Cant, Marzena Ciechomska and Jacob M van Laar
    Abstract Interleukin-6 (IL-6) is a classic pro-inflammatory cytokine critical in mounting an effective immune response. It is secreted by a wide array of cell types; however, its effector cells are more restricted, owing to the fact that very few cells, except lymphocytes and hepatocytes, express the functional membrane IL-6 receptor thus reducing the number of IL-6-responsive cells. Trans-signalling, the shedding of the membrane-bound form of the IL-6 receptor into the local microenvironment, greatly increases the range of cells that can respond. IL-6 has been demonstrated to have a pivotal role in the pathogenesis of rheumatoid arthritis, Castleman’s disease and Crohn’s...
  • Tumor Blocker May Fight Fibrosis

    05/30/2012 10:29:17 PM PDT · by neverdem · 7 replies
    ScienceNOW ^ | 30 May 2012 | Mitch Leslie
    Enlarge Image Thick-skinned. Fragments of the anticancer drug endostatin can halt fibrosis in a slab of human skin. Credit: Feghali-Bostwick Laboratory Connective tissue holds our bodies together, but in a condition called fibrosis, an overabundance of the material devastates organs such as the liver, heart, and lungs. A new study suggests that fragments of a promising cancer drug can rein in fibrosis, which is currently untreatable. Fibrosis occurs when cells pump out excess collagen and other connective tissue proteins, which harm organs. Pulmonary fibrosis, for example, stiffens the lungs, eventually suffocating patients unless they receive a lung transplant. In...
  • Texas Woman Induced Labor for Dying Husband to Hold Baby

    02/11/2012 12:39:32 AM PST · by DemforBush · 6 replies
    Yahoo (AP) ^ | 2/11/12 | ALYSSA NEWCOMB
    Savannah Aulger will never have snapshots with her father on her first birthday, on Christmas or at a school event. The only picture she will ever have of them is the one as sweet as it is heartbreaking. Hooked up to an oxygen mask at the hospital, the man she would call dad cradled her in his arms for 45 minutes...
  • Dream comes true in form of tank (OK bring tissues)

    12/20/2005 4:38:40 PM PST · by SandRat · 28 replies · 694+ views
    Marine Corps News ^ | Dec 20, 2005 | Lance Cpl. Lucian Friel
    MARINE CORPS BASE CAMP LEJEUNE, N.C. (Dec. 20, 2005) -- Most children grow up playing with trucks and tanks, but few of them have the chance to ever experience riding the “Iron Horse.” Thanks to the Make-a-Wish Foundation and the Marines of 2nd Tank Battalion, 2nd Marine Division, that experience came alive for six-year-old Brandon Rasnick of Lehigh Acres, Fla. Brandon, who was promoted to the rank of sergeant by his fellow Marines, has cystic fibrosis, a genetic lung disorder. Since his one wish was train with Marines and to “save the world,” the Marines of 2nd Tanks arranged a...
  • Scientists in Britain claim breakthrough in stem cell research

    09/08/2004 7:58:37 PM PDT · by Flavius · 7 replies · 439+ views
    ap ^ | Wed, Sep 08, 2004 | na
    N (AFP) - Scientists in Britain said they have produced the world's first colonies of embryonic stem cells containing the genetic defect behind cystic fibrosis, in an apparent breakthrough in the fight against the disease. Researchers from King's College London, speaking at the British Association Festival of Science at the University of Exeter, said it is the first definitive case of stem cells being created containing any kind of genetic disease defect. The scientists are now looking for specialists around the world who can develop further the cells and use them to investigate new treatments, according to Stephen Minger, who...