Pfizer reports promising results for cancer drug

Associated Press ^ | Apr 6, 2014 7:42 PM EDT | Christopher S. Rugaber

[Olog-hai]

An experimental drug has shown encouraging results in treating advanced breast cancer in an early clinical trial, pharmaceutical giant Pfizer reported Sunday.

Pfizer, the world’s second largest drugmaker, said the drug prevented breast cancer from worsening for 20.2 months in a trial involving 165 patients. Current medications do so for 10.2 months. The drug, known as palbociclib, is among a new class of cancer drugs that target specific proteins to block tumors. …

[albie]

There hasn’t been a “cure” for anything since polio. Too much money to be made.

[ComputerGuy]

The Salk and Sabin polio vaccines didn't cure polio.
They prevented it.

[Grams A]

I’ve been amazed to see how large the medical research community has become, especially in places like Houston. Often wondered where all these people would work if they actually had to get a real job and not be funded by the never ending availability of research grants. Maybe they would have to discover some new diseases.

[1_Rain_Drop]

pal-bo-cic-lib

Weird name.

Is it for pals and libs? b.o. and c.i.c.?

[GailA]

FMS drugs Fibromyalgia mimics the disease!

SLICK AD CAMPAIGN ON TV RIGHT NOW FOR THIS, TO BE EXPANDED TO PERIPHERAL NEUROPATHY

Lyrica anti-epileptic http://www.rxlist.com/lyrica-side-effects-drug-center.htm
50% SIDE EFFECT FAILURE RATE
Often used beside Lyrica.

Gabapentin Side Effects anti-epileptic
http://www.drugs.com/sfx/gabapentin-side-effects.html

NEW TO MARKET
Savella http://www.rxlist.com/savella-side-effects-drug-center.htm

Cymbalta mind fogging, fatigue joint & muscle pain, GERD/IBS
http://www.rxlist.com/cymbalta-side-effects-drug-center.htm

Xanax mind fogging, fatigue, joint & muscle pain, GERD/IBS

http://www.rxlist.com/xanax-side-effects-drug-center.htm

OP DRUGS

FDA ALERT RECLAST higher risk of Kidney Failure and A Fib.
http://www.natap.org/2011/newsUpdates/090911_03.htm

Reclast UPS kidney failure, A FIB risk.
http://www.webmd.com/osteoporosis/news/20110901/fda-osteoporsis-drug_ups-kidney-failure-risk

Safety update for osteoporosis drugs, bisphosphonates, and atypical fractures
http://www.fda.gov/drugs/drugsafety/drugsafetypodcasts/ucm229800.htm

Panel issues exercise recommendations for people with osteoporosis and spine fractures
http://www.osteofound.org/news/panel-issues-exercise-recommendations-people-osteoporosis-and-spine-fractures

MY BRUSH With FOSAMAX! muscle/joint, abdominal pain, hands, and GERD/IBS. 5 pills and it went in the TRASH!

Fosamax daily pill
http://www.drugs.com/sfx/fosamax-side-effects.html

Boniva daily pill
http://www.rxlist.com/boniva-side-effects-drug-center.htm

Prolia 6 month shot
http://www.drugs.com/sfx/prolia-side-effects.html

Forteo Side Effects ( ALL GAIN REVERSES ITSELF after treatment course!) epi pen, needs refrigerated
http://www.drugs.com/sfx/forteo-side-effects.html

Reclast 1 yr IV

http://www.rxlist.com/reclast-side-effects-drug-center.htm
Reclast (zoledronic acid) is used to treat Paget’s disease, high blood levels of calcium caused by cancer (hypercalcemia of malignancy, multiple myeloma (a type of bone marrow cancer) or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, and to increase bone mass in men with osteoporosis. It is also used to treat or prevent osteoporosis in people who will be taking certain steroid medicines for 12 months or longer. It is in a group of medicines called bisphosphonates. Common side effects include nausea, tiredness, flu-like symptoms (e.g., fever, chills, muscle/joint aches), dizziness, headache, or pain/redness/swelling at the injection site. Most of these side effects occur within 3 days of treatment.

I’ve listed the 2 most common since I take both. 30 yrs on Synthroid. No one told me about the bone density issue with it, I am 65 so have Drug Induced OP that could have been slowed or prevented. My back takes the brunt of injuries so far.

MUST READ BOOK!
Your Bones: How You Can Prevent Osteoporosis and Have Strong Bones for Life - Naturally Dr Lara Pizzorno
2013 SHE DARES TO CALL THEM WHAT THEY ARE POISON!
http://www.amazon.com/Your-Bones-Prevent-Osteoporosis-Naturally/dp/160766013X/ref=pd_rhf_cr_p_d_1

MY BRUSH With FOSAMAX! muscle/joint, abdominal pain, hands, and GERD/IBS. 5 pills and it went in the TRASH!

Fosamax daily pill
http://www.drugs.com/sfx/fosamax-side-effects.html

Forteo Side Effects ( ALL GAIN REVERSES ITSELF after treatment course!) epi pen, needs refrigerated
http://www.drugs.com/sfx/forteo-side-effects.html

Boniva daily pill
http://www.rxlist.com/boniva-side-effects-drug-center.htm

Prolia 6 month shot
http://www.drugs.com/sfx/prolia-side-effects.html

Reclast 1 yr IV

http://www.rxlist.com/reclast-side-effects-drug-center.htm
not to give it to someone with asthma

Reclast (zoledronic acid) is used to treat Paget’s disease, high blood levels of calcium caused by cancer (hypercalcemia of malignancy, multiple myeloma (a type of bone marrow cancer) or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, and to increase bone mass in men with osteoporosis. It is also used to treat or prevent osteoporosis in people who will be taking certain steroid medicines for 12 months or longer. It is in a group of medicines called bisphosphonates. Common side effects include nausea, tiredness, flu-like symptoms (e.g., fever, chills, muscle/joint aches), dizziness, headache, or pain/redness/swelling at the injection site. Most of these side effects occur within 3 days of treatment.

I’ve listed the 2 most common since I take both. 30 yrs on Synthroid. No one told me about the bone density issue with it, I am 65 so have Drug Induced OP that could have been slowed or prevented. My back takes the brunt of injuries so far.

List of medicines that can cause bone density issues.
Medicines that cause Bone Loss
http://nof.org/articles/6

Synthroid
http://www.rxlist.com/synthroid-drug/side-effects-interactions.htm

29 pills that interact with Thyroid
http://www.worstpills.org/public/page.cfm?op_id=420

The Synthroid for it causes bone density issues http://www.drugs.com/synthroid.html

Nexium
Bone density side effects, and Barret’s Esophagus
http://www.valleyhealthcancercenter.com/Cancer-Services/Barretts-Esophagus- GERD
Upper GI every 2 yrs biopsy.

Cholesterol : Dietary guidelines are wrong on saturated fats, claims cardiovascular researcher
http://www.foodnavigator.com/Science-Nutrition/Dietary-guidelines-are-wrong-on-saturated-fats-claims-cardiovascular-researcher

[GailA]

BTW what is the cost of 1,100 People to KIDNEY FAILURE, JAW DEGENERATION, FEMUR DEGENERATION? THESE DRUGS ARE SUPPOSED TO HELP OSTEOPOROSIS, NOT MAKE IT WORSE.

I Tried the Fosamax, could not take the bone pain beyond 5 days. I have FMS to top that off that causes muscle and joint pain. Chief complaint on Patient board is drug side effects especially these 2 drug classes. Can’t take the FMS drugs either.

And DOD is MANDATING which to me is loss of FREEDOM I purchase my meds from Express Scripts. I have had the same low cost Pharmacy for 30 yrs, I am family to them, they know my name, I’m not a number either, and when there is a shortage in my meds I get a note telling me to come back in a week when new supply is in. This artificial drug shortage is creating havoc with the pharmacies.

[GailA]

The only place that has had high results with treating childhood cancer is St Judes in Memphis. And it is FREE.

We do the ham radio operations during the Marathon every December. This frees up PD/EMT lines, when it is only a pooped out runner, we all in for a non ER pick up. Keep hydration, bathrooms, etc stocked for the route. This year’s was cancelled due to winter storms, that are not natural to the region. Colder than usual.

[flaglady47]

“Often wondered where all these people would work if they actually had to get a real job and not be funded by the never ending availability of research grants. Maybe they would have to discover some new diseases.”

Well, I suppose you could just die faster of one of the old ones. I want more research. Do you realize how many diseases would have killed you off in the past? Try having lived in the year 1860. No morphine or anesthetics then, just a bottle of booze to drink from while they were chopping your leg off. No 2 inch incisions for operations, they would slice you open from stem to stern, and that was only 15 or so years ago. No stents for heart disease, no penicillin. You can’t mean what you say. Give me the wonders of modern day medicine and procedures, thank you.

[albie]

They prevented it. “

…point taken. My point is a cure or preventative for cancer isn’t a money maker. It won’t happen anytime soon.

[ronnie raygun]

Great! is this covered by crapcare? I thought so!

[ComputerGuy]

I agree.

[sheana]

I couldn’t take the drugs such as Fosamax. Tried them all. They caused what the doctor called gastrointestinal distress. I started getting Reclast infusions once a year instead. No problems from them.

[GailA]

You are lucky. I can’t take any of them. And with the FDA warnings on them I WON’T take them. I am going the Vit/min route.

They don’t kill, drugs do. OP drugs of this class has 1100 Kidney failure deaths from Reclast, 2400 JAW degeneration lawsuits. This holds about right for the other OP drugs.

FDA’s latest warning is for no more than 3 yr use!

Reclast 1 yr IV GERD/A Fib/ Kidney Failure death, Jaw Degeneration, which stops all dental work and does not repair. Cancer causer too. SO TAKE at your own risk!

http://www.rxlist.com/reclast-side-effects-drug-center.htm
not to give it to someone with asthma

Reclast (zoledronic acid) is used to treat Paget’s disease, high blood levels of calcium caused by cancer (hyperglycemia of malignancy, multiple myeloma (a type of bone marrow cancer) or cancer that has spread from elsewhere in the body to the bone, to treat or prevent osteoporosis in postmenopausal women, and to increase bone mass in men with osteoporosis. It is also used to treat or prevent osteoporosis in people who will be taking certain steroid medicines for 12 months or longer. It is in a group of medicines called bisphosphonates. Common side effects include nausea, tiredness, flu-like symptoms (e.g., fever, chills, muscle/joint aches), dizziness, headache, or pain/redness/swelling at the injection site. Most of these side effects occur within 3 days of treatment.

Since I am on a OP patient board. I can tell you most of the side effects last YEARS! Not 3 days.

[sheana]

I have had absolutely no side effects from it. I read up on it before I started the injections.