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A blood test to screen for colorectal cancer in average-risk individuals without symptoms accurately detected the malignancy in 83% of people confirmed to have the disease, a study released Wednesday showed. The study was published in The New England Journal of Medicine. Researchers said the blood test's accuracy rate for colorectal cancer is similar to at-home stool tests. It's a promising step, they said, to developing more accessible screening tools for catching the disease early -- when it's easier to treat. The test would could improve upon low levels of colorectal cancer screening -- a major cause of cancer-related mortality...

Yesterday the Expose published an article which highlighted just a few of the various diseases that were found to be potentially caused by parasites, including cancers. A recent review of nine published research papers by Doctor William Makis further supports the views in the article, but Dr Makis is more qualified to say “it is a reasonable hypothesis that COVID-19 mRNA Vaccine Turbo Cancer patients could benefit significantly from anti-parasitic drugs.” One anti parasitic drug in particular, Fenbendazole, however, has not been sanctioned for human use by the FDA, but despite lacking “official” approval, it is cheap, safe and more...

Colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is a challenging disease to treat with a relatively poor prognosis. However, recent advances in treatment strategies have led to improved outcomes for patients with SPM. The optimal treatment approach for CRC with SPM remains controversial. A growing body of evidence suggests that comprehensive treatment, including cytoreductive surgery (CRS), chemotherapy, and hyperthermic intraperitoneal chemotherapy (HIPEC), may improve patient outcomes. A recent study evaluated the treatment strategies and outcomes of patients with CRC with SPM. The study included a large sample of patients and the findings suggest that comprehensive treatment was associated with...

Urolithin A, a metabolite of ellagitannins in pomegranates, boosts immune cells’ ability to combat tumors by inducing a process known as mitophagy. STORY AT-A-GLANCE Urolithin A (UA) has emerged as a powerhouse player in the fight against cancer, as it may naturally boost tumor-fighting immune cells. UA is a metabolite of ellagitannins in pomegranates that has anti-inflammatory and anticancer effects. UA “recycles and renews mitochondria” by inducing a biological pathway known as mitophagy—the process of cleaning out your mitochondria, allowing them to function at their best. This changes T cells’ genetic program, making them more able to fight tumors. In...

High levels of ammonia in tumors leads to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, findings revealed. Researchers found that ammonia inhibits the growth and function of T cells, which are vital for anti-tumor immunity. "We identified the mechanism of how ammonia dysregulates T cell function and showed that reducing ammonia levels using FDA-approved drugs for hyperammonemia can reduce tumor size in several different models including metastatic colorectal cancer," says Hannah Bell, Ph.D. "Use of this drug also synergizes with immunotherapy. If you treat mice with immunotherapy when you also treat them with this ammonia...

Regular physical activity can extend colorectal cancer patients' lives. In a first-ever study, scientists looked at the impact of exercise on the gut microbiome of cancer patients and reported a positive association. Researchers found physical activity was also beneficial to obese cancer patients, who typically have a less healthy gut microbiome. The team found that regular physical activity can aid in creating a healthy gut microbiome, while also reducing inflammation. These findings were reported in patients independent of their body mass index (BMI). "A patient who is active has a more diverse microbiome and lower abundances of colorectal cancer-promoting bacteria,...

New clinical research shows that lamivudine, a reverse transcriptase inhibitor widely used in HIV therapy, stopped disease progression in 25% of patients with fourth-line metastatic colorectal cancer. Findings from the trial raise the possibility of an unexpected promising direction in cancer treatment, not just colorectal cancer. The trial included 32 patients with advanced metastatic colon cancer whose disease progressed despite four lines of previous cancer treatments. The first nine patients received the standard HIV-approved dose of lamivudine. "After giving them only this one drug—nothing else—we saw signs of disease stability," says co-senior author David T. Ting, MD, of the Mass...

A new meta-analysis by researchers adds to evidence that taller adults may be more likely than shorter ones to develop colorectal cancer or colon polyps that can later become malignant. While the association between taller height and colorectal cancer has been previously investigated, the researchers say those studies offered conflicting results, carried inconsistent measures of height and failed to include the risk of adenomas, which are precancerous colon polyps. "This is the largest study of its kind to date. It builds on evidence that taller height is an overlooked risk factor, and should be considered when evaluating and recommending patients...

Actor Chadwick Boseman died last year at the age of 43 from stage 4 colon cancer. The “Black Panther” star represents a troubling trend of men younger than 49 who are at an unusually high risk of dying from colorectal cancer. According to a study published in the American Journal of Cancer Research, despite the overall reduction in the cases of colorectal cancer in America, there are geographical “hot spots” where cases of this potentially deadly cancer are soaring. June is National Men’s Health Month and it is critical that American men pay attention to their risk factors for developing...

A new paper in JNCI Cancer Spectrum, published by Oxford University Press, indicates that several non-genetic factors — including greater red meat intake, lower educational attainment, and heavier alcohol use — are associated with an increase in colorectal cancer in people under 50. In the United States, incidence rates of early-onset colorectal cancer have nearly doubled between 1992 and 2013 (from 8.6 to 13.1 per 100,000), with most of this increase due to early-onset cancers of the rectum. Approximately 1 in 10 diagnoses of colorectal cancer in this country occur in people under 50. Researchers have observed the rise particularly...

Based on survival rates at 5 years for stage III-IV CRC, the results showed a significant 11.9% increase in deaths when comparing a 0-3 month delay to a >12 month delay. New research presented today at UEG Week Virtual 2020 has shown that delays in colorectal cancer (CRC) screening caused by COVID-19 has resulted in significantly increased death rates for the cancer. Researchers at the University of Bologna produced a model to forecast the impact of time delays in CRC screening on CRC mortality caused by COVID-19. The results found that moderate (7-12 months) and large (>12 months) delays in...

Clever and well written. https://www.youtube.com/embed/ _43f9RzAqMM

Dr. Boone Goodgame, an assistant professor in the departments of internal medicine and oncology at the University of Texas at Austin, and his colleagues focused on more recent trends. Using data from the National Cancer Database registry, they found that 12.2% of colorectal cancer diagnoses in the U.S. in 2015 were in people under the age of 50 years compared with 10% in 2004. The team also found that the percentage of colorectal cancer diagnoses in younger individuals went up in urban but not rural regions. In addition, doctors detected signs of advanced disease in more than half (51.6%) of...

A new study finds that compared to people born around 1950, when colorectal cancer risk was lowest, those born in 1990 have double the risk of colon cancer and quadruple the risk of rectal cancer. The study is led by American Cancer Society scientists and appears in the Journal of the National Cancer Institute. It finds colorectal cancer (CRC) incidence rates are rising in young and middle-aged adults, including people in their early 50s, with rectal cancer rates increasing particularly fast. As a result, three in ten rectal cancer diagnoses are now in patients younger than age 55. Overall, CRC...

LONDON (Reuters) - Scientists said on Tuesday they may have found a reason why eating too much red meat increases the risk of colorectal cancer. By studying cells from volunteers eating different diets, they discovered that red meat raises levels of compounds in the large bowel, which can alter DNA and increase the likelihood of cancer. "It is the first definite link between red meat and the very first stage in cancer," said Professor Sheila Bingham, of the Medical Research Council Dunn Nutrition Unit in Cambridge, England. In earlier research, Bingham and her team showed there was a strong correlation...

Potentially cancerous growths missed 95 percent of the timePHILADELPHIA - A common screening test failed to detect potentially cancerous colon growths 95 percent of the time, falsely reassuring patients and doctors, according to a new study.Researchers found that the digital, in-office test on stool samples was not as reliable as a six-sample test given to patients to do on their own at home — although even that test detected potentially cancerous growths less than 24 percent of the time."What we found is that it was pretty worthless," Dr. David Lieberman, one of the study's authors, said of the in-office test....