Bella Twin, a tiny Cree woman, shot and killed a world record grizzly bear with a single shot .22 rifle in 1953.
http://gunwatch.blogspot.com/2017/06/bella-twin-22-used-to-take-1953-world.html
Kudos to Bella. Also, obviously, someone was looking out for her.
Bella knew about Shot Placement...
In The Temple,
Between the Ear and Eye.