It sounds like an allergy, as others have mentioned. Does your family use Tide laundry detergent? I did for decades, and every once in a while, more often during the winter, I would get strange itching, redness, puffiness. Often where my clothes were making tighter contact with my body, like my waist. But sometimes in areas, like my lips, that were not in contact with any clothes. I tried everything to figure it out. Eventually I discovered it was from washing my clothes in Tide laundry detergent. Once I figured out the problem, it was easy to find that many others, on the web, have this problem. I switched to All laundry detergent, which says it is hypoallergenic, and I was cured/never had the problem again. Not to bash Tide, it’s a fine product, but just stating my reality.
Our family is a bundle of allergies, so my daughter only uses certain detergents without fragrance, etc.
Thanks for your reply. Grandson seems to be on the mend now, and I am one relieved grandma. :-0