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Ibuprofen works wonders for your headaches, joint pain, muscle aches, and menstrual cramps, so it's probably no surprise that it's the second most common over-the-counter (OTC) drug behind paracetamol (Tylenol), according to a 2023 article https://pubmed.ncbi.nlm.nih.gov/36876700/ in the European Review for Medical and Pharmacological Sciences. You might get a prescription for ibuprofen if you have rheumatoid arthritis or osteoarthritis to reduce the pain and swelling from these conditions. Ibuprofen might also be used for psoriatic arthritis, arthritis of the spine, and gouty arthritis. Like other non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen works by blocking an enzyme that makes prostaglandins that cause...

An anti-inflammatory drug commonly used to treat gout could significantly improve outcomes in patients with mild-to-moderate COVID-19 infections, according to research by a team led by Ralph Tripp. In a dose-range study of probenecid, researchers showed significant improvements both in preventing the transmission of COVID-19 and the speed at which symptoms cleared in patients. In comparison to other FDA-approved drugs used to treat the virus, probenecid helped clear symptoms several days faster, Tripp said. "This is a significant development," said Tripp. "It shows improvement in both virus clearance and symptom reduction." TrippBio enrolled 75 non-hospitalized patients with mild-to-moderate COVID-19. The...

Xanthine dehydrogenase/oxidase blockers may reduce the risk for neurodegenerative diseases, according to a study. Yizhe Song and colleagues conducted a population-based, case-control study of U.S. Medicare beneficiaries in 2009 to identify prescription medications associated with a lower risk for three neurodegenerative diseases: Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis. The analysis included 42,885 patients with neurodegenerative disease and 334,387 randomly selected controls. All filled medications were categorized according to their biological targets and mechanisms of action of those targets using medication data from 2006 to 2007. The odds ratios were estimated for 141 target-action pairs and each neurodegenerative disease....

Sleep deprivation, especially common during postmenopause, has been linked with a number of health problems, including hyperuricemia (elevated serum uric acid), which can often lead to gout and other life-threatening conditions such as heart disease. A new study suggests that weekend catch-up sleep may minimize the risk of hyperuricemia in postmenopausal women. Hyperuricemia is most often associated with gout, an increasingly common form of arthritis characterized by severe pain, redness, and tenderness in joints. Pain and inflammation occur when too much uric acid crystallizes and deposits in the joints. In addition, hyperuricemia is associated with metabolic syndrome, diabetes, hypertension, and...

A history of gout is associated with an increased risk for benign paroxysmal positional vertigo (BPPV) and Meniere disease, according to a study. Hyo Geun Choi, M.D. and colleagues examined the impact of preexisting gout on the occurrence of BPPV, Meniere disease, and vestibular neuronitis in a retrospective analysis conducted using 2002 to 2019 Korean National Health Insurance Service Health Screening Cohort data. A total of 23,827 patients with gout were matched with 95,268 controls. The researchers found that compared with the matched control group, the hazard ratios for BPPV and Meniere disease were 1.13 (95 percent confidence interval, 1.06...

The anti-inflammatory benefits of a common gout medicine may help save the lives of heart failure patients, researchers say. The medication, colchicine, could also reduce the risk of heart attack and stroke in patients whose arteries are clogged with cholesterol, according to the study authors. "The signal for benefit with colchicine in these patients was very impressive, and I expect that these findings will have quite a significant impact on clinical care in heart failure and future research for patients with this condition," Dr. Kenneth Bilchick said. He's a professor of cardiovascular medicine. For the study, Bilchick and his team...

A conventional gout medication that is utilised widely around the world has proven to be effective at combatting COVID-19, potentially adding a new weapon in defeating the virus.The discovery, achieved by a team of researchers at the University of Georgia, provides new hope of a variable therapeutic that is proficient in defeating the deadly disease that has caused over four million deaths globally. The team discovered that Probenecid – a gout medication – displayed broad antiviral properties that make it a prime candidate to fight SARS-CoV-2 infection. The gout medication may also aid in treating common and deadly respiratory viruses...

Probenecid, an FDA-approved gout treatment with “powerful antiviral properties” and minimal side effects, is “a prime candidate” for treating COVID-19 according to a new study.SciTechDaily reports on recent research from the University of Georgia, where they found that probenecid “works as a prophylactic prior to virus exposure and as a post-exposure treatment in animal models against SARS-CoV-2 and flu.”Ralph Tripp, lead author of the study, concluded, “This antiviral works for all RNA respiratory viruses we tested, including SARS-CoV-2. RSV, coronavirus and flu all circulate in the same season. Bottom line is you can potentially reduce infection and disease using this...

Published in Nature's Scientific Reports, the study found that probenecid has broad antiviral properties, making it a prime candidate to combat not only SARS-CoV-2 infection but also other common and deadly respiratory viruses like RSV and flu. Probenecid is an FDA-approved medication that's primarily used to treat gout, and it's already widely available in the U.S. The drug has been on the market for over 40 years and has minimal side effects.

Jailed former Trump campaign chairman Paul Manafort is suffering from depression, anxiety and “severe gout” while behind bars, his lawyers say in new court filings. Manafort is being kept in solitary confinement “to ensure his safety” but the conditions “have taken a toll on his physical and mental health,” his attorneys wrote in a document made public Tuesday. “As just one example, for several months Mr. Manafort has suffered from severe gout, at times confining him to a wheelchair,” they write. “He also suffers from depression and anxiety and, due to the facility’s visitation regulations, has had very little contact...

Italian Skeletons Reveal Old World Diseases By Rossella Lorenzi, Discovery News Columbus: Syphilis Spreader? April 12, 2004 — Researchers investigating Italian cemeteries have found further evidence to confirm that syphilis and rheumatoid arthritis plagued the Americas long before the arrival of Columbus. Involving various sites throughout Italy, the study examined 688 skeletons dating from the Bronze Age to the Black Plague epidemic of 1485-1486. The remains were investigated for the presence of bony alterations characteristic of rheumatoid arthritis, gout, spondyloarthropathy and syphilis-causing organisms, called treponemes. Indeed, syphilis is known to scar and deform bones. Legend holds that Columbus and his...

North Korean state media reports also serve to educate local elite who know how to read between the lines. “These are signals but signals only for people in the know,” says Lankov. “I am quite sure the official media reports about his ill health would have been signed off on by the great man himself.” Another possible hint that Kim is not fully incapacitated, as some of the wilder North Korea rumors have it: a leadership shuffle was recently announced in Pyongyang. “I don’t think that would have been authorized without him,” says Lankov. “He may be undergoing some sort...

North Korean leader Kim Jong-un is said to be suffering from gout, a hereditary disease which he seems to have inherited from his father and grandfather. The ruling North Korean leader, who is believed to be his early 30s, has not been seen in public for more than three weeks. He also skipped the regular session at the Supreme People's Assembly in Pyongyang on Thursday amid increasing speculation that he is severely ill.

(LEAD) N. Korean leader suffering from gout: source 2014/09/26 14:30 SEOUL, Sept. 26 (Yonhap) -- North Korean leader Kim Jong-un is believed to be suffering from gout due to his poor management of his health as well as family traits, a source familiar with North Korea affairs said Friday. Speculation has been rife that the young leader in his early 30s may have a health problem as recent video footage released from the North has shown him walking with a limp. Kim last appeared in public on Sept. 3 to attend a concert. He was absent from this year's second...

The first time Margaret Dron organized the Gluten Free Expo early last year, it was inside the gymnasium of a small community centre in east Vancouver. She had recruited one volunteer, two speakers, 38 vendors and expected 500 attendees. There was no entrance fee—instead, people were to bring gluten-free goods for the local food bank; three boxes were set aside for the collection. Six hours later, more than 3,000 people had turned out, and the volunteer had to call a one-tonne truck to pick up the donations. In one Sunday afternoon, Dron realized, “there is some serious potential here. So...

* A diet high in fructose can increase uric acid levels, but allopurinol may help lower the resulting high blood pressure, researchers say. Men who took the drug to mitigate the effects of a high-fructose diet did not experience the increase in blood pressure observed among men on the same diet who did not take the drug, Richard Johnson, MD, of the University of Colorado, and colleagues said at the American Heart Association's High Blood Pressure Research Conference in Chicago. "These results support the idea that fructose, such as present in table sugar and high-fructose corn syrup, could have a...

DR. FUDMAN is in private practice in Austin, Texas. He reports that he has no conflicts of interest. The price of colchicine is increasing by 50-fold, from about $0.10 per tablet to $5 per tablet, unless physicians and patients can convince the Food and Drug Administration to allow the colchicine made by generic manufacturers to stay on the market. A twice-daily dose of colchicine will increase from $6/month to $300/month because one company has taken advantage of FDA rules and the orphan drug law to the detriment of patients. Colchicine has technically been an “unapproved drug” rather than a “generic...

It might be your preference to crack open a bottle of red wine at the end of a hard day but you may be better off pouring a pint. Researchers at the German Cancer Research Centre in Heidelberg have discovered that beer contains a powerful molecule that helps protect against breast and prostate cancers. Found in hops, the substance called xanthohumol blocks the excessive action of testosterone and oestrogen. It also helps to prevent the release of a protein called PSA which encourages the spread of prostate cancer. Scientists have long known that substances in hops help to block oestrogen....

OK Guys/Gals. I have not had an attack in years but after attending a couple of Brewfests and relizing how good Ale is (I quit drinking beer do to gout years ago) and forgetting how crippling and excrutiating an attack of gout is well I have a whole foot invovled. As a careprovider I have to get up (I have an old wheelchair to use the pain is that bad). I dont want to go to the Doc and thought I would try some home flushing of the uric acid. Right now I have a combo in one ice pitcher...

Study Shows Vitamin C From Food or Supplements May Reduce the Risk of Gout Reviewed By Louise Chang, MD Boosting vitamin C intake may be a simple way to help prevent one of the most common forms of arthritis. A new study shows the vitamin better known for fighting colds may also prevent gout. Researchers found men who had the highest vitamin C intake from supplements and food were up to 45% less likely to develop the painful condition than those who had the lowest. Vitamin C is found naturally in citrus fruit, broccoli, and other fruits and vegetables; it...