Posted on 03/21/2022 8:54:49 PM PDT by ConservativeMind
A study has identified a key regulatory mechanism in inflammation that may lead to new targets for resolving that inflammation—and the inflammation of patients with sepsis, cancer and COVID.
The scientists discovered a pathway that regulates the immune response after infection or injury, such as burns. Dysregulation of this pathway could differentiate those who are at risk of fatal sepsis or help identify targets to resolve this unregulated inflammation.
The team found that the metabolites of linoleic acid formed by the enzyme, soluble epoxide hydrolase (sEH), drive deleterious inflammation after injury. These metabolites, known as lipid mediators, regulate inflammation, blood pressure and pain. Drugs that inhibit the sEH enzyme and resolve inflammation could lead to a better patient outcome.
…"This dysregulation has fatal consequences in serious diseases such as COVID, cancer, sepsis, burn, where fatality rates can be as high as 40 percent in severe cases," she said.
"The immunological disbalance we see in many cases of severe burn injury, trauma and sepsis pose a huge clinical challenge as we lack the understanding of how to diagnose and treat it," said co-lead author Dr. Christian Bergmann. "With this work, we reveal an important mechanism how immune cells are functionally disabled by sEH-derived metabolites of linoleic acid."
"The natural compounds we are studying in this paper are metabolites of linoleic acid (LA), an essential fatty acid the body needs in very small amounts to survive and is only available through the diet," McReynolds explained. "At lower concentrations, these metabolites are necessary for regulating thermogenesis and heart health but promote inflammation at higher concentrations."
"At higher concentrations, the immune system was unable to properly respond to infection, thereby promoting a sustained immune response."
(Excerpt) Read more at medicalxpress.com ...
Monounsaturated and saturated fats do not directly affect that ratio, but replacing Omega-6 fat with either would help bring it down.
I get a lot of Omega 3s. A test said I need more of some Omega 6s.
You are the first person I have heard had that problem.
Interesting.
Olive oil is one of the highest in linoleic acid. It’s not an industrial seed oil and has been associated with many health benefits.
What gives?
I did a quick search, and found this article on REDUCING Omega-3 and INCREASING Omega-6, in diets....
https://www.samterssociety.org/the-omega-diet
It’s for a specific ailment, but....the guidelines of what to eat/avoid may be beneficial.
“Area percentage of linoleic acid in borage oil is 38.47%, in evening primrose oil is 74%, in canola oil 20.12%, in corn oil 59.27%, in sunflower oil 71.17%, in cottonseed oil 56.35%, in linseed oil 15.18%, in soybean oil 56%, in olive oil, 7%, in extra olive virgin oil 8.64%, in olive pomace oil 10.33%, in peanut oil 31%, in rice bran oil 36.28%, in palm oil 10.62% and in palm kernel oil 2.76%.”
https://www.news-medical.net/health/Oils-Rich-in-Linoleic-Acid.aspx
I don’t think many people do some of these tests.
Olive oil is one of the highest in linoleic acid.
- - - - - -
Source?
Anyone who uses soy, corn, sunflower, or cottonseed oil gets a lot of Omega-6 fat.
It’s hard to eat more Omega-3 fat, over Omega-6 fat.
Omega 6 and omega 3 fats should be reduced.
Omega 3 fats smell disgusting and people naturally avoid them.
The omega 3 PR is a scam to sell a waste product for billions of dollars.
- - - - - - -
Seed oils are high in omega 6 fats. People started using them because they were cheaper. They cause obesity and cancer.
As the percentage of fat in people’s bodies that is omega 6 fats increases, they break records on frequency of obesity and cancer.
- - - - - - -
Sardines packed in olive oil taste better and are healthier because they have less omega 3 fats.
The omega 3 fats move to the oil that you can throw away.
The article I linked, upthread, lists deep fried foods as one of the Omega-3 culprits....as well as processed foods and baked goods.
Jane, the article you posted is completely describing REDUCING OMEGA-6 and INCREASING OMEGA-3.
You didn’t read your own article.
You have it exactly backwards.
I know...I just looked, again.....with glasses :)
Sorry about that....and, I *almost* made a screen grab, of their chart...yikes.
Thanks.
👍🏻
So eat more salmon and sardines (wild-caught is better, but farmed is better than nothing)and supplement. The generic Omega-3s at Costco and Sams Club are very cheap compared to the benefits - and priceless if they give you extra years of healthy life.
Bttt.
now maybe the Medical Industrial Complex can figure out the key regulatory mechanisms that allow them to get away with declaring false pandemics and charging whatever they feel like charging for medical billing
A good rule is any food that the children of Israel were given in abundance in the Promised Land is probably good for you.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.