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Keyword: regenerativemedicine

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  • Cells Reprogrammed in Living Mice

    09/12/2013 6:34:31 PM PDT · by neverdem · 1 replies
    ScienceNOW ^ | 2013-09-11 | Gretchen Vogel
    Sagrario Ortega/Spanish National Cancer Research Center (CNIO), MadridPregnant with possibilities. Cells reprogrammed in living mice (green) can contribute to both the placenta and body tissues of a developing mouse. Cells Reprogrammed in Living Mice Researchers have discovered a surprisingly effective way to “reprogram” mature mouse cells into an embryolike state, able to become any of the body’s cell types. Their recipe: Let the transformation happen in a living animal instead of a petri dish. The finding could help scientists better understand how reprogramming works and it may one day help breed replacement tissues or organs in the lab—or in patients.In...
  • Computational biology: Cells reprogrammed on the computer

    08/01/2013 4:37:41 PM PDT · by neverdem · 5 replies
    Biology News Net ^ | July 31, 2013 | NA
    Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have developed a model that makes predictions from which differentiated cells – for instance skin cells – can be very efficiently changed into completely different cell types – such as nerve cells, for example. This can be done entirely without stem cells. These computer-based instructions for reprogramming cells are of huge significance for regenerative medicine. The LCSB researchers present their results today in the prestigious scientific journal Stem Cells. This is the first paper based solely on theoretical, yet practically proven, results of computational biology to...
  • Press P to print

    07/23/2013 11:17:17 PM PDT · by neverdem · 10 replies
    Chemistry World ^ | 25 June 2013 | Katharine Sanderson
    The use of 3D printers to create lab equipment, deliver reagents and even build biomaterials is on the rise. Katharine Sanderson installs drivers and prints away © Frank WojciechowskiThe latest piece of cool technology at the top of every self-confessed geek’s wish list is quite likely to be a 3D printer. Who wouldn’t want the wherewithal to print a range of gadgets on a whim, from plastic toys to a spare pair of glasses or even pizza? And now seems like the perfect time to splash out on your own 3D printer: companies like MakerBot are selling 3D printers...
  • Tissue engineering: How to build a heart

    07/04/2013 2:23:05 PM PDT · by neverdem · 6 replies
    Nature News ^ | 03 July 2013 | Brendan Maher
    With thousands of people in need of heart transplants, researchers are trying to grow new organs. Doris Taylor doesn't take it as an insult when people call her Dr Frankenstein. “It was actually one of the bigger compliments I've gotten,” she says — an affirmation that her research is pushing the boundaries of the possible. Given the nature of her work as director of regenerative medicine research at the Texas Heart Institute in Houston, Taylor has to admit that the comparison is apt. She regularly harvests organs such as hearts and lungs from the newly dead, re-engineers them starting from...
  • Nineteenth Century Technique Turns Old Mouse Hearts Young

    05/15/2013 2:09:10 PM PDT · by neverdem · 16 replies
    ScienceNOW ^ | 9 May 2013 | Paul Gabrielsen
    Enlarge Image Young at heart. Cross-sections of mouse ventricles show the visible change in size when old hearts are immersed in young blood. Credit: Francesco Loffredo It's time to turn back the clock on an aging ticker. Drawing on an odd experimental technique invented more than a century ago but rarely done now, researchers have found that a blood-borne protein makes old mouse hearts appear young and healthy again. It's not clear yet whether humans would react the same way, but scientists are hopeful that this discovery may help treat one of the heart's most frustrating ailments. "This is probably...
  • Printable 'bionic' ear melds electronics and biology

    05/08/2013 2:44:49 PM PDT · by neverdem · 13 replies
    Biology News Net ^ | May 1, 2013 | NA
    Scientists used 3-D printing to merge tissue and an antenna capable of receiving radio signals.Scientists at Princeton University used off-the-shelf printing tools to create a functional ear that can "hear" radio frequencies far beyond the range of normal human capability. The researchers' primary purpose was to explore an efficient and versatile means to merge electronics with tissue. The scientists used 3D printing of cells and nanoparticles followed by cell culture to combine a small coil antenna with cartilage, creating what they term a bionic ear. "In general, there are mechanical and thermal challenges with interfacing electronic materials with biological materials,"...
  • Lab-grown kidneys transplanted into rats

    04/16/2013 7:16:05 PM PDT · by neverdem · 6 replies
    Nature News ^ | 14 April 2013 | Ed Yong
    Engineered organs produce urine, though not as efficiently as natural ones. Scientists at Massachusetts General Hospital in Boston have fitted rats with kidneys that were grown in a lab from stripped-down kidney scaffolds. When transplanted, these 'bioengineered' organs starting filtering the rodents’ blood and making urine. The team, led by organ-regeneration specialist Harald Ott, started with the kidneys of recently deceased rats and used detergent to strip away the cells, leaving behind the underlying scaffold of connective tissues such as the structural components of blood vessels. They then regenerated the organ by seeding this scaffold with two cell types: human...
  • Scam Cell - California’s embryonic stem-cell research institute fails to deliver.

    03/23/2013 4:52:19 PM PDT · by neverdem · 24 replies
    City Journal ^ | 14 March 2013 | LLOYD BILLINGSLEY
    The California Institute for Regenerative Medicine, the state’s controversial, $3 billion stem-cell research agency, has yet to follow recommendations from a December report by the Institute of Medicine, a division of the National Academy of Sciences. The report, which urged the agency to overhaul its board of directors, did not fully convey the magnitude of CIRM’s failure—but it did confirm that CIRM might be better described as Conflict of Interest Research Money. Almost all members of the CIRM board, investigators noted, “are interested parties with a personal or financial stake in the allocation of CIRM fundings.” In fact, CIRM directed...
  • Painkillers mobilize blood stem cells

    03/14/2013 9:26:32 PM PDT · by neverdem · 5 replies
    Nature News ^ | 13 March 2013 | Thea Cunningham
    Aspirin-related drugs suggest a way towards more effective stem-cell transplants. Aspirin-like drugs could improve the success of stem-cell transplants for patients with blood or bone-marrow disorders, a study suggests. The compounds coax stem cells from bone marrow into the bloodstream where they can be harvested for use in transplantation — and they do so with fewer side effects than drugs now in use. For patients with blood disorders such as leukaemia, multiple myeloma or non-Hodgkin’s lymphoma, transplantation of haematopoietic stem cells — precursor cells that reside in the bone marrow and give rise to all types of blood cell —...
  • Diabetes Reversal In Mice Via Stem Cells

    03/07/2013 3:15:32 PM PST · by neverdem · 18 replies
    redOrbit ^ | June 28, 2012 | Connie K. Ho
    Diabetes is a detrimental disease. In order to combat the illness, University of British Columbia (UBC) researchers conducted a study with an industry partner and discovered that stem cells can reverse Type 1 diabetes in mice. The discovery leads the way for the development of innovative treatments of diabetes, which is caused by deficient production of insulin by the pancreas. Insulin allows glucose to be held by the bodyÂ’s muscle, fat, and liver; in turn, itÂ’s used as fuel for the body. Blindness, heart attack, kidney failure, nerve damage, and stroke are possible consequences of low insulin production. The research...
  • Newt sequencing may set back efforts to regrow human limbs

    02/27/2013 2:15:32 AM PST · by neverdem · 9 replies
    Nature News ^ | 21 February 2013 | Zoe Cormier
    Amphibian's unique proteins cast doubt on existence of latent potential for regeneration. The ability of some animals to regenerate tissue is generally considered to be an ancient quality of all multicellular animals. A genetic analysis of newts, however, now suggests that it evolved much more recently. Tiny and delicate it may be, but the red spotted newt (Notophthalmus viridescens) has tissue-engineering skills that far surpass the most advanced biotechnology labs. The newt can regenerate lost tissue, including heart muscle, components of its central nervous system and even the lens of its eye. Doctors hope that this skill relies on a...
  • Researchers Develop Injectable Gel to Repair Damaged Hearts

    02/25/2013 9:31:30 PM PST · by neverdem · 22 replies
    Voice of America ^ | February 21, 2013 | Jessica Berman
    People who suffer heart attacks are at increased risk of having a second and potentially fatal occurrence because of the damage the heart attack does to cardiac muscle tissue. Now scientists at the University of California San Diego have developed a new biomaterial - an injectable hydrogel  - that can repair the damage from heart attacks, and help promote the growth of new heart tissue.   Millions of people around the world suffer heart attacks every year and survive. These traumatic events occur when blood supply to the heart muscles is somehow blocked, robbing them of oxygen and causing them...
  • Repair damaged eyes with stem cell discs

    12/13/2012 8:25:58 PM PST · by neverdem · 9 replies
    Futurity ^ | December 11, 2012 | Amy Stone-Sheffield
    U. SHEFFIELD (UK) — Engineers have developed a new technique to graft a biodegradable disc loaded with stem cells onto damaged eyes.The team at the University of Sheffield describes the method, which involves producing membranes to assist with grafting, in the journal Acta Biomaterialia. The goal is to treat damage to the cornea, the transparent layer on the front of the eye, which is one of the major causes of blindness in the world.Using a combination of techniques known as microstereolithography and electrospinning, the researchers made a disc of biodegradable material that can be fixed over the cornea. The disc...
  • Heart cells coaxed to divide and conquer

    12/06/2012 12:33:50 AM PST · by neverdem · 9 replies
    NATURE NEWS ^ | 05 December 2012 | Kerri Smith
    The heart does have a limited ability to heal itself — and a genetic 'trick' can harness this. Can heart cells renew themselves, and can scientists help them do so? Two papers published online in Nature today suggest that heart muscle cells can make copies of themselves at a very low rate1, but that a genetic trick can prompt them to do a better job2. Those results give hope that hearts damaged by cardiovascular disease — which causes the deaths of almost 17 million people a year — could be coaxed to regenerate themselves. Heart muscle cannot renew itself very...
  • 'Fountain of youth' technique rejuvenates aging stem cells

    11/29/2012 7:38:28 PM PST · by neverdem · 4 replies
    Biology News Net ^ | November 27, 2012 | NA
    This is an image of an aged stem cell after growth factors were added. A new method of growing cardiac tissue is teaching old stem cells new tricks. The discovery, which transforms aged stem cells into cells that function like much younger ones, may one day enable scientists to grow cardiac patches for damaged or diseased hearts from a patient's own stem cells—no matter what age the patient—while avoiding the threat of rejection. Stem cell therapies involving donated bone marrow stem cells run the risk of patient rejection in a portion of the population, argues Milica Radisic, Canada Research Chair...
  • Designing Regenerative Biomaterial Therapies for the Clinic

    11/15/2012 8:36:27 PM PST · by neverdem
    Science Translational Medicine ^ | 14 November 2012 | E. Thomas Pashuck and Molly M. Stevens
    Vol. 4, Issue 160, p. 160sr4 Sci. Transl. Med. DOI: 10.1126/scitranslmed.3002717 STATE OF THE ART REVIEW The ability to regenerate damaged tissue is one of the great challenges in biomaterials and medicine. Successful treatments will require advances in areas ranging from basic cell biology to materials synthesis, but there have been major hurdles in translating the biomedical advances, such as scaffolds that direct stem cell differentiation, into marketed products. Careful consideration of the challenges going from bench to bedside is paramount in maximizing the chances that a good idea becomes a good treatment. We look at a variety of material-based...
  • President Obama and the Embryonic Backfire

    11/08/2012 12:54:57 AM PST · by neverdem · 21 replies | November 7, 2012 | Robin L. Smith
    Here's the link.
  • Thyroid is latest success in regenerative medicine

    10/11/2012 5:03:43 PM PDT · by neverdem · 13 replies
    NATURE NEWS ^ | 10 October 2012 | Dan Jones
    Hormone-producing gland can be created from (mouse) embryonic stem cells. A series of achievements have stoked excitement about the potential of regenerative medicine, which aims to tackle diseases by replacing or regenerating damaged cells, tissues and organs. A paper in Nature today1 reports another step towards this goal: the generation of working thyroid cells from stem cells. Sabine Costagliola, a molecular embryologist at the Free University of Brussels, and her team study the development of the thyroid gland, which regulates how the body uses energy and affects sensitivity to other hormones. Their research shows that thyroid function can be re-established...
  • Reprogrammed Cells Earn Nobel Honor

    10/08/2012 7:27:15 PM PDT · by neverdem · 8 replies
    ScienceNOW ^ | 8 October 2012 | Gretchen Vogel
    The discovery that cellular development is not a one-way street has earned this year's Nobel Prize in physiology or medicine. John B. Gurdon, a developmental biologist at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge in the United Kingdom, and Shinya Yamanaka, a stem cell researcher at Kyoto University in Japan and the Gladstone Institute at the University of California, San Francisco, have won the prize for their discovery that mature cells can be reprogrammed to resemble the versatile cells of a very early embryo. These so-called pluripotent cells have the ability to become any of...
  • One Day, Growing Spare Parts Inside the Body

    09/29/2012 7:50:29 PM PDT · by neverdem · 10 replies
    NY Times ^ | September 17, 2012 | HENRY FOUNTAIN
    Dr. Tracy Grikscheit held a length of intestine in her gloved hands, examining it inch by inch as if she were checking a bicycle tube for leaks... --snip-- Dr. Grikscheit’s work is at the forefront of efforts in laboratories around the world to build replacement organs and tissues. Although the long-sought goal of creating complex organs like hearts and livers to ease transplant shortages remains a long way off, researchers are having success making simpler structures like bladders and windpipes, thanks to advances in understanding stem cells... --snip-- This kind of seeding of scaffolds with cells is a common approach...
  • Human Muscle, Regrown on Animal Scaffolding

    09/29/2012 6:45:56 PM PDT · by neverdem · 17 replies
    NY Times ^ | September 16, 2012 | HENRY FOUNTAIN
    In the months after a roadside bomb in Afghanistan blew off part of his left thigh, Sgt. Ron Strang wondered if he would ever be able to walk normally again. The explosion and subsequent rounds of surgery left Sergeant Strang, 28, a Marine, with a huge divot in his upper thigh where the quadriceps muscle had been. He could move the leg backward, but with so much of the muscle gone he could not kick it forward. He could walk, but only awkwardly. “I got really good at falling,” he said of his efforts. And Sergeant Strang... --snip-- “I thought,...
  • A First: Organs Tailor-Made With Body’s Own Cells

    09/29/2012 4:40:56 PM PDT · by neverdem · 2 replies
    NY Times ^ | September 15, 2012 | HENRY FOUNTAIN
    Andemariam Beyene sat by the hospital window, the low Arctic sun on his face, and talked about the time he thought he would die. Two and a half years ago doctors in Iceland, where Mr. Beyene was studying to be an engineer, discovered a golf-ball-size tumor growing into his windpipe. Despite surgery and radiation, it kept growing. In the spring of 2011, when Mr. Beyene came to Sweden to see another doctor, he was practically out of options. “I was almost dead,” he said. “There was suffering. A lot of suffering.” But the doctor, Paolo Macchiarini, at the Karolinska Institute...
  • African spiny mice can regrow lost skin - Rodents are first mammals observed regenerating tissue.

    09/26/2012 10:57:08 PM PDT · by neverdem · 4 replies
    NATURE NEWS ^ | 26 September 2012 | Zoe Cormier
    Two species of African spiny mouse have been caught at something no other mammal is known to do — completely regenerating damaged tissue1. The work could help improve wound healing in humans. The species — Acomys kempi and Acomys percivali — have skin that is brittle and easily torn, which helps them to escape predators by jettisoning patches of their skin when caught or bitten. Researchers report today in Nature that whereas normal laboratory mice (Mus musculus) grow scar tissue when their skin is removed, African spiny mice can regrow complete suites of hair follicles, skin, sweat glands, fur and...
  • Regenerative medicine repairs mice from top to toe - Three separate studies in mice show normal...

    04/18/2012 8:33:49 PM PDT · by neverdem · 3 replies
    Nature | News ^ | 18 April 2012 | Leila Haghighat
    Three separate studies in mice show normal function can be restored to hair, eye and heart cells. At the turn of the twentieth century... --snip-- Beating hearts But stem-cell transplants aren't always straightforward: if the cells fail to integrate into the desired tissue, they can form tumours instead. To avoid this problem, researchers have been trying to reprogram fully developed adult cells directly so that they form other cell types. Now, in a study published in Nature3, a team of researchers at the University of California, San Francisco (UCSF), has managed to achieve just that using cardiac fibroblasts. Deepak Srivastava,...
  • CA: Stem cell institute to work with foreign agencies

    04/01/2012 10:06:53 AM PDT · by NormsRevenge · 8 replies ^ | 4/1/12 | David Perlman
    California's $3 billion stem cell agency, now more than 7 years old, has joined research partnerships with science and health agencies in eight foreign countries, the San Francisco institute announced. The agreements call for collaboration in efforts aimed at speeding stem cell research from the laboratory to the hospital, where researchers hope that basic human cells will be programmed to treat scores of human degenerative diseases. Research partnerships between American and foreign stem cell scientists are encouraged, but the California institute's funds would only be spent within the state, institute officials said. Alan Trounson, president of the California Institute for...
  • Stem Cell Treatment for Eye Diseases Shows Promise

    01/25/2012 12:51:34 AM PST · by neverdem · 5 replies
    NY Times ^ | January 23, 2012 | ANDREW POLLACK
    A treatment for eye diseases that is derived from human embryonic stem cells might have improved the vision of two patients, bolstering the beleaguered field, researchers reported Monday. Dr. Steven Schwartz, a retina specialist at the University of California, Los Angeles, conducted the trial with two patients. Sue Freeman said her vision improved in a meaningful way after the treatment, which used embryonic stem cells. The report, published online in the medical journal The Lancet, is the first to describe the effect on patients of a therapy involving human embryonic stem cells. The paper comes two months after the Geron...
  • Synthetic Windpipe Is Used to Replace Cancerous One

    01/15/2012 9:43:14 PM PST · by neverdem · 15 replies
    NY Times ^ | January 12, 2012 | HENRY FOUNTAIN
    Surgeons in Sweden have replaced the cancerous windpipe of a Maryland man with one made in a laboratory and seeded with the man’s cells. The windpipe, or trachea, made from minuscule plastic fibers and covered in stem cells taken from the man’s bone marrow, was implanted in November. The patient, Christopher Lyles, 30, whose tracheal cancer had progressed to the point where it was considered inoperable, arrived home in Baltimore on Wednesday. It was the second procedure of its kind and the first for an American. “I’m feeling good,” Mr. Lyles said in a telephone interview from his home, where...
  • Spare Parts for Humans: Tissue Engineers Aim for Lab-Grown Limbs, Lungs and More

    12/19/2011 11:33:46 PM PST · by neverdem · 12 replies
    PBS NewsHour ^ | Dec. 15, 2011 | Miles O'Brien
    A new research breakthrough has enabled scientists to grow human tissue to repair or replace organs, and someday, maybe even limbs. Science correspondent Miles O'Brien reports.Be advised: Some of the images are graphic.MILES O'BRIEN: I am not sure when or why I thought it was a good idea to go for a bike ride on a 100-degree Texas afternoon with a 26-year-old Marine corporal. There I was eating Isaias Hernandez's dirt. No surprise, right? Well, take a look at his right thigh.CPL. ISAIAS HERNANDEZ, U.S. Marine Corps: It looked like a chicken, like if you would take a bite out...
  • Researchers use human cells to engineer functional anal sphincters in lab (No, not in D.C.)

    08/09/2011 12:23:02 PM PDT · by decimon · 29 replies
    Wake Forest Baptist Medical Center ^ | August 9, 2011 | Unknown
    WINSTON-SALEM, N.C. – August 9, 2011 – Researchers have built the first functional anal sphincters in the laboratory, suggesting a potential future treatment for both fecal and urinary incontinence. Made from muscle and nerve cells, the sphincters developed a blood supply and maintained function when implanted in mice. The results are reported in the medical journal Gastroenterology. "In essence, we have built a replacement sphincter that we hope can one day benefit human patients. This is the first bioengineered sphincter made with both muscle and nerve cells, making it 'pre-wired' for placement in the body," said senior author Khalil N....
  • South Korea back in stem cell spotlight with new treatment

    07/10/2011 12:17:47 PM PDT · by neverdem · 12 replies
    Reuters ^ | Jul 7, 2011 | Heejung Jung and Yi Hyun-young
    SEONGNAM, South Korea (Reuters) - More than five years after South Korea's scientific reputation was shattered by a cloning research scandal, the country has approved stem cell medication in the form of a treatment for heart attack victims for the world's first clinical use... --snip-- SHARES SOAR ON GROUND-BREAKING TREATMENT FCB-Pharmicell specializes in developing stem cell drugs for incurable diseases. Hearticellgram-AMI takes somatic stem cells extracted from the patient's own bone marrow that are then cultured and directly injected into the damaged heart. "Our first goal is to apply them in patients with illnesses that are not curable through conventional...
  • Stem cell hope for heart patients

    07/09/2011 12:43:57 AM PDT · by neverdem · 5 replies
    BBC ^ | 8 July 2011 | NA
    Scientists have raised hope that stem cell therapy could provide significant relief for patients disabled by untreatable chest pain.Patients with severe angina had stem cells from their blood injected into their heart.The therapy, carried out by Chicago's Northwestern University, halved the number of bouts of angina chest pain.But UK experts have stressed the work is still at an early stage, and the potential longer benefit is unknown.The procedure may also carry a risk: it is suspected of causing heart muscle damage in two patients, and others reported bone and chest pain.The study, reported in the journal Circulation Research, was carried...
  • Researchers Coax Hearts to Heal Themselves

    06/08/2011 3:49:04 PM PDT · by neverdem · 3 replies
    ScienceNOW ^ | 8 June 2011 | Mitch Leslie
    Enlarge Image Self-healing? After a heart attack like this patient has suffered, cells in the heart might be able to make new muscle, a mouse study suggests. Credit: Fotosearch Heart attacks kill because they strangle heart muscle, destroying cells and preventing the organ from pumping properly. Now, researchers reveal that they have nudged cells within mouse hearts to repair some of the damage, a discovery that might prompt new treatments for heart attacks in humans. Researchers are probing several ways to encourage the heart to fix itself. Last year, for instance, cardiac stem cell biologist Deepak Srivastava of the...
  • Swedish team turns skin into nerve cells

    06/07/2011 8:07:52 AM PDT · by WesternCulture · 14 replies ^ | 06/07/2011 | Peter Vinthagen Simpson
    A team of researchers at Lund University in southern Sweden have managed to develop nerve cells from human skin cells without using stem cells - a development described as an ethical and medical breakthrough. "This fundamentally changes how we look at mature cells and their capacity. Previously a skin cell was thought to always remain a skin cell, but we have shown that it can be any cell," said Malin Parmar, the Lund University researcher leading the study, to The Local on Tuesday. The new technique works by reprogramming connective tissue cells, so-called human fibroblasts, directly into nerve cells, opening...
  • The Curious Case of the Backwardly Aging Mouse

    12/04/2010 10:06:50 AM PST · by neverdem · 24 replies
    ScienceNOW ^ | 29 November 2010 | Jennifer Carpenter
    Enlarge Image Golden years. Mice without active telomerase (right) look much older than those with the enzyme (left). Credit: Mariela Jaskelioff/Harvard Medical School In F. Scott Fitzgerald's short story, "The Curious Case of Benjamin Button," an old man gets younger with each passing day, a fantastic concept recently brought to life on film by Brad Pitt. In a lab in Boston, a research team has used genetic engineering to accomplish something similarly curious, turning frail-looking mice into younger versions of themselves by stimulating the regeneration of certain tissues. The study helps explain why certain organs and tissues break down...
  • New Corneas in Sight?

    08/28/2010 1:10:06 AM PDT · by neverdem · 3 replies
    ScienceNOW ^ | 25 August 2010 | Jennifer Couzin-Frankel
    Enlarge Image Clear-eyed. A biosynthetic cornea, shown here 1 day after implantation (left, lines are sutures) and 2 years later, allowed nerves in the eye to regenerate over time and left the eye looking normal. Credit: Per Fagerholm and Neil Lagali At least 8 million people worldwide could see again with new corneas, the thin, clear layer of collagen and cells at the front of the eye that helps it focus. But most never get transplants. A few years ago researchers developed biosynthetic corneas and now, 2 years after implanting them into patients, they appear safe and have helped...
  • In breakthrough, nerve connections are regenerated after spinal cord injury

    08/08/2010 10:23:36 AM PDT · by decimon · 48 replies · 1+ views
    University of California - Irvine ^ | August 8, 2010 | Unknown
    Researchers from UCI, UCSD and Harvard deleted a cell growth inhibitor called PTENIrvine, Calif. — Researchers for the first time have induced robust regeneration of nerve connections that control voluntary movement after spinal cord injury, showing the potential for new therapeutic approaches to paralysis and other motor function impairments. In a study on rodents, the UC Irvine, UC San Diego and Harvard University team achieved this breakthrough by turning back the developmental clock in a molecular pathway critical for the growth of corticospinal tract nerve connections. They did this by deleting an enzyme called PTEN (a phosphatase and tensin homolog),...
  • Two New Paths to the Dream: Regeneration

    08/08/2010 12:48:43 PM PDT · by neverdem · 5 replies
    NY Times ^ | August 5, 2010 | NICHOLAS WADE
    Two research reports published Friday offer novel approaches to the age-old dream of regenerating the body from its own cells. Animals like newts and zebra fish can regenerate limbs, fins, even part of the heart. If only people could do the same, amputees might grow new limbs and stricken hearts be coaxed to repair themselves. But humans have very little regenerative capacity, probably because of an evolutionary trade-off: suppressing cell growth reduced the risk of cancer, enabling humans to live longer. A person can renew his liver to some extent, and regrow a fingertip while very young, but not much...
  • Turning Scar Tissue Into a Beating Heart

    08/07/2010 12:53:27 AM PDT · by neverdem · 15 replies
    ScienceNOW ^ | August 5, 2010 | Gretchen Vogel
    Enlarge Image Cellular alchemy. A cocktail of three genes can turn common structural cells in the heart into beating muscle cells. Credit: M. Ieda et al., Cell,142 (6 August 2010) ©Elsevier Inc. Cell biologists often seem like modern-day alchemists. Instead of turning lead or straw into gold, they're looking for ways to turn one kind of cell into another, potentially more useful, cell. Now, one research team has found a way to turn a very common heart cell into a cell missing in injured hearts. A healthy heart is a mix of several kinds of cells, including cardiomyocytes, the muscle...
  • Tooth Regeneration Gel Could Replace Painful Fillings

    08/01/2010 10:05:39 PM PDT · by neverdem · 29 replies · 1+ views
    Discovery ^ | Jun 28, 2010 | Eric Bland
    Could this new gel be the biggest dental breakthrough since the introduction of fluoride? THE GIST A new gel could soon eliminate painful fillings and root canals. The technology doesn't prevent cavities; it heals teeth by regenerating them. Although this is good news for teeth, the research could also be applied to heal bones and other tissues in the body. Dentists could soon hang up their drills. A new peptide, embedded in a soft gel or a thin, flexible film and placed next to a cavity, encourages cells inside teeth to regenerate in about a month, according to a new...
  • Natural artificial muscles

    05/06/2010 8:53:23 AM PDT · by neverdem · 9 replies · 336+ views
    Chemistry World ^ | 05 May 2010 | Mike Brown
    Scientists in Canada and the US have developed artificial proteins that mimic the elastic and mechanical properties of the muscle protein, titin. When cross-linked into biomaterials, these proteins are tough and stretchy just like muscle tissue, the researchers say.There has been intense research to develop synthetic elastomers that mimic muscle tissue for use in biomedical applications. However there are limitations in using these materials for implants as they cannot help with tissue repair or regeneration, and the artificial material can often be attacked by the immune system and rejected by the host's body. The development of artificial muscle tissue using proteins could...
  • How Zebrafish Mend a Broken Heart

    03/25/2010 12:46:02 AM PDT · by neverdem · 7 replies · 590+ views
    ScienceNOW ^ | March 24, 2010 | Gretchen Vogel
    Enlarge Image Expert repair. Muscle cells (green) in a zebrafish heart regenerate lost tissue 7 days (left), 14 days (middle), and 30 days (right) after an injury. Credit: Adapted from Jopling et al., Nature, 464 (25 March 2010) Zebrafish hearts can take a licking and keep on ticking. Even if they lose up to 20% of a ventricle, the animals form a clot that stops bleeding within seconds and then gradually replace the lost tissue. Within a month or so, they are back to normal. The impressive repair work is accomplished not by stem cells in the heart but...
  • Research Offers Clue Into How Hearts Can Regenerate in Some Species

    03/25/2010 12:24:33 AM PDT · by neverdem · 3 replies · 402+ views
    NY Times ^ | March 24, 2010 | NICHOLAS WADE
    Doctors who have treated heart attack patients with injections of stem cells have had little success so far in making the heart regenerate its stricken tissues. Researchers have now discovered that in nature, hearts are regenerated in a quite different way, one that does not depend on stem cells. The finding may explain the lack of clinical success with the stem cells, as well as suggest new approaches. Humans can regenerate the liver but cannot replace limbs and other organs. But fish and... --snip-- Charles Murry, an expert on heart cell biology at the University of Washington in Seattle, said...
  • Breakthrough reveals blood vessel cells are key to growing unlimited amounts of adult stem cells

    03/04/2010 2:56:49 PM PST · by decimon · 6 replies · 259+ views
    Promises broad clinical benefits, from bone marrow transplantation to therapies for heart, brain, skin and lungsNEW YORK (March 4, 2010) -- In a leap toward making stem cell therapy widely available, researchers at the Ansary Stem Cell Institute at Weill Cornell Medical College have discovered that endothelial cells, the most basic building blocks of the vascular system, produce growth factors that can grow copious amounts of adult stem cells and their progeny over the course of weeks. Until now, adult stem cell cultures would die within four or five days despite best efforts to grow them. "This is groundbreaking research...
  • Stem cells restore sight in mouse model of retinitis pigmentosa

    02/24/2010 11:16:01 AM PST · by decimon · 2 replies · 154+ views
    Columbia University Medical Center ^ | Feb 23, 2010 | Unknown
    Findings could affect future treatments for macular degeneration, stargardt disease & other forms of retinal diseaseNEW YORK (February 24, 2010) – An international research team led by Columbia University Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. This strategy could potentially become a new treatment for retinitis pigmentosa, a leading cause of blindness that affects approximately one in 3,000 to 4,000 people, or 1.5 million people worldwide. The study appears online ahead of print in the journal Transplantation (March 27, 2010 print issue). Specialized retinal...
  • Stem cells rescue nerve cells by direct contact

    02/01/2010 2:44:06 PM PST · by decimon · 4 replies · 290+ views
    Karolinska Institutet ^ | Feb 1, 2010 | Unknown
    Scientists at the Swedish medical university Karolinska Institutet have shown how transplanted stem cells can connect with and rescue threatened neurons and brain tissue. The results point the way to new possible treatments for brain damage and neurodegenerative diseases. A possible strategy for treating neurodegenerative diseases is to transplant stem cells into the brain that prevent existing nerve cells from dying. The method has proved successful in different models, but the mechanisms behind it are still unknown. According to one hypothesis, the stem cells mature into fully-mature neurons that communicate with the threatened brain tissue; according to another, the stem...
  • Skin cells turned directly into neurons

    01/28/2010 4:55:50 PM PST · by Ramius · 11 replies · 408+ views
    Financial Times ^ | 1/28/10 | Clive Cookson
    Skin cells turned directly into neurons By Clive Cookson Published: January 28 2010 02:00 | Last updated: January 28 2010 02:00 Stem cell scientists at Stanford University in California announced "a huge step forward" last night, with the publication of research that turned skin into nerve cells without any intermediate step. The production of neurons [nerve cells] directly from other adult cells, without making stem cells en route, could transform "regenerative medicine" - providing a plentiful supply of neurons for treating people with degenerative brain diseases such as Parkinson's or those with spinal injuries. "We actively and directly induced one...
  • New Device Prints Human Tissue

    01/02/2010 2:39:02 PM PST · by decimon · 13 replies · 531+ views
    Live Science ^ | Jan 2, 2009 | Bill Christensen
    Invetech has delivered what it calls the "world's first production model 3D bio-printer" to Organovo, developers of the proprietary NovoGen bioprinting technology. Organovo will in turn supply the devices to institutions investigating human tissue repair and organ replacement. Keith Murphy, CEO of Organovo, based in San Diego, said the units represent a breakthrough because they provide for the first time a flexible technology platform for organizations working on many different types of tissue construction and organ replacement. "Scientists and engineers can use the 3D bio printers to enable placing cells of almost any type into a desired pattern in 3D,"...
  • Citrus surprise: Vitamin C boosts the reprogramming of adult cells into stem cells

    12/24/2009 10:02:06 AM PST · by decimon · 6 replies · 901+ views
    Cell Press ^ | Dec 4, 2009 | Unknown
    Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells. Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes....
  • Regeneration Can Be Achieved After Chronic Spinal Cord Injury

    10/31/2009 9:34:11 PM PDT · by bogusname · 25 replies · 661+ views
    ScienceDaily ^ | Oct. 31, 2009 | ScienceDaily
    Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment delayed is more than a year after the original spinal cord injury...
  • Induced Pluripotent Stem Cells Repair Heart

    07/21/2009 2:28:31 PM PDT · by neverdem · 4 replies · 668+ views
    In a proof-of-concept study, Mayo Clinic investigators have demonstrated that induced pluripotent stem (iPS) cells can be used to treat heart disease. iPS cells are stem cells converted from adult cells. In this study, the researchers reprogrammed ordinary fibroblasts, cells that contribute to scars such as those resulting from a heart attack, converting them into stem cells that fix heart damage caused by infarction. The findings appear in the current online issue of the journal Circulation. "This study establishes the real potential for using iPS cells in cardiac treatment," says Timothy Nelson, M.D., Ph.D., first author on the Mayo Clinic...