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Curcumin, an ingredient in the curry spice turmeric, may help prevent heart failure. That's according to two new studies done on rats, not people. In both studies, researchers gave curcumin to rats. The rats then got surgery or drugs designed to put them at risk of heart failure. The rats that got curcumin showed more resistance to heart failure and inflammation than comparison groups of rats that didn't get curcumin. Also, in one of the studies, the researchers saw signs that curcumin treatment reversed heart enlargement. The other study didn't include that experiment. Together, the studies suggest that curcumin short-circuited...

Major depressive disorder is a common and complex condition that impacts about 15% of the population of the United States, yet very little is known about the mechanisms behind the psychiatric disorder. What is known is that there are clinical parallels between depressive symptoms and the symptoms of certain inflammatory disorders. In findings published electronically in Molecular Psychiatry, researchers from University of Miami found polymorphisms in inflammation-related genes that are associated with susceptibility to major depression and antidepressant response. Two genes critical for T-cell function in the immune system have been associated with susceptibility for major depressive disorder and antidepressant...

NEW YORK (Reuters Health) - Men with high levels of hostility, anger and depression show increases in a key marker of inflammation over time, which may put them at greater risk of heart disease, a new study shows."This is further data suggesting that this stuff is bad for your health," Dr. Stephen H. Boyle of Duke University Medical Center in Durham, North Carolina, the study's lead author, told Reuters Health. "It's not good to have high levels of hostility, anger and depression."Such psychological factors have long been linked to heart disease, but the mechanism through which they harm the heart...

Psoriasis linked to tripled risk of heart attack 21:00 10 October 2006 NewScientist.com news service Roxanne Khamsi Patients with the common inflammatory skin condition psoriasis have a tripled risk of heart attack, a new study has revealed. The study’s researchers speculate that the systemic inflammation seen in psoriasis might weaken the cardiovascular system, thereby increasing the chance of such heart problems. Psoriasis is an inflammatory system disorder that affects around 2% of people in the US and is characterised by sore, scaly patches of red skin. Recent studies suggest that genetic mutations and lifestyle factors such as stress and smoking...

An arthritis drug shows promise in a small, experimental study targeting a root cause of Alzheimer's -- inflammation in the brain. WALTER Skotchdopole worked for 20 years as a police officer and 20 years in the film industry before succumbing to the relentless decline of Alzheimer's disease. In his prime, he joked with everyone he met. By his early 70s, he had become a shell of his former self. "He's there, but he's not," says his son James Skotchdopole. "There's no real interaction, no real stake in life." Walter Skotchdopole had tried several drugs, with no noticeable improvement. But when...

Immortality is within our grasp . . . In Fantastic Voyage, high-tech visionary Ray Kurzweil teams up with life-extension expert Terry Grossman, M.D., to consider the awesome benefits to human health and longevity promised by the leading edge of medical science--and what you can do today to take full advantage of these startling advances. Citing extensive research findings that sound as radical as the most speculative science fiction, Kurzweil and Grossman offer a program designed to slow aging and disease processes to such a degree that you should be in good health and good spirits when the more extreme...

HOUSTON (Sept. 16, 2005) - Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke. They say the discovery, reported in Journal of the American College of Cardiology, goes a long way to explain why people who are overweight generally have higher levels of the molecule, known as C-reactive protein (CRP), which is now used diagnostically to predict future cardiovascular events. And they also report...

The researchers, from Joslin Diabetes Center in Boston, discovered a genetic ''master switch" in the liver that is turned on when people become obese. Obesity has long been linked to diabetes, but the reason, until now, has been unknown. Joslin researchers found that once on, this switch produces low-level inflammation, which disrupts the body's ability to process insulin, causing type 2 diabetes. Reasoning that aspirin-like drugs are used to quell inflammation, they successfully used the drugs, called salicylates, to eliminate the symptoms of type 2 diabetes in mice. Human tests are already underway in Boston, though no results have been...

Reducing the levels of a protein secreted by the body during inflammation may be as powerful in slowing heart disease and preventing heart attacks and deaths as lowering cholesterol, two teams of researchers are reporting. The studies, published in Thursday's issue of The New England Journal of Medicine, provide the strongest evidence yet for the role of the protein, known as CRP for C-reactive protein, in heart disease. The participants were patients with severe heart disease who were taking high doses of statin drugs, which lower both cholesterol and CRP. Lower CRP levels, the researchers found, were linked to a...

<p>The future of heart disease treatment is coming into focus with a growing emphasis on potent drug cocktails that fight obesity, help smokers quit, ease inflammation and restore a healthy blood-cholesterol balance.</p> <p>The shift may arrive in time for many aging baby boomers, doctors say, with several promising drugs undergoing pivotal tests in humans.</p>

Alzheimer's disease can seem unrelentingly grim. There is no cure, no known way to prevent the illness, and the benefits of current treatments are modest at best. But in laboratories around the country, scientists are uncovering clues that may eventually — perhaps even in the next two decades — allow them to prevent, slow or even reverse the ruthless progression of the illness. "Things are more hopeful than perhaps people think," Dr. Karen Duff of the Nathan Kline Institute of New York University said. "We are on the cusp of having something really useful." That hope comes on the heels...

The body's first line of defense just may be the 'root of all evil' | By Karen Kreeger Courtesy of Keith Crutcher IMMUNITY IN MIND: Cultured microglial (N9) cells (red) on a tissue section containing an Alzheimer plaque (green). There is continuing controversy about whether these types of inflammatory cells are responding to plaques or causing them. A finger catches the sharp edge of an envelope; a noseful of tree pollen is accidentally inhaled; the latest virus finds host after human host. In all cases the assaulted body reacts through inflammation, a well known, but not well defined process, especially...