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Me, too! I am usually a very positive person, but, several years ago, I got "the blues" for much longer than a day or two. Since I am a Christian, I thought I could just give it up to God and He would take care of it, but that did not seem to be working. My husband convinced me to go visit my doctor of over 25 years at the time and he gave me some samples of Celexa which was a fairly new drug back then. He cautioned me that it might take 3-4 weeks to notice a difference, but my husband will tell you to this day that he could see a change in me in a week! I have a MA in Biology and am a Medical Technologist as well so I know all about the placebo effect, but I strongly believe that the medication made all the difference in my situation. I still take it today, but have cut back to half a tablet.