[NVD]

This article obviously is referring to genetic mutations. But, what is a mutation? Since each gene is a code of instructions, a mutation is akin to a typing error a changed letter here, a spelling error there. But, this poses a problem for the evolutionary philosophy; if you introduce a missing phrase or spelling errors into a report, it is unlikely to make the report more understandable. As we can see in your post, most mutations are harmful, and sometimes lethal, so if the mutations were to accumulate, wouldn't the result be devolution?

[RightWhale]

wouldn't the result be devolution

The contrary to evolution in involution, not devolution. Evolution does not imply linear progress, even though Huxley and the other soldiers of Darwinism took that stance.