Posted on 01/31/2023 2:05:08 PM PST by ConservativeMind
Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction. The intestinal barrier plays a vital role in the process of sepsis, and its disruption exacerbates sepsis.
A study has found that promoting autophagy, the process by which cells break down and destroy damaged or abnormal proteins, with rapamycin, an immunosuppressant, reduced intestinal epithelial cell death and restored intestinal barrier function during sepsis.
The study also suggests that the interplay of mammalian target of rapamycin (mTOR), a negative regulator of autophagy, and polo-like kinase 1 (PLK1) is crucial in sepsis-induced barrier dysfunction and may provide novel insights for treatment of sepsis.
In the study, mice were subjected to cecal ligation and puncture (CLP), a perforation of the cecum allowing the release of fecal material into the peritoneal cavity, which established a sepsis model in vivo.
Compared to mice in sham group, the CLP mice had severe intestinal mucosal injury and increased intestinal mucosal permeability. Under rapamycin treatment, activation of autophagy inhibited enterocyte apoptosis and restored the disrupted intestinal barrier, suggesting that autophagy plays a protective role in sepsis-induced intestinal barrier dysfunction.
To determine whether the protective role of PLK relies on autophagy, mice modified with the PLK1 gene (CAG-PLK1 mice) underwent CLP. Activation of autophagy was observed, and apoptosis was alleviated. However, these ameliorative phenomena deteriorated in mice treated with chloroquine, an inhibitor of autophagy, compared with mice treated with rapamycin.
To further explore whether PLK1 promotes autophagy via the mTOR pathway in intestinal epithelial cells, the investigators observed the physical interaction between PLK1 and mTOR in an in vitro model of human colonic epithelial cells. They found that PLK1 also promotes cell autophagy and improves autophagy and high permeability.
(Excerpt) Read more at medicalxpress.com ...
It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis
https://pubmed.ncbi.nlm.nih.gov/23193422/
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https://www.sciencedaily.com/releases/2007/11/071108115608.htm
I got sepsis in 1999 apparently from some kind of rotator cuff injury in my shoulder I didn’t even know I had.
My wife was sure I was in critical condition but the doctor said it was serious, not critical.
I was in the hospital for nine days. My doctor said he would get a specialist and when the specialist walked in I could swear the guy was Columbo - rumpled clothes and ragged look, but this guy knew what he was doing. Quite an episode.
Over the years I have read anecdotal reports of miraculous recoveries after IV injections of mega doses of Vitamin C -— 15,000 mg (?) or more. However, I didn’t save the stories at the time.
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