Free Republic
Browse · Search
General/Chat
Topics · Post Article

To: RinaseaofDs; ElenaM

http://www.ncbi.nlm.nih.gov/pubmed/24860690

This was the most helpful phylogeny paper for me.

It still shows a different branch than Reston.

HOWEVER, that’s sequence identity over the whole genome. I wonder how different the sequence from the pneumovirus analog ElenaM mentioned is for its homologues in Reston and Zebola Guinea.

If that protein were to be involved in airborne transmission that could be expected to show similarity at least between Reston and Zebola Guinea.


2,100 posted on 09/17/2014 12:28:10 PM PDT by Black Agnes
[ Post Reply | Private Reply | To 2097 | View Replies ]


To: Black Agnes

http://www.ncbi.nlm.nih.gov/pubmed/23689899

Now THIS was a fun abstract.


2,103 posted on 09/17/2014 12:55:56 PM PDT by Black Agnes
[ Post Reply | Private Reply | To 2100 | View Replies ]

To: Black Agnes
Fascinating paper, thank you! I like the way they covered all their bases in the conclusion.

The phylogenetic analysis of the five ebolavirus species here does not substantially improve on that presented by Baize et al. in that even when partitioning the alignment into coding and non-coding regions we get inconsistent rooting positions for the EBOV clade. We believe that at present no suitable outgroup sequences to root the EBOV phylogeny exist and that a temporal rooting gives the most consistent results.

This approach indicates that the outbreak in Guinea is likely caused by a Zaire ebolavirus lineage that has spread from Central Africa into Guinea and West Africa in recent decades, and does not represent the emergence of a divergent and endemic virus.

As the GP sequences show, without more diverse sequences, especially those from the animal reservoir, it is difficult to narrow down the estimates of when and through what means the Central African EBOV lineage has been introduced into West Africa.

I haven't located any information on the analogous pneumoviridae protein or comparison with the Ebola version. If you find something please share.

2,148 posted on 09/18/2014 5:24:27 AM PDT by ElenaM
[ Post Reply | Private Reply | To 2100 | View Replies ]

Free Republic
Browse · Search
General/Chat
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson