Your comment about .45 is ridiculous.
As a hunter, and someone who grew up in/around guns (primarily rifles), you see a lot of deer shot.
Here’s the breakdown
1) KNOCKDOWN It matters WHERE you get shot. Caliber/FPS makes no difference if you don’t hit large mass. Arm/leg through and through does not knock down. IF you hit a bone, FPS / Caliber does not matter, you get knockdown. The ONLY slight edge a big, slow bullet has is in knockdown.
2) GET UP - after knockdown, the deer can still get up, it’s running on adrenaline. It can’t get up though if heart or headshot, or broken support bone.
3) RUNOFF - the less blood, the longer the animal can continue to run/struggle.
4) SHOCK — This occurs NO matter if you get a major hit or not, the animal CHANGES it behavior. If it’s a human shooter, he ducks/covers INSTINCTIVELY even if he has no fear — he will come out after his instincts take over.
ANY GUN is better. They GUN you left at home that’s a .45 is worse than a .22 revolver. BTW, a LOT of people have been killed with a .22 it’s a nasty round, especially in hollow point.
Gunblast has a great video of a professional shooter (the bearded guy) who can put 10 .22 holes in the size of a end of a cup at 10 yards in 3 seconds. About twice as fast/accurate as when he shoots 9mm or .45
My friend who is an retired cop was making the point that had he been in the theatre with his .45 and had gotten a shot off on the Aurora shooter, that would have knocked him off his game so he may have been stopped. A 9mm would not have been effective against the body armor. Made enough since to me that I've decided to trade a couple 9's for the new Springfield XDS .45..To each is own