Size - 150lbs - does matter in a wolf. At that size, they can clamp your throat and drag you off like a bunny.
Imagine the european wolves that clandestinely mated with the English Mastiffs the Lords and King kept... 300lbs of pure nightmare that kept you from poaching the King’s deer and more than likely spawned the Werewolf meme 500 years ago.
My point was, whatever their size...if you have no defense, they are all deadly.