I was raised a secular humanist, and never had an interest in things spiritual until I did psilocybin in college. Given the right set, setting and dosage, the stuff does seem to have the power to direct one's attention towards the Divine. In my case, that ended up being Christian mysticism, wherein I learned that you can attain even higher states through prayer, meditation, fasting, liturgical ceremonies, and other non-drug techniques.
I never got to experience the spiritual side of mushrooms. I was too busy laughing.