Keyword: cholesterol
-
Alternate day fasting (ADF) has gained growing attention due to its dramatic effects on improving disordered metabolic parameters. However, the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal models. Using atherogenic mice, scientists have worked jointly and reported that ADF aggravated Western diet (WD)–induced atherosclerotic lesion formation, and they also validated that such effects were mediated by inhibiting the expression of hepatic activating transcription factor 3 (ATF3) under ADF intervention. The findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis. In this study, 11-week-old...
-
Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and tumors that develop from them, depend heavily on tramped-up production of cholesterol, according to a preclinical study. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors. The researchers analyzed mice that develop serrated polyps and tumors. They confirmed their findings in analyses of human serrated polyps and tumors and showed in mouse models that replicate the human cancer that blocking cholesterol production prevented the progression of these types of intestinal tumors. Cholesterol is considered a pro-growth molecule. "Trials of statins to prevent colorectal cancer...
-
Abnormally high levels of HDL-C, colloquially known as "good cholesterol," are associated with an increased risk of dementia in older adults, a study has found. Researchers said very high levels of HDL-C linked to dementia risk in this study were uncommon and not diet related, but more likely to reflect a metabolic disorder. The findings may help doctors to recognize a group of older patients potentially at risk of dementia. Over an average 6.3 years, participants with very high HDL-C (>80 mg/dL or >2.07 mmol/L) at study entry were observed to have a 27% higher risk of dementia compared to...
-
"Bad" cholesterol isn't the only culprit linked with a higher risk of cardiovascular disease, according to a trio of recent studies showing that a different kind of cholesterol is also a strong risk factor for people worldwide. Remnant cholesterol (RC) was confirmed as a strong risk factor for coronary heart disease, heart attacks and stroke, the largest of the studies showed. RC is produced from the metabolism of triglycerides. Using data from almost one million participants—the findings are the first to show, on a large scale, a causal link between high RC and risk of cardiovascular illness. "This tells us...
-
Obesity often involves hyperlipidemia (high concentrations of fats/lipids in the blood), diabetes, hypertension, chronic inflammation and oxidative stress, which increase susceptibility to CVD. Low-density lipoprotein (LDL) is a nanoparticle that transports cholesterol in blood. Cholesterol, which is good in moderation, is essential for normal cellular function. "Our results showed that in obesity, it is not the quantity but the quality of LDL that contributes to disease: 'bad cholesterol' becomes worse due to obesity-associated inflammation. As a result, cholesterol delivery is shifted from normal to abnormal, so more cholesterol is retained in the arterial wall, ultimately forming plaques that occlude the...
-
* Cholesterol, long vilified as the cause of cardiovascular disease, is a vital component to nearly every cell in your body for the construction of cell membranes, regulation of cell signaling and neurological health * A review of three large industry-funded studies found it was impossible for cholesterol to be the main cause of heart disease as those with low levels had the same levels of arterial sclerosis as those with high levels * The same study found benefits claimed by statin supporters are ineffective and unsafe, as statements are invalid, compromised by misleading statistics and excluding information from unsuccessful...
-
Kidney stones are a common condition that affects millions of people worldwide. While genetics and various other factors can contribute to kidney stones, dietary components play a significant role in their formation. Previous research has isolated specific dietary culprits such as high oxalate or calcium intake. However, understanding of the effects of specific dietary components on stone formation remains limited. In this study, researchers used male CD-1 mice to explore the potential correlation between dietary intake and KS. Initially, the size of urinary sediment particles was analyzed in mice that were administered with cholesterol and fruit tannins by gavage. The...
-
Patients who have suffered a heart attack should immediately be offered a combination of cholesterol lowering drugs with statins and ezetimibe, according to research. The study showed that people with acute coronary syndrome (ACS), which includes those who have experienced a heart attack or unstable angina, are 47% less likely to die within three years if they start taking a high dose statin and ezetimibe straight away, compared to those only taking a high dose statin. Researchers say that if treatment guidelines are changed to reflect these findings, it could prevent many thousands of deaths each year. The study included...
-
Whole body cryostimulation is a useful "add-on" treatment for obesity, research suggests. Levels of cholesterol and other blood fats improved twice as much in individuals, compared with individuals given a sham treatment. Those who had whole body cryostimulation (WBC) also experienced a greater reduction in waist circumference and in blood sugar levels. 29 participants (12 men and 17 women, BMI >30 kg/m2) were non-randomly allocated either to a group receiving 10 2-min WBC sessions at minus 110°C in a cryochamber over two weeks (WBC) or a control group receiving the same intervention at non-cryostimulating temperatures of minus 55°C (SHAM). Triglycerides,...
-
Atherosclerosis is a disease in which fat, cholesterol, and other substances build up inside artery walls. This can can block arteries and cause heart attacks and strokes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been shown to have anti-inflammatory and antioxidant properties, which could help to prevent the buildup of fatty deposits in arteries— a major cause of heart attacks and strokes. DHA supplements are often consumed orally, but most are poorly absorbed by the gut. . To improve the absorption, a research team worked on laboratory models to deliver DHA to the bloodstream that could be more effective...
-
In a new large, comprehensive analysis that looked at data from more than 5 million patients, the Martin/Hopkins method developed by Johns Hopkins researchers to calculate low-density lipoprotein (LDL) cholesterol—so-called bad cholesterol—produces higher accuracy rates than the nearly two dozen other available equations. The findings reveal that overall, the Martin/Hopkins algorithm correctly classified 89.6% of patients' LDL cholesterol values, followed by the Sampson method, which correctly classified 86.3%. The previous gold standard of testing LDL cholesterol levels, the Friedewald method, correctly classified 83.2% of patients. An even larger advantage of the Martin/Hopkins algorithm was seen over other methods for patients...
-
Puberty often begins early for children who are obese. Now, a team of scientists offers what may be a partial explanation. Early puberty, also known as precocious puberty, can leave children with psychological and social problems, as well as causing them to be shorter than they would otherwise be. The more body fat a child has, the greater their likelihood of beginning puberty at an earlier age. Professor Rewitz and the research team tested their hypothesis by putting fruit fly larvae on a fatty diet of cholesterol-packed foods. "We observed that larvae on the cholesterol diet consistently grew faster and...
-
A real-world, retrospective analysis by the Family Heart Foundation, a leading non-profit research and advocacy organization, found that high-risk Americans who do not maintain levels of LDL-cholesterol (LDL-C) recommended in the 2018 American College of Cardiology/American Heart Association cholesterol treatment guidelines, had a 44% higher rate of cardiovascular events compared to those who did achieve and maintained recommended LDL-C levels. The study findings were based on data from the Family Heart Database of more than 300 million Americans. "This real-world evaluation shows how important it is for people at high risk for cardiovascular events to get the care they need...
-
Blood levels of HDL, the famously "good" kind of cholesterol, may not make a big difference to heart health after all -- particularly for Black people, a large new study suggests. The study, of nearly 24,000 U.S. adults, found that low HDL levels were tied to a somewhat higher risk of heart attack among White people. That was not the case for Black adults, however. Meanwhile, high HDL levels -- traditionally lauded as heart-healthy -- made no difference in heart risks for Black or White adults. Experts said the findings call for a reevaluation of how HDL is used to...
-
New research from RCSI University of Medicine and Health Sciences has revealed that the link between 'bad' cholesterol (LDL-C) and poor health outcomes, such as heart attack and stroke, may not be as strong as previously thought. Published in JAMA Internal Medicine, the research questions the efficacy of statins when prescribed with the aim of lowering LDL-C and therefore reducing the risk of cardiovascular disease (CVD). Previous research has suggested that using statins to lower LDL-C positively affects health outcomes, and this is reflected in the various iterations of expert guidelines for the prevention of CVD. Statins are now commonly...
-
Two drugs approved decades ago not only counteract brain damage caused by Alzheimer's disease in animal models, the same therapeutic combination may also improve cognition. A promising series of early studies is highlighting two well known medicine cabinet standbys—gemfibrosil, an old-school cholesterol-lowering drug, and retinoic acid, a vitamin A derivative. Gemfibrosil, is sold as Lopid and while it's still used, it is not widely prescribed. Doctors now prefer to prescribe statins to lower cholesterol. Retinoic acid has been used in various formulations to treat everything from acne to psoriasis to cancer. The two drugs are being studied for their robust...
-
Statin use associated with type 2 diabetes progression -Doctors prescribe statins to lower cholesterol levels in a person’s blood. -This reduces their chance of developing cardiovascular disease. -Researchers have found associations between statins and decreased insulin sensitivity, which can lead to type 2 diabetes. -In the present study, the team found people with type 2 diabetes who took statins were more likely to have greater disease progression. In a new study, researchers found a link between statin use and an increased likelihood of type 2 diabetes disease progression. The research, which appears in the journal JAMA Internal MedicineTrusted Source, gives...
-
An antioxidant drug reverses atherosclerosis and could be used to prevent heart attacks and strokes due to clots. Atherosclerosis is the build-up of fatty deposits in the arteries. When a type of fat called LDL cholesterol becomes oxidized and builds up to form plaques in the artery walls, inflammation and damage increase which can cause the plaques to rupture and cause blood to clot. These clots can block vital arteries that allow blood to flow to the heart, causing a heart attack, or to the brain causing a stroke. Previously, researchers at the University of Reading discovered that LDL cholesterol...
-
My Dr. put me on a statin even though my cholesterol was only 177. She said they have a new formula they use that uses your age, weight, and some other parameters that indicated I was at an elevated risk for a heart attack. I asked her what would happen If I lost 30 lbs, could I skip the statins, she seemed to indicate yes. I am 5'9''and 205. Is anyone familiar with this new formula?
-
Key to living past 100 may hinge on your gut health, study of centenarians shows TOKYO — Centenarians have unique gut bacteria that enables them to live to a ripe old age, according to new research. Scientists in Japan say this unique gut makeup fuels bile acids that protect against disease. The discovery could lead to yogurts and other probiotic foods that increase longevity. “In people over the age of 100, an enrichment in a distinct set of gut microbes generate unique bile acids,” says lead author Professor Kenya Honda of Keio University in a statement per South West News...
|
|
|