My guess is the last scene of the last episode will reveal the entire series to be a dream by House who is a mass murderer locked up in an insane asylum.
I can't think of a good ending, but that might tick me off.
I don't watch a lot of tv, but made the exception this season with House, that I used to watch regularly.
Whoa! I saw in a small piece of the previews that House was propped up against a stone wall.....like in a Hannibal Lecter cell wall........now wouldn’t that be a hoot??? LOL