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Keyword: prions

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  • House votes to repeal country-of-origin labeling on meat

    06/11/2015 4:27:10 PM PDT · by Diogenesis · 63 replies
    MyWay ^ | Jun 11, 2015 | MARY CLARE JALONICK
    House votes to repeal country-of-origin labeling on meat WASHINGTON (AP) — Under threat of trade retaliation from Canada and Mexico, the House has voted to to repeal a law requiring country-of-origin labels on packages of beef, pork and poultry. The World Trade Organization rejected a U.S. appeal last month, ruling the labels that say where animals were born, raised and slaughtered are discriminatory against the two U.S. border countries. Agriculture Secretary Tom Vilsack has said it's up to Congress to change the law to avoid retaliation from the two countries. The law was initially written at the behest of northern...
  • Proteins behind mad-cow disease also help brain to develop

    02/15/2013 1:15:08 AM PST · by neverdem · 3 replies
    Nature News ^ | 14 February 2013 | Mo Costandi
    When not misfolded, prions lend a hand in forming neuronal connections. Prions are best known as the infectious agents that cause ‘mad cow’ disease and the human versions of it, such as variant Creutzfeldt–Jakob Disease. But the proteins also have at least one known useful function, in the cells that insulate nerves, and are suspected to have more. Now researchers have provided the first direct evidence that the proteins play an important role in neurons themselves. The team reports in the Journal of Neuroscience1 that prions are involved in developmental plasticity, the process by which the structure and function of...
  • Prions in the brain eliminated by homing molecules

    04/28/2012 2:16:56 AM PDT · by neverdem · 10 replies ^ | April 24, 2012 | NA
    Toxic prions in the brain can be detected with self-illuminating polymers. The originators, at Linköping University in Sweden, has now shown that the same molecules can also render the prions harmless, and potentially cure fatal nerve-destroying illnesses. Linköping researchers and their colleagues at the University Hospital in Zürich tested the luminescent conjugated polymers, or LCPs, on tissue sections from the brains of mice that had been infected with prions. The results show that the number of prions, as well as their toxicity and infectibility, decreased drastically. This is the first time anyone has been able to demonstrate the possibility of...
  • Prions and chaperones: Outside the fold

    02/16/2012 11:49:25 PM PST · by neverdem · 3 replies
    Nature News ^ | 15 February 2012 | Bijal P. Trivedi1
    Susan Lindquist has challenged conventional thinking on how misfolded proteins drive disease and may power evolution. But she still finds that criticism stings. On a frigid winter's morning in 1992, Susan Lindquist, then a biologist at the University of Chicago in Illinois, trudged through the snow to the campus's intellectual-property office to share an unconventional idea for a cancer drug. A protein that she had been working on, Hsp90, guides misfolded proteins into their proper conformation. But it also applies its talents to misfolded mutant proteins in tumour cells, activating them and helping cancer to advance. Lindquist suspected that blocking...
  • Prion Diseases: No Accomplice Needed

    01/28/2010 8:22:08 PM PST · by neverdem · 21 replies · 567+ views
    ScienceNOW Daily News ^ | 28 January 2010 | Jennifer Couzin-Frankel
    Enlarge ImageSpongy mess. Injected into mice, synthetic prions punch tiny holes in brain tissue (right), compared with healthy animals (left).Credit: Fei Wang et al., Science Since 1982, when neurologist and biochemist Stanley Prusiner first claimed to purify prion proteins, controversy has dogged the field. Do prions--misfolded versions of healthy protein linked to mad cow and other neurological diseases--infect and cause disease all on their own? Or do they need a partner in crime? Some say a new study provides the most compelling evidence to date for the "protein only" hypothesis. But die-hard skeptics remain unconvinced. Five years ago, Prusiner...
  • 'Lifeless' prion proteins are 'capable of evolution'

    01/07/2010 1:12:54 PM PST · by OldNavyVet · 61 replies · 1,281+ views
    BBC News ^ | 1 January 2010 | BBC News / Scripps Research Institute
    Scientists have shown for the first time that "lifeless" prion proteins, devoid of all genetic material, can evolve just like higher forms of life. The Scripps Research Institute in the US says the prions can change to suit their environment and go on to develop drug resistance. Prions are associated with 20 different brain diseases in humans and animals.
  • Let's Find a Cure for Stupid

    07/02/2008 12:37:09 PM PDT · by pharmamom · 20 replies · 119+ views
    WhenWeAreQueen ^ | July 2, 2008 | pharmamom
    WWAQ, we will unleash the cumulative brainpower of the pharmaceutical industry to find that so-far elusive cure for stupid. Damn the FDA, full speed ahead! I’m not thinking of the Jackass kind of stupid (I was sort-of morbidly fascinated by that movie); that kind of idiocy has a way of taking itself out of the gene pool. Nor am I considering the kind of stupid that leads an 18 year old girl to tattoo a sun around her navel (imagine her face when she gets pregnant and her belly goes supernova). The Queens are looking to cure the kind of...
  • Why you shouldn't eat your mother (Prions)

    09/24/2007 6:21:25 AM PDT · by Renfield · 4 replies · 135+ views
    We live in the age of the prion, says New York writer DT Max in his introduction to this neat little medical whodunit. The claim sounds worthy of a car advert. You are never alone with a prion. That sort of thing. In fact, the prion is a strange, non-living infectious agent whose behaviour was widely disputed until US medical researcher Stanley Prusiner confirmed its existence in a series of elegant experiments that won him a Nobel Prize for physiology in 1997. Now, most scientists accept prions are responsible for a range of modern curses: mad cow disease, the fatal...
  • Early Fix: Prion disease remedied in mice

    02/10/2007 10:41:41 AM PST · by neverdem · 1 replies · 280+ views
    Science News Online ^ | Feb. 3, 2007 | Nathan Seppa
    Mad cow disease and other brain disorders stemming from prion proteins have long resisted cure. Now, in a test in mice, a prion disease caught early has been reversed. Prions—misfolded versions of a natural protein called PrP—trigger normal PrP to misfold in the same way. Over time, prion infection kills so many neurons that the brain becomes riddled with holes. In the new study, neurologist Giovanna R. Mallucci of the Institute of Neurology in London and her colleagues tested whether shutting off the prions' supply of PrP could alter the course of disease. They worked with genetically engineered mice that...
  • Could Genetic Engineering Eradicate Mad Cow Disease?

    01/02/2007 7:31:55 PM PST · by indcons · 17 replies · 412+ views
    Medical News Today ^ | 02 Jan 2007 | Catharine Paddock
    dozen calves that don't have prions - the infectious proteins that cause mad cow disease. The research project is reported in the online journal Nature Biotechnology. Preliminary tests suggest that the brains of the genetically engineered calves are immune to Bovine Spongiform Encephalopathy (BSE, or mad cow disease). The scientists verified this by trying to infect post mortem brain tissue from two of the 20-month old calves with prions, but the tissue remained healthy. This follows a long process using donor cattle cells in which the gene known to trigger the production of prions was "switched off". The cells were...
  • Prions removed from animal blood

    12/23/2006 12:32:40 PM PST · by neverdem · 21 replies · 537+ views ^ | 22 December 2006 | Michael Hopkin
    Close window Published online: 22 December 2006; | doi:10.1038/news061218-13 Prions removed from animal bloodFiltration technique could make transfusions safer, its inventors say.Michael Hopkin A US-led research team has developed a technique to filter potentially deadly prion proteins from blood. They suggest that the method should be used routinely in attempts to remove prions, which can cause variant Creutzfeldt-Jakob disease (vCJD), from blood products used for transfusions. The method could offer better protection than the current practice of removing white blood cells from donated blood, say the researchers, led by Robert Rohwer of the University of Maryland, Baltimore. Previous studies...
  • New vCJD Scare Rocks The UK

    12/08/2006 12:16:38 PM PST · by blam · 2 replies · 418+ views
    New Scientist ^ | 08 December 2006 | Debora McKenzie
    New vCJD scare rocks the UK 18:10 08 December 2006 news service Debora MacKenzie A third person in the UK has caught variant CJD from another human, in a blood transfusion. Many more people may be at risk of this human form of BSE, experts warn. Three of eight people tested so far in the UK are now confirmed to have been infected with vCJD through blood transfusions, autopsies have revealed. A total of 66 people in UK are known to have received transfusions from blood donors who later went on to develop vCJD. Of those, 34 later died...
  • New approach to BSE successful in lab

    12/01/2006 8:13:57 PM PST · by annie laurie · 6 replies · 422+ views ^ | 1-Dec-2006
    Prion-infected mice survive longer A new method of treatment can appreciably slow down the progress of the fatal brain disease scrapie in mice. This has been established by researchers from the Universities of Munich and Bonn together with their colleagues at the Max Planck Institute in Martinsried. To do this they used an effect discovered by the US researchers Craig Mello and Andrew Fire, for which they were awarded this year’s Nobel Prize for Medicine. Scrapie is a variant of the cattle disease BSE and the human equivalent Creutzfeld-Jakob disease. However, it will take years for the method to be...
  • BSE could incubate in people 50 years or more before symptoms show: study

    06/22/2006 9:52:41 PM PDT · by familyop · 12 replies · 769+ views (The Canadian Press) ^ | 22JUN06 | Sheryl Ubelacker
    TORONTO (CP) - It could take half a century or more for someone infected with prions - the cause of mad cow-like diseases - to start showing symptoms, say researchers, who drew that conclusion after studying a similar illness among Papua New Guinean people who once feasted on their dead. Their findings suggest that the number of human cases of variant Creutzfeld-Jacob disease (vCJD) could end up being much larger than originally suspected, say the researchers, whose study is published in Friday's edition of The Lancet. With 160 cases, the United Kingdom has the highest number of recorded cases in...
  • U.S. mad cow cases are mysterious strain

    06/11/2006 8:27:46 PM PDT · by neverdem · 8 replies · 448+ views
    Seattle Post-Intelligencer ^ | June 11, 2006 | LIBBy QUAID
    AP FOOD AND FARM WRITER WASHINGTON -- Two cases of mad cow disease in Texas and Alabama seem to have resulted from a mysterious strain that could appear spontaneously in cattle, researchers say. Government officials are trying to play down differences between the two U.S. cases and the mad cow epidemic that has led to the slaughter of thousands of cattle in Britain since the 1980s. It is precisely these differences that are complicating efforts to understand the brain-wasting disorder, known medically as bovine spongiform encephalopathy, or BSE for short. "It's most important right now, till the science tells us...
  • Soil-bound Prions That Cause CWD Remain Infectious

    04/16/2006 11:19:58 PM PDT · by neverdem · 21 replies · 818+ views
    Scientists have confirmed that prions, the mysterious proteins thought to cause chronic wasting disease (CWD) in deer, latch on tightly to certain minerals in soil and remain infectious. The discovery that prions stay deadly despite sticking to soil comes as a surprise, because while many proteins can bind to soil, that binding usually changes their shapes and activities. In a paper published in the journal PLoS Pathogens (April 14), scientists at the University of Wisconsin-Madison suggest that certain soil types serve as natural prion repositories in the wild. As animals regularly consume soil to meet their mineral needs, it's possible...
  • New way to study prions found [CWD]

    03/20/2006 4:15:38 PM PST · by SJackson · 2 replies · 386+ views
    Research could lead to better understanding of wasting diseases By The Associated Press GREAT FALLS -- Scientists at McLaughlin Research Center have discovered a new way to study prions, the infectious agents that cause brain-wasting diseases, and hope the work could lead to a better understanding of who is more at risk to contract such diseases. Scientists infected stem cell cultures from fetal mouse brains with prions and found the infection could be detected within weeks. Injecting mice with the prions and waiting for infection to develop can take months and sometimes years. The tissue cultures allow the researchers to...
  • 'Human remains link' to BSE cases

    02/08/2006 6:32:59 AM PST · by Calpernia · 18 replies · 392+ views
    BBC News science ^ | By Paul Rincon
    The first cases of BSE or "mad cow disease" could have been caused by animal feed contaminated with human remains, says a controversial theory. Some raw materials for fertiliser and feed imported from South Asia in the 60s and 70s contained human bones and soft tissue, the Lancet reports. Bone collectors could have picked up the remains of corpses deposited in the Ganges river to sell for export. If infected with prion diseases, they could have been the source for BSE. But the theory has been greeted with scepticism by several experts on Bovine Spongiform Encephalopathy (BSE). The authors admit...
  • Prions Present a Positive Side (stem cells)

    02/03/2006 12:04:32 AM PST · by neverdem · 9 replies · 501+ views
    ScienceNOW Daily News ^ | 30 January 2006 | Jennifer Couzin
    Scientists have long eyed an enigmatic protein called PrP as the culprit behind deadly prion diseases, including "mad cow" disease. Now they've identified one of its functions in healthy animals: helping certain stem cells in bone marrow divide and survive. It's not clear what the find means for the protein's behavior in the brain, but prion experts say that uncovering any function for PrP is a big step forward. PrP is found throughout the body, and it's especially abundant in the brain. In rare cases, PrP can misfold and clump together, potentially leading to fatal prion diseases. But scientists have...
  • Eating wild deer unsafe

    01/27/2006 6:52:28 PM PST · by LurkedLongEnough · 21 replies · 862+ views - Biological Agents ^ | January 27, 2006 | John Soltes
    Deer and elk that are infected with mad cow-like disease, known as chronic wasting disease (CWD), carry infectious agents called prions in their leg muscles, indicating that those handling and eating infected deer meat may contract the same disease, University of Kentucky researchers reported on Jan. 26 in the journal Science. This newfound evidence is shocking because the public has been informed that the infectious prion protein for CWD was only present in parts of the nervous system such as brains and backbones. It was thought in the past that only nervous tissues from infected deer were susceptible to spreading...
  • New fears about deer (chronic wasting disease)

    01/27/2006 3:06:00 PM PST · by neverdem · 22 replies · 720+ views
    Milwaukee Journal Sentinel ^ | Jan. 26, 2006 | JOHN FAUBER
                       Return to regular view Original URL: New fears about deer Study raises more fears about chronic wasting disease By JOHN Posted: Jan. 26, 2006 Ever since chronic wasting disease was detected in Wisconsin nearly four years ago, hunters were reassured that they could greatly reduce their risk of getting the deadly neurological disorder by avoiding tissue from the brain and central nervous system of the animal. Chronic Wasting Disease Online Poll How concerned are you about CWD and eating deer meat? Not at...
  • Infectious prions found in deer meat

    01/27/2006 9:35:14 AM PST · by girlangler · 55 replies · 1,892+ views
    The Denver Post ^ | Jan. 27, 2006 | Katy Human
    Infectious prions found in deer meat Research finds the matter, which causes chronic wasting disease, in muscle. It had been thought to be only in nervous-system tissue. By Katy Human Denver Post Staff Writer A person who eats venison could swallow the proteins shown to cause a deadly brain disease in deer, elk and moose, researchers reported today. Their article in the journal Science represents the first time scientists have found the proteins that cause the affliction, chronic wasting disease, in the meat and muscle of deer. Previously, it had been found only in the brain, spinal and lymph tissues....
  • (Vanity) FreeRepublic Folding@Home Project Update (Top 1,000! - WooHoo!!)

    12/29/2005 8:34:56 PM PST · by systematic · 420 replies · 5,412+ views
    systematic ^ | 12-29-2005 | systematic
    OK, new thread to celebrate reaching a major milestone! Within a few hours Team FreeRepublic will be in the Top1000!!!! We should pass Dean for America, around noon tommorrow. Other liberal teams want to challenge us (DUmmies and Kos) but we're humiliating them beyond description.
  • (Vanity) FreeRepublic Folding@Home Project Update (We're in the Top 1,200!)

    12/25/2005 7:13:22 PM PST · by texas booster · 377 replies · 4,850+ views
    OK, new thread for the next week. First, a big shout out to the SETI members who have added CPUs to the effort. Remember, its Team 36120, NOT Team 0. Next, congrats to all for bumping our team up to 104 processors and 76 users. We have a number of new users in the team, with Clara Lou, fzx12345, SamfromLivingston, brityank, manwiththehands and Tami all popping onto the hit list this week. Malsua, uriah and Ken in Texas are solidly in the top 10. Malsua is continuing to add systems and now accounts for 10% of the FR total. Great...
  • (Vanity) FreeRepublic Folding@Home Project Update (We're in the Top 1,450)

    12/18/2005 10:03:55 AM PST · by texas booster · 132 replies · 2,905+ views
    OK, new thread for the next week. First, a big shout out to the SETI members who have added CPUs to the effort. Remember, its Team 36120, NOT Team 0. Next, congrats to all for bumping our team up to 65 processors. ArgentCent is the latest to have joined our happy band of folders and jumps in at # 36 with his first completed WU. We now have 51 members in the team, and about 45 active participants. Malsua, uriah and Ken in Texas are solidly in the top 10. One of these will probably be the new Numero Uno...
  • (Vanity) FreeRepublic Folding@Home Project Update (We're in the Top 1,550)

    12/15/2005 9:44:48 PM PST · by systematic · 40 replies · 1,004+ views
    FreeRepublic Team Ranked #1,550 (of 41,708 teams)
  • (Vanity) FreeRepublic Folding@Home Project Update

    FR Team ranking up to number 1782 of 41608
  • (Vanity) FreeRepublic Folding@Home Project (Rank 15,162 of 41,347)

    11/25/2005 6:48:15 PM PST · by systematic · 33 replies · 795+ views
    Folding@Home update: 3 Work Units completed, 2 computers, 138 points, overall team rank #15,162
  • Folding@Home

    11/23/2005 11:04:07 PM PST · by systematic · 17 replies · 681+ views
    Any Freepers "folding@home"???? For those not familiar with F@H -> some diseases such as cancer, Alzheimer and even "mad cow" disease are believed to be linked to protein (mis)folding. A scientist team from Stanford University studies this phenomenon to try and find a cure to these diseases. To do this, they have designed a software (folding@home) which enables people to donate unused power from their computer to speed up medical research!
  • Prions suspected in milk

    11/03/2005 10:44:47 PM PST · by neverdem · 23 replies · 838+ views ^ | 3 November 2005 | Andreas von Bubnoff
    Sheep mammaries shown to contain agents of fatal brain disease. The inflamed mammary glands of sheep have been found to contain protein particles that cause scrapie, a sickness similar to mad cow disease. This suggests that the suspect proteins, called prions, may also be present in the milk of infected animals. If prions exist in the milk of cows infected with both an inflammatory illness and mad cow disease, formally known as bovine spongiform encephalopathy (BSE), this raises concerns for human health. Consumption of prion-contaminated meat from cows with BSE is believed to cause the fatal variant Creutzfeldt-Jakob disease (vCJD)...
  • Prions found in urine

    10/18/2005 12:23:50 AM PDT · by neverdem · 42 replies · 3,771+ views ^ | 13 October 2005 | Andreas von Bubnoff
    Mystery of infections in deer and elk may have a solution. The protein particles that cause illnesses such as mad cow disease can be found in the urine of infected mice, researchers report. Their study may solve the mystery of how such 'prion' diseases spread among animals such as sheep, elk and deer. But it also raises concerns that the urine of humans with variant Creutzfeldt-Jakob disease (vCJD) may contain dangerous proteins. Prions are primarily found in the brain, the spinal cord and the immune system. British cows are thought to have developed the prion disease bovine spongiform encephalopathy (BSE)...
  • Feeding human remains to cows may have triggered BSE outbreak, scientists say

    09/01/2005 6:12:29 PM PDT · by M. Espinola · 27 replies · 808+ views
    (The Canadian Press via COMTEX) ^ | September 1st, 2005 | Helen Branswell
    A leading medical journal has published a disturbing theory on the origins of mad cow disease, suggesting it may have developed because human remains from the Indian subcontinent were mixed into cattle feed in Britain in the 1960s and 1970s. The authors say the practice may still be taking place elsewhere, adding it is important to discover whether other countries are importing animal byproducts contaminated with human remains that are destined for feed mills. Canada's leading expert on transmissible spongiform encephalopathies - as mad cow and its sister diseases are called - says the unsettling hypothesis may be accurate....
  • New Case of Mad Cow In U.S.

    06/24/2005 12:38:53 PM PDT · by My Favorite Headache · 159 replies · 4,311+ views
    AP | 6-24-05
    A new case of Mad Cow disease has been reported by the Dept.of Agriculture in the U.S....BREAKING.......
  • Town's Venison Banquet Puts a State on Alert

    04/09/2005 8:07:01 PM PDT · by neverdem · 32 replies · 1,684+ views
    NY Times ^ | April 10, 2005 | MICHELLE YORK
    VERONA, N.Y., April 7 - For years, David L. Smith cooked wild game for his Fire Department's annual fund-raising sportsmen banquet. It was his way to help out after he retired from the department's volunteer corps. At this year's banquet, on March 13, more than 300 townsfolk sampled his dishes - the venison meatballs, chili and patties. Three weeks later, Mr. Smith was trying to forget the whole affair with a whiskey at the local V.F.W. "My wife said they'd come to get me," he said. Through unlucky circumstance, tissue samples from a deer that one farmer donated for the...
  • Filter design sifts deadly prions from blood supply

    08/23/2004 8:17:57 AM PDT · by null and void · 6 replies · 333+ views
    CleanRooms ^ | August, 2004 | Steve Smith
    EAST HILLS, N.Y.—For the second time this summer, a major advance has been unveiled in the battle against infectious prions associated with Mad Cow Disease, Creutzfeldt-Jakob Disease (vCJD). The latest, announced last month by Pall Corp. (, is a proprietary filter technology that's said to reduce deadly prions from the blood supply before it is used for transfusions. Earlier this summer, Serologicals Corp. (Atlanta, Ga.; www.serologicals) was granted a patent on its proprietary purification process that clears the Mad Cow prions from bovine-based pharmaceuticals. More than 60 percent of pharmaceuticals on the market have involved bovine-based products in their development...
  • Researchers Create an Artificial Prion (Mad Cow, deer and elk Chronic Wasting Disease, ALERT)

    07/29/2004 6:07:07 PM PDT · by neverdem · 11 replies · 880+ views
    NY Times ^ | July 29, 2004 | SANDRA BLAKESLEE
    Scientists are reporting that, for the first time, they have made an artificial prion, or misfolded protein, that can, by itself, produce a deadly infectious disease in mice and may help explain the roots of mad cow disease. The findings, being reported on Friday in the journal Science, are strong evidence for the so-called "protein only hypothesis," the controversial idea that a protein, acting alone without the help of DNA or RNA, can cause certain kinds of infectious diseases. The concept was introduced in 1982 by Dr. Stanley Prusiner, a neurology professor at the University of California in San Francisco,...
  • Research in Italy Turns Up a New Form of Mad Cow Disease

    02/16/2004 9:29:23 PM PST · by neverdem · 7 replies · 123+ views
    NY Times ^ | February 17, 2004 | DONALD G. McNEIL Jr.
    A new form of mad cow disease has been found in Italy, according to a study released yesterday, and scientists believe that it may be the cause of some cases of human brain-wasting disease. While the strain has been found in only two Italian cows, both apparently healthy, scientists in Europe and the United States said it should provide new impetus in Washington for the Department of Agriculture to adopt the more sensitive rapid tests used in Europe because it may not show up in those used in the United States. Along with the Italian study, there have been recent...
  • Mad-cow quarantine grows; herds face slaughter

    12/27/2003 12:56:27 AM PST · by sarcasm · 9 replies · 92+ views
    Seattle Times ^ | December 27, 2003 | Jonathan Martin and Ray Rivera
    An intense investigation into the family tree of the nation's first mad-cow case could lead to a quick death for hundreds, and possibly thousands, of Central Washington cows. The U.S. Department of Agriculture (USDA) expanded its quarantine of Washington cattle yesterday after tracing the newborn calf of the infected cow to a Sunnyside, Yakima County, ranch. Because the calf didn't have an identifying ear tag, federal protocols call for more than 400 calves under 30 days old to be killed and tested for the disease, said Linda Waring, spokeswoman for the state Department of Agriculture. A second offspring remains at...
  • 'Mad cow' mechanism may be integral to storing memory

    12/25/2003 5:06:05 AM PST · by AdmSmith · 6 replies · 135+ views
    Whitehead Institute for Biomedical Research ^ | 24-Dec-2003 | David Cameron & Kelli Whitlock
    CAMBRIDGE, Mass. (Dec. 24, 2003) ? Scientists have discovered a new process for how memories might be stored, a finding that could help explain one of the least-understood activities of the brain. What's more, the key player in this process is a protein that acts just like a prion ? a class of proteins that includes the deadly agents involved in neurodegenerative conditions such as mad cow disease. The study, published as two papers in the Dec. 26 issue of the journal Cell, suggests that this protein does its good work while in a prion state, contradicting a widely held...
  • Dairy Under Quarantine on Mad Cow Report

    12/25/2003 12:26:36 AM PST · by torstars · 68 replies · 340+ views
    Associate Press ^ | 12/25/03 | SHANNON DININNY
    MABTON, Wash. - Residents of this tiny south central Washington town rallied around neighboring dairy owners as news leaked that a local farm was the source of what could be the nation's first case of mad cow disease. There are about eight dairy farms in Mabton _ population 2,045 _ and dozens more in the surrounding area. A government source familiar with the investigation told The Associated Press that the cow came from Sunny Dene Ranch in Mabton. Mayor David Conradt said he did not expect "any financial hit" to the town, as long as the disease is limited to...
  • Eighth possible mad cow case in Japan

    10/06/2003 4:04:31 AM PDT · by Clive · 189+ views
    TOKYO (CP) - Japan has detected a possible eighth case of mad cow disease, the Health Ministry announced Monday, underlining concerns about how widespread the illness may be in Japan. The finding, still to be confirmed as an actual case, comes nearly nine months after the last mad cow diagnosis in January. The latest animal tested positive for signs of the disease on Sept. 29 when it was brought to a slaughterhouse in Ibaraki prefecture (state) just north of Tokyo, said Health Ministry official Makoto Kanie. Follow up tests by the National Institute of Infectious Diseases backed the initial findings....
  • Prions - The Terminators

    07/26/2003 10:43:19 AM PDT · by forsnax5 · 1 replies · 119+ views
    The Scientist ( ^ | July 28, 2003 | Mignon Fogarty
    What are they? The prion protein (PrP) is a widely expressed, membrane-associated protein transcribed from the PRNP gene, which is highly conserved among mammals. PrPs exist in two forms: a common, harmless alpha-helical form, and a rare beta-sheet form that causes fatal mammalian brain diseases such as scrapie, Creutzfeld-Jacob disease, and mad cow disease. Prion diseases collectively are called spongiform encephalopathies, causing sponge-like vacuoles in the brain. Symptoms include dementia and ataxia. What do normal PrPs do? That function is still unknown, although they may be involved in response to oxidative stress. Glycosylation, which occurs in various complex combinations, may...