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Researchers at Brigham and Women’s Hospital have found a way to use cancer cells to fight cancer. In a study published in Science Translational Medicine, the team led by Khalid Shah demonstrated that their cell therapy could eliminate established tumors and create long-term immunity in an advanced mouse model of glioblastoma, a type of brain cancer. The vaccine works by training the immune system to prevent cancer from returning. These results are encouraging and suggest that this approach may be effective in treating cancer in humans. Dual-action cell therapy engineered to eliminate established tumors and train the immune system to...

Company partners with Merck for "new treatment paradigm." Moderna, the bio-tech company behind one of the now-ubiquitous COVID-19 vaccinations, said this week that it is actively moving forward with the development of a "personalized" anti-cancer vaccination. The Cambridge, Mass.-based company said in a press release that pharmaceutical company Merck had opted to " exercis[e] its option to jointly develop and commercialize [a] personalized cancer vaccine" with Moderna itself. "We have been collaborating with Merck on PCVs since 2016, and together we have made significant progress in advancing mRNA-4157 as an investigational personalized cancer treatment," Moderna President Stephen Hoge said in...

An experimental cancer vaccine showed promise in a small clinical trial, according to a study in Nature Medicine. Mount Sinai tested the treatment in 11 patients with lymphoma. The vaccine is used in people who already have cancer. It’s not preventive like the flu shot. experimental cancer “vaccine” showed promising results in a small clinical trial of patients with lymphoma, according to a study published Monday in the journal Nature Medicine. Researchers at New York’s Mount Sinai Hospital tested the treatment in 11 patients with lymphoma. Their results were successful enough to warrant another clinical trial in March on lymphoma...

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. The approach works for many different types of cancers, including those that arise spontaneously, the study found.

Activating T cells in tumors eliminated even distant metastases in mice, Stanford researchers found. Lymphoma patients are being recruited to test the technique in a clinical trial. Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. The approach works for many different types of cancers, including those that arise spontaneously, the study found.

Vaccine, which contains two safe drugs, may cause just fever and site sorenessIf approved, researchers expect it will be one-to-two years before it is availableRather than creating lasting immunity, the vaccine activates the immune systemThis then attack tumours in certain forms of the disease, such as lymphomaApproximately 1.7 million new people develop cancer every year in the US A cancer vaccine that cured 97 percent of blood tumours in mice will be tested on humans with low-grade lymphoma later this year.Patients receiving the vaccine, which contains two drugs proven for their safety, will not require any chemotherapy, with the...

A new approach to fighting cancerous tumors in mice by Stanford University researchers has been found to not only eliminate the tumors they targeted, it eliminated all cancer found in the mice. The researchers used a one-time application of two agents injected directly into a tumor. The agents work by stimulating the immune cells only inside the tumor itself, but doctors found some of the T-cells stimulated kept on working after their initial job was done. Dr. Ronald Levy, senior author of the study published in the journal Science Translation Medicine, says one of the agents (CpG oligonucleotide) works with...

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. The approach works for many different types of cancers, including those that arise spontaneously, the study found. The researchers believe the local application of very small amounts of the agents could serve as a rapid and relatively inexpensive cancer therapy that is unlikely to cause the adverse side effects often seen with bodywide immune stimulation. "When we use these two agents...

Scientists devised a pinpointed immunotherapy regimen that eradicated tumors throughout the body in mice. Credit: Sagiv-Barfi et al., Science Translational Medicine (2018) __________________________________________________________________________________________________________________________________________________

Engineering immune cells to attack cancer is a form of treatment that is showing great promise, but it is complex because it involves extracting and modifying T cells before injecting them back into the body. Scientists have now demonstrated a way to not just arm immune cells while still inside the body, but equip them with the ability to fight any kind of cancer, providing an early proof-of-concept for a cheap, universal vaccine for the deadly disease. ............Snip............ But German scientists are now reporting an immunotherapy breakthrough that is significant in more ways than one. Led by Professor Ugur Sahin...

A universal cancer vaccine is on the horizon after scientists discovered how to rewire immune cells to fight any type of disease. The potential new therapy involves injecting tiny particles of genetic code into the body which travel to the immune cells and teach them to recognise specific cancers.

A vaccine that can train cancer patients' own bodies to seek out and destroy tumour cells has been developed by scientists. The therapy, which targets a molecule found in 90 per cent of all cancers, could provide a universal injection that allows patients' immune systems to fight off common cancers including breast and prostate cancer. Preliminary results from early clinical trials have shown the vaccine can trigger an immune response in patients and reduce levels of disease. The scientists behind the vaccine now hope to conduct larger trials in patients to prove it can be effective against a range of...

Vaxil’s groundbreaking therapeutic vaccine, developed in Israel, could keep about 90 percent of cancers from coming back. As the world’s population lives longer than ever, if we don’t succumb to heart disease, strokes or accidents, it is more likely that cancer will get us one way or another. Cancer is tough to fight, as the body learns how to outsmart medical approaches that often kill normal cells while targeting the malignant ones.

CORPUS CHRISTI — Gov. Rick Perry is under attack for trying to prevent a cancer whose yearly death toll exceeds this nation’s 9/11 losses by more than a thousand. On this issue, we are compelled to defend him — an unfamiliar role — and to wonder whether the master politician hand-picked his attackers. We speak, of course, of the other Republican presidential candidates and their assault on Perry’s 2007 executive order that all sixth-grade girls be vaccinated against HPV, a sexually transmitted virus that causes cervical cancer and genital warts. The order was soon overturned in a hail of criticism...

Heather Burcham died in 2007 when she was 31. Cervical cancer killed her. She was misdiagnosed at age 26, and by the time she knew she had cancer, it was too late for effective treatment. But she changed lives by living hers so passionately. She was deeply religious, quick-witted, loving, with a quirky sense of humor; and she was determined to save other young women. Her passion for a cause made her a "Person of the Week" on ABC's "World News" program in 2007. Heather likely would have been shouting from the rooftops in frustration, listening to the current political...

I’ve been leaning towards Rick Perry for a few weeks with Michele Bachmann as my second choice if he implodes. My first preference didn’t change last night but my second place choice did. Last night Michele Bachmann lost my support. She not only lost it for consideration as a presidential nominee, she lost it period. Full stop. In my view she beclowned herself beyond redemption and the sooner she disappears from the national stage the better. For reasons that seem to have more to do with being behind Ron Paul in the polls and trying to scab some of the...

Gov. Rick Perry's 2007 attempt to require that girls in Texas be vaccinated against the human papillomavirus, commonly known as HPV, has become a political hot potato. But Dr. Ronald DePinho, the new president of MD Anderson Cancer Center in Houston, says the vaccine is not just sound but "one of the great scientific advances in the history of medicine." In last night's GOP presidential debate, Perry faced repeated criticism from other candidates for his HPV push. Michele Bachmann said it was “flat out wrong” to require that “innocent little 12-year-old girls be forced to have a government injection through...

American scientists say they have developed a vaccine which has prevented breast cancer from developing in mice. The researchers - whose findings are published in the journal, Nature Medicine - are now planning to conduct trials of the drug in humans. But they warn that it could be some years before the vaccine is widely available. The immunologist who led the research says the vaccine targets a protein found in most breast tumours. Vincent Tuohy, from the Cleveland Clinic Lerner Research Institute, said: "We believe that this vaccine will someday be used to prevent breast cancer in adult women in...

Embryonic stem cells, the controversial and versatile cells that seem able to do just about anything, have now expanded their repertoire into cancer prevention. A vaccine made from these cells shields mice against developing lung cancer under conditions thought to mimic the effects of smoking. Safety concerns about injecting stem cells into humans mean that regulatory agencies are unlikely to approve human tests of the vaccine, says lead researcher John Eaton at the University of Louisville in Kentucky. Nevertheless, he thinks the vaccine is worth testing in people at high risk of developing cancer, such as heavy smokers or people...