Heck, yeah!
I've consolidated around .45 ACP, 9mm, and 7.62x39.
A good friend of mine went one step further and consolidated around 9mm and 5.56/.223 ONLY.
I'm kind of built around .45 ACP, .223, and .308. Also have a ton of .40 S&W, some .38, .44 mag, .357 mag., and even some .22. But in a pinch, the .45, .223, and .308 (and maybe the .40) would be my choices.
I need a 9 mm - they're common.