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The COVID-19 pandemic has driven great interest in the therapeutic potential of repurposed drugs with well-established benefits and safety profiles (toxicity, bioavailability, etc.), many of which act via signal transduction pathways. One category of such drugs is those that reduce acid production in gastroenterological contexts. Acid-suppressing drugs belong to two main classes, based on their mechanisms of action: (i) proton-pump inhibitors (PPIs) sterically block H+/K+-ATPase pumps, impeding the final step of acid release in the gastric mucosa. (ii) Histamine H2 receptor antagonists (H2RA) competitively bind the H2R, a type of G-protein coupled receptor (GPCR),1 and block the natural stimulation of...

The Nationwide Crime Wave Is Building As the homicide rate keeps rising in many cities, even some who dismissed the ‘Ferguson effect’ admit the phenomenon is real. By Heather Mac Donald May 23, 2016 Federal Bureau of Investigation Director James Comey has again drawn the wrath of the White House for calling attention to the rising violence in urban areas. Homicides increased 9% in the largest 63 cities in the first quarter of 2016; nonfatal shootings were up 21%, according to a Major Cities Chiefs Association survey. Those increases come on top of last year’s 17% rise in homicides in...

President Obama's foreign policy has provided many examples of leading from behind. The expression "leading from behind," as used in this article, means: 1. Waiting while allies decide what to do and then following along. Doing that assumes substantial congruity of interest with our allies. To the extent that such congruity may exist at all, it is neither uniform nor perpetual nor consistent. 2. "Leading from behind" also, and of more significance here, means reactive leadership -- waiting for a bad and perhaps irreversible situation to develop and then scrambling to find politically convenient explanations to offer and actions to...

Typically, a foreign consulate in the United States doles out passports, helps travelers in crisis and serves as a liaison to the home country. But the Mexican Consulate in Los Angeles has become an almost de facto public agency in recent years, forming partnerships with government officials and nonprofits here to provide healthcare, offer mental health counseling, fight labor violations and hold literacy classes. The consulate took another step earlier this year to meet the needs of Mexicans living in L.A. County by teaming up with the Superior Court and the county's Department of Children and Family Services to regularly...

Dennis Kucinich is currently on the floor of the House presenting his bill to impeach President George W. Bush. C-SPAN, 8:00 PM 9 Jun 2008.

The owner of Towne Market Mobil in this suburb north of Milwaukee shut down his pumps for 24 hours, hoping to start a movement aimed at persuading oil companies to lower their prices. "Somebody out there is making money at these prices, but not me," said Pollack, 57. "So I just thought: What can I do to help the consumer?" Yellow caution tape surrounded Pollack's six idle pumps for his protest, which drew dozens of drivers. One in a green minivan rolled down her window and shouted "Thank you!" Maria McClory, 38, drove 10 miles out of her way to...

WASHINGTON, May 11, 2006 – Continuing America's longstanding tradition of helping those in need, the U.S. Navy recently deployed the hospital ship USNS Mercy on a proactive humanitarian mission to Southeast Asia, the commander of the U.S. Pacific Fleet said here yesterday. "The Mercy deployment (is) an exciting and important opportunity to assist friends and neighbors in the Asia-Pacific region, and to facilitate the security and stability and the prosperity, particularly in the maritime domain, in this region, in which we all share common interests," U.S. Navy Adm. Gary Roughead said during a State Department Foreign Press Center briefing. The...

Lt. Col. Joe Faucett will start his 16-hour return trip to active duty with the United States Army in Iraq on Monday, Jan. 23, after spending a 15-day leave with his family in the Marinette/Menominee area. It was his first visit home since being deployed to Iraq 8 months ago. Much as he hates to leave his family again, Faucett said United States forces need to stay in Iraq until the job is done. That, he believes, will be when the Iraqis are able to take over security for their own country. He expects his own tour of duty there...

A new opinion poll by Zogby International indicates Americans are hardly pleased with the Bush administration on the subject of illegal immigration. The poll, cited on CNN's "Lou Dobbs Tonight" program yesterday, noted a huge majority – 81 percent – believes local and state police should help federal authorities enforce laws against illegal immigration. Only 14 percent disagreed. Voters were also asked, "Do you support or oppose the Bush administration's proposal to give millions of illegal aliens guest worker status and the opportunity to become citizens?" Only 35 percent gave their support, and 56 percent said no. "A majority opposed...

CAIRO, Egypt (AP) - A militant group posted a video on the Web on Wednesday showing gunmen killing execution-style two Iraqis said to have set up an Internet system in northern Iraq to help in this month's elections. The two men are shown in the video kneeling blindfolded next to a stone wall before being shot in the head. "This is the end of any apostate who cooperates with the crusader troops in Iraq in their war against Islam," the militant group Ansar al-Sunnah Army said in a statement screened on the video after the slaying. The group accused the...

Inspectors from Federal Protective Services — a branch of the Homeland Security Department — arrested a Bettendorf chiropractor Friday accused of making harassing phone calls to the Department of Veterans Affairs office in Des Moines. Kenneth C. Tennant, 45, 3447 Magnolia Court, remained in the Polk County, Iowa, jail late Friday afternoon, charged with third-degree harassment. Although it is a state charge — and a misdemeanor — Federal Protective Service, or FPS, personnel were involved because the VA office is a federal facility, said special agent Wil Calvey. The FPS provides law enforcement and security services to more than 1...

DISTRIBUTION A: Approved for public release; distribution is unlimited. Document created: 25 March 02Aerospace Power Journal - Spring 2002Fighting Stupid, Defending Smart Col Richard Szafranski, USAF, Retired Editorial Abstract: Are America’s terrorist enemies smart or stupid? From the attacks of 11 September 2001, the author deduces that their intent is to destroy our economic strength and that by openly announcing their strategy, they have committed a cardinal error. He argues that a smart defense concentrates on defending the pillars of US economic strength while conducting the offensive war against terrorism.   To bend the enemy’s will, one must put him...

This as an ACTION PLAN for PASSIONATE CONSERVATIVES to counter the lefts anti-war demonstrations using small groups of patriots to reach the most people: (1) Utilize key highway OVERPASSES to get out our message. Anti-war activists are already using some of these bridges to display their banners. If so, monitor their websites to obtain day and time of their banner placement. Place our banners before they arive. (2) COUNTER DEMONSTRATIONS include waving Old Glory (Rally 'Round the Flag) and holding large banner(s). Don't tie banner to overpass fence as this is illegal. You do have the constitutional right to hold...