I’ve been running a bunch (250-ish) through my Springfield XD. Problem or not, do you think?
If I could always count on perfect hits I'd use a .22lr and aim for the eyes, accuracy will always be your best friend.
I used to get into the round ball debate, everyone else was going for .54s, 58s, and me with my little .45. I could put a .45 round ball in the neck and the deer would be DRT, no muss no fuss, no drama. My old rig is scary accurate, why waste powder and lead?